HIPHOP chemogenomics database

YGR070W / ROM1

GDP/GTP exchange protein (GEP) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP

Zygosity: Homozygous strain

fixedexpanded
Profile for YGR070W / ROM1

Click on Significant Values for Screen Details

Top fitness defect scores for YGR070W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_1926	methyl fluorone black	9.11	53.6 µM	6.29E-19	DNA intercalators	5	4.27E-20
2	SGTC_219	mitoxanthrone	9.08	164.4 µM	7.97E-19	DNA intercalators	11	5.49E-20
3	SGTC_2772	vinpocetine	6.64	57.1 µM	6.82E-11		2	1.56E-11
4	SGTC_126	0417-1624	5.44	672.5 µM	7.54E-8	DNA intercalators	4	2.74E-8
5	SGTC_115	0527-0192	5.41	112.0 µM	8.67E-8		22	3.18E-8
6	SGTC_2604	4'-hydroxychalcone	5.25	11.3 µM	1.94E-7		11	7.49E-8
7	SGTC_1746	st038117	5.21	42.0 µM	2.43E-7		13	9.53E-8
8	SGTC_131	0141-0277	5.16	33.9 µM	3.17E-7		14	1.26E-7
9	SGTC_2305	7443522	4.95	69.2 µM	8.77E-7		2	3.74E-7
10	SGTC_113	0099-0221	4.93	2.5 µM	9.39E-7		11	4.02E-7
11	SGTC_1493	4348-0038	4.79	111.0 µM	1.90E-6	RSC complex & mRNA processing	9	8.52E-7
12	SGTC_145	3737-0113	4.73	38.4 µM	2.41E-6	DNA intercalators	53	1.10E-6
13	SGTC_2812	7970281	4.69	58.4 µM	2.96E-6		10	1.37E-6
14	SGTC_2429	5902844	4.67	64.4 µM	3.31E-6		9	1.54E-6
15	SGTC_1867	st057372	4.50	64.0 µM	7.08E-6		3	3.47E-6
16	SGTC_316	k060-0003	4.36	58.6 µM	1.30E-5		8	6.62E-6
17	SGTC_128	0906-2981	4.26	13.4 µM	1.99E-5		10	1.04E-5
18	SGTC_3062	9077494	4.19	49.5 µM	2.59E-5	mitochondrial response to ROS	30	1.38E-5
19	SGTC_2750	bromebric acid	4.14	70.2 µM	3.21E-5		23	1.73E-5
20	SGTC_125	0133-0007	4.11	11.8 µM	3.64E-5	DNA intercalators	5	1.98E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.294	7.53E-68	YMR168C	CEP3	het	Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain
0.275	3.96E-59	YEL064C	AVT2	hom	Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
0.259	1.66E-52	YHL039W	EFM1	hom	Lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.245	5.56E-47	YMR166C_p	YMR166C_p	hom	Predicted transporter of the mitochondrial inner membrane; has similarity to human mitochondrial ATP-Mg/Pi carriers; YMR166C is not an essential gene
0.239	1.38E-44	YGL002W	ERP6	hom	Member of the p24 family involved in ER to Golgi transport; similar to Emp24p and Erv25p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; ERP6 has a paralog, ERP1, that arose from the whole genome duplication
0.208	4.57E-34	YHR149C	SKG6	hom	Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p
0.197	1.30E-30	YMR044W	IOC4	hom	Member of a complex (Isw1b) with Isw1p and Ioc2p; interacts directly with H3K36me3 nucleosomes through its PWWP domain to recruit the Isw1b complex to open reading frames in a Set2p-dependent manner; Isw1b exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing
0.188	5.05E-28	YGL118C_d	YGL118C_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.186	1.72E-27	YEL017C-A	PMP2	hom	Proteolipid associated with plasma membrane H(+)-ATPase (Pma1p); regulates plasma membrane H(+)-ATPase activity; protein abundance increases in response to DNA replication stress; PMP2 has a paralog, PMP1, that arose from the whole genome duplication
0.178	3.58E-25	YDL223C	HBT1	hom	Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis
0.175	1.42E-24	YBR182C-A_p	YBR182C-A_p	hom	Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.175	1.68E-24	YMR262W_p	YMR262W_p	hom	Protein of unknown function; interacts weakly with Knr4p; YMR262W is not an essential gene
0.170	3.61E-23	YPL197C_d	YPL197C_d	hom	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the ribosomal gene RPB7B
0.166	5.08E-22	YPL262W	FUM1	hom	Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial distribution determined by the N-terminal targeting sequence, protein conformation, and status of glyoxylate shunt; phosphorylated in mitochondria
0.164	1.14E-21	YMR289W	ABZ2	hom	Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase), catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis