YGR078C / PAC10

Part of the heteromeric co-chaperone GimC/prefoldin complex, which promotes efficient protein folding

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR078C / PAC10

Click on Significant Values for Screen Details ID:SGTC_41|Compound:0478-0632|FD-Score:4.41|P-value:6.35E-5 ID:SGTC_117|Compound:lucigenin|FD-Score:4.55|P-value:3.93E-5 ID:SGTC_163|Compound:1327-0036|FD-Score:6.78|P-value:1.84E-9 ID:SGTC_212|Compound:3807-4682|FD-Score:5.55|P-value:6.94E-7 ID:SGTC_408|Compound:cantharidin|FD-Score:5.94|P-value:1.18E-7 ID:SGTC_413|Compound:propylparaben|FD-Score:4.13|P-value:1.68E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:4.12|P-value:1.76E-4 ID:SGTC_502|Compound:l-744,832|FD-Score:4.83|P-value:1.36E-5 ID:SGTC_515|Compound:4092-1064|FD-Score:-3.61|P-value:7.52E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:4.44|P-value:5.72E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.91|P-value:3.03E-4 ID:SGTC_579|Compound:4491-1009|FD-Score:3.65|P-value:7.62E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:4.81|P-value:1.46E-5 ID:SGTC_583|Compound:1488-1091|FD-Score:3.64|P-value:7.92E-4 ID:SGTC_663|Compound:1486-0733|FD-Score:3.88|P-value:3.83E-4 ID:SGTC_752|Compound:1896-0090|FD-Score:4.17|P-value:1.48E-4 ID:SGTC_812|Compound:4251-0442|FD-Score:4.18|P-value:1.43E-4 ID:SGTC_830|Compound:4076-0286|FD-Score:3.92|P-value:3.30E-4 ID:SGTC_880|Compound:0833-0487|FD-Score:3.73|P-value:5.96E-4 ID:SGTC_985|Compound:1493-0307|FD-Score:-4.05|P-value:1.89E-4 ID:SGTC_1003|Compound:4049-0218|FD-Score:4.31|P-value:9.16E-5 ID:SGTC_1052|Compound:3253-3998|FD-Score:3.64|P-value:7.97E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:5.43|P-value:1.19E-6 ID:SGTC_1226|Compound:3909-7979|FD-Score:-3.81|P-value:4.11E-4 ID:SGTC_1238|Compound:0333-0287|FD-Score:5.16|P-value:3.72E-6 ID:SGTC_1279|Compound:0874-0590|FD-Score:-3.83|P-value:3.82E-4 ID:SGTC_1304|Compound:1165-0502|FD-Score:4.29|P-value:9.79E-5 ID:SGTC_1305|Compound:1181-0477|FD-Score:6.07|P-value:6.57E-8 ID:SGTC_1308|Compound:1187-1617|FD-Score:-3.77|P-value:4.63E-4 ID:SGTC_1316|Compound:1272-0050|FD-Score:-4.83|P-value:1.16E-5 ID:SGTC_1319|Compound:1306-0155|FD-Score:5.14|P-value:4.05E-6 ID:SGTC_1395|Compound:3486-0190|FD-Score:3.94|P-value:3.12E-4 ID:SGTC_1518|Compound:st038567|FD-Score:3.96|P-value:2.97E-4 ID:SGTC_1521|Compound:st012942|FD-Score:3.85|P-value:4.11E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:4.00|P-value:2.57E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:4.54|P-value:4.04E-5 ID:SGTC_1607|Compound:st000305|FD-Score:7.20|P-value:1.92E-10 ID:SGTC_1610|Compound:st001799|FD-Score:7.41|P-value:5.63E-11 ID:SGTC_1616|Compound:st002734|FD-Score:6.72|P-value:2.52E-9 ID:SGTC_1643|Compound:st009866|FD-Score:3.89|P-value:3.70E-4 ID:SGTC_1715|Compound:st032160|FD-Score:-4.59|P-value:2.88E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:-12.10|P-value:2.35E-26 ID:SGTC_1730|Compound:st033808|FD-Score:6.80|P-value:1.67E-9 ID:SGTC_1737|Compound:st035557|FD-Score:5.01|P-value:6.65E-6 ID:SGTC_1824|Compound:st053723|FD-Score:4.90|P-value:1.05E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:5.58|P-value:6.02E-7 ID:SGTC_1849|Compound:st056239|FD-Score:3.72|P-value:6.28E-4 ID:SGTC_1884|Compound:5633444|FD-Score:-4.01|P-value:2.16E-4 ID:SGTC_1982|Compound:st072467|FD-Score:3.60|P-value:8.83E-4 ID:SGTC_2007|Compound:4011539|FD-Score:5.06|P-value:5.55E-6 ID:SGTC_2009|Compound:4012297|FD-Score:3.69|P-value:6.86E-4 ID:SGTC_2023|Compound:5144124|FD-Score:4.55|P-value:3.85E-5 ID:SGTC_2050|Compound:5263056|FD-Score:-4.86|P-value:1.01E-5 ID:SGTC_2051|Compound:5263410|FD-Score:8.28|P-value:2.79E-13 ID:SGTC_2055|Compound:5235184|FD-Score:-4.71|P-value:1.84E-5 ID:SGTC_2058|Compound:5236698|FD-Score:-3.54|P-value:9.36E-4 ID:SGTC_2286|Compound:7945697|FD-Score:7.80|P-value:5.70E-12 ID:SGTC_2329|Compound:6138490|FD-Score:7.08|P-value:3.56E-10 ID:SGTC_2455|Compound:5377712|FD-Score:4.19|P-value:1.35E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:4.50|P-value:4.69E-5 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:4.36|P-value:7.78E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:14.70|P-value:1.00E-37 ID:SGTC_2586|Compound:curcumin|FD-Score:-4.34|P-value:7.05E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:6.68|P-value:3.04E-9 ID:SGTC_2679|Compound:rapamycin|FD-Score:4.25|P-value:1.10E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:9.16|P-value:7.47E-16 ID:SGTC_2696|Compound:st077691|FD-Score:-3.78|P-value:4.55E-4 ID:SGTC_2710|Compound:st078562|FD-Score:4.60|P-value:3.21E-5 ID:SGTC_2935|Compound:9038016|FD-Score:6.77|P-value:1.93E-9 ID:SGTC_2950|Compound:9072895|FD-Score:7.37|P-value:7.26E-11 ID:SGTC_3185|Compound:9108267|FD-Score:4.48|P-value:5.03E-5 ID:SGTC_41|Compound:0478-0632|FD-Score:4.41|P-value:6.35E-5 ID:SGTC_117|Compound:lucigenin|FD-Score:4.55|P-value:3.93E-5 ID:SGTC_163|Compound:1327-0036|FD-Score:6.78|P-value:1.84E-9 ID:SGTC_212|Compound:3807-4682|FD-Score:5.55|P-value:6.94E-7 ID:SGTC_408|Compound:cantharidin|FD-Score:5.94|P-value:1.18E-7 ID:SGTC_413|Compound:propylparaben|FD-Score:4.13|P-value:1.68E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:4.12|P-value:1.76E-4 ID:SGTC_502|Compound:l-744,832|FD-Score:4.83|P-value:1.36E-5 ID:SGTC_515|Compound:4092-1064|FD-Score:-3.61|P-value:7.52E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:4.44|P-value:5.72E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.91|P-value:3.03E-4 ID:SGTC_579|Compound:4491-1009|FD-Score:3.65|P-value:7.62E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:4.81|P-value:1.46E-5 ID:SGTC_583|Compound:1488-1091|FD-Score:3.64|P-value:7.92E-4 ID:SGTC_663|Compound:1486-0733|FD-Score:3.88|P-value:3.83E-4 ID:SGTC_752|Compound:1896-0090|FD-Score:4.17|P-value:1.48E-4 ID:SGTC_812|Compound:4251-0442|FD-Score:4.18|P-value:1.43E-4 ID:SGTC_830|Compound:4076-0286|FD-Score:3.92|P-value:3.30E-4 ID:SGTC_880|Compound:0833-0487|FD-Score:3.73|P-value:5.96E-4 ID:SGTC_985|Compound:1493-0307|FD-Score:-4.05|P-value:1.89E-4 ID:SGTC_1003|Compound:4049-0218|FD-Score:4.31|P-value:9.16E-5 ID:SGTC_1052|Compound:3253-3998|FD-Score:3.64|P-value:7.97E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:5.43|P-value:1.19E-6 ID:SGTC_1226|Compound:3909-7979|FD-Score:-3.81|P-value:4.11E-4 ID:SGTC_1238|Compound:0333-0287|FD-Score:5.16|P-value:3.72E-6 ID:SGTC_1279|Compound:0874-0590|FD-Score:-3.83|P-value:3.82E-4 ID:SGTC_1304|Compound:1165-0502|FD-Score:4.29|P-value:9.79E-5 ID:SGTC_1305|Compound:1181-0477|FD-Score:6.07|P-value:6.57E-8 ID:SGTC_1308|Compound:1187-1617|FD-Score:-3.77|P-value:4.63E-4 ID:SGTC_1316|Compound:1272-0050|FD-Score:-4.83|P-value:1.16E-5 ID:SGTC_1319|Compound:1306-0155|FD-Score:5.14|P-value:4.05E-6 ID:SGTC_1395|Compound:3486-0190|FD-Score:3.94|P-value:3.12E-4 ID:SGTC_1518|Compound:st038567|FD-Score:3.96|P-value:2.97E-4 ID:SGTC_1521|Compound:st012942|FD-Score:3.85|P-value:4.11E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:4.00|P-value:2.57E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:4.54|P-value:4.04E-5 ID:SGTC_1607|Compound:st000305|FD-Score:7.20|P-value:1.92E-10 ID:SGTC_1610|Compound:st001799|FD-Score:7.41|P-value:5.63E-11 ID:SGTC_1616|Compound:st002734|FD-Score:6.72|P-value:2.52E-9 ID:SGTC_1643|Compound:st009866|FD-Score:3.89|P-value:3.70E-4 ID:SGTC_1715|Compound:st032160|FD-Score:-4.59|P-value:2.88E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:-12.10|P-value:2.35E-26 ID:SGTC_1730|Compound:st033808|FD-Score:6.80|P-value:1.67E-9 ID:SGTC_1737|Compound:st035557|FD-Score:5.01|P-value:6.65E-6 ID:SGTC_1824|Compound:st053723|FD-Score:4.90|P-value:1.05E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:5.58|P-value:6.02E-7 ID:SGTC_1849|Compound:st056239|FD-Score:3.72|P-value:6.28E-4 ID:SGTC_1884|Compound:5633444|FD-Score:-4.01|P-value:2.16E-4 ID:SGTC_1982|Compound:st072467|FD-Score:3.60|P-value:8.83E-4 ID:SGTC_2007|Compound:4011539|FD-Score:5.06|P-value:5.55E-6 ID:SGTC_2009|Compound:4012297|FD-Score:3.69|P-value:6.86E-4 ID:SGTC_2023|Compound:5144124|FD-Score:4.55|P-value:3.85E-5 ID:SGTC_2050|Compound:5263056|FD-Score:-4.86|P-value:1.01E-5 ID:SGTC_2051|Compound:5263410|FD-Score:8.28|P-value:2.79E-13 ID:SGTC_2055|Compound:5235184|FD-Score:-4.71|P-value:1.84E-5 ID:SGTC_2058|Compound:5236698|FD-Score:-3.54|P-value:9.36E-4 ID:SGTC_2286|Compound:7945697|FD-Score:7.80|P-value:5.70E-12 ID:SGTC_2329|Compound:6138490|FD-Score:7.08|P-value:3.56E-10 ID:SGTC_2455|Compound:5377712|FD-Score:4.19|P-value:1.35E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:4.50|P-value:4.69E-5 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:4.36|P-value:7.78E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:14.70|P-value:1.00E-37 ID:SGTC_2586|Compound:curcumin|FD-Score:-4.34|P-value:7.05E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:6.68|P-value:3.04E-9 ID:SGTC_2679|Compound:rapamycin|FD-Score:4.25|P-value:1.10E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:9.16|P-value:7.47E-16 ID:SGTC_2696|Compound:st077691|FD-Score:-3.78|P-value:4.55E-4 ID:SGTC_2710|Compound:st078562|FD-Score:4.60|P-value:3.21E-5 ID:SGTC_2935|Compound:9038016|FD-Score:6.77|P-value:1.93E-9 ID:SGTC_2950|Compound:9072895|FD-Score:7.37|P-value:7.26E-11 ID:SGTC_3185|Compound:9108267|FD-Score:4.48|P-value:5.03E-5

Top fitness defect scores for YGR078C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2582 agaric acid 14.70 100.0 µM 1.00E-37 redox potentiating 16 5.01E-49
2 SGTC_2688 kanamycin b 9.16 96.7 µM 7.47E-16 calcium & mitochondrial duress 40 2.54E-20
3 SGTC_2051 5263410 8.28 176.0 µM 2.79E-13 2 5.99E-17
4 SGTC_2286 7945697 7.80 125.0 µM 5.70E-12 8 3.12E-15
5 SGTC_1610 st001799 7.41 48.1 µM 5.63E-11 1 6.26E-14
6 SGTC_2950 9072895 7.37 21.5 µM 7.26E-11 2 8.75E-14
7 SGTC_1607 st000305 7.20 50.6 µM 1.92E-10 1 3.12E-13
8 SGTC_2329 6138490 7.08 200.0 µM 3.56E-10 5 7.00E-13
9 SGTC_1730 st033808 6.80 45.1 µM 1.67E-9 4 5.30E-12
10 SGTC_163 1327-0036 6.78 7.5 µM 1.84E-9 35 6.00E-12
11 SGTC_2935 9038016 6.77 30.0 µM 1.93E-9 4 6.40E-12
12 SGTC_1616 st002734 6.72 56.1 µM 2.52E-9 6 9.08E-12
13 SGTC_2651 1327-0036 6.68 5.0 µM 3.04E-9 53 1.16E-11
14 SGTC_1305 1181-0477 6.07 144.0 µM 6.57E-8 4 6.47E-10
15 SGTC_408 cantharidin 5.94 100.0 µM 1.18E-7 cell wall signaling 9 1.40E-9
16 SGTC_1844 rapamycin 5.58 4.0 nM 6.02E-7 99 1.17E-8
17 SGTC_212 3807-4682 5.55 38.8 µM 6.94E-7 tubulin folding & SWR complex 32 1.41E-8
18 SGTC_1133 3473-0247 5.43 50.0 µM 1.19E-6 RSC complex & mRNA processing 15 2.86E-8
19 SGTC_1238 0333-0287 5.16 48.8 µM 3.72E-6 Golgi 10 1.26E-7
20 SGTC_1319 1306-0155 5.14 43.7 µM 4.05E-6 6 1.41E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.290 5.67E-66 YLR200W YKE2 hom Subunit of the heterohexameric Gim/prefoldin protein complex involved in the folding of alpha-tubulin, beta-tubulin, and actin
0.237 6.82E-44 YJL179W PFD1 hom Subunit of heterohexameric prefoldin, which binds cytosolic chaperonin and transfers target proteins to it; involved in the biogenesis of actin and of alpha- and gamma-tubulin
0.223 8.07E-39 YIL129C TAO3 het Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with protein kinase Cbk1p and also with Kic1p
0.222 1.93E-38 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.199 2.77E-31 YIR008C PRI1 het Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
0.192 4.40E-29 YNL106C INP52 hom Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.192 5.31E-29 YNL084C END3 hom EH domain-containing protein involved in endocytosis, actin cytoskeletal organization and cell wall morphogenesis; forms a complex with Sla1p and Pan1p
0.191 7.05E-29 YEL003W GIM4 hom Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it
0.183 1.04E-26 YIR012W SQT1 het Protein involved in 60S ribosomal subunit assembly or modification; contains multiple WD repeats; interacts with Qsr1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress
0.176 1.03E-24 YML052W SUR7 hom Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants
0.174 5.03E-24 YIL019W FAF1 het Protein required for pre-rRNA processing and 40S ribosomal subunit assembly
0.172 1.46E-23 YBR082C UBC4 hom Ubiquitin-conjugating enzyme (E2); mediates degradation of abnormal or excess proteins, including calmodulin and histone H3; interacts with many SCF ubiquitin protein ligases; component of the cellular stress response; UBC4 has a paralog, UBC5, that arose from the whole genome duplication
0.166 4.62E-22 YEL042W GDA1 hom Guanosine diphosphatase located in the Golgi, involved in the transport of GDP-mannose into the Golgi lumen by converting GDP to GMP after mannose is transferred its substrate
0.164 1.27E-21 YJR013W GPI14 het Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M
0.163 2.34E-21 YDR417C_d YDR417C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RPL12B/YDR418W