YGR072W / UPF3

Component of the nonsense-mediated mRNA decay (NMD) pathway, along with Nam7p and Nmd2p; involved in decay of mRNA containing nonsense codons; involved in telomere maintenance

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR072W / UPF3

Click on Significant Values for Screen Details ID:SGTC_188|Compound:3229-0966|FD-Score:3.26|P-value:2.76E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:3.05|P-value:6.29E-4 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:3.31|P-value:2.25E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:2.99|P-value:7.81E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:3.41|P-value:1.51E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:4.14|P-value:5.72E-6 ID:SGTC_917|Compound:harmaline|FD-Score:-3.31|P-value:2.20E-4 ID:SGTC_944|Compound:3370-0224|FD-Score:4.03|P-value:1.00E-5 ID:SGTC_950|Compound:1165-0508|FD-Score:-3.61|P-value:6.42E-5 ID:SGTC_951|Compound:1171-0579|FD-Score:-3.08|P-value:5.36E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:4.19|P-value:4.65E-6 ID:SGTC_1461|Compound:k072-0203|FD-Score:-3.36|P-value:1.82E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-5.03|P-value:4.77E-8 ID:SGTC_1463|Compound:k081-0032|FD-Score:-7.72|P-value:1.34E-16 ID:SGTC_1745|Compound:st081495|FD-Score:-3.30|P-value:2.28E-4 ID:SGTC_1864|Compound:st057645|FD-Score:-2.92|P-value:9.81E-4 ID:SGTC_1876|Compound:myriocin|FD-Score:3.38|P-value:1.75E-4 ID:SGTC_1947|Compound:st076332|FD-Score:-3.27|P-value:2.56E-4 ID:SGTC_1996|Compound:st072960|FD-Score:3.43|P-value:1.38E-4 ID:SGTC_1998|Compound:st075797|FD-Score:3.03|P-value:6.82E-4 ID:SGTC_2051|Compound:5263410|FD-Score:-3.01|P-value:6.84E-4 ID:SGTC_2123|Compound:5259487|FD-Score:3.46|P-value:1.24E-4 ID:SGTC_2139|Compound:5578692|FD-Score:4.04|P-value:9.46E-6 ID:SGTC_2141|Compound:5621638|FD-Score:4.89|P-value:1.14E-7 ID:SGTC_2158|Compound:5657123|FD-Score:2.99|P-value:7.86E-4 ID:SGTC_2160|Compound:5660466|FD-Score:4.60|P-value:5.44E-7 ID:SGTC_2162|Compound:5663267|FD-Score:3.92|P-value:1.68E-5 ID:SGTC_2163|Compound:5671233|FD-Score:3.15|P-value:4.32E-4 ID:SGTC_2164|Compound:5685496|FD-Score:4.34|P-value:2.21E-6 ID:SGTC_2423|Compound:st077119|FD-Score:-3.22|P-value:3.11E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.97|P-value:1.32E-5 ID:SGTC_2797|Compound:7859098|FD-Score:3.56|P-value:8.19E-5 ID:SGTC_2808|Compound:7946468|FD-Score:4.28|P-value:2.90E-6 ID:SGTC_2810|Compound:7959871|FD-Score:3.32|P-value:2.18E-4 ID:SGTC_2830|Compound:7992007|FD-Score:-3.93|P-value:1.55E-5 ID:SGTC_2832|Compound:7992762|FD-Score:-4.37|P-value:1.76E-6 ID:SGTC_2833|Compound:9001315|FD-Score:5.91|P-value:1.88E-10 ID:SGTC_3129|Compound:9127257|FD-Score:-3.31|P-value:2.22E-4 ID:SGTC_3152|Compound:9099253|FD-Score:-3.63|P-value:5.80E-5 ID:SGTC_3160|Compound:9100216|FD-Score:3.10|P-value:5.15E-4 ID:SGTC_3162|Compound:9099653|FD-Score:3.00|P-value:7.43E-4 ID:SGTC_3317|Compound:9138495|FD-Score:-4.06|P-value:8.14E-6 ID:SGTC_188|Compound:3229-0966|FD-Score:3.26|P-value:2.76E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:3.05|P-value:6.29E-4 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:3.31|P-value:2.25E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:2.99|P-value:7.81E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:3.41|P-value:1.51E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:4.14|P-value:5.72E-6 ID:SGTC_917|Compound:harmaline|FD-Score:-3.31|P-value:2.20E-4 ID:SGTC_944|Compound:3370-0224|FD-Score:4.03|P-value:1.00E-5 ID:SGTC_950|Compound:1165-0508|FD-Score:-3.61|P-value:6.42E-5 ID:SGTC_951|Compound:1171-0579|FD-Score:-3.08|P-value:5.36E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:4.19|P-value:4.65E-6 ID:SGTC_1461|Compound:k072-0203|FD-Score:-3.36|P-value:1.82E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-5.03|P-value:4.77E-8 ID:SGTC_1463|Compound:k081-0032|FD-Score:-7.72|P-value:1.34E-16 ID:SGTC_1745|Compound:st081495|FD-Score:-3.30|P-value:2.28E-4 ID:SGTC_1864|Compound:st057645|FD-Score:-2.92|P-value:9.81E-4 ID:SGTC_1876|Compound:myriocin|FD-Score:3.38|P-value:1.75E-4 ID:SGTC_1947|Compound:st076332|FD-Score:-3.27|P-value:2.56E-4 ID:SGTC_1996|Compound:st072960|FD-Score:3.43|P-value:1.38E-4 ID:SGTC_1998|Compound:st075797|FD-Score:3.03|P-value:6.82E-4 ID:SGTC_2051|Compound:5263410|FD-Score:-3.01|P-value:6.84E-4 ID:SGTC_2123|Compound:5259487|FD-Score:3.46|P-value:1.24E-4 ID:SGTC_2139|Compound:5578692|FD-Score:4.04|P-value:9.46E-6 ID:SGTC_2141|Compound:5621638|FD-Score:4.89|P-value:1.14E-7 ID:SGTC_2158|Compound:5657123|FD-Score:2.99|P-value:7.86E-4 ID:SGTC_2160|Compound:5660466|FD-Score:4.60|P-value:5.44E-7 ID:SGTC_2162|Compound:5663267|FD-Score:3.92|P-value:1.68E-5 ID:SGTC_2163|Compound:5671233|FD-Score:3.15|P-value:4.32E-4 ID:SGTC_2164|Compound:5685496|FD-Score:4.34|P-value:2.21E-6 ID:SGTC_2423|Compound:st077119|FD-Score:-3.22|P-value:3.11E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.97|P-value:1.32E-5 ID:SGTC_2797|Compound:7859098|FD-Score:3.56|P-value:8.19E-5 ID:SGTC_2808|Compound:7946468|FD-Score:4.28|P-value:2.90E-6 ID:SGTC_2810|Compound:7959871|FD-Score:3.32|P-value:2.18E-4 ID:SGTC_2830|Compound:7992007|FD-Score:-3.93|P-value:1.55E-5 ID:SGTC_2832|Compound:7992762|FD-Score:-4.37|P-value:1.76E-6 ID:SGTC_2833|Compound:9001315|FD-Score:5.91|P-value:1.88E-10 ID:SGTC_3129|Compound:9127257|FD-Score:-3.31|P-value:2.22E-4 ID:SGTC_3152|Compound:9099253|FD-Score:-3.63|P-value:5.80E-5 ID:SGTC_3160|Compound:9100216|FD-Score:3.10|P-value:5.15E-4 ID:SGTC_3162|Compound:9099653|FD-Score:3.00|P-value:7.43E-4 ID:SGTC_3317|Compound:9138495|FD-Score:-4.06|P-value:8.14E-6

Top fitness defect scores for YGR072W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2833 9001315 5.91 45.5 µM 1.88E-10 amide catabolism 19 1.67E-9
2 SGTC_2141 5621638 4.89 7.7 µM 1.14E-7 tubulin folding & SWR complex 20 5.13E-7
3 SGTC_2160 5660466 4.60 132.9 µM 5.44E-7 60S ribosome export 5 2.08E-6
4 SGTC_2164 5685496 4.34 200.0 µM 2.21E-6 15 7.27E-6
5 SGTC_2808 7946468 4.28 45.5 µM 2.90E-6 14 9.29E-6
6 SGTC_1230 0170-0365 4.19 3.8 µM 4.65E-6 endomembrane recycling 57 1.42E-5
7 SGTC_878 0828-0289 4.14 13.7 µM 5.72E-6 40 1.71E-5
8 SGTC_2139 5578692 4.04 56.5 µM 9.46E-6 superoxide 16 2.67E-5
9 SGTC_944 3370-0224 4.03 231.0 µM 1.00E-5 20 2.82E-5
10 SGTC_2757 clomiphene 3.97 4.2 µM 1.32E-5 fatty acid desaturase (OLE1) 41 3.60E-5
11 SGTC_2162 5663267 3.92 200.0 µM 1.68E-5 13 4.48E-5
12 SGTC_2797 7859098 3.56 81.8 µM 8.19E-5 40 1.85E-4
13 SGTC_2123 5259487 3.46 200.0 µM 1.24E-4 29 2.69E-4
14 SGTC_1996 st072960 3.43 66.8 µM 1.38E-4 34 2.96E-4
15 SGTC_705 1124-0212 3.41 310.0 µM 1.51E-4 32 3.21E-4
16 SGTC_1876 myriocin 3.38 605.0 nM 1.75E-4 56 3.66E-4
17 SGTC_2810 7959871 3.32 45.5 µM 2.18E-4 copper-dependent oxidative stress 67 4.45E-4
18 SGTC_563 tetrahydrosecaminediol 3.31 614.0 µM 2.25E-4 amide catabolism 30 4.58E-4
19 SGTC_188 3229-0966 3.26 278.5 µM 2.76E-4 63 5.50E-4
20 SGTC_2163 5671233 3.15 125.0 µM 4.32E-4 53 8.23E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.293 1.76E-67 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.290 4.59E-66 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.277 8.26E-60 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.276 2.69E-59 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.263 3.69E-54 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.262 1.79E-53 YDL176W YDL176W hom Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.228 1.02E-40 YMR106C YKU80 hom Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair
0.224 1.68E-39 YBR221W-A_p YBR221W-A_p hom Putative protein of unknown function; identified by expression profiling and mass spectrometry
0.220 4.19E-38 YDL157C_p YDL157C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.218 3.02E-37 YDR312W SSF2 hom Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication
0.216 1.55E-36 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.209 2.70E-34 YLR179C YLR179C hom Protein of unknown function with similarity to Tfs1p; transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus
0.200 1.86E-31 YIL152W_p YIL152W_p hom Putative protein of unknown function
0.199 2.23E-31 YBL017C PEP1 hom Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments
0.199 3.20E-31 YFL014W HSP12 hom Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension