YGR075C / PRP38

Unique component of the U4/U6.U5 tri-snRNP particle, required for conformational changes which result in the catalytic activation of the spliceosome; dispensible for spliceosome assembly

Zygosity: Heterozygous strain
fixedexpanded
Profile for YGR075C / PRP38

Click on Significant Values for Screen Details ID:SGTC_37|Compound:0566-0070|FD-Score:3.12|P-value:9.57E-4 ID:SGTC_38|Compound:0929-0051|FD-Score:-3.37|P-value:3.64E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:-3.36|P-value:3.70E-4 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:4.65|P-value:1.78E-6 ID:SGTC_1139|Compound:k015-0024|FD-Score:3.80|P-value:7.63E-5 ID:SGTC_1141|Compound:3253-0389|FD-Score:3.31|P-value:4.89E-4 ID:SGTC_1254|Compound:0550-0035|FD-Score:-3.68|P-value:1.12E-4 ID:SGTC_1391|Compound:3442-0225|FD-Score:3.43|P-value:3.18E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:4.84|P-value:7.22E-7 ID:SGTC_1508|Compound:1080-0625|FD-Score:-3.26|P-value:5.29E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:4.03|P-value:2.99E-5 ID:SGTC_1643|Compound:st009866|FD-Score:3.88|P-value:5.56E-5 ID:SGTC_1730|Compound:st033808|FD-Score:-5.92|P-value:1.53E-9 ID:SGTC_1737|Compound:st035557|FD-Score:-3.54|P-value:1.88E-4 ID:SGTC_1837|Compound:st055472|FD-Score:-3.29|P-value:4.79E-4 ID:SGTC_1840|Compound:st055363|FD-Score:3.56|P-value:1.97E-4 ID:SGTC_1847|Compound:st056231|FD-Score:-3.33|P-value:4.23E-4 ID:SGTC_1859|Compound:st055998|FD-Score:4.43|P-value:5.06E-6 ID:SGTC_1860|Compound:st056228|FD-Score:4.27|P-value:1.07E-5 ID:SGTC_1912|Compound:st060209|FD-Score:3.88|P-value:5.50E-5 ID:SGTC_1917|Compound:st066507|FD-Score:3.58|P-value:1.79E-4 ID:SGTC_1949|Compound:st076024|FD-Score:3.22|P-value:6.88E-4 ID:SGTC_1970|Compound:st070122|FD-Score:5.56|P-value:1.46E-8 ID:SGTC_1975|Compound:st070967|FD-Score:3.43|P-value:3.24E-4 ID:SGTC_2106|Compound:5357045|FD-Score:3.40|P-value:3.54E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:3.99|P-value:3.51E-5 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:4.05|P-value:2.78E-5 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:4.53|P-value:3.13E-6 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:5.22|P-value:1.00E-7 ID:SGTC_2690|Compound:usnic acid|FD-Score:3.46|P-value:2.84E-4 ID:SGTC_2701|Compound:st077767|FD-Score:-3.31|P-value:4.43E-4 ID:SGTC_2837|Compound:9008476|FD-Score:-3.66|P-value:1.21E-4 ID:SGTC_2842|Compound:9000675|FD-Score:5.19|P-value:1.17E-7 ID:SGTC_3003|Compound:9075612|FD-Score:-3.47|P-value:2.53E-4 ID:SGTC_3019|Compound:9081971|FD-Score:3.39|P-value:3.75E-4 ID:SGTC_3157|Compound:9099274|FD-Score:-3.89|P-value:4.78E-5 ID:SGTC_3158|Compound:9100007|FD-Score:5.53|P-value:1.72E-8 ID:SGTC_3211|Compound:9128781|FD-Score:3.15|P-value:8.56E-4 ID:SGTC_3218|Compound:9131285|FD-Score:-3.55|P-value:1.82E-4 ID:SGTC_3312|Compound:9133330|FD-Score:3.71|P-value:1.11E-4 ID:SGTC_3316|Compound:9136639|FD-Score:3.85|P-value:6.19E-5 ID:SGTC_3322|Compound:9139058|FD-Score:4.12|P-value:2.03E-5 ID:SGTC_3330|Compound:9141424|FD-Score:-3.68|P-value:1.13E-4 ID:SGTC_3334|Compound:9142812|FD-Score:-3.57|P-value:1.68E-4 ID:SGTC_37|Compound:0566-0070|FD-Score:3.12|P-value:9.57E-4 ID:SGTC_38|Compound:0929-0051|FD-Score:-3.37|P-value:3.64E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:-3.36|P-value:3.70E-4 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:4.65|P-value:1.78E-6 ID:SGTC_1139|Compound:k015-0024|FD-Score:3.80|P-value:7.63E-5 ID:SGTC_1141|Compound:3253-0389|FD-Score:3.31|P-value:4.89E-4 ID:SGTC_1254|Compound:0550-0035|FD-Score:-3.68|P-value:1.12E-4 ID:SGTC_1391|Compound:3442-0225|FD-Score:3.43|P-value:3.18E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:4.84|P-value:7.22E-7 ID:SGTC_1508|Compound:1080-0625|FD-Score:-3.26|P-value:5.29E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:4.03|P-value:2.99E-5 ID:SGTC_1643|Compound:st009866|FD-Score:3.88|P-value:5.56E-5 ID:SGTC_1730|Compound:st033808|FD-Score:-5.92|P-value:1.53E-9 ID:SGTC_1737|Compound:st035557|FD-Score:-3.54|P-value:1.88E-4 ID:SGTC_1837|Compound:st055472|FD-Score:-3.29|P-value:4.79E-4 ID:SGTC_1840|Compound:st055363|FD-Score:3.56|P-value:1.97E-4 ID:SGTC_1847|Compound:st056231|FD-Score:-3.33|P-value:4.23E-4 ID:SGTC_1859|Compound:st055998|FD-Score:4.43|P-value:5.06E-6 ID:SGTC_1860|Compound:st056228|FD-Score:4.27|P-value:1.07E-5 ID:SGTC_1912|Compound:st060209|FD-Score:3.88|P-value:5.50E-5 ID:SGTC_1917|Compound:st066507|FD-Score:3.58|P-value:1.79E-4 ID:SGTC_1949|Compound:st076024|FD-Score:3.22|P-value:6.88E-4 ID:SGTC_1970|Compound:st070122|FD-Score:5.56|P-value:1.46E-8 ID:SGTC_1975|Compound:st070967|FD-Score:3.43|P-value:3.24E-4 ID:SGTC_2106|Compound:5357045|FD-Score:3.40|P-value:3.54E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:3.99|P-value:3.51E-5 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:4.05|P-value:2.78E-5 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:4.53|P-value:3.13E-6 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:5.22|P-value:1.00E-7 ID:SGTC_2690|Compound:usnic acid|FD-Score:3.46|P-value:2.84E-4 ID:SGTC_2701|Compound:st077767|FD-Score:-3.31|P-value:4.43E-4 ID:SGTC_2837|Compound:9008476|FD-Score:-3.66|P-value:1.21E-4 ID:SGTC_2842|Compound:9000675|FD-Score:5.19|P-value:1.17E-7 ID:SGTC_3003|Compound:9075612|FD-Score:-3.47|P-value:2.53E-4 ID:SGTC_3019|Compound:9081971|FD-Score:3.39|P-value:3.75E-4 ID:SGTC_3157|Compound:9099274|FD-Score:-3.89|P-value:4.78E-5 ID:SGTC_3158|Compound:9100007|FD-Score:5.53|P-value:1.72E-8 ID:SGTC_3211|Compound:9128781|FD-Score:3.15|P-value:8.56E-4 ID:SGTC_3218|Compound:9131285|FD-Score:-3.55|P-value:1.82E-4 ID:SGTC_3312|Compound:9133330|FD-Score:3.71|P-value:1.11E-4 ID:SGTC_3316|Compound:9136639|FD-Score:3.85|P-value:6.19E-5 ID:SGTC_3322|Compound:9139058|FD-Score:4.12|P-value:2.03E-5 ID:SGTC_3330|Compound:9141424|FD-Score:-3.68|P-value:1.13E-4 ID:SGTC_3334|Compound:9142812|FD-Score:-3.57|P-value:1.68E-4

Top fitness defect scores for YGR075C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1970 st070122 5.56 35.8 µM 1.46E-8 TSC3-RPN4 5 1.33E-8 0.70
2 SGTC_3158 9100007 5.53 49.5 µM 1.72E-8 2 1.56E-8 1.04
3 SGTC_2633 5,7-dihydroxyisoflavone 5.22 100.0 µM 1.00E-7 1 9.15E-8 0.63
4 SGTC_2842 9000675 5.19 19.5 µM 1.17E-7 2 1.07E-7 0.02
5 SGTC_1401 3807-4679 4.84 7.6 µM 7.22E-7 tubulin folding & SWR complex 1 6.65E-7 0.48
6 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 4.65 44.4 nM 1.78E-6 DNA damage response 4 1.65E-6 0.27
7 SGTC_2598 perillyl alcohol 4.53 100.0 µM 3.13E-6 4 2.90E-6 0.27
8 SGTC_1859 st055998 4.43 20.0 µM 5.06E-6 4 4.70E-6 0.60
9 SGTC_1860 st056228 4.27 74.6 µM 1.07E-5 4 9.94E-6 0.06
10 SGTC_3322 9139058 4.12 2.1 µM 2.03E-5 cell wall 13 1.89E-5 0.18
11 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 4.05 100.0 µM 2.78E-5 7 2.59E-5 0.09
12 SGTC_1512 0259-0544 4.03 12.2 µM 2.99E-5 4 2.79E-5 0.20
13 SGTC_2408 sulbentine 3.99 18.4 µM 3.51E-5 34 3.28E-5 0.08
14 SGTC_1912 st060209 3.88 90.8 µM 5.50E-5 11 5.15E-5 0.08
15 SGTC_1643 st009866 3.88 20.2 µM 5.56E-5 24 5.21E-5 0.07
16 SGTC_3316 9136639 3.85 10.6 µM 6.19E-5 4 5.81E-5 0.03
17 SGTC_1139 k015-0024 3.80 46.9 µM 7.63E-5 PDR1 3 7.16E-5 0.38
18 SGTC_3312 9133330 3.71 71.4 µM 1.11E-4 6 1.04E-4 0.31
19 SGTC_1917 st066507 3.58 28.5 µM 1.79E-4 Golgi 12 1.69E-4 0.04
20 SGTC_1840 st055363 3.56 71.0 µM 1.97E-4 4 1.85E-4 0.19

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.168 1.02E-22 YML095C RAD10 hom Single-stranded DNA endonuclease (with Rad1p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human ERCC1 protein
0.161 7.07E-21 YGR258C RAD2 hom Single-stranded DNA endonuclease, cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPG protein
0.144 4.73E-17 YMR201C RAD14 hom Protein that recognizes and binds damaged DNA during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); contains zinc finger motif; homolog of human XPA protein
0.137 1.57E-15 YGR067C_p YGR067C_p hom Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p
0.134 5.89E-15 YER162C RAD4 hom Protein that recognizes and binds damaged DNA (with Rad23p) during nucleotide excision repair; subunit of Nuclear Excision Repair Factor 2 (NEF2); also involved, with Rad23p, in turnover of ubiquitylated proteins
0.125 4.03E-13 YPL022W RAD1 hom Single-stranded DNA endonuclease (with Rad10p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human XPF protein
0.113 4.82E-11 YKL094W YJU3 hom Monoglyceride lipase (MGL), functional ortholog of mammalian MGL, localizes to lipid particles and membranes, also member of the eukaryotic serine hydrolase family
0.110 1.80E-10 YJL057C IKS1 hom Protein kinase of unknown cellular role; putative serine/threonine kinase; expression is induced during mild heat stress; deletion mutants are hypersensitive to copper sulphate and resistant to sorbate; interacts with an N-terminal fragment of Sst2p
0.106 6.80E-10 YNL074C MLF3 hom Serine-rich protein of unknown function, predicted to be palmitoylated; overproduction suppresses the growth inhibition caused by exposure to the immunosuppressant leflunomide
0.104 1.77E-9 YER069W ARG5,6 hom Acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase; N-acetyl-L-glutamate kinase (NAGK) catalyzes the 2nd and N-acetyl-gamma-glutamyl-phosphate reductase (NAGSA), the 3rd step in arginine biosynthesis; synthesized as a precursor which is processed in the mitochondrion to yield mature NAGK and NAGSA; enzymes form a metabolon complex with Arg2p; NAGK C-terminal domain stabilizes the enzymes, slows catalysis and is involved in feed-back inhibition by arginine
0.098 1.09E-8 YFL042C_p YFL042C_p hom Putative protein of unknown function; YFL042C is not an essential gene
0.091 1.12E-7 YNL001W DOM34 hom Protein that facilitates ribosomal subunit dissociation; acts when translation is stalled, with binding partner Hbs1p; required for RNA cleavage in no-go decay, but reports conflict on endonuclease activity; Pelota ortholog; protein abundance increases in response to DNA replication stress; DOM34 has a paralog, YCL001W-B, that arose from the whole genome duplication
0.091 1.35E-7 YEL037C RAD23 hom Protein with ubiquitin-like N terminus, subunit of Nuclear Excision Repair Factor 2 (NEF2) with Rad4p that binds damaged DNA; enhances protein deglycosylation activity of Png1p; also involved, with Rad4p, in ubiquitylated protein turnover
0.089 2.75E-7 YIR013C GAT4 hom Protein containing GATA family zinc finger motifs
0.085 7.32E-7 YLR229C CDC42 het Small rho-like GTPase, essential for establishment and maintenance of cell polarity; mutants have defects in the organization of actin and septins