YGR073C_d

Dubious open reading frame unlikely to encode a functional protein, extensively overlaps essential SMD1 gene encoding a U6 snRNP protein

Zygosity: Heterozygous strain
fixedexpanded
Profile for YGR073C / YGR073C

Click on Significant Values for Screen Details ID:SGTC_72|Compound:0744-0168|FD-Score:3.46|P-value:5.74E-4 ID:SGTC_76|Compound:0433-0009|FD-Score:4.82|P-value:2.76E-6 ID:SGTC_263|Compound:alizarin|FD-Score:5.18|P-value:5.11E-7 ID:SGTC_264|Compound:promethazine|FD-Score:5.67|P-value:4.41E-8 ID:SGTC_276|Compound:colchicine|FD-Score:3.30|P-value:9.93E-4 ID:SGTC_319|Compound:1348-1596|FD-Score:3.47|P-value:5.60E-4 ID:SGTC_321|Compound:4534-3890|FD-Score:3.54|P-value:4.49E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:-4.58|P-value:5.64E-6 ID:SGTC_395|Compound:anisomycin|FD-Score:3.85|P-value:1.46E-4 ID:SGTC_420|Compound:mitomycin C|FD-Score:-3.24|P-value:8.96E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:5.41|P-value:1.68E-7 ID:SGTC_593|Compound:1203-0218|FD-Score:3.44|P-value:6.13E-4 ID:SGTC_927|Compound:2425-1185|FD-Score:3.42|P-value:6.65E-4 ID:SGTC_1142|Compound:3253-1408|FD-Score:3.57|P-value:3.94E-4 ID:SGTC_1277|Compound:0873-0036|FD-Score:5.62|P-value:5.91E-8 ID:SGTC_1355|Compound:1499-0035|FD-Score:3.30|P-value:9.67E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:3.60|P-value:3.64E-4 ID:SGTC_1538|Compound:2',3',6-trimethoxyflavanone|FD-Score:-3.27|P-value:8.13E-4 ID:SGTC_1638|Compound:st008370|FD-Score:-3.77|P-value:1.45E-4 ID:SGTC_1717|Compound:st033143|FD-Score:-3.81|P-value:1.24E-4 ID:SGTC_2044|Compound:5102272|FD-Score:3.44|P-value:6.21E-4 ID:SGTC_2049|Compound:5262831|FD-Score:4.37|P-value:1.93E-5 ID:SGTC_2053|Compound:5265679|FD-Score:5.00|P-value:1.23E-6 ID:SGTC_2256|Compound:7954252|FD-Score:3.41|P-value:6.82E-4 ID:SGTC_2267|Compound:7931562|FD-Score:3.45|P-value:5.96E-4 ID:SGTC_2364|Compound:9055074|FD-Score:4.67|P-value:5.58E-6 ID:SGTC_2424|Compound:5537928|FD-Score:4.23|P-value:3.41E-5 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:3.39|P-value:7.32E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:3.95|P-value:1.02E-4 ID:SGTC_2666|Compound:tannic acid|FD-Score:3.69|P-value:2.68E-4 ID:SGTC_2700|Compound:st077718|FD-Score:3.67|P-value:2.85E-4 ID:SGTC_2770|Compound:toltrazuril|FD-Score:-3.64|P-value:2.30E-4 ID:SGTC_2802|Compound:7925815|FD-Score:5.43|P-value:1.51E-7 ID:SGTC_2816|Compound:7982706|FD-Score:3.53|P-value:4.51E-4 ID:SGTC_2851|Compound:9015922|FD-Score:-3.80|P-value:1.29E-4 ID:SGTC_2908|Compound:7930301|FD-Score:3.31|P-value:9.65E-4 ID:SGTC_2909|Compound:7941780|FD-Score:-3.90|P-value:9.06E-5 ID:SGTC_2914|Compound:7968218|FD-Score:-4.00|P-value:6.05E-5 ID:SGTC_2944|Compound:9067346|FD-Score:-3.27|P-value:8.30E-4 ID:SGTC_2988|Compound:9073640|FD-Score:4.04|P-value:7.23E-5 ID:SGTC_3067|Compound:9117431|FD-Score:4.74|P-value:4.08E-6 ID:SGTC_3072|Compound:9116419|FD-Score:-3.56|P-value:3.07E-4 ID:SGTC_3075|Compound:9116269|FD-Score:-4.20|P-value:2.82E-5 ID:SGTC_3108|Compound:9121785|FD-Score:-3.78|P-value:1.41E-4 ID:SGTC_3173|Compound:9105693|FD-Score:3.35|P-value:8.41E-4 ID:SGTC_3200|Compound:9114385|FD-Score:4.37|P-value:1.93E-5 ID:SGTC_3213|Compound:9129884|FD-Score:3.45|P-value:6.04E-4 ID:SGTC_3277|Compound:9138724|FD-Score:-3.63|P-value:2.42E-4 ID:SGTC_3278|Compound:9139605|FD-Score:-5.00|P-value:8.42E-7 ID:SGTC_72|Compound:0744-0168|FD-Score:3.46|P-value:5.74E-4 ID:SGTC_76|Compound:0433-0009|FD-Score:4.82|P-value:2.76E-6 ID:SGTC_263|Compound:alizarin|FD-Score:5.18|P-value:5.11E-7 ID:SGTC_264|Compound:promethazine|FD-Score:5.67|P-value:4.41E-8 ID:SGTC_276|Compound:colchicine|FD-Score:3.30|P-value:9.93E-4 ID:SGTC_319|Compound:1348-1596|FD-Score:3.47|P-value:5.60E-4 ID:SGTC_321|Compound:4534-3890|FD-Score:3.54|P-value:4.49E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:-4.58|P-value:5.64E-6 ID:SGTC_395|Compound:anisomycin|FD-Score:3.85|P-value:1.46E-4 ID:SGTC_420|Compound:mitomycin C|FD-Score:-3.24|P-value:8.96E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:5.41|P-value:1.68E-7 ID:SGTC_593|Compound:1203-0218|FD-Score:3.44|P-value:6.13E-4 ID:SGTC_927|Compound:2425-1185|FD-Score:3.42|P-value:6.65E-4 ID:SGTC_1142|Compound:3253-1408|FD-Score:3.57|P-value:3.94E-4 ID:SGTC_1277|Compound:0873-0036|FD-Score:5.62|P-value:5.91E-8 ID:SGTC_1355|Compound:1499-0035|FD-Score:3.30|P-value:9.67E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:3.60|P-value:3.64E-4 ID:SGTC_1538|Compound:2',3',6-trimethoxyflavanone|FD-Score:-3.27|P-value:8.13E-4 ID:SGTC_1638|Compound:st008370|FD-Score:-3.77|P-value:1.45E-4 ID:SGTC_1717|Compound:st033143|FD-Score:-3.81|P-value:1.24E-4 ID:SGTC_2044|Compound:5102272|FD-Score:3.44|P-value:6.21E-4 ID:SGTC_2049|Compound:5262831|FD-Score:4.37|P-value:1.93E-5 ID:SGTC_2053|Compound:5265679|FD-Score:5.00|P-value:1.23E-6 ID:SGTC_2256|Compound:7954252|FD-Score:3.41|P-value:6.82E-4 ID:SGTC_2267|Compound:7931562|FD-Score:3.45|P-value:5.96E-4 ID:SGTC_2364|Compound:9055074|FD-Score:4.67|P-value:5.58E-6 ID:SGTC_2424|Compound:5537928|FD-Score:4.23|P-value:3.41E-5 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:3.39|P-value:7.32E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:3.95|P-value:1.02E-4 ID:SGTC_2666|Compound:tannic acid|FD-Score:3.69|P-value:2.68E-4 ID:SGTC_2700|Compound:st077718|FD-Score:3.67|P-value:2.85E-4 ID:SGTC_2770|Compound:toltrazuril|FD-Score:-3.64|P-value:2.30E-4 ID:SGTC_2802|Compound:7925815|FD-Score:5.43|P-value:1.51E-7 ID:SGTC_2816|Compound:7982706|FD-Score:3.53|P-value:4.51E-4 ID:SGTC_2851|Compound:9015922|FD-Score:-3.80|P-value:1.29E-4 ID:SGTC_2908|Compound:7930301|FD-Score:3.31|P-value:9.65E-4 ID:SGTC_2909|Compound:7941780|FD-Score:-3.90|P-value:9.06E-5 ID:SGTC_2914|Compound:7968218|FD-Score:-4.00|P-value:6.05E-5 ID:SGTC_2944|Compound:9067346|FD-Score:-3.27|P-value:8.30E-4 ID:SGTC_2988|Compound:9073640|FD-Score:4.04|P-value:7.23E-5 ID:SGTC_3067|Compound:9117431|FD-Score:4.74|P-value:4.08E-6 ID:SGTC_3072|Compound:9116419|FD-Score:-3.56|P-value:3.07E-4 ID:SGTC_3075|Compound:9116269|FD-Score:-4.20|P-value:2.82E-5 ID:SGTC_3108|Compound:9121785|FD-Score:-3.78|P-value:1.41E-4 ID:SGTC_3173|Compound:9105693|FD-Score:3.35|P-value:8.41E-4 ID:SGTC_3200|Compound:9114385|FD-Score:4.37|P-value:1.93E-5 ID:SGTC_3213|Compound:9129884|FD-Score:3.45|P-value:6.04E-4 ID:SGTC_3277|Compound:9138724|FD-Score:-3.63|P-value:2.42E-4 ID:SGTC_3278|Compound:9139605|FD-Score:-5.00|P-value:8.42E-7

Top fitness defect scores for YGR073C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_264 promethazine 5.67 12.5 mM 4.41E-8 DNA intercalators 10 7.08E-9 0.02
2 SGTC_1277 0873-0036 5.62 22.0 µM 5.91E-8 PDR1 1 9.80E-9 1.44
3 SGTC_2802 7925815 5.43 54.5 µM 1.51E-7 2 2.78E-8 0.40
4 SGTC_515 4092-1064 5.41 102.0 µM 1.68E-7 plasma membrane duress 7 3.13E-8 0.08
5 SGTC_263 alizarin 5.18 107.9 µM 5.11E-7 iron homeostasis 6 1.08E-7 0.15
6 SGTC_2053 5265679 5.00 138.0 µM 1.23E-6 4 2.86E-7 0.79
7 SGTC_76 0433-0009 4.82 400.3 µM 2.76E-6 5 7.05E-7 0.53
8 SGTC_3067 9117431 4.74 49.5 µM 4.08E-6 2 1.09E-6 0.32
9 SGTC_2364 9055074 4.67 200.0 µM 5.58E-6 2 1.54E-6 1.15
10 SGTC_2049 5262831 4.37 67.2 µM 1.93E-5 4 6.11E-6 0.21
11 SGTC_3200 9114385 4.37 49.5 µM 1.93E-5 13 6.14E-6 0.11
12 SGTC_2424 5537928 4.23 59.2 µM 3.41E-5 6 1.15E-5 0.02
13 SGTC_2988 9073640 4.04 71.4 µM 7.23E-5 12 2.66E-5 0.10
14 SGTC_2633 5,7-dihydroxyisoflavone 3.95 100.0 µM 1.02E-4 4 3.90E-5 0.19
15 SGTC_395 anisomycin 3.85 6.2 µM 1.46E-4 3 5.80E-5 0.07
16 SGTC_2666 tannic acid 3.69 100.0 µM 2.68E-4 iron homeostasis 13 1.14E-4 0.09
17 SGTC_2700 st077718 3.67 96.8 µM 2.85E-4 6 1.22E-4 0.11
18 SGTC_1377 2944-0135 3.60 198.0 µM 3.64E-4 calcium & mitochondrial duress 8 1.61E-4 0.06
19 SGTC_1142 3253-1408 3.57 9.8 µM 3.94E-4 3 1.76E-4 0.52
20 SGTC_321 4534-3890 3.54 65.3 µM 4.49E-4 RPP1 & pyrimidine depletion 12 2.03E-4 0.08

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.116 1.92E-11 YGR065C VHT1 het High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin
0.107 6.00E-10 YEL032W MCM3 het Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex
0.106 6.55E-10 YMR166C_p YMR166C_p hom Predicted transporter of the mitochondrial inner membrane; has similarity to human mitochondrial ATP-Mg/Pi carriers; YMR166C is not an essential gene
0.104 1.61E-9 YOR133W EFT1 hom Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT1 has a paralog, EFT2, that arose from the whole genome duplication
0.103 2.15E-9 YHL039W EFM1 hom Lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.103 2.32E-9 YMR289W ABZ2 hom Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase), catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis
0.102 2.91E-9 YGL200C EMP24 hom Component of the p24 complex; binds to GPI anchor proteins and mediates their efficient transport from the ER to the Golgi; integral membrane protein that associates with endoplasmic reticulum-derived COPII-coated vesicles
0.098 1.13E-8 YMR168C CEP3 het Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain
0.092 1.06E-7 YFR012W-A_p YFR012W-A_p hom Putative protein of unknown function; identified by homology
0.089 2.56E-7 YDL223C HBT1 hom Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis
0.088 3.69E-7 YGL118C_d YGL118C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.085 8.78E-7 YJL025W RRN7 het Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p
0.083 1.44E-6 YGL042C_d YGL042C_d hom Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation blocks replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene DST1
0.080 3.67E-6 YNL264C PDR17 hom Phosphatidylinositol transfer protein (PITP), downregulates Plb1p-mediated turnover of phosphatidylcholine, found in the cytosol and microsomes, homologous to Pdr16p, deletion affects phospholipid composition
0.079 4.19E-6 YDR472W TRS31 het One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic