YGR069W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR069W / YGR069W

Click on Significant Values for Screen Details ID:SGTC_113|Compound:0099-0221|FD-Score:3.70|P-value:2.84E-4 ID:SGTC_170|Compound:4197-0004|FD-Score:4.43|P-value:1.80E-5 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:8.36|P-value:3.00E-15 ID:SGTC_308|Compound:4092-1169|FD-Score:-4.33|P-value:2.62E-5 ID:SGTC_358|Compound:0075-0058|FD-Score:-4.57|P-value:9.81E-6 ID:SGTC_464|Compound:bw-b 70c|FD-Score:-3.82|P-value:1.75E-4 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:6.08|P-value:7.17E-9 ID:SGTC_776|Compound:4476-4378|FD-Score:3.60|P-value:3.97E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:-3.41|P-value:7.08E-4 ID:SGTC_1040|Compound:k898-0338|FD-Score:3.36|P-value:8.59E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:3.55|P-value:4.74E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:4.29|P-value:3.13E-5 ID:SGTC_1325|Compound:1431-0015|FD-Score:-4.04|P-value:7.83E-5 ID:SGTC_1361|Compound:1608-0041|FD-Score:-3.49|P-value:5.55E-4 ID:SGTC_1447|Compound:4239-0816|FD-Score:-3.38|P-value:7.93E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:-3.31|P-value:9.96E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:6.00|P-value:1.10E-8 ID:SGTC_1789|Compound:tunicamycin|FD-Score:-4.20|P-value:4.31E-5 ID:SGTC_2188|Compound:6126565|FD-Score:4.33|P-value:2.74E-5 ID:SGTC_2204|Compound:7233102|FD-Score:-3.36|P-value:8.35E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:3.96|P-value:1.13E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:-3.75|P-value:2.31E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:3.39|P-value:7.93E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:-5.39|P-value:2.42E-7 ID:SGTC_2801|Compound:7907800|FD-Score:-3.54|P-value:4.64E-4 ID:SGTC_2805|Compound:7950783|FD-Score:5.23|P-value:5.38E-7 ID:SGTC_2807|Compound:7945238|FD-Score:-3.91|P-value:1.30E-4 ID:SGTC_2812|Compound:7970281|FD-Score:3.69|P-value:2.89E-4 ID:SGTC_2878|Compound:9043973|FD-Score:3.81|P-value:1.88E-4 ID:SGTC_2900|Compound:5328528|FD-Score:-3.54|P-value:4.74E-4 ID:SGTC_2909|Compound:7941780|FD-Score:4.54|P-value:1.16E-5 ID:SGTC_2917|Compound:7979103|FD-Score:3.82|P-value:1.84E-4 ID:SGTC_2926|Compound:9010726|FD-Score:-4.00|P-value:9.08E-5 ID:SGTC_3025|Compound:9087895|FD-Score:5.29|P-value:3.94E-7 ID:SGTC_3037|Compound:9091026|FD-Score:6.88|P-value:7.02E-11 ID:SGTC_3048|Compound:9093155|FD-Score:5.18|P-value:6.65E-7 ID:SGTC_3050|Compound:9093513|FD-Score:-6.23|P-value:2.91E-9 ID:SGTC_3052|Compound:9092717|FD-Score:-3.38|P-value:7.98E-4 ID:SGTC_3053|Compound:9095903|FD-Score:4.58|P-value:9.91E-6 ID:SGTC_3054|Compound:9094397|FD-Score:7.31|P-value:4.46E-12 ID:SGTC_3064|Compound:1327-0027|FD-Score:3.72|P-value:2.59E-4 ID:SGTC_3145|Compound:9085516|FD-Score:4.28|P-value:3.27E-5 ID:SGTC_3160|Compound:9100216|FD-Score:3.63|P-value:3.62E-4 ID:SGTC_3216|Compound:9129716|FD-Score:-11.90|P-value:4.27E-29 ID:SGTC_3217|Compound:9129673|FD-Score:-8.61|P-value:4.32E-16 ID:SGTC_3222|Compound:9128301|FD-Score:-3.34|P-value:8.96E-4 ID:SGTC_3253|Compound:9135987|FD-Score:3.34|P-value:9.15E-4 ID:SGTC_3264|Compound:9137442|FD-Score:3.75|P-value:2.36E-4 ID:SGTC_113|Compound:0099-0221|FD-Score:3.70|P-value:2.84E-4 ID:SGTC_170|Compound:4197-0004|FD-Score:4.43|P-value:1.80E-5 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:8.36|P-value:3.00E-15 ID:SGTC_308|Compound:4092-1169|FD-Score:-4.33|P-value:2.62E-5 ID:SGTC_358|Compound:0075-0058|FD-Score:-4.57|P-value:9.81E-6 ID:SGTC_464|Compound:bw-b 70c|FD-Score:-3.82|P-value:1.75E-4 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:6.08|P-value:7.17E-9 ID:SGTC_776|Compound:4476-4378|FD-Score:3.60|P-value:3.97E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:-3.41|P-value:7.08E-4 ID:SGTC_1040|Compound:k898-0338|FD-Score:3.36|P-value:8.59E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:3.55|P-value:4.74E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:4.29|P-value:3.13E-5 ID:SGTC_1325|Compound:1431-0015|FD-Score:-4.04|P-value:7.83E-5 ID:SGTC_1361|Compound:1608-0041|FD-Score:-3.49|P-value:5.55E-4 ID:SGTC_1447|Compound:4239-0816|FD-Score:-3.38|P-value:7.93E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:-3.31|P-value:9.96E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:6.00|P-value:1.10E-8 ID:SGTC_1789|Compound:tunicamycin|FD-Score:-4.20|P-value:4.31E-5 ID:SGTC_2188|Compound:6126565|FD-Score:4.33|P-value:2.74E-5 ID:SGTC_2204|Compound:7233102|FD-Score:-3.36|P-value:8.35E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:3.96|P-value:1.13E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:-3.75|P-value:2.31E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:3.39|P-value:7.93E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:-5.39|P-value:2.42E-7 ID:SGTC_2801|Compound:7907800|FD-Score:-3.54|P-value:4.64E-4 ID:SGTC_2805|Compound:7950783|FD-Score:5.23|P-value:5.38E-7 ID:SGTC_2807|Compound:7945238|FD-Score:-3.91|P-value:1.30E-4 ID:SGTC_2812|Compound:7970281|FD-Score:3.69|P-value:2.89E-4 ID:SGTC_2878|Compound:9043973|FD-Score:3.81|P-value:1.88E-4 ID:SGTC_2900|Compound:5328528|FD-Score:-3.54|P-value:4.74E-4 ID:SGTC_2909|Compound:7941780|FD-Score:4.54|P-value:1.16E-5 ID:SGTC_2917|Compound:7979103|FD-Score:3.82|P-value:1.84E-4 ID:SGTC_2926|Compound:9010726|FD-Score:-4.00|P-value:9.08E-5 ID:SGTC_3025|Compound:9087895|FD-Score:5.29|P-value:3.94E-7 ID:SGTC_3037|Compound:9091026|FD-Score:6.88|P-value:7.02E-11 ID:SGTC_3048|Compound:9093155|FD-Score:5.18|P-value:6.65E-7 ID:SGTC_3050|Compound:9093513|FD-Score:-6.23|P-value:2.91E-9 ID:SGTC_3052|Compound:9092717|FD-Score:-3.38|P-value:7.98E-4 ID:SGTC_3053|Compound:9095903|FD-Score:4.58|P-value:9.91E-6 ID:SGTC_3054|Compound:9094397|FD-Score:7.31|P-value:4.46E-12 ID:SGTC_3064|Compound:1327-0027|FD-Score:3.72|P-value:2.59E-4 ID:SGTC_3145|Compound:9085516|FD-Score:4.28|P-value:3.27E-5 ID:SGTC_3160|Compound:9100216|FD-Score:3.63|P-value:3.62E-4 ID:SGTC_3216|Compound:9129716|FD-Score:-11.90|P-value:4.27E-29 ID:SGTC_3217|Compound:9129673|FD-Score:-8.61|P-value:4.32E-16 ID:SGTC_3222|Compound:9128301|FD-Score:-3.34|P-value:8.96E-4 ID:SGTC_3253|Compound:9135987|FD-Score:3.34|P-value:9.15E-4 ID:SGTC_3264|Compound:9137442|FD-Score:3.75|P-value:2.36E-4

Top fitness defect scores for YGR069W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_219 mitoxanthrone 8.36 164.4 µM 3.00E-15 DNA intercalators 13 3.04E-17
2 SGTC_3054 9094397 7.31 49.5 µM 4.46E-12 fatty acid desaturase (OLE1) 4 1.31E-13
3 SGTC_3037 9091026 6.88 49.5 µM 7.02E-11 NEO1-PIK1 30 3.07E-12
4 SGTC_471 1-acyl-paf 6.08 4.0 µM 7.17E-9 DNA intercalators 6 6.12E-10
5 SGTC_1520 flindersine 6.00 88.0 µM 1.10E-8 8 9.95E-10
6 SGTC_3025 9087895 5.29 49.5 µM 3.94E-7 PDR1 23 5.97E-8
7 SGTC_2805 7950783 5.23 58.4 µM 5.38E-7 8 8.53E-8
8 SGTC_3048 9093155 5.18 49.5 µM 6.65E-7 1 1.09E-7
9 SGTC_3053 9095903 4.58 49.5 µM 9.91E-6 Golgi 3 2.38E-6
10 SGTC_2909 7941780 4.54 10.5 µM 1.16E-5 8 2.85E-6
11 SGTC_170 4197-0004 4.43 226.0 µM 1.80E-5 12 4.72E-6
12 SGTC_2188 6126565 4.33 140.7 µM 2.74E-5 mitochondrial processes 9 7.59E-6
13 SGTC_1206 3978-0017 4.29 132.0 µM 3.13E-5 ERG2 24 8.83E-6
14 SGTC_3145 9085516 4.28 49.5 µM 3.27E-5 fatty acid desaturase (OLE1) 19 9.30E-6
15 SGTC_2605 digitonin 3.96 300.0 nM 1.13E-4 29 3.82E-5
16 SGTC_2917 7979103 3.82 53.8 µM 1.84E-4 33 6.65E-5
17 SGTC_2878 9043973 3.81 26.0 µM 1.88E-4 23 6.83E-5
18 SGTC_3264 9137442 3.75 49.5 µM 2.36E-4 18 8.84E-5
19 SGTC_3064 1327-0027 3.72 10.0 µM 2.59E-4 12 9.83E-5
20 SGTC_113 0099-0221 3.70 2.5 µM 2.84E-4 32 1.10E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.233 2.18E-42 YDR382W RPP2B hom Ribosomal protein P2 beta, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm
0.145 3.56E-17 YEL056W HAT2 hom Subunit of the Hat1p-Hat2p histone acetyltransferase complex; required for high affinity binding of the complex to free histone H4, thereby enhancing Hat1p activity; similar to human RbAp46 and 48; has a role in telomeric silencing
0.140 3.95E-16 YJR135C MCM22 hom Outer kinetochore protein and component of the Ctf3 subcomplex; binds to centromeric DNA in a Ctf19p-dependent manner; involved in chromosome segregation and minichromosome maintenance; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-K and fission yeast sim4
0.132 1.42E-14 YFR042W KEG1 het Integral membrane protein of the ER; physically interacts with Kre6p; has a role in the synthesis of beta-1,6-glucan in the cell wall; required for cell viability
0.119 5.75E-12 YBL100W-C_p YBL100W-C_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.111 1.26E-10 YMR044W IOC4 hom Member of a complex (Isw1b) with Isw1p and Ioc2p; interacts directly with H3K36me3 nucleosomes through its PWWP domain to recruit the Isw1b complex to open reading frames in a Set2p-dependent manner; Isw1b exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing
0.109 2.87E-10 YFL041W FET5 hom Multicopper oxidase, integral membrane protein with similarity to Fet3p; may have a role in iron transport
0.103 2.22E-9 YMR168C CEP3 het Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain
0.102 3.24E-9 YNL281W HCH1 hom Heat shock protein regulator; binds to Hsp90p and may stimulate ATPase activity; originally identified as a high-copy number suppressor of a HSP90 loss-of-function mutation; GFP-fusion protein localizes to the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress
0.101 4.91E-9 YHL039W EFM1 hom Lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.100 6.43E-9 YGL111W NSA1 het Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis
0.100 6.59E-9 YPR056W TFB4 het Subunit of TFIIH complex, involved in transcription initiation, similar to 34 kDa subunit of human TFIIH; interacts with Ssl1p
0.097 2.15E-8 YDR469W SDC1 hom Subunit of the COMPASS (Set1C) complex, which methylates lysine 4 of histone H3 and is required in chromatin silencing at telomeres; contains a Dpy-30 domain that mediates interaction with Bre2p; similar to C. elegans and human DPY-30
0.096 2.35E-8 YDR406W PDR15 hom Plasma membrane ATP binding cassette (ABC) transporter, multidrug transporter and general stress response factor implicated in cellular detoxification; regulated by Pdr1p, Pdr3p and Pdr8p; promoter contains a PDR responsive element
0.096 2.98E-8 YDR141C DOP1 het Golgi-localized, leucine-zipper domain containing protein; involved in endosome to Golgi transport, organization of the ER, establishing cell polarity, and morphogenesis; detected in highly purified mitochondria in high-throughput studies