YGR081C / SLX9

Protein required for pre-rRNA processing; associated with the 90S pre-ribosome and 43S small ribosomal subunit precursor; interacts with U3 snoRNA; deletion mutant has synthetic fitness defect with an sgs1 deletion mutant

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR081C / SLX9

Click on Significant Values for Screen Details ID:SGTC_15|Compound:0266-0086|FD-Score:3.71|P-value:4.14E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:3.72|P-value:3.99E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:-5.23|P-value:1.73E-6 ID:SGTC_306|Compound:1672-3436|FD-Score:-3.66|P-value:6.02E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:4.64|P-value:1.51E-5 ID:SGTC_540|Compound:1187-0821|FD-Score:-3.62|P-value:6.77E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:3.75|P-value:3.68E-4 ID:SGTC_651|Compound:3253-0966|FD-Score:3.75|P-value:3.65E-4 ID:SGTC_661|Compound:1304-0007|FD-Score:3.93|P-value:1.99E-4 ID:SGTC_834|Compound:0312-0008|FD-Score:3.83|P-value:2.75E-4 ID:SGTC_961|Compound:1252-1571|FD-Score:-3.65|P-value:6.22E-4 ID:SGTC_1062|Compound:mesoridazine|FD-Score:4.37|P-value:4.11E-5 ID:SGTC_1068|Compound:loratadine|FD-Score:4.05|P-value:1.32E-4 ID:SGTC_1089|Compound:terbinafine|FD-Score:-4.21|P-value:9.82E-5 ID:SGTC_1178|Compound:0988-0033|FD-Score:-3.68|P-value:5.69E-4 ID:SGTC_1180|Compound:1193-0155|FD-Score:3.45|P-value:9.16E-4 ID:SGTC_1352|Compound:1496-0991|FD-Score:4.40|P-value:3.75E-5 ID:SGTC_1360|Compound:1598-0022|FD-Score:3.89|P-value:2.29E-4 ID:SGTC_1378|Compound:2093-0007|FD-Score:-3.50|P-value:9.85E-4 ID:SGTC_1442|Compound:4112-3290|FD-Score:3.95|P-value:1.86E-4 ID:SGTC_1453|Compound:4237-0541|FD-Score:-3.79|P-value:3.94E-4 ID:SGTC_1494|Compound:4358-1428|FD-Score:-4.44|P-value:4.19E-5 ID:SGTC_1694|Compound:st024011|FD-Score:3.52|P-value:7.60E-4 ID:SGTC_1719|Compound:st032227|FD-Score:4.18|P-value:8.25E-5 ID:SGTC_1722|Compound:st034304|FD-Score:4.96|P-value:4.15E-6 ID:SGTC_1732|Compound:st034308|FD-Score:-4.45|P-value:4.04E-5 ID:SGTC_1738|Compound:st035555|FD-Score:-6.59|P-value:2.41E-9 ID:SGTC_1742|Compound:st038235|FD-Score:-3.74|P-value:4.65E-4 ID:SGTC_1744|Compound:st037937|FD-Score:4.41|P-value:3.57E-5 ID:SGTC_1751|Compound:st044839|FD-Score:-4.19|P-value:1.02E-4 ID:SGTC_1781|Compound:st038725|FD-Score:4.81|P-value:7.50E-6 ID:SGTC_1806|Compound:st050005|FD-Score:3.59|P-value:5.97E-4 ID:SGTC_1811|Compound:st050069|FD-Score:-3.62|P-value:6.86E-4 ID:SGTC_1813|Compound:st051246|FD-Score:-4.07|P-value:1.57E-4 ID:SGTC_1855|Compound:st056195|FD-Score:-4.25|P-value:8.44E-5 ID:SGTC_1909|Compound:st060837|FD-Score:-3.53|P-value:9.15E-4 ID:SGTC_2062|Compound:5245942|FD-Score:4.31|P-value:5.32E-5 ID:SGTC_2113|Compound:5491891|FD-Score:3.52|P-value:7.60E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:6.61|P-value:1.51E-9 ID:SGTC_2307|Compound:7538926|FD-Score:4.05|P-value:1.33E-4 ID:SGTC_2388|Compound:9080168|FD-Score:3.86|P-value:2.50E-4 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:-3.58|P-value:7.70E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:-5.89|P-value:8.65E-8 ID:SGTC_2620|Compound:irigenin|FD-Score:-3.81|P-value:3.80E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:4.45|P-value:3.04E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:7.38|P-value:1.75E-11 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:3.89|P-value:2.30E-4 ID:SGTC_2716|Compound:st080858|FD-Score:-3.75|P-value:4.48E-4 ID:SGTC_2917|Compound:7979103|FD-Score:5.44|P-value:5.15E-7 ID:SGTC_2924|Compound:9010168|FD-Score:-4.04|P-value:1.75E-4 ID:SGTC_2996|Compound:9066192|FD-Score:7.66|P-value:3.26E-12 ID:SGTC_3028|Compound:9087778|FD-Score:3.94|P-value:1.95E-4 ID:SGTC_3041|Compound:9091929|FD-Score:4.09|P-value:1.14E-4 ID:SGTC_3087|Compound:9117406|FD-Score:4.24|P-value:6.65E-5 ID:SGTC_3123|Compound:9126162|FD-Score:4.00|P-value:1.58E-4 ID:SGTC_3126|Compound:9127922|FD-Score:8.39|P-value:2.71E-14 ID:SGTC_3129|Compound:9127257|FD-Score:-4.69|P-value:1.61E-5 ID:SGTC_3140|Compound:9094243|FD-Score:3.51|P-value:7.76E-4 ID:SGTC_3232|Compound:9132874|FD-Score:-3.87|P-value:3.10E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-4.35|P-value:5.92E-5 ID:SGTC_15|Compound:0266-0086|FD-Score:3.71|P-value:4.14E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:3.72|P-value:3.99E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:-5.23|P-value:1.73E-6 ID:SGTC_306|Compound:1672-3436|FD-Score:-3.66|P-value:6.02E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:4.64|P-value:1.51E-5 ID:SGTC_540|Compound:1187-0821|FD-Score:-3.62|P-value:6.77E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:3.75|P-value:3.68E-4 ID:SGTC_651|Compound:3253-0966|FD-Score:3.75|P-value:3.65E-4 ID:SGTC_661|Compound:1304-0007|FD-Score:3.93|P-value:1.99E-4 ID:SGTC_834|Compound:0312-0008|FD-Score:3.83|P-value:2.75E-4 ID:SGTC_961|Compound:1252-1571|FD-Score:-3.65|P-value:6.22E-4 ID:SGTC_1062|Compound:mesoridazine|FD-Score:4.37|P-value:4.11E-5 ID:SGTC_1068|Compound:loratadine|FD-Score:4.05|P-value:1.32E-4 ID:SGTC_1089|Compound:terbinafine|FD-Score:-4.21|P-value:9.82E-5 ID:SGTC_1178|Compound:0988-0033|FD-Score:-3.68|P-value:5.69E-4 ID:SGTC_1180|Compound:1193-0155|FD-Score:3.45|P-value:9.16E-4 ID:SGTC_1352|Compound:1496-0991|FD-Score:4.40|P-value:3.75E-5 ID:SGTC_1360|Compound:1598-0022|FD-Score:3.89|P-value:2.29E-4 ID:SGTC_1378|Compound:2093-0007|FD-Score:-3.50|P-value:9.85E-4 ID:SGTC_1442|Compound:4112-3290|FD-Score:3.95|P-value:1.86E-4 ID:SGTC_1453|Compound:4237-0541|FD-Score:-3.79|P-value:3.94E-4 ID:SGTC_1494|Compound:4358-1428|FD-Score:-4.44|P-value:4.19E-5 ID:SGTC_1694|Compound:st024011|FD-Score:3.52|P-value:7.60E-4 ID:SGTC_1719|Compound:st032227|FD-Score:4.18|P-value:8.25E-5 ID:SGTC_1722|Compound:st034304|FD-Score:4.96|P-value:4.15E-6 ID:SGTC_1732|Compound:st034308|FD-Score:-4.45|P-value:4.04E-5 ID:SGTC_1738|Compound:st035555|FD-Score:-6.59|P-value:2.41E-9 ID:SGTC_1742|Compound:st038235|FD-Score:-3.74|P-value:4.65E-4 ID:SGTC_1744|Compound:st037937|FD-Score:4.41|P-value:3.57E-5 ID:SGTC_1751|Compound:st044839|FD-Score:-4.19|P-value:1.02E-4 ID:SGTC_1781|Compound:st038725|FD-Score:4.81|P-value:7.50E-6 ID:SGTC_1806|Compound:st050005|FD-Score:3.59|P-value:5.97E-4 ID:SGTC_1811|Compound:st050069|FD-Score:-3.62|P-value:6.86E-4 ID:SGTC_1813|Compound:st051246|FD-Score:-4.07|P-value:1.57E-4 ID:SGTC_1855|Compound:st056195|FD-Score:-4.25|P-value:8.44E-5 ID:SGTC_1909|Compound:st060837|FD-Score:-3.53|P-value:9.15E-4 ID:SGTC_2062|Compound:5245942|FD-Score:4.31|P-value:5.32E-5 ID:SGTC_2113|Compound:5491891|FD-Score:3.52|P-value:7.60E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:6.61|P-value:1.51E-9 ID:SGTC_2307|Compound:7538926|FD-Score:4.05|P-value:1.33E-4 ID:SGTC_2388|Compound:9080168|FD-Score:3.86|P-value:2.50E-4 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:-3.58|P-value:7.70E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:-5.89|P-value:8.65E-8 ID:SGTC_2620|Compound:irigenin|FD-Score:-3.81|P-value:3.80E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:4.45|P-value:3.04E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:7.38|P-value:1.75E-11 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:3.89|P-value:2.30E-4 ID:SGTC_2716|Compound:st080858|FD-Score:-3.75|P-value:4.48E-4 ID:SGTC_2917|Compound:7979103|FD-Score:5.44|P-value:5.15E-7 ID:SGTC_2924|Compound:9010168|FD-Score:-4.04|P-value:1.75E-4 ID:SGTC_2996|Compound:9066192|FD-Score:7.66|P-value:3.26E-12 ID:SGTC_3028|Compound:9087778|FD-Score:3.94|P-value:1.95E-4 ID:SGTC_3041|Compound:9091929|FD-Score:4.09|P-value:1.14E-4 ID:SGTC_3087|Compound:9117406|FD-Score:4.24|P-value:6.65E-5 ID:SGTC_3123|Compound:9126162|FD-Score:4.00|P-value:1.58E-4 ID:SGTC_3126|Compound:9127922|FD-Score:8.39|P-value:2.71E-14 ID:SGTC_3129|Compound:9127257|FD-Score:-4.69|P-value:1.61E-5 ID:SGTC_3140|Compound:9094243|FD-Score:3.51|P-value:7.76E-4 ID:SGTC_3232|Compound:9132874|FD-Score:-3.87|P-value:3.10E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-4.35|P-value:5.92E-5

Top fitness defect scores for YGR081C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3126 9127922 8.39 49.5 µM 2.71E-14 fatty acid desaturase (OLE1) 9 2.47E-17
2 SGTC_2996 9066192 7.66 71.4 µM 3.26E-12 4 9.61E-15
3 SGTC_2688 kanamycin b 7.38 96.7 µM 1.75E-11 calcium & mitochondrial duress 92 7.73E-14
4 SGTC_2232 chlorophetanol 6.61 41.5 µM 1.51E-9 TRP & mitochondrial translation 32 1.96E-11
5 SGTC_2917 7979103 5.44 53.8 µM 5.15E-7 7 2.72E-8
6 SGTC_1722 st034304 4.96 3.6 µM 4.15E-6 mitochondrial processes 11 3.59E-7
7 SGTC_1781 st038725 4.81 66.3 µM 7.50E-6 NEO1 78 7.45E-7
8 SGTC_364 0083-0097 4.64 67.7 µM 1.51E-5 15 1.77E-6
9 SGTC_2687 chenodiol 4.45 100.0 µM 3.04E-5 15 4.20E-6
10 SGTC_1744 st037937 4.41 38.9 µM 3.57E-5 18 5.10E-6
11 SGTC_1352 1496-0991 4.40 99.0 µM 3.75E-5 tubulin folding & SWR complex 25 5.42E-6
12 SGTC_1062 mesoridazine 4.37 14.2 µM 4.11E-5 13 6.08E-6
13 SGTC_2062 5245942 4.31 200.0 µM 5.32E-5 8 8.34E-6
14 SGTC_3087 9117406 4.24 49.5 µM 6.65E-5 14 1.10E-5
15 SGTC_1719 st032227 4.18 49.2 µM 8.25E-5 19 1.43E-5
16 SGTC_3041 9091929 4.09 49.5 µM 1.14E-4 redox potentiating 19 2.13E-5
17 SGTC_1068 loratadine 4.05 26.9 µM 1.32E-4 19 2.56E-5
18 SGTC_2307 7538926 4.05 6.3 µM 1.33E-4 41 2.59E-5
19 SGTC_3123 9126162 4.00 49.5 µM 1.58E-4 17 3.18E-5
20 SGTC_1442 4112-3290 3.95 3.0 µM 1.86E-4 12 3.88E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.141 2.45E-16 YCR075W-A_p YCR075W-A_p hom Putative protein of unknown function; identified by homology to Ashbya gossypii; YCR075W-A has a paralog, YNR034W-A, that arose from the whole genome duplication
0.137 1.64E-15 YDR101C ARX1 hom Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex
0.131 2.19E-14 YHR203C RPS4B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S4, no bacterial homolog; RPS4B has a paralog, RPS4A, that arose from the whole genome duplication
0.125 3.20E-13 YGR214W RPS0A hom Ribosomal 40S subunit protein S0A; required for maturation of 18S rRNA along with Rps0Bp; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2; RPS0A has a paralog, RPS0B, that arose from the whole genome duplication;
0.125 3.35E-13 YJL136C RPS21B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21B has a paralog, RPS21A, that arose from the whole genome duplication
0.119 3.85E-12 YDL081C RPP1A hom Ribosomal stalk protein P1 alpha, involved in the interaction between translational elongation factors and the ribosome; accumulation of P1 in the cytoplasm is regulated by phosphorylation and interaction with the P2 stalk component
0.113 5.69E-11 YLR048W RPS0B hom Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2
0.109 2.25E-10 YOR293W RPS10A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10A has a paralog, RPS10B, that arose from the whole genome duplication
0.106 7.29E-10 YJL053W PEP8 hom Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress
0.105 1.23E-9 YDL033C SLM3 hom tRNA-specific 2-thiouridylase, responsible for 2-thiolation of the wobble base of mitochondrial tRNAs; human ortholog is implicated in myoclonus epilepsy associated with ragged red fibers (MERRF)
0.103 2.46E-9 YGL088W_d YGL088W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps snR10, a snoRNA required for preRNA processing
0.101 4.97E-9 YML036W CGI121 hom Component of the EKC/KEOPS complex with Bud32p, Kae1p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription; Cgi121p is dispensable for tRNA modification
0.099 1.08E-8 YFR051C RET2 het Delta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER
0.098 1.14E-8 YPL125W KAP120 hom Karyopherin responsible for the nuclear import of ribosome maturation factor Rfp1p
0.098 1.28E-8 YGL246C RAI1 hom Nuclear protein with decapping endonuclease activity targeted toward mRNAs with unmethylated 7-methylguanosine cap structures; binds to and stabilizes the exoribonuclease Rat1p; required for pre-rRNA processing; homologous to human DOM3Z