YGR070W / ROM1

GDP/GTP exchange protein (GEP) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR070W / ROM1

Click on Significant Values for Screen Details ID:SGTC_9|Compound:0092-0002|FD-Score:3.45|P-value:4.37E-4 ID:SGTC_113|Compound:0099-0221|FD-Score:4.93|P-value:9.39E-7 ID:SGTC_115|Compound:0527-0192|FD-Score:5.41|P-value:8.67E-8 ID:SGTC_125|Compound:0133-0007|FD-Score:4.11|P-value:3.64E-5 ID:SGTC_126|Compound:0417-1624|FD-Score:5.44|P-value:7.54E-8 ID:SGTC_128|Compound:0906-2981|FD-Score:4.26|P-value:1.99E-5 ID:SGTC_131|Compound:0141-0277|FD-Score:5.16|P-value:3.17E-7 ID:SGTC_145|Compound:3737-0113|FD-Score:4.73|P-value:2.41E-6 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:9.08|P-value:7.97E-19 ID:SGTC_229|Compound:benomyl|FD-Score:3.32|P-value:6.93E-4 ID:SGTC_256|Compound:clotrimazole|FD-Score:3.21|P-value:9.69E-4 ID:SGTC_264|Compound:promethazine|FD-Score:3.24|P-value:8.99E-4 ID:SGTC_316|Compound:k060-0003|FD-Score:4.36|P-value:1.30E-5 ID:SGTC_370|Compound:0180-0345|FD-Score:3.87|P-value:9.40E-5 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:-3.40|P-value:4.57E-4 ID:SGTC_638|Compound:3970-0837|FD-Score:3.95|P-value:6.97E-5 ID:SGTC_843|Compound:0310-0051|FD-Score:3.52|P-value:3.47E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:-3.26|P-value:7.43E-4 ID:SGTC_946|Compound:3434-1334|FD-Score:-3.90|P-value:7.44E-5 ID:SGTC_1025|Compound:k007-0731|FD-Score:4.09|P-value:3.91E-5 ID:SGTC_1174|Compound:0739-0097|FD-Score:4.05|P-value:4.68E-5 ID:SGTC_1180|Compound:1193-0155|FD-Score:3.48|P-value:3.98E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:3.63|P-value:2.30E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:-3.87|P-value:8.15E-5 ID:SGTC_1396|Compound:3511-0007|FD-Score:3.58|P-value:2.74E-4 ID:SGTC_1431|Compound:4049-0260|FD-Score:3.61|P-value:2.44E-4 ID:SGTC_1439|Compound:4092-1168|FD-Score:3.74|P-value:1.52E-4 ID:SGTC_1493|Compound:4348-0038|FD-Score:4.79|P-value:1.90E-6 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:3.22|P-value:9.55E-4 ID:SGTC_1738|Compound:st035555|FD-Score:-3.33|P-value:5.96E-4 ID:SGTC_1746|Compound:st038117|FD-Score:5.21|P-value:2.43E-7 ID:SGTC_1748|Compound:st037455|FD-Score:-3.22|P-value:8.46E-4 ID:SGTC_1750|Compound:st081859|FD-Score:-4.75|P-value:1.90E-6 ID:SGTC_1835|Compound:st008666|FD-Score:-3.17|P-value:9.91E-4 ID:SGTC_1867|Compound:st057372|FD-Score:4.50|P-value:7.08E-6 ID:SGTC_1880|Compound:MG-132|FD-Score:3.79|P-value:1.27E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:9.11|P-value:6.29E-19 ID:SGTC_2069|Compound:5228469|FD-Score:-3.51|P-value:3.12E-4 ID:SGTC_2305|Compound:7443522|FD-Score:4.95|P-value:8.77E-7 ID:SGTC_2331|Compound:7980721|FD-Score:-3.64|P-value:1.98E-4 ID:SGTC_2359|Compound:9039622|FD-Score:3.24|P-value:8.81E-4 ID:SGTC_2427|Compound:5545055|FD-Score:3.71|P-value:1.73E-4 ID:SGTC_2429|Compound:5902844|FD-Score:4.67|P-value:3.31E-6 ID:SGTC_2570|Compound:licareol|FD-Score:-3.54|P-value:2.84E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:-3.61|P-value:2.18E-4 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:-3.36|P-value:5.41E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:5.25|P-value:1.94E-7 ID:SGTC_2686|Compound:alizarin|FD-Score:3.33|P-value:6.60E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:3.65|P-value:2.16E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:4.14|P-value:3.21E-5 ID:SGTC_2772|Compound:vinpocetine|FD-Score:6.64|P-value:6.82E-11 ID:SGTC_2812|Compound:7970281|FD-Score:4.69|P-value:2.96E-6 ID:SGTC_3055|Compound:9094636|FD-Score:3.24|P-value:8.92E-4 ID:SGTC_3062|Compound:9077494|FD-Score:4.19|P-value:2.59E-5 ID:SGTC_9|Compound:0092-0002|FD-Score:3.45|P-value:4.37E-4 ID:SGTC_113|Compound:0099-0221|FD-Score:4.93|P-value:9.39E-7 ID:SGTC_115|Compound:0527-0192|FD-Score:5.41|P-value:8.67E-8 ID:SGTC_125|Compound:0133-0007|FD-Score:4.11|P-value:3.64E-5 ID:SGTC_126|Compound:0417-1624|FD-Score:5.44|P-value:7.54E-8 ID:SGTC_128|Compound:0906-2981|FD-Score:4.26|P-value:1.99E-5 ID:SGTC_131|Compound:0141-0277|FD-Score:5.16|P-value:3.17E-7 ID:SGTC_145|Compound:3737-0113|FD-Score:4.73|P-value:2.41E-6 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:9.08|P-value:7.97E-19 ID:SGTC_229|Compound:benomyl|FD-Score:3.32|P-value:6.93E-4 ID:SGTC_256|Compound:clotrimazole|FD-Score:3.21|P-value:9.69E-4 ID:SGTC_264|Compound:promethazine|FD-Score:3.24|P-value:8.99E-4 ID:SGTC_316|Compound:k060-0003|FD-Score:4.36|P-value:1.30E-5 ID:SGTC_370|Compound:0180-0345|FD-Score:3.87|P-value:9.40E-5 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:-3.40|P-value:4.57E-4 ID:SGTC_638|Compound:3970-0837|FD-Score:3.95|P-value:6.97E-5 ID:SGTC_843|Compound:0310-0051|FD-Score:3.52|P-value:3.47E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:-3.26|P-value:7.43E-4 ID:SGTC_946|Compound:3434-1334|FD-Score:-3.90|P-value:7.44E-5 ID:SGTC_1025|Compound:k007-0731|FD-Score:4.09|P-value:3.91E-5 ID:SGTC_1174|Compound:0739-0097|FD-Score:4.05|P-value:4.68E-5 ID:SGTC_1180|Compound:1193-0155|FD-Score:3.48|P-value:3.98E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:3.63|P-value:2.30E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:-3.87|P-value:8.15E-5 ID:SGTC_1396|Compound:3511-0007|FD-Score:3.58|P-value:2.74E-4 ID:SGTC_1431|Compound:4049-0260|FD-Score:3.61|P-value:2.44E-4 ID:SGTC_1439|Compound:4092-1168|FD-Score:3.74|P-value:1.52E-4 ID:SGTC_1493|Compound:4348-0038|FD-Score:4.79|P-value:1.90E-6 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:3.22|P-value:9.55E-4 ID:SGTC_1738|Compound:st035555|FD-Score:-3.33|P-value:5.96E-4 ID:SGTC_1746|Compound:st038117|FD-Score:5.21|P-value:2.43E-7 ID:SGTC_1748|Compound:st037455|FD-Score:-3.22|P-value:8.46E-4 ID:SGTC_1750|Compound:st081859|FD-Score:-4.75|P-value:1.90E-6 ID:SGTC_1835|Compound:st008666|FD-Score:-3.17|P-value:9.91E-4 ID:SGTC_1867|Compound:st057372|FD-Score:4.50|P-value:7.08E-6 ID:SGTC_1880|Compound:MG-132|FD-Score:3.79|P-value:1.27E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:9.11|P-value:6.29E-19 ID:SGTC_2069|Compound:5228469|FD-Score:-3.51|P-value:3.12E-4 ID:SGTC_2305|Compound:7443522|FD-Score:4.95|P-value:8.77E-7 ID:SGTC_2331|Compound:7980721|FD-Score:-3.64|P-value:1.98E-4 ID:SGTC_2359|Compound:9039622|FD-Score:3.24|P-value:8.81E-4 ID:SGTC_2427|Compound:5545055|FD-Score:3.71|P-value:1.73E-4 ID:SGTC_2429|Compound:5902844|FD-Score:4.67|P-value:3.31E-6 ID:SGTC_2570|Compound:licareol|FD-Score:-3.54|P-value:2.84E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:-3.61|P-value:2.18E-4 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:-3.36|P-value:5.41E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:5.25|P-value:1.94E-7 ID:SGTC_2686|Compound:alizarin|FD-Score:3.33|P-value:6.60E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:3.65|P-value:2.16E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:4.14|P-value:3.21E-5 ID:SGTC_2772|Compound:vinpocetine|FD-Score:6.64|P-value:6.82E-11 ID:SGTC_2812|Compound:7970281|FD-Score:4.69|P-value:2.96E-6 ID:SGTC_3055|Compound:9094636|FD-Score:3.24|P-value:8.92E-4 ID:SGTC_3062|Compound:9077494|FD-Score:4.19|P-value:2.59E-5

Top fitness defect scores for YGR070W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1926 methyl fluorone black 9.11 53.6 µM 6.29E-19 DNA intercalators 5 4.27E-20
2 SGTC_219 mitoxanthrone 9.08 164.4 µM 7.97E-19 DNA intercalators 11 5.49E-20
3 SGTC_2772 vinpocetine 6.64 57.1 µM 6.82E-11 2 1.56E-11
4 SGTC_126 0417-1624 5.44 672.5 µM 7.54E-8 DNA intercalators 4 2.74E-8
5 SGTC_115 0527-0192 5.41 112.0 µM 8.67E-8 22 3.18E-8
6 SGTC_2604 4'-hydroxychalcone 5.25 11.3 µM 1.94E-7 11 7.49E-8
7 SGTC_1746 st038117 5.21 42.0 µM 2.43E-7 13 9.53E-8
8 SGTC_131 0141-0277 5.16 33.9 µM 3.17E-7 14 1.26E-7
9 SGTC_2305 7443522 4.95 69.2 µM 8.77E-7 2 3.74E-7
10 SGTC_113 0099-0221 4.93 2.5 µM 9.39E-7 11 4.02E-7
11 SGTC_1493 4348-0038 4.79 111.0 µM 1.90E-6 RSC complex & mRNA processing 9 8.52E-7
12 SGTC_145 3737-0113 4.73 38.4 µM 2.41E-6 DNA intercalators 53 1.10E-6
13 SGTC_2812 7970281 4.69 58.4 µM 2.96E-6 10 1.37E-6
14 SGTC_2429 5902844 4.67 64.4 µM 3.31E-6 9 1.54E-6
15 SGTC_1867 st057372 4.50 64.0 µM 7.08E-6 3 3.47E-6
16 SGTC_316 k060-0003 4.36 58.6 µM 1.30E-5 8 6.62E-6
17 SGTC_128 0906-2981 4.26 13.4 µM 1.99E-5 10 1.04E-5
18 SGTC_3062 9077494 4.19 49.5 µM 2.59E-5 mitochondrial response to ROS 30 1.38E-5
19 SGTC_2750 bromebric acid 4.14 70.2 µM 3.21E-5 23 1.73E-5
20 SGTC_125 0133-0007 4.11 11.8 µM 3.64E-5 DNA intercalators 5 1.98E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.294 7.53E-68 YMR168C CEP3 het Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain
0.275 3.96E-59 YEL064C AVT2 hom Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
0.259 1.66E-52 YHL039W EFM1 hom Lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.245 5.56E-47 YMR166C_p YMR166C_p hom Predicted transporter of the mitochondrial inner membrane; has similarity to human mitochondrial ATP-Mg/Pi carriers; YMR166C is not an essential gene
0.239 1.38E-44 YGL002W ERP6 hom Member of the p24 family involved in ER to Golgi transport; similar to Emp24p and Erv25p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; ERP6 has a paralog, ERP1, that arose from the whole genome duplication
0.208 4.57E-34 YHR149C SKG6 hom Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p
0.197 1.30E-30 YMR044W IOC4 hom Member of a complex (Isw1b) with Isw1p and Ioc2p; interacts directly with H3K36me3 nucleosomes through its PWWP domain to recruit the Isw1b complex to open reading frames in a Set2p-dependent manner; Isw1b exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing
0.188 5.05E-28 YGL118C_d YGL118C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.186 1.72E-27 YEL017C-A PMP2 hom Proteolipid associated with plasma membrane H(+)-ATPase (Pma1p); regulates plasma membrane H(+)-ATPase activity; protein abundance increases in response to DNA replication stress; PMP2 has a paralog, PMP1, that arose from the whole genome duplication
0.178 3.58E-25 YDL223C HBT1 hom Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis
0.175 1.42E-24 YBR182C-A_p YBR182C-A_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.175 1.68E-24 YMR262W_p YMR262W_p hom Protein of unknown function; interacts weakly with Knr4p; YMR262W is not an essential gene
0.170 3.61E-23 YPL197C_d YPL197C_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the ribosomal gene RPB7B
0.166 5.08E-22 YPL262W FUM1 hom Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial distribution determined by the N-terminal targeting sequence, protein conformation, and status of glyoxylate shunt; phosphorylated in mitochondria
0.164 1.14E-21 YMR289W ABZ2 hom Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase), catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis