YGR091W / PRP31

Splicing factor, component of the U4/U6-U5 snRNP complex

Zygosity: Heterozygous strain
fixedexpanded
Profile for YGR091W / PRP31

Click on Significant Values for Screen Details ID:SGTC_130|Compound:0136-0219|FD-Score:3.60|P-value:5.64E-5 ID:SGTC_133|Compound:0724-0033|FD-Score:4.01|P-value:8.24E-6 ID:SGTC_164|Compound:4100-3994|FD-Score:5.10|P-value:2.21E-8 ID:SGTC_168|Compound:3970-0862|FD-Score:-3.68|P-value:4.10E-5 ID:SGTC_357|Compound:1325-0123|FD-Score:4.02|P-value:8.05E-6 ID:SGTC_657|Compound:3534-0529|FD-Score:3.46|P-value:1.03E-4 ID:SGTC_680|Compound:0417-1641|FD-Score:-3.32|P-value:1.92E-4 ID:SGTC_693|Compound:4161-2696|FD-Score:-2.98|P-value:7.08E-4 ID:SGTC_817|Compound:1391-0715|FD-Score:3.21|P-value:2.90E-4 ID:SGTC_943|Compound:3253-1379|FD-Score:3.47|P-value:9.72E-5 ID:SGTC_1127|Compound:asiatic acid|FD-Score:-3.92|P-value:1.36E-5 ID:SGTC_1250|Compound:0485-0349|FD-Score:-2.91|P-value:9.32E-4 ID:SGTC_1322|Compound:1348-1070|FD-Score:4.04|P-value:7.20E-6 ID:SGTC_1329|Compound:1447-1697|FD-Score:3.06|P-value:5.02E-4 ID:SGTC_1332|Compound:1480-0653|FD-Score:3.05|P-value:5.32E-4 ID:SGTC_1335|Compound:1486-0900|FD-Score:4.11|P-value:5.16E-6 ID:SGTC_1372|Compound:2752-0194|FD-Score:-3.14|P-value:3.96E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:-2.90|P-value:9.57E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:-3.06|P-value:5.38E-4 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:3.54|P-value:7.27E-5 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:3.64|P-value:4.75E-5 ID:SGTC_1594|Compound:piperine|FD-Score:3.15|P-value:3.58E-4 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:3.03|P-value:5.69E-4 ID:SGTC_1702|Compound:st027038|FD-Score:3.10|P-value:4.37E-4 ID:SGTC_1867|Compound:st057372|FD-Score:-2.90|P-value:9.52E-4 ID:SGTC_2004|Compound:4023728|FD-Score:3.16|P-value:3.52E-4 ID:SGTC_2010|Compound:4012422|FD-Score:3.65|P-value:4.40E-5 ID:SGTC_2055|Compound:5235184|FD-Score:3.02|P-value:6.00E-4 ID:SGTC_2248|Compound:tofa|FD-Score:3.53|P-value:7.42E-5 ID:SGTC_2261|Compound:9010538|FD-Score:2.94|P-value:8.07E-4 ID:SGTC_2290|Compound:7904846|FD-Score:2.94|P-value:7.91E-4 ID:SGTC_2492|Compound:derrusnin|FD-Score:4.13|P-value:4.71E-6 ID:SGTC_2537|Compound:larixol|FD-Score:-3.11|P-value:4.34E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:-4.16|P-value:4.15E-6 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:-3.71|P-value:3.57E-5 ID:SGTC_2749|Compound:bexarotene|FD-Score:3.03|P-value:5.62E-4 ID:SGTC_2807|Compound:7945238|FD-Score:2.95|P-value:7.79E-4 ID:SGTC_2820|Compound:7989630|FD-Score:3.14|P-value:3.81E-4 ID:SGTC_2850|Compound:9015429|FD-Score:-3.98|P-value:1.03E-5 ID:SGTC_2852|Compound:9023854|FD-Score:3.21|P-value:2.82E-4 ID:SGTC_3044|Compound:9093193|FD-Score:3.64|P-value:4.64E-5 ID:SGTC_3065|Compound:9113888|FD-Score:3.70|P-value:3.56E-5 ID:SGTC_3127|Compound:9126946|FD-Score:3.88|P-value:1.55E-5 ID:SGTC_3131|Compound:9127911|FD-Score:3.30|P-value:2.02E-4 ID:SGTC_3135|Compound:9127742|FD-Score:-3.70|P-value:3.67E-5 ID:SGTC_3166|Compound:9102297|FD-Score:3.14|P-value:3.72E-4 ID:SGTC_3193|Compound:9111931|FD-Score:3.87|P-value:1.65E-5 ID:SGTC_3219|Compound:9131112|FD-Score:3.39|P-value:1.37E-4 ID:SGTC_3324|Compound:9138759|FD-Score:-8.09|P-value:2.18E-18 ID:SGTC_3330|Compound:9141424|FD-Score:2.98|P-value:6.86E-4 ID:SGTC_3333|Compound:9141820|FD-Score:3.83|P-value:2.01E-5 ID:SGTC_3334|Compound:9142812|FD-Score:-3.42|P-value:1.27E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:3.60|P-value:5.64E-5 ID:SGTC_133|Compound:0724-0033|FD-Score:4.01|P-value:8.24E-6 ID:SGTC_164|Compound:4100-3994|FD-Score:5.10|P-value:2.21E-8 ID:SGTC_168|Compound:3970-0862|FD-Score:-3.68|P-value:4.10E-5 ID:SGTC_357|Compound:1325-0123|FD-Score:4.02|P-value:8.05E-6 ID:SGTC_657|Compound:3534-0529|FD-Score:3.46|P-value:1.03E-4 ID:SGTC_680|Compound:0417-1641|FD-Score:-3.32|P-value:1.92E-4 ID:SGTC_693|Compound:4161-2696|FD-Score:-2.98|P-value:7.08E-4 ID:SGTC_817|Compound:1391-0715|FD-Score:3.21|P-value:2.90E-4 ID:SGTC_943|Compound:3253-1379|FD-Score:3.47|P-value:9.72E-5 ID:SGTC_1127|Compound:asiatic acid|FD-Score:-3.92|P-value:1.36E-5 ID:SGTC_1250|Compound:0485-0349|FD-Score:-2.91|P-value:9.32E-4 ID:SGTC_1322|Compound:1348-1070|FD-Score:4.04|P-value:7.20E-6 ID:SGTC_1329|Compound:1447-1697|FD-Score:3.06|P-value:5.02E-4 ID:SGTC_1332|Compound:1480-0653|FD-Score:3.05|P-value:5.32E-4 ID:SGTC_1335|Compound:1486-0900|FD-Score:4.11|P-value:5.16E-6 ID:SGTC_1372|Compound:2752-0194|FD-Score:-3.14|P-value:3.96E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:-2.90|P-value:9.57E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:-3.06|P-value:5.38E-4 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:3.54|P-value:7.27E-5 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:3.64|P-value:4.75E-5 ID:SGTC_1594|Compound:piperine|FD-Score:3.15|P-value:3.58E-4 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:3.03|P-value:5.69E-4 ID:SGTC_1702|Compound:st027038|FD-Score:3.10|P-value:4.37E-4 ID:SGTC_1867|Compound:st057372|FD-Score:-2.90|P-value:9.52E-4 ID:SGTC_2004|Compound:4023728|FD-Score:3.16|P-value:3.52E-4 ID:SGTC_2010|Compound:4012422|FD-Score:3.65|P-value:4.40E-5 ID:SGTC_2055|Compound:5235184|FD-Score:3.02|P-value:6.00E-4 ID:SGTC_2248|Compound:tofa|FD-Score:3.53|P-value:7.42E-5 ID:SGTC_2261|Compound:9010538|FD-Score:2.94|P-value:8.07E-4 ID:SGTC_2290|Compound:7904846|FD-Score:2.94|P-value:7.91E-4 ID:SGTC_2492|Compound:derrusnin|FD-Score:4.13|P-value:4.71E-6 ID:SGTC_2537|Compound:larixol|FD-Score:-3.11|P-value:4.34E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:-4.16|P-value:4.15E-6 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:-3.71|P-value:3.57E-5 ID:SGTC_2749|Compound:bexarotene|FD-Score:3.03|P-value:5.62E-4 ID:SGTC_2807|Compound:7945238|FD-Score:2.95|P-value:7.79E-4 ID:SGTC_2820|Compound:7989630|FD-Score:3.14|P-value:3.81E-4 ID:SGTC_2850|Compound:9015429|FD-Score:-3.98|P-value:1.03E-5 ID:SGTC_2852|Compound:9023854|FD-Score:3.21|P-value:2.82E-4 ID:SGTC_3044|Compound:9093193|FD-Score:3.64|P-value:4.64E-5 ID:SGTC_3065|Compound:9113888|FD-Score:3.70|P-value:3.56E-5 ID:SGTC_3127|Compound:9126946|FD-Score:3.88|P-value:1.55E-5 ID:SGTC_3131|Compound:9127911|FD-Score:3.30|P-value:2.02E-4 ID:SGTC_3135|Compound:9127742|FD-Score:-3.70|P-value:3.67E-5 ID:SGTC_3166|Compound:9102297|FD-Score:3.14|P-value:3.72E-4 ID:SGTC_3193|Compound:9111931|FD-Score:3.87|P-value:1.65E-5 ID:SGTC_3219|Compound:9131112|FD-Score:3.39|P-value:1.37E-4 ID:SGTC_3324|Compound:9138759|FD-Score:-8.09|P-value:2.18E-18 ID:SGTC_3330|Compound:9141424|FD-Score:2.98|P-value:6.86E-4 ID:SGTC_3333|Compound:9141820|FD-Score:3.83|P-value:2.01E-5 ID:SGTC_3334|Compound:9142812|FD-Score:-3.42|P-value:1.27E-4

Top fitness defect scores for YGR091W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_164 4100-3994 5.10 89.6 µM 2.21E-8 3 1.68E-7 0.01
2 SGTC_2492 derrusnin 4.13 100.0 µM 4.71E-6 4 1.82E-5 0.09
3 SGTC_1335 1486-0900 4.11 202.0 µM 5.16E-6 3 1.98E-5 0.51
4 SGTC_1322 1348-1070 4.04 12.0 µM 7.20E-6 3 2.65E-5 0.60
5 SGTC_357 1325-0123 4.02 420.0 µM 8.05E-6 2 2.92E-5 0.37
6 SGTC_133 0724-0033 4.01 378.9 µM 8.24E-6 9 2.98E-5 0.30
7 SGTC_3127 9126946 3.88 49.5 µM 1.55E-5 ERG2 12 5.18E-5 0.14
8 SGTC_3193 9111931 3.87 49.5 µM 1.65E-5 9 5.46E-5 0.12
9 SGTC_3333 9141820 3.83 12.1 µM 2.01E-5 7 6.50E-5 0.20
10 SGTC_3065 9113888 3.70 49.5 µM 3.56E-5 7 1.07E-4 0.12
11 SGTC_2010 4012422 3.65 159.0 µM 4.40E-5 7 1.29E-4 0.18
12 SGTC_3044 9093193 3.64 49.5 µM 4.64E-5 7 1.35E-4 0.05
13 SGTC_1579 chlormadinone acetate 3.64 49.4 µM 4.75E-5 7 1.38E-4 0.14
14 SGTC_130 0136-0219 3.60 337.7 µM 5.64E-5 13 1.60E-4 0.27
15 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 3.54 66.5 µM 7.27E-5 2 2.00E-4 0.17
16 SGTC_2248 tofa 3.53 1.1 µM 7.42E-5 sphingolipid biosynthesis & PDR1 35 2.04E-4 0.06
17 SGTC_943 3253-1379 3.47 105.0 µM 9.72E-5 12 2.58E-4 0.15
18 SGTC_657 3534-0529 3.46 86.7 µM 1.03E-4 7 2.72E-4 0.12
19 SGTC_3219 9131112 3.39 49.5 µM 1.37E-4 Golgi 25 3.49E-4 0.09
20 SGTC_3131 9127911 3.30 49.5 µM 2.02E-4 11 4.90E-4 0.04

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.102 2.66E-9 YKL198C PTK1 hom Putative serine/threonine protein kinase that regulates spermine uptake; involved in polyamine transport; possible mitochondrial protein
0.099 7.72E-9 YJL042W MHP1 hom Microtubule-associated protein involved in assembly and stabilization of microtubules; overproduction results in cell cycle arrest at G2 phase; similar to Drosophila protein MAP and to mammalian MAP4 proteins
0.096 2.15E-8 YMR092C AIP1 hom Actin cortical patch component; interacts with the actin depolymerizing factor cofilin; required to restrict cofilin localization to cortical patches; contains WD repeats; protein increases in abundance and relocalizes from cytoplasm to plasma membrane upon DNA replication stress
0.096 2.35E-8 YKR031C SPO14 hom Phospholipase D; catalyzes the hydrolysis of phosphatidylcholine, producing choline and phosphatidic acid; involved in Sec14p-independent secretion; required for meiosis and spore formation; differently regulated in secretion and meiosis; participates in transcription initiation and/or early elongation of specific genes; interacts with foot domain of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions
0.095 3.11E-8 YFR012W-A_p YFR012W-A_p hom Putative protein of unknown function; identified by homology
0.089 2.43E-7 YOL069W NUF2 het Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering
0.088 2.93E-7 YKL072W STB6 hom Protein that binds Sin3p in a two-hybrid assay
0.087 3.88E-7 YPL114W_d YPL114W_d hom Dubious open reading frame, unlikely to encode a functional protein; largely overlaps ORF YPL113C; diploid deletion in BY4743 strain background exhibits high budding index
0.084 1.06E-6 YLR132C USB1 het Putative phosphodiesterase specific for U6 snRNA 3' end modification; trims the 3' poly(u) tract to leave a terminal 3' phosphate; human homolog, hUSB1 (aka C16orf57) produces a 2',3' cyclic phosphate; mutations in hUSB1 are associated with a rare skin condition (OMIM 604173); essential protein that localizes to the nucleus and mitochondria; overexpression suppresses the respiratory defects of oxa1 and mtf2 mutants
0.081 2.96E-6 YNL137C NAM9 het Mitochondrial ribosomal component of the small subunit
0.080 3.24E-6 YNL046W_p YNL046W_p hom Putative protein of unknown function; expression depends on Swi5p; GFP-fusion protein localizes to the endoplasmic reticulum; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
0.080 3.48E-6 YOR338W_p YOR338W_p hom Putative protein of unknown function; YOR338W transcription is regulated by Azf1p and its transcript is a specific target of the G protein effector Scp160p; identified as being required for sporulation in a high-throughput mutant screen; YOR338W has a paralog, FUN19, that arose from the whole genome duplication
0.078 6.03E-6 YKL216W URA1 hom Dihydroorotate dehydrogenase, catalyzes the fourth enzymatic step in the de novo biosynthesis of pyrimidines, converting dihydroorotic acid into orotic acid
0.076 9.75E-6 YNR053C NOG2 het Putative GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation
0.075 1.29E-5 YBR130C SHE3 hom Protein that acts as an adaptor between Myo4p and the She2p-mRNA complex; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud; also required for cortical ER inheritance