YGR082W / TOM20

Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteins

Zygosity: Heterozygous strain
fixedexpanded
Profile for YGR082W / TOM20

Click on Significant Values for Screen Details ID:SGTC_69|Compound:0096-0274|FD-Score:5.39|P-value:1.35E-10 ID:SGTC_70|Compound:0141-0289|FD-Score:2.65|P-value:9.96E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-3.29|P-value:5.28E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:3.50|P-value:2.14E-5 ID:SGTC_430|Compound:0958-0115|FD-Score:-2.79|P-value:5.13E-4 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:3.09|P-value:1.50E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.48|P-value:2.13E-5 ID:SGTC_902|Compound:1120-0002|FD-Score:-2.75|P-value:5.99E-4 ID:SGTC_1114|Compound:scopoletin|FD-Score:2.72|P-value:7.40E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:4.61|P-value:3.41E-8 ID:SGTC_1132|Compound:3456-3614|FD-Score:4.53|P-value:5.77E-8 ID:SGTC_1305|Compound:1181-0477|FD-Score:2.68|P-value:8.80E-4 ID:SGTC_1307|Compound:1187-1599|FD-Score:-2.73|P-value:6.58E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:-3.21|P-value:7.82E-5 ID:SGTC_1521|Compound:st012942|FD-Score:3.38|P-value:3.88E-5 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:2.71|P-value:7.69E-4 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:-3.16|P-value:9.72E-5 ID:SGTC_1606|Compound:st000094|FD-Score:4.33|P-value:2.07E-7 ID:SGTC_1607|Compound:st000305|FD-Score:-2.66|P-value:8.63E-4 ID:SGTC_1674|Compound:st016616|FD-Score:-3.10|P-value:1.29E-4 ID:SGTC_1676|Compound:st018489|FD-Score:-3.14|P-value:1.06E-4 ID:SGTC_1682|Compound:st012968|FD-Score:-6.61|P-value:3.90E-15 ID:SGTC_1697|Compound:st025554|FD-Score:-2.65|P-value:8.89E-4 ID:SGTC_1920|Compound:st075728|FD-Score:4.10|P-value:8.18E-7 ID:SGTC_1924|Compound:st058459|FD-Score:4.20|P-value:4.40E-7 ID:SGTC_2023|Compound:5144124|FD-Score:-3.07|P-value:1.48E-4 ID:SGTC_2076|Compound:5212012|FD-Score:2.65|P-value:9.92E-4 ID:SGTC_2101|Compound:5377231|FD-Score:2.69|P-value:8.30E-4 ID:SGTC_2125|Compound:5246583|FD-Score:3.06|P-value:1.73E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:2.71|P-value:7.87E-4 ID:SGTC_2430|Compound:5571206|FD-Score:2.98|P-value:2.49E-4 ID:SGTC_2433|Compound:5607874|FD-Score:-2.73|P-value:6.54E-4 ID:SGTC_2482|Compound:5981709|FD-Score:-2.66|P-value:8.70E-4 ID:SGTC_2484|Compound:5809818|FD-Score:-3.07|P-value:1.48E-4 ID:SGTC_2491|Compound:paeonol|FD-Score:2.70|P-value:8.18E-4 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:-4.21|P-value:3.57E-7 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:2.69|P-value:8.27E-4 ID:SGTC_2507|Compound:purpurin|FD-Score:-4.30|P-value:2.06E-7 ID:SGTC_2583|Compound:asiatic acid|FD-Score:7.18|P-value:2.12E-17 ID:SGTC_2587|Compound:piperic acid|FD-Score:-4.81|P-value:7.91E-9 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:4.29|P-value:2.58E-7 ID:SGTC_2753|Compound:fluvastatin|FD-Score:2.94|P-value:2.99E-4 ID:SGTC_2794|Compound:7785382|FD-Score:3.13|P-value:1.28E-4 ID:SGTC_2824|Compound:7998404|FD-Score:-2.86|P-value:3.76E-4 ID:SGTC_2918|Compound:7977171|FD-Score:3.18|P-value:1.02E-4 ID:SGTC_2925|Compound:9010536|FD-Score:-3.05|P-value:1.66E-4 ID:SGTC_2973|Compound:9094665|FD-Score:2.81|P-value:5.06E-4 ID:SGTC_2995|Compound:9067767|FD-Score:2.89|P-value:3.63E-4 ID:SGTC_3209|Compound:9113616|FD-Score:3.46|P-value:2.61E-5 ID:SGTC_69|Compound:0096-0274|FD-Score:5.39|P-value:1.35E-10 ID:SGTC_70|Compound:0141-0289|FD-Score:2.65|P-value:9.96E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-3.29|P-value:5.28E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:3.50|P-value:2.14E-5 ID:SGTC_430|Compound:0958-0115|FD-Score:-2.79|P-value:5.13E-4 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:3.09|P-value:1.50E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.48|P-value:2.13E-5 ID:SGTC_902|Compound:1120-0002|FD-Score:-2.75|P-value:5.99E-4 ID:SGTC_1114|Compound:scopoletin|FD-Score:2.72|P-value:7.40E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:4.61|P-value:3.41E-8 ID:SGTC_1132|Compound:3456-3614|FD-Score:4.53|P-value:5.77E-8 ID:SGTC_1305|Compound:1181-0477|FD-Score:2.68|P-value:8.80E-4 ID:SGTC_1307|Compound:1187-1599|FD-Score:-2.73|P-value:6.58E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:-3.21|P-value:7.82E-5 ID:SGTC_1521|Compound:st012942|FD-Score:3.38|P-value:3.88E-5 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:2.71|P-value:7.69E-4 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:-3.16|P-value:9.72E-5 ID:SGTC_1606|Compound:st000094|FD-Score:4.33|P-value:2.07E-7 ID:SGTC_1607|Compound:st000305|FD-Score:-2.66|P-value:8.63E-4 ID:SGTC_1674|Compound:st016616|FD-Score:-3.10|P-value:1.29E-4 ID:SGTC_1676|Compound:st018489|FD-Score:-3.14|P-value:1.06E-4 ID:SGTC_1682|Compound:st012968|FD-Score:-6.61|P-value:3.90E-15 ID:SGTC_1697|Compound:st025554|FD-Score:-2.65|P-value:8.89E-4 ID:SGTC_1920|Compound:st075728|FD-Score:4.10|P-value:8.18E-7 ID:SGTC_1924|Compound:st058459|FD-Score:4.20|P-value:4.40E-7 ID:SGTC_2023|Compound:5144124|FD-Score:-3.07|P-value:1.48E-4 ID:SGTC_2076|Compound:5212012|FD-Score:2.65|P-value:9.92E-4 ID:SGTC_2101|Compound:5377231|FD-Score:2.69|P-value:8.30E-4 ID:SGTC_2125|Compound:5246583|FD-Score:3.06|P-value:1.73E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:2.71|P-value:7.87E-4 ID:SGTC_2430|Compound:5571206|FD-Score:2.98|P-value:2.49E-4 ID:SGTC_2433|Compound:5607874|FD-Score:-2.73|P-value:6.54E-4 ID:SGTC_2482|Compound:5981709|FD-Score:-2.66|P-value:8.70E-4 ID:SGTC_2484|Compound:5809818|FD-Score:-3.07|P-value:1.48E-4 ID:SGTC_2491|Compound:paeonol|FD-Score:2.70|P-value:8.18E-4 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:-4.21|P-value:3.57E-7 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:2.69|P-value:8.27E-4 ID:SGTC_2507|Compound:purpurin|FD-Score:-4.30|P-value:2.06E-7 ID:SGTC_2583|Compound:asiatic acid|FD-Score:7.18|P-value:2.12E-17 ID:SGTC_2587|Compound:piperic acid|FD-Score:-4.81|P-value:7.91E-9 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:4.29|P-value:2.58E-7 ID:SGTC_2753|Compound:fluvastatin|FD-Score:2.94|P-value:2.99E-4 ID:SGTC_2794|Compound:7785382|FD-Score:3.13|P-value:1.28E-4 ID:SGTC_2824|Compound:7998404|FD-Score:-2.86|P-value:3.76E-4 ID:SGTC_2918|Compound:7977171|FD-Score:3.18|P-value:1.02E-4 ID:SGTC_2925|Compound:9010536|FD-Score:-3.05|P-value:1.66E-4 ID:SGTC_2973|Compound:9094665|FD-Score:2.81|P-value:5.06E-4 ID:SGTC_2995|Compound:9067767|FD-Score:2.89|P-value:3.63E-4 ID:SGTC_3209|Compound:9113616|FD-Score:3.46|P-value:2.61E-5

Top fitness defect scores for YGR082W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2583 asiatic acid 7.18 100.0 µM 2.12E-17 2 3.57E-13 2.11
2 SGTC_69 0096-0274 5.39 206.7 µM 1.35E-10 mitochondrial processes 25 3.44E-8 0.05
3 SGTC_1130 3454-2858 4.61 15.9 µM 3.41E-8 NEO1 7 2.00E-6 0.15
4 SGTC_1132 3456-3614 4.53 2.5 µM 5.77E-8 tubulin folding & SWR complex 6 2.95E-6 0.01
5 SGTC_1606 st000094 4.33 49.2 µM 2.07E-7 60S ribosome export 5 7.56E-6 0.36
6 SGTC_2588 indole-3-carbinol 4.29 100.0 µM 2.58E-7 4 8.89E-6 0.04
7 SGTC_1924 st058459 4.20 75.1 µM 4.40E-7 5 1.32E-5 0.06
8 SGTC_1920 st075728 4.10 45.7 µM 8.18E-7 4 2.08E-5 0.13
9 SGTC_236 1509-0011 3.50 5.3 µM 2.14E-5 32 2.33E-4 0.08
10 SGTC_3209 9113616 3.46 49.5 µM 2.61E-5 10 2.70E-4 0.09
11 SGTC_1521 st012942 3.38 49.4 µM 3.88E-5 8 3.62E-4 0.24
12 SGTC_2918 7977171 3.18 22.1 µM 1.02E-4 8 7.41E-4 0.02
13 SGTC_2794 7785382 3.13 27.3 µM 1.28E-4 27 8.81E-4 0.14
14 SGTC_503 tyrphostin 8 3.09 294.0 µM 1.50E-4 TSC3-RPN4 12 9.88E-4 0.07
15 SGTC_2125 5246583 3.06 200.0 µM 1.73E-4 tubulin folding & SWR complex 13 0.00110 0.02
16 SGTC_2430 5571206 2.98 200.0 µM 2.49E-4 31 0.00144 0.07
17 SGTC_2753 fluvastatin 2.94 17.1 µM 2.99E-4 azole & statin 22 0.00165 0.14
18 SGTC_2995 9067767 2.89 71.4 µM 3.63E-4 14 0.00191 0.16
19 SGTC_2973 9094665 2.81 18.0 µM 5.06E-4 NEO1 40 0.00245 0.01
20 SGTC_1114 scopoletin 2.72 1.7 µM 7.40E-4 12 0.00325 0.09

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.174 2.67E-24 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.159 1.91E-20 YLR117C CLF1 het Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; homolog of Drosophila crooked neck protein; interacts with U1 snRNP proteins
0.154 2.54E-19 YLR416C_d YLR416C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.138 8.26E-16 YAL014C SYN8 hom Endosomal SNARE related to mammalian syntaxin 8
0.136 3.22E-15 YNL290W RFC3 het Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon
0.131 2.92E-14 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.129 5.38E-14 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.129 7.50E-14 YKL183W LOT5 hom Protein of unknown function; gene expression increases in cultures shifted to a lower temperature; protein abundance increases in response to DNA replication stress
0.128 9.54E-14 YJL033W HCA4 het DEAD box RNA helicase; high-copy number suppression of a U14 snoRNA processing mutant suggests an involvement in 18S rRNA synthesis
0.128 1.03E-13 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.127 1.90E-13 YOL027C MDM38 hom Mitochondrial protein, forms a complex with Mba1p to facilitate recruitment of mRNA-specific translational activators to ribosomes; roles in protein export and K+/H+ exchange; human ortholog Letm1 implicated in Wolf-Hirschhorn syndrome
0.124 4.51E-13 YBR153W RIB7 het Diaminohydroxyphoshoribosylaminopyrimidine deaminase; catalyzes the second step of the riboflavin biosynthesis pathway
0.124 6.04E-13 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.122 1.45E-12 YMR286W MRPL33 hom Mitochondrial ribosomal protein of the large subunit
0.121 1.61E-12 YPL121C MEI5 hom Meiosis specific protein involved in DMC1-dependent meiotic recombination, forms heterodimer with Sae3p; proposed to be an assembly factor for Dmc1p