YGR092W / DBF2

Ser/Thr kinase involved in transcription and stress response; functions as part of a network of genes in exit from mitosis; localization is cell cycle regulated; activated by Cdc15p during the exit from mitosis; also plays a role in regulating the stability of SWI5 and CLB2 mRNAs; phosphorylates Chs2p to regulate primary septum formation and Hof1p to regulate cytokinesis

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR092W / DBF2

Click on Significant Values for Screen Details ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:8.75|P-value:1.90E-13 ID:SGTC_42|Compound:0133-0086|FD-Score:-3.62|P-value:7.91E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:22.50|P-value:1.62E-79 ID:SGTC_57|Compound:miconazole|FD-Score:-6.75|P-value:3.48E-9 ID:SGTC_87|Compound:0100-0052|FD-Score:5.45|P-value:3.78E-6 ID:SGTC_91|Compound:0417-1751|FD-Score:4.64|P-value:7.37E-5 ID:SGTC_103|Compound:0844-0104|FD-Score:12.40|P-value:2.33E-25 ID:SGTC_138|Compound:0850-0259|FD-Score:4.54|P-value:1.02E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:5.32|P-value:6.32E-6 ID:SGTC_159|Compound:3970-0959|FD-Score:-3.81|P-value:4.59E-4 ID:SGTC_161|Compound:4065-0411|FD-Score:7.85|P-value:4.09E-11 ID:SGTC_178|Compound:4092-0806|FD-Score:4.21|P-value:3.00E-4 ID:SGTC_208|Compound:k072-0098|FD-Score:5.79|P-value:9.36E-7 ID:SGTC_210|Compound:3551-0445|FD-Score:4.07|P-value:4.58E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:-3.86|P-value:3.85E-4 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:4.61|P-value:8.05E-5 ID:SGTC_278|Compound:4092-0821|FD-Score:5.71|P-value:1.29E-6 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.82|P-value:4.39E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-9.82|P-value:2.74E-17 ID:SGTC_312|Compound:4092-0653|FD-Score:4.42|P-value:1.52E-4 ID:SGTC_327|Compound:1273-0057|FD-Score:-3.60|P-value:8.48E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:4.41|P-value:1.56E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:4.76|P-value:4.77E-5 ID:SGTC_373|Compound:0844-0104|FD-Score:4.56|P-value:9.42E-5 ID:SGTC_384|Compound:k007-0144|FD-Score:5.54|P-value:2.59E-6 ID:SGTC_395|Compound:anisomycin|FD-Score:4.51|P-value:1.12E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:3.94|P-value:6.76E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:8.53|P-value:7.40E-13 ID:SGTC_575|Compound:k072-0246|FD-Score:4.41|P-value:1.55E-4 ID:SGTC_595|Compound:3909-8003|FD-Score:8.43|P-value:1.37E-12 ID:SGTC_658|Compound:3253-0951|FD-Score:6.17|P-value:1.83E-7 ID:SGTC_685|Compound:1278-0033|FD-Score:6.16|P-value:1.95E-7 ID:SGTC_759|Compound:3486-0358|FD-Score:3.88|P-value:8.00E-4 ID:SGTC_793|Compound:0488-0545|FD-Score:4.11|P-value:3.99E-4 ID:SGTC_839|Compound:0122-0028|FD-Score:5.43|P-value:4.12E-6 ID:SGTC_857|Compound:0438-0306|FD-Score:4.20|P-value:3.02E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:13.30|P-value:6.21E-29 ID:SGTC_879|Compound:0831-1030|FD-Score:9.69|P-value:4.01E-16 ID:SGTC_978|Compound:1416-0512|FD-Score:4.64|P-value:7.43E-5 ID:SGTC_1026|Compound:k007-1105|FD-Score:4.68|P-value:6.41E-5 ID:SGTC_1263|Compound:0774-1208|FD-Score:-4.10|P-value:1.81E-4 ID:SGTC_1272|Compound:0839-0021|FD-Score:4.23|P-value:2.74E-4 ID:SGTC_1354|Compound:1498-1681|FD-Score:3.89|P-value:7.64E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:-4.76|P-value:1.94E-5 ID:SGTC_1446|Compound:4239-0190|FD-Score:5.36|P-value:5.39E-6 ID:SGTC_1512|Compound:0259-0544|FD-Score:-3.99|P-value:2.65E-4 ID:SGTC_1513|Compound:0337-0559|FD-Score:-3.99|P-value:2.60E-4 ID:SGTC_1516|Compound:st013856|FD-Score:-4.80|P-value:1.68E-5 ID:SGTC_1571|Compound:st070080|FD-Score:4.27|P-value:2.46E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:5.08|P-value:1.52E-5 ID:SGTC_1609|Compound:st001574|FD-Score:4.09|P-value:4.32E-4 ID:SGTC_1651|Compound:st011928|FD-Score:11.10|P-value:1.56E-20 ID:SGTC_1658|Compound:st012944|FD-Score:8.52|P-value:7.87E-13 ID:SGTC_1754|Compound:st042065|FD-Score:-6.21|P-value:4.71E-8 ID:SGTC_1758|Compound:st042942|FD-Score:-4.01|P-value:2.44E-4 ID:SGTC_1760|Compound:st045453|FD-Score:-4.99|P-value:8.15E-6 ID:SGTC_1776|Compound:st049249|FD-Score:4.47|P-value:1.28E-4 ID:SGTC_1859|Compound:st055998|FD-Score:4.54|P-value:1.04E-4 ID:SGTC_1892|Compound:st058411|FD-Score:4.54|P-value:1.02E-4 ID:SGTC_1904|Compound:st060225|FD-Score:4.88|P-value:3.13E-5 ID:SGTC_1946|Compound:st076057|FD-Score:3.89|P-value:7.69E-4 ID:SGTC_1947|Compound:st076332|FD-Score:5.24|P-value:8.46E-6 ID:SGTC_2051|Compound:5263410|FD-Score:4.25|P-value:2.62E-4 ID:SGTC_2058|Compound:5236698|FD-Score:22.30|P-value:3.05E-78 ID:SGTC_2077|Compound:5212015|FD-Score:4.72|P-value:5.48E-5 ID:SGTC_2092|Compound:5303694|FD-Score:4.26|P-value:2.56E-4 ID:SGTC_2124|Compound:5246320|FD-Score:5.61|P-value:2.00E-6 ID:SGTC_2166|Compound:5933061|FD-Score:-4.75|P-value:1.97E-5 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:5.35|P-value:5.42E-6 ID:SGTC_2233|Compound:sulbentine|FD-Score:4.26|P-value:2.50E-4 ID:SGTC_2289|Compound:7946404|FD-Score:4.04|P-value:4.93E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:6.26|P-value:1.24E-7 ID:SGTC_2411|Compound:st077133|FD-Score:5.62|P-value:1.93E-6 ID:SGTC_2487|Compound:5918373|FD-Score:4.99|P-value:2.10E-5 ID:SGTC_2526|Compound:patulin|FD-Score:7.90|P-value:3.09E-11 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:6.58|P-value:2.84E-8 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:-4.15|P-value:1.58E-4 ID:SGTC_2549|Compound:cedrol|FD-Score:-3.84|P-value:4.20E-4 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:8.66|P-value:3.47E-13 ID:SGTC_2555|Compound:cholic acid|FD-Score:3.93|P-value:6.86E-4 ID:SGTC_2560|Compound:caryophyllene|FD-Score:4.17|P-value:3.36E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:5.44|P-value:3.86E-6 ID:SGTC_2666|Compound:tannic acid|FD-Score:4.83|P-value:3.85E-5 ID:SGTC_2672|Compound:12a-hydroxy-5-deoxydehydromunduserone|FD-Score:4.24|P-value:2.72E-4 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:4.16|P-value:3.40E-4 ID:SGTC_2797|Compound:7859098|FD-Score:6.85|P-value:7.73E-9 ID:SGTC_2798|Compound:7813637|FD-Score:5.03|P-value:1.85E-5 ID:SGTC_2801|Compound:7907800|FD-Score:5.57|P-value:2.35E-6 ID:SGTC_2831|Compound:7999036|FD-Score:7.05|P-value:2.79E-9 ID:SGTC_2835|Compound:9006588|FD-Score:-4.55|P-value:4.12E-5 ID:SGTC_2921|Compound:7974240|FD-Score:3.98|P-value:5.87E-4 ID:SGTC_2926|Compound:9010726|FD-Score:5.11|P-value:1.35E-5 ID:SGTC_2974|Compound:9094440|FD-Score:-3.68|P-value:6.64E-4 ID:SGTC_3142|Compound:9086498|FD-Score:5.14|P-value:1.21E-5 ID:SGTC_3203|Compound:9113543|FD-Score:-4.94|P-value:9.76E-6 ID:SGTC_3286|Compound:9117135|FD-Score:-3.71|P-value:6.05E-4 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:8.75|P-value:1.90E-13 ID:SGTC_42|Compound:0133-0086|FD-Score:-3.62|P-value:7.91E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:22.50|P-value:1.62E-79 ID:SGTC_57|Compound:miconazole|FD-Score:-6.75|P-value:3.48E-9 ID:SGTC_87|Compound:0100-0052|FD-Score:5.45|P-value:3.78E-6 ID:SGTC_91|Compound:0417-1751|FD-Score:4.64|P-value:7.37E-5 ID:SGTC_103|Compound:0844-0104|FD-Score:12.40|P-value:2.33E-25 ID:SGTC_138|Compound:0850-0259|FD-Score:4.54|P-value:1.02E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:5.32|P-value:6.32E-6 ID:SGTC_159|Compound:3970-0959|FD-Score:-3.81|P-value:4.59E-4 ID:SGTC_161|Compound:4065-0411|FD-Score:7.85|P-value:4.09E-11 ID:SGTC_178|Compound:4092-0806|FD-Score:4.21|P-value:3.00E-4 ID:SGTC_208|Compound:k072-0098|FD-Score:5.79|P-value:9.36E-7 ID:SGTC_210|Compound:3551-0445|FD-Score:4.07|P-value:4.58E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:-3.86|P-value:3.85E-4 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:4.61|P-value:8.05E-5 ID:SGTC_278|Compound:4092-0821|FD-Score:5.71|P-value:1.29E-6 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.82|P-value:4.39E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-9.82|P-value:2.74E-17 ID:SGTC_312|Compound:4092-0653|FD-Score:4.42|P-value:1.52E-4 ID:SGTC_327|Compound:1273-0057|FD-Score:-3.60|P-value:8.48E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:4.41|P-value:1.56E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:4.76|P-value:4.77E-5 ID:SGTC_373|Compound:0844-0104|FD-Score:4.56|P-value:9.42E-5 ID:SGTC_384|Compound:k007-0144|FD-Score:5.54|P-value:2.59E-6 ID:SGTC_395|Compound:anisomycin|FD-Score:4.51|P-value:1.12E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:3.94|P-value:6.76E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:8.53|P-value:7.40E-13 ID:SGTC_575|Compound:k072-0246|FD-Score:4.41|P-value:1.55E-4 ID:SGTC_595|Compound:3909-8003|FD-Score:8.43|P-value:1.37E-12 ID:SGTC_658|Compound:3253-0951|FD-Score:6.17|P-value:1.83E-7 ID:SGTC_685|Compound:1278-0033|FD-Score:6.16|P-value:1.95E-7 ID:SGTC_759|Compound:3486-0358|FD-Score:3.88|P-value:8.00E-4 ID:SGTC_793|Compound:0488-0545|FD-Score:4.11|P-value:3.99E-4 ID:SGTC_839|Compound:0122-0028|FD-Score:5.43|P-value:4.12E-6 ID:SGTC_857|Compound:0438-0306|FD-Score:4.20|P-value:3.02E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:13.30|P-value:6.21E-29 ID:SGTC_879|Compound:0831-1030|FD-Score:9.69|P-value:4.01E-16 ID:SGTC_978|Compound:1416-0512|FD-Score:4.64|P-value:7.43E-5 ID:SGTC_1026|Compound:k007-1105|FD-Score:4.68|P-value:6.41E-5 ID:SGTC_1263|Compound:0774-1208|FD-Score:-4.10|P-value:1.81E-4 ID:SGTC_1272|Compound:0839-0021|FD-Score:4.23|P-value:2.74E-4 ID:SGTC_1354|Compound:1498-1681|FD-Score:3.89|P-value:7.64E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:-4.76|P-value:1.94E-5 ID:SGTC_1446|Compound:4239-0190|FD-Score:5.36|P-value:5.39E-6 ID:SGTC_1512|Compound:0259-0544|FD-Score:-3.99|P-value:2.65E-4 ID:SGTC_1513|Compound:0337-0559|FD-Score:-3.99|P-value:2.60E-4 ID:SGTC_1516|Compound:st013856|FD-Score:-4.80|P-value:1.68E-5 ID:SGTC_1571|Compound:st070080|FD-Score:4.27|P-value:2.46E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:5.08|P-value:1.52E-5 ID:SGTC_1609|Compound:st001574|FD-Score:4.09|P-value:4.32E-4 ID:SGTC_1651|Compound:st011928|FD-Score:11.10|P-value:1.56E-20 ID:SGTC_1658|Compound:st012944|FD-Score:8.52|P-value:7.87E-13 ID:SGTC_1754|Compound:st042065|FD-Score:-6.21|P-value:4.71E-8 ID:SGTC_1758|Compound:st042942|FD-Score:-4.01|P-value:2.44E-4 ID:SGTC_1760|Compound:st045453|FD-Score:-4.99|P-value:8.15E-6 ID:SGTC_1776|Compound:st049249|FD-Score:4.47|P-value:1.28E-4 ID:SGTC_1859|Compound:st055998|FD-Score:4.54|P-value:1.04E-4 ID:SGTC_1892|Compound:st058411|FD-Score:4.54|P-value:1.02E-4 ID:SGTC_1904|Compound:st060225|FD-Score:4.88|P-value:3.13E-5 ID:SGTC_1946|Compound:st076057|FD-Score:3.89|P-value:7.69E-4 ID:SGTC_1947|Compound:st076332|FD-Score:5.24|P-value:8.46E-6 ID:SGTC_2051|Compound:5263410|FD-Score:4.25|P-value:2.62E-4 ID:SGTC_2058|Compound:5236698|FD-Score:22.30|P-value:3.05E-78 ID:SGTC_2077|Compound:5212015|FD-Score:4.72|P-value:5.48E-5 ID:SGTC_2092|Compound:5303694|FD-Score:4.26|P-value:2.56E-4 ID:SGTC_2124|Compound:5246320|FD-Score:5.61|P-value:2.00E-6 ID:SGTC_2166|Compound:5933061|FD-Score:-4.75|P-value:1.97E-5 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:5.35|P-value:5.42E-6 ID:SGTC_2233|Compound:sulbentine|FD-Score:4.26|P-value:2.50E-4 ID:SGTC_2289|Compound:7946404|FD-Score:4.04|P-value:4.93E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:6.26|P-value:1.24E-7 ID:SGTC_2411|Compound:st077133|FD-Score:5.62|P-value:1.93E-6 ID:SGTC_2487|Compound:5918373|FD-Score:4.99|P-value:2.10E-5 ID:SGTC_2526|Compound:patulin|FD-Score:7.90|P-value:3.09E-11 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:6.58|P-value:2.84E-8 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:-4.15|P-value:1.58E-4 ID:SGTC_2549|Compound:cedrol|FD-Score:-3.84|P-value:4.20E-4 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:8.66|P-value:3.47E-13 ID:SGTC_2555|Compound:cholic acid|FD-Score:3.93|P-value:6.86E-4 ID:SGTC_2560|Compound:caryophyllene|FD-Score:4.17|P-value:3.36E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:5.44|P-value:3.86E-6 ID:SGTC_2666|Compound:tannic acid|FD-Score:4.83|P-value:3.85E-5 ID:SGTC_2672|Compound:12a-hydroxy-5-deoxydehydromunduserone|FD-Score:4.24|P-value:2.72E-4 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:4.16|P-value:3.40E-4 ID:SGTC_2797|Compound:7859098|FD-Score:6.85|P-value:7.73E-9 ID:SGTC_2798|Compound:7813637|FD-Score:5.03|P-value:1.85E-5 ID:SGTC_2801|Compound:7907800|FD-Score:5.57|P-value:2.35E-6 ID:SGTC_2831|Compound:7999036|FD-Score:7.05|P-value:2.79E-9 ID:SGTC_2835|Compound:9006588|FD-Score:-4.55|P-value:4.12E-5 ID:SGTC_2921|Compound:7974240|FD-Score:3.98|P-value:5.87E-4 ID:SGTC_2926|Compound:9010726|FD-Score:5.11|P-value:1.35E-5 ID:SGTC_2974|Compound:9094440|FD-Score:-3.68|P-value:6.64E-4 ID:SGTC_3142|Compound:9086498|FD-Score:5.14|P-value:1.21E-5 ID:SGTC_3203|Compound:9113543|FD-Score:-4.94|P-value:9.76E-6 ID:SGTC_3286|Compound:9117135|FD-Score:-3.71|P-value:6.05E-4

Top fitness defect scores for YGR092W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_46 0329-0187a 22.50 2.2 µM 1.62E-79 3 1.69E-112
2 SGTC_2058 5236698 22.30 133.0 µM 3.05E-78 1 1.08E-110
3 SGTC_871 0574-0004 13.30 149.0 µM 6.21E-29 3 9.73E-41
4 SGTC_103 0844-0104 12.40 51.8 µM 2.33E-25 ERAD & cell cycle 15 1.17E-35
5 SGTC_1651 st011928 11.10 86.1 µM 1.56E-20 RSC complex & mRNA processing 1 8.44E-29
6 SGTC_879 0831-1030 9.69 162.0 µM 4.01E-16 5 1.59E-22
7 SGTC_28 pentachloropyridine N-oxide 8.75 1.6 µM 1.90E-13 TSC3-RPN4 5 1.02E-18
8 SGTC_2553 4-methylesculetin 8.66 85.1 µM 3.47E-13 1 2.41E-18
9 SGTC_568 1193-0097 8.53 7.5 µM 7.40E-13 ERAD & cell cycle 32 7.09E-18
10 SGTC_1658 st012944 8.52 20.0 µM 7.87E-13 iron homeostasis 8 7.74E-18
11 SGTC_595 3909-8003 8.43 73.7 µM 1.37E-12 1 1.71E-17
12 SGTC_2526 patulin 7.90 37.6 µM 3.09E-11 15 1.44E-15
13 SGTC_161 4065-0411 7.85 162.2 µM 4.09E-11 16 2.15E-15
14 SGTC_2831 7999036 7.05 19.5 µM 2.79E-9 3 8.80E-13
15 SGTC_2797 7859098 6.85 81.8 µM 7.73E-9 2 3.76E-12
16 SGTC_2540 epiandrosterone 6.58 100.0 µM 2.84E-8 18 2.41E-11
17 SGTC_2405 ticlatone 6.26 3.5 µM 1.24E-7 28 1.96E-10
18 SGTC_658 3253-0951 6.17 102.0 µM 1.83E-7 calcium & mitochondrial duress 14 3.41E-10
19 SGTC_685 1278-0033 6.16 54.9 µM 1.95E-7 60S ribosome export 2 3.74E-10
20 SGTC_208 k072-0098 5.79 12.4 µM 9.36E-7 heme biosynthesis & mitochondrial translocase 14 3.50E-9

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.189 1.93E-28 YOL002C IZH2 hom Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc
0.184 7.58E-27 YAL024C LTE1 hom Protein similar to GDP/GTP exchange factors but without detectable GEF activity; required for asymmetric localization of Bfa1p at daughter-directed spindle pole bodies and for mitotic exit at low temperatures
0.168 1.34E-22 YDR199W_d YDR199W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VPS64; computationally predicted to have thiol-disulfide oxidoreductase activity
0.167 1.69E-22 YMR022W UBC7 hom Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly
0.165 6.15E-22 YDR186C YDR186C hom Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.164 1.16E-21 YIL030C SSM4 hom Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation
0.161 8.32E-21 YMR116C ASC1 hom G-protein beta subunit and guanine nucleotide dissociation inhibitor for Gpa2p; ortholog of RACK1 that inhibits translation; core component of the small (40S) ribosomal subunit; regulates P-body formation induced by replication stress; represses Gcn4p in the absence of amino acid starvation
0.153 5.40E-19 YOR233W KIN4 hom Serine/threonine protein kinase; inhibits the mitotic exit network (MEN) when the spindle position checkpoint is activated; localized asymmetrically to mother cell cortex, spindle pole body and bud neck; KIN4 has a paralog, FRK1, that arose from the whole genome duplication
0.152 1.14E-18 YNL298W CLA4 hom Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p
0.150 2.00E-18 YDL190C UFD2 hom Ubiquitin chain assembly factor (E4) that cooperates with a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), and a ubiquitin protein ligase (E3) to conjugate ubiquitin to substrates; also functions as an E3
0.149 3.83E-18 YGR044C RME1 hom Zinc finger protein involved in control of meiosis; prevents meiosis by repressing IME1 expression and promotes mitosis by activating CLN2 expression; directly repressed by a1-alpha2 regulator; mediates cell type control of sporulation; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.148 7.34E-18 YER084W_p YER084W_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.141 2.77E-16 YMR052C-A_d YMR052C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.136 2.44E-15 YIL052C RPL34B hom Ribosomal 60S subunit protein L34B; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34B has a paralog, RPL34A, that arose from the whole genome duplication
0.135 4.17E-15 YMR067C UBX4 hom UBX domain-containing protein that interacts with Cdc48p; involved in degradation of polyubiquitinated proteins via the ERAD (ER-associated degradation) pathway; modulates the Cdc48p-Nplp-Ufd1p AAA ATPase complex during its role in delivery of misfolded proteins to the proteasome; protein abundance increases in response to DNA replication stress