YGR079W_p

Putative protein of unknown function; YGR079W is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR079W / YGR079W

Click on Significant Values for Screen Details ID:SGTC_15|Compound:0266-0086|FD-Score:3.70|P-value:3.92E-5 ID:SGTC_131|Compound:0141-0277|FD-Score:4.76|P-value:1.68E-7 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:5.06|P-value:2.90E-8 ID:SGTC_345|Compound:1362-0200|FD-Score:4.35|P-value:1.65E-6 ID:SGTC_500|Compound:h-89|FD-Score:2.93|P-value:9.15E-4 ID:SGTC_530|Compound:4358-1714|FD-Score:3.61|P-value:5.85E-5 ID:SGTC_611|Compound:3453-1652|FD-Score:3.86|P-value:1.83E-5 ID:SGTC_722|Compound:3534-0461|FD-Score:3.12|P-value:4.55E-4 ID:SGTC_804|Compound:1595-0054|FD-Score:-2.81|P-value:9.60E-4 ID:SGTC_941|Compound:3237-0776|FD-Score:3.23|P-value:2.87E-4 ID:SGTC_942|Compound:3253-1115|FD-Score:3.49|P-value:9.76E-5 ID:SGTC_952|Compound:1185-0122|FD-Score:5.17|P-value:1.53E-8 ID:SGTC_1007|Compound:4101-0031|FD-Score:3.81|P-value:2.34E-5 ID:SGTC_1012|Compound:4112-3522|FD-Score:3.59|P-value:6.26E-5 ID:SGTC_1033|Compound:k072-0102|FD-Score:3.89|P-value:1.59E-5 ID:SGTC_1036|Compound:k216-0215|FD-Score:-3.23|P-value:1.83E-4 ID:SGTC_1041|Compound:0206-0046|FD-Score:3.17|P-value:3.69E-4 ID:SGTC_1078|Compound:idebenone|FD-Score:4.19|P-value:3.77E-6 ID:SGTC_1147|Compound:3809-1045|FD-Score:3.82|P-value:2.24E-5 ID:SGTC_1401|Compound:3807-4679|FD-Score:3.51|P-value:9.08E-5 ID:SGTC_1522|Compound:st012842|FD-Score:3.57|P-value:7.00E-5 ID:SGTC_1524|Compound:corynanthine|FD-Score:5.33|P-value:5.40E-9 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:4.55|P-value:5.63E-7 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:3.26|P-value:2.61E-4 ID:SGTC_1678|Compound:st019265|FD-Score:3.19|P-value:3.36E-4 ID:SGTC_1689|Compound:st020265|FD-Score:3.17|P-value:3.73E-4 ID:SGTC_1695|Compound:st026914|FD-Score:3.15|P-value:3.91E-4 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:5.29|P-value:7.06E-9 ID:SGTC_1717|Compound:st033143|FD-Score:3.07|P-value:5.46E-4 ID:SGTC_1845|Compound:st056753|FD-Score:3.10|P-value:4.87E-4 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:-3.29|P-value:1.46E-4 ID:SGTC_1932|Compound:st074806|FD-Score:-4.21|P-value:1.93E-6 ID:SGTC_1934|Compound:st074720|FD-Score:-3.35|P-value:1.10E-4 ID:SGTC_2166|Compound:5933061|FD-Score:3.75|P-value:3.14E-5 ID:SGTC_2239|Compound:6685329|FD-Score:3.48|P-value:1.04E-4 ID:SGTC_2302|Compound:7771753|FD-Score:3.12|P-value:4.54E-4 ID:SGTC_2348|Compound:9022543|FD-Score:-3.66|P-value:2.82E-5 ID:SGTC_2440|Compound:5628896|FD-Score:4.15|P-value:4.54E-6 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-3.83|P-value:1.30E-5 ID:SGTC_2568|Compound:diosmetin|FD-Score:5.67|P-value:5.72E-10 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:3.27|P-value:2.42E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:-3.10|P-value:3.15E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-3.12|P-value:2.93E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:-3.32|P-value:1.26E-4 ID:SGTC_2681|Compound:menadione|FD-Score:3.28|P-value:2.34E-4 ID:SGTC_2698|Compound:st077697|FD-Score:3.65|P-value:4.88E-5 ID:SGTC_2723|Compound:salbutamol|FD-Score:3.05|P-value:5.83E-4 ID:SGTC_2732|Compound:terfenadine|FD-Score:-3.08|P-value:3.38E-4 ID:SGTC_2740|Compound:felodipine|FD-Score:3.55|P-value:7.59E-5 ID:SGTC_2774|Compound:tamoxifen|FD-Score:3.42|P-value:1.31E-4 ID:SGTC_2888|Compound:9058547|FD-Score:-3.08|P-value:3.46E-4 ID:SGTC_2943|Compound:9068529|FD-Score:-3.32|P-value:1.25E-4 ID:SGTC_2953|Compound:9074162|FD-Score:4.21|P-value:3.41E-6 ID:SGTC_3102|Compound:9121669|FD-Score:-3.11|P-value:3.03E-4 ID:SGTC_3128|Compound:9127691|FD-Score:3.28|P-value:2.37E-4 ID:SGTC_3314|Compound:9135860|FD-Score:3.83|P-value:2.14E-5 ID:SGTC_15|Compound:0266-0086|FD-Score:3.70|P-value:3.92E-5 ID:SGTC_131|Compound:0141-0277|FD-Score:4.76|P-value:1.68E-7 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:5.06|P-value:2.90E-8 ID:SGTC_345|Compound:1362-0200|FD-Score:4.35|P-value:1.65E-6 ID:SGTC_500|Compound:h-89|FD-Score:2.93|P-value:9.15E-4 ID:SGTC_530|Compound:4358-1714|FD-Score:3.61|P-value:5.85E-5 ID:SGTC_611|Compound:3453-1652|FD-Score:3.86|P-value:1.83E-5 ID:SGTC_722|Compound:3534-0461|FD-Score:3.12|P-value:4.55E-4 ID:SGTC_804|Compound:1595-0054|FD-Score:-2.81|P-value:9.60E-4 ID:SGTC_941|Compound:3237-0776|FD-Score:3.23|P-value:2.87E-4 ID:SGTC_942|Compound:3253-1115|FD-Score:3.49|P-value:9.76E-5 ID:SGTC_952|Compound:1185-0122|FD-Score:5.17|P-value:1.53E-8 ID:SGTC_1007|Compound:4101-0031|FD-Score:3.81|P-value:2.34E-5 ID:SGTC_1012|Compound:4112-3522|FD-Score:3.59|P-value:6.26E-5 ID:SGTC_1033|Compound:k072-0102|FD-Score:3.89|P-value:1.59E-5 ID:SGTC_1036|Compound:k216-0215|FD-Score:-3.23|P-value:1.83E-4 ID:SGTC_1041|Compound:0206-0046|FD-Score:3.17|P-value:3.69E-4 ID:SGTC_1078|Compound:idebenone|FD-Score:4.19|P-value:3.77E-6 ID:SGTC_1147|Compound:3809-1045|FD-Score:3.82|P-value:2.24E-5 ID:SGTC_1401|Compound:3807-4679|FD-Score:3.51|P-value:9.08E-5 ID:SGTC_1522|Compound:st012842|FD-Score:3.57|P-value:7.00E-5 ID:SGTC_1524|Compound:corynanthine|FD-Score:5.33|P-value:5.40E-9 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:4.55|P-value:5.63E-7 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:3.26|P-value:2.61E-4 ID:SGTC_1678|Compound:st019265|FD-Score:3.19|P-value:3.36E-4 ID:SGTC_1689|Compound:st020265|FD-Score:3.17|P-value:3.73E-4 ID:SGTC_1695|Compound:st026914|FD-Score:3.15|P-value:3.91E-4 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:5.29|P-value:7.06E-9 ID:SGTC_1717|Compound:st033143|FD-Score:3.07|P-value:5.46E-4 ID:SGTC_1845|Compound:st056753|FD-Score:3.10|P-value:4.87E-4 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:-3.29|P-value:1.46E-4 ID:SGTC_1932|Compound:st074806|FD-Score:-4.21|P-value:1.93E-6 ID:SGTC_1934|Compound:st074720|FD-Score:-3.35|P-value:1.10E-4 ID:SGTC_2166|Compound:5933061|FD-Score:3.75|P-value:3.14E-5 ID:SGTC_2239|Compound:6685329|FD-Score:3.48|P-value:1.04E-4 ID:SGTC_2302|Compound:7771753|FD-Score:3.12|P-value:4.54E-4 ID:SGTC_2348|Compound:9022543|FD-Score:-3.66|P-value:2.82E-5 ID:SGTC_2440|Compound:5628896|FD-Score:4.15|P-value:4.54E-6 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-3.83|P-value:1.30E-5 ID:SGTC_2568|Compound:diosmetin|FD-Score:5.67|P-value:5.72E-10 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:3.27|P-value:2.42E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:-3.10|P-value:3.15E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-3.12|P-value:2.93E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:-3.32|P-value:1.26E-4 ID:SGTC_2681|Compound:menadione|FD-Score:3.28|P-value:2.34E-4 ID:SGTC_2698|Compound:st077697|FD-Score:3.65|P-value:4.88E-5 ID:SGTC_2723|Compound:salbutamol|FD-Score:3.05|P-value:5.83E-4 ID:SGTC_2732|Compound:terfenadine|FD-Score:-3.08|P-value:3.38E-4 ID:SGTC_2740|Compound:felodipine|FD-Score:3.55|P-value:7.59E-5 ID:SGTC_2774|Compound:tamoxifen|FD-Score:3.42|P-value:1.31E-4 ID:SGTC_2888|Compound:9058547|FD-Score:-3.08|P-value:3.46E-4 ID:SGTC_2943|Compound:9068529|FD-Score:-3.32|P-value:1.25E-4 ID:SGTC_2953|Compound:9074162|FD-Score:4.21|P-value:3.41E-6 ID:SGTC_3102|Compound:9121669|FD-Score:-3.11|P-value:3.03E-4 ID:SGTC_3128|Compound:9127691|FD-Score:3.28|P-value:2.37E-4 ID:SGTC_3314|Compound:9135860|FD-Score:3.83|P-value:2.14E-5

Top fitness defect scores for YGR079W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2568 diosmetin 5.67 100.0 µM 5.72E-10 4 7.04E-9
2 SGTC_1524 corynanthine 5.33 62.1 µM 5.40E-9 8 4.89E-8
3 SGTC_1698 5-fluorocytosine 5.29 1.1 µM 7.06E-9 exosome 1 6.16E-8
4 SGTC_952 1185-0122 5.17 232.0 µM 1.53E-8 9 1.20E-7
5 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 5.06 4.6 µM 2.90E-8 heat shock/prefoldin 21 2.09E-7
6 SGTC_131 0141-0277 4.76 33.9 µM 1.68E-7 18 9.55E-7
7 SGTC_1592 4',5'-dihydroxyflavone 4.55 8.8 µM 5.63E-7 60S ribosome export 6 2.72E-6
8 SGTC_345 1362-0200 4.35 395.0 µM 1.65E-6 8 6.92E-6
9 SGTC_2953 9074162 4.21 66.5 µM 3.41E-6 17 1.30E-5
10 SGTC_1078 idebenone 4.19 36.1 µM 3.77E-6 Golgi 35 1.42E-5
11 SGTC_2440 5628896 4.15 157.8 µM 4.54E-6 22 1.66E-5
12 SGTC_1033 k072-0102 3.89 21.3 µM 1.59E-5 60S ribosome export 24 4.93E-5
13 SGTC_611 3453-1652 3.86 23.7 µM 1.83E-5 24 5.58E-5
14 SGTC_3314 9135860 3.83 59.4 µM 2.14E-5 20 6.39E-5
15 SGTC_1147 3809-1045 3.82 12.3 µM 2.24E-5 25 6.65E-5
16 SGTC_1007 4101-0031 3.81 70.0 µM 2.34E-5 22 6.91E-5
17 SGTC_2166 5933061 3.75 31.5 µM 3.14E-5 tubulin folding & SWR complex 49 8.92E-5
18 SGTC_15 0266-0086 3.70 27.1 µM 3.92E-5 endomembrane recycling 74 1.08E-4
19 SGTC_2698 st077697 3.65 67.5 µM 4.88E-5 22 1.31E-4
20 SGTC_530 4358-1714 3.61 28.0 µM 5.85E-5 55 1.53E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.126 1.96E-13 YDL111C RRP42 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp42p (EXOSC7)
0.115 2.38E-11 YGR195W SKI6 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp41p (EXOSC4)
0.112 6.95E-11 YLR390W-A CCW14 hom Covalently linked cell wall glycoprotein, present in the inner layer of the cell wall
0.110 1.72E-10 YPL044C_d YPL044C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP4/YPL043W
0.102 2.67E-9 YGR158C MTR3 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hMtr3p (EXOSC6)
0.096 2.45E-8 YBR142W MAK5 het Essential nucleolar protein, putative DEAD-box RNA helicase required for maintenance of M1 dsRNA virus; involved in biogenesis of large (60S) ribosomal subunits
0.085 8.02E-7 YNL085W MKT1 hom Protein that forms a complex with Pbp1p; complex may mediate posttranscriptional regulation of HO; involved in propagation of M2 dsRNA satellite of L-A virus; allelic variation affects mitochondrial genome stability, drug resistance, and more; forms cytoplasmic foci upon DNA replication stress
0.077 8.65E-6 YDL086W_p YDL086W_p hom Putative carboxymethylenebutenolidase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL086W is not an essential gene
0.076 9.66E-6 YFR024C-A LSB3 hom Protein containing a C-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein abundance increases in response to DNA replication stress; LSB3 has a paralog, YSC84, that arose from the whole genome duplication
0.075 1.43E-5 YGR084C MRP13 hom Mitochondrial ribosomal protein of the small subunit
0.075 1.47E-5 YAL034W-A MTW1 het Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; critical to kinetochore assembly
0.071 3.83E-5 YOR310C NOP58 het Protein involved in pre-rRNA processing, 18S rRNA synthesis, and snoRNA synthesis; component of the small subunit processome complex, which is required for processing of pre-18S rRNA
0.070 4.71E-5 YDR277C MTH1 hom Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation
0.070 5.27E-5 YOL021C DIS3 het Exosome core complex catalytic subunit; possesses both endonuclease and 3'-5' exonuclease activity; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase R and to human DIS3; protein abundance increases in response to DNA replication stress
0.069 6.91E-5 YBL097W BRN1 het Subunit of the condensin complex; required for chromosome condensation and for clustering of tRNA genes at the nucleolus; may influence multiple aspects of chromosome transmission