YGR090W / UTP22

Component of the small-subunit processome; required for nuclear export of tRNAs; may facilitate binding of Utp8p to aminoacylated tRNAs and their delivery to Los1p for export; conserved from yeast to mammals

Zygosity: Heterozygous strain
fixedexpanded
Profile for YGR090W / UTP22

Click on Significant Values for Screen Details ID:SGTC_57|Compound:miconazole|FD-Score:3.40|P-value:3.46E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:4.61|P-value:2.04E-6 ID:SGTC_86|Compound:0417-1630|FD-Score:6.73|P-value:8.92E-12 ID:SGTC_122|Compound:0236-0016|FD-Score:3.63|P-value:1.41E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:3.98|P-value:3.43E-5 ID:SGTC_141|Compound:0443-0274|FD-Score:-4.15|P-value:1.71E-5 ID:SGTC_163|Compound:1327-0036|FD-Score:3.51|P-value:2.26E-4 ID:SGTC_199|Compound:4063-0024|FD-Score:3.11|P-value:9.58E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:3.55|P-value:1.95E-4 ID:SGTC_256|Compound:clotrimazole|FD-Score:5.95|P-value:1.41E-9 ID:SGTC_285|Compound:1486-1325|FD-Score:-3.21|P-value:6.72E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:6.92|P-value:2.44E-12 ID:SGTC_363|Compound:0455-0021|FD-Score:4.92|P-value:4.38E-7 ID:SGTC_378|Compound:3970-0959|FD-Score:3.39|P-value:3.54E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:-3.55|P-value:1.96E-4 ID:SGTC_539|Compound:4859-0462|FD-Score:7.03|P-value:1.10E-12 ID:SGTC_560|Compound:2332-1943|FD-Score:3.35|P-value:4.09E-4 ID:SGTC_601|Compound:0986-0029|FD-Score:5.54|P-value:1.57E-8 ID:SGTC_617|Compound:3770-0098|FD-Score:8.61|P-value:4.09E-18 ID:SGTC_649|Compound:1123-0311|FD-Score:3.62|P-value:1.48E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:3.91|P-value:4.76E-5 ID:SGTC_778|Compound:3456-2434|FD-Score:-4.23|P-value:1.24E-5 ID:SGTC_797|Compound:k781-0471|FD-Score:3.35|P-value:4.06E-4 ID:SGTC_969|Compound:1313-0238|FD-Score:5.11|P-value:1.67E-7 ID:SGTC_1072|Compound:oxiconazole|FD-Score:3.60|P-value:1.61E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:-3.56|P-value:1.91E-4 ID:SGTC_1237|Compound:0330-0133|FD-Score:3.63|P-value:1.44E-4 ID:SGTC_1289|Compound:0976-0073|FD-Score:4.37|P-value:6.28E-6 ID:SGTC_1379|Compound:2144-0755|FD-Score:3.47|P-value:2.62E-4 ID:SGTC_1524|Compound:corynanthine|FD-Score:3.49|P-value:2.43E-4 ID:SGTC_1526|Compound:st051518|FD-Score:-4.26|P-value:1.05E-5 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:3.42|P-value:3.21E-4 ID:SGTC_1610|Compound:st001799|FD-Score:5.46|P-value:2.40E-8 ID:SGTC_1611|Compound:st001856|FD-Score:3.90|P-value:4.86E-5 ID:SGTC_1681|Compound:tripelennamine|FD-Score:3.20|P-value:6.92E-4 ID:SGTC_1754|Compound:st042065|FD-Score:-3.59|P-value:1.74E-4 ID:SGTC_1961|Compound:st076550|FD-Score:3.79|P-value:7.77E-5 ID:SGTC_2089|Compound:5281248|FD-Score:4.66|P-value:1.59E-6 ID:SGTC_2213|Compound:7173844|FD-Score:3.29|P-value:5.04E-4 ID:SGTC_2241|Compound:6772625|FD-Score:3.82|P-value:6.82E-5 ID:SGTC_2246|Compound:7293507|FD-Score:5.28|P-value:6.55E-8 ID:SGTC_2248|Compound:tofa|FD-Score:3.80|P-value:7.34E-5 ID:SGTC_2297|Compound:7971671|FD-Score:5.23|P-value:8.53E-8 ID:SGTC_2398|Compound:5228213|FD-Score:4.81|P-value:7.83E-7 ID:SGTC_2407|Compound:paclitaxel|FD-Score:4.07|P-value:2.40E-5 ID:SGTC_2411|Compound:st077133|FD-Score:5.87|P-value:2.20E-9 ID:SGTC_2445|Compound:5742597|FD-Score:3.50|P-value:2.34E-4 ID:SGTC_2475|Compound:5812728|FD-Score:4.01|P-value:3.13E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.20|P-value:1.34E-5 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:5.65|P-value:8.54E-9 ID:SGTC_2601|Compound:securinine|FD-Score:6.73|P-value:9.17E-12 ID:SGTC_2612|Compound:dictamnine|FD-Score:7.04|P-value:1.04E-12 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:3.20|P-value:6.84E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-4.66|P-value:1.65E-6 ID:SGTC_2912|Compound:7964298|FD-Score:-3.39|P-value:3.58E-4 ID:SGTC_2962|Compound:9082311|FD-Score:-3.37|P-value:3.87E-4 ID:SGTC_3003|Compound:9075612|FD-Score:-3.20|P-value:7.16E-4 ID:SGTC_3078|Compound:9116413|FD-Score:-3.69|P-value:1.18E-4 ID:SGTC_3211|Compound:9128781|FD-Score:4.25|P-value:1.10E-5 ID:SGTC_57|Compound:miconazole|FD-Score:3.40|P-value:3.46E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:4.61|P-value:2.04E-6 ID:SGTC_86|Compound:0417-1630|FD-Score:6.73|P-value:8.92E-12 ID:SGTC_122|Compound:0236-0016|FD-Score:3.63|P-value:1.41E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:3.98|P-value:3.43E-5 ID:SGTC_141|Compound:0443-0274|FD-Score:-4.15|P-value:1.71E-5 ID:SGTC_163|Compound:1327-0036|FD-Score:3.51|P-value:2.26E-4 ID:SGTC_199|Compound:4063-0024|FD-Score:3.11|P-value:9.58E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:3.55|P-value:1.95E-4 ID:SGTC_256|Compound:clotrimazole|FD-Score:5.95|P-value:1.41E-9 ID:SGTC_285|Compound:1486-1325|FD-Score:-3.21|P-value:6.72E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:6.92|P-value:2.44E-12 ID:SGTC_363|Compound:0455-0021|FD-Score:4.92|P-value:4.38E-7 ID:SGTC_378|Compound:3970-0959|FD-Score:3.39|P-value:3.54E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:-3.55|P-value:1.96E-4 ID:SGTC_539|Compound:4859-0462|FD-Score:7.03|P-value:1.10E-12 ID:SGTC_560|Compound:2332-1943|FD-Score:3.35|P-value:4.09E-4 ID:SGTC_601|Compound:0986-0029|FD-Score:5.54|P-value:1.57E-8 ID:SGTC_617|Compound:3770-0098|FD-Score:8.61|P-value:4.09E-18 ID:SGTC_649|Compound:1123-0311|FD-Score:3.62|P-value:1.48E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:3.91|P-value:4.76E-5 ID:SGTC_778|Compound:3456-2434|FD-Score:-4.23|P-value:1.24E-5 ID:SGTC_797|Compound:k781-0471|FD-Score:3.35|P-value:4.06E-4 ID:SGTC_969|Compound:1313-0238|FD-Score:5.11|P-value:1.67E-7 ID:SGTC_1072|Compound:oxiconazole|FD-Score:3.60|P-value:1.61E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:-3.56|P-value:1.91E-4 ID:SGTC_1237|Compound:0330-0133|FD-Score:3.63|P-value:1.44E-4 ID:SGTC_1289|Compound:0976-0073|FD-Score:4.37|P-value:6.28E-6 ID:SGTC_1379|Compound:2144-0755|FD-Score:3.47|P-value:2.62E-4 ID:SGTC_1524|Compound:corynanthine|FD-Score:3.49|P-value:2.43E-4 ID:SGTC_1526|Compound:st051518|FD-Score:-4.26|P-value:1.05E-5 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:3.42|P-value:3.21E-4 ID:SGTC_1610|Compound:st001799|FD-Score:5.46|P-value:2.40E-8 ID:SGTC_1611|Compound:st001856|FD-Score:3.90|P-value:4.86E-5 ID:SGTC_1681|Compound:tripelennamine|FD-Score:3.20|P-value:6.92E-4 ID:SGTC_1754|Compound:st042065|FD-Score:-3.59|P-value:1.74E-4 ID:SGTC_1961|Compound:st076550|FD-Score:3.79|P-value:7.77E-5 ID:SGTC_2089|Compound:5281248|FD-Score:4.66|P-value:1.59E-6 ID:SGTC_2213|Compound:7173844|FD-Score:3.29|P-value:5.04E-4 ID:SGTC_2241|Compound:6772625|FD-Score:3.82|P-value:6.82E-5 ID:SGTC_2246|Compound:7293507|FD-Score:5.28|P-value:6.55E-8 ID:SGTC_2248|Compound:tofa|FD-Score:3.80|P-value:7.34E-5 ID:SGTC_2297|Compound:7971671|FD-Score:5.23|P-value:8.53E-8 ID:SGTC_2398|Compound:5228213|FD-Score:4.81|P-value:7.83E-7 ID:SGTC_2407|Compound:paclitaxel|FD-Score:4.07|P-value:2.40E-5 ID:SGTC_2411|Compound:st077133|FD-Score:5.87|P-value:2.20E-9 ID:SGTC_2445|Compound:5742597|FD-Score:3.50|P-value:2.34E-4 ID:SGTC_2475|Compound:5812728|FD-Score:4.01|P-value:3.13E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.20|P-value:1.34E-5 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:5.65|P-value:8.54E-9 ID:SGTC_2601|Compound:securinine|FD-Score:6.73|P-value:9.17E-12 ID:SGTC_2612|Compound:dictamnine|FD-Score:7.04|P-value:1.04E-12 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:3.20|P-value:6.84E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-4.66|P-value:1.65E-6 ID:SGTC_2912|Compound:7964298|FD-Score:-3.39|P-value:3.58E-4 ID:SGTC_2962|Compound:9082311|FD-Score:-3.37|P-value:3.87E-4 ID:SGTC_3003|Compound:9075612|FD-Score:-3.20|P-value:7.16E-4 ID:SGTC_3078|Compound:9116413|FD-Score:-3.69|P-value:1.18E-4 ID:SGTC_3211|Compound:9128781|FD-Score:4.25|P-value:1.10E-5

Top fitness defect scores for YGR090W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_617 3770-0098 8.61 35.0 µM 4.09E-18 exosome 7 3.73E-18 0.28
2 SGTC_2612 dictamnine 7.04 15.5 µM 1.04E-12 RNA pol III & RNase P/MRP 15 9.86E-13 0.13
3 SGTC_539 4859-0462 7.03 2.5 µM 1.10E-12 RNA pol III & RNase P/MRP 8 1.04E-12 0.17
4 SGTC_341 1486-1430 6.92 230.0 µM 2.44E-12 6 2.31E-12 1.22
5 SGTC_86 0417-1630 6.73 471.9 µM 8.92E-12 ubiquinone biosynthesis & proteasome 9 8.47E-12 0.36
6 SGTC_2601 securinine 6.73 100.0 µM 9.17E-12 4 8.70E-12 0.96
7 SGTC_256 clotrimazole 5.95 625.0 nM 1.41E-9 ergosterol depletion effects on membrane 9 1.36E-9 0.53
8 SGTC_2411 st077133 5.87 39.9 µM 2.20E-9 RNA pol III & RNase P/MRP 13 2.12E-9 0.01
9 SGTC_2598 perillyl alcohol 5.65 100.0 µM 8.54E-9 3 8.25E-9 1.11
10 SGTC_601 0986-0029 5.54 62.9 µM 1.57E-8 calcium & mitochondrial duress 8 1.52E-8 0.06
11 SGTC_1610 st001799 5.46 48.1 µM 2.40E-8 1 2.32E-8 1.76
12 SGTC_2246 7293507 5.28 91.6 µM 6.55E-8 6 6.36E-8 0.26
13 SGTC_2297 7971671 5.23 152.3 µM 8.53E-8 RNA processing & uracil transport 4 8.29E-8 0.40
14 SGTC_969 1313-0238 5.11 134.0 µM 1.67E-7 mitochondrial processes 10 1.62E-7 0.12
15 SGTC_363 0455-0021 4.92 3.1 µM 4.38E-7 azole & statin 11 4.27E-7 0.02
16 SGTC_2398 5228213 4.81 48.8 µM 7.83E-7 iron homeostasis 11 7.65E-7 0.35
17 SGTC_2089 5281248 4.66 129.7 µM 1.59E-6 superoxide 8 1.55E-6 0.69
18 SGTC_64 000l-0018 4.61 272.1 µM 2.04E-6 ubiquinone biosynthesis & proteasome 38 1.99E-6 0.05
19 SGTC_1289 0976-0073 4.37 69.1 µM 6.28E-6 2 6.17E-6 0.65
20 SGTC_3211 9128781 4.25 49.5 µM 1.10E-5 13 1.08E-5 0.11

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.212 2.46E-35 YCL031C RRP7 het Essential protein involved in rRNA processing and ribosome biogenesis; protein abundance increases in response to DNA replication stress
0.192 3.18E-29 YNL221C POP1 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P
0.170 3.92E-23 YLR202C_d YLR202C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YLR201C; ORF contains a putative intron
0.167 2.06E-22 YOR260W GCD1 het Gamma subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
0.155 1.93E-19 YDR204W COQ4 hom Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex
0.153 6.05E-19 YBL004W UTP20 het Component of the small-subunit (SSU) processome, which is involved in the biogenesis of the 18S rRNA
0.147 1.12E-17 YNR041C COQ2 hom Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis
0.144 4.30E-17 YGL119W COQ8 hom Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication
0.144 6.32E-17 YOR125C CAT5 hom Protein required for ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes; required for gluconeogenic gene activation
0.135 4.11E-15 YLR015W BRE2 hom Subunit of COMPASS (Set1C) complex, which methylates Lys4 of histone H3 and functions in silencing at telomeres; has a C-terminal Sdc1 Dpy-30 Interaction (SDI) domain that mediates binding to Sdc1p; similar to trithorax-group protein ASH2L
0.131 2.63E-14 YGR083C GCD2 het Delta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
0.124 4.69E-13 YGR255C COQ6 hom Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS)
0.121 1.85E-12 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.120 3.57E-12 YAL034W-A MTW1 het Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; critical to kinetochore assembly
0.120 3.66E-12 YOL096C COQ3 hom O-methyltransferase, catalyzes two different O-methylation steps in ubiquinone (Coenzyme Q) biosynthesis; component of a mitochondrial ubiquinone-synthesizing complex; phosphoprotein