YGR094W / VAS1

Mitochondrial and cytoplasmic valyl-tRNA synthetase

Zygosity: Heterozygous strain
fixedexpanded
Profile for YGR094W / VAS1

Click on Significant Values for Screen Details ID:SGTC_31|Compound:0508-1974|FD-Score:-3.02|P-value:5.63E-4 ID:SGTC_112|Compound:phenothiazine|FD-Score:-4.01|P-value:8.59E-6 ID:SGTC_168|Compound:3970-0862|FD-Score:-3.24|P-value:2.47E-4 ID:SGTC_500|Compound:h-89|FD-Score:3.55|P-value:1.21E-4 ID:SGTC_507|Compound:nimesulide|FD-Score:-3.89|P-value:1.46E-5 ID:SGTC_572|Compound:0960-0087|FD-Score:4.71|P-value:4.92E-7 ID:SGTC_575|Compound:k072-0246|FD-Score:4.32|P-value:3.70E-6 ID:SGTC_579|Compound:4491-1009|FD-Score:3.64|P-value:8.39E-5 ID:SGTC_585|Compound:0kpi-0023|FD-Score:-5.72|P-value:5.19E-10 ID:SGTC_622|Compound:1348-1566|FD-Score:3.46|P-value:1.75E-4 ID:SGTC_703|Compound:3875-0075|FD-Score:4.39|P-value:2.58E-6 ID:SGTC_946|Compound:3434-1334|FD-Score:3.54|P-value:1.26E-4 ID:SGTC_950|Compound:1165-0508|FD-Score:4.08|P-value:1.17E-5 ID:SGTC_977|Compound:1348-1378|FD-Score:3.42|P-value:2.03E-4 ID:SGTC_1111|Compound:tnp00062|FD-Score:-2.90|P-value:8.81E-4 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:-3.33|P-value:1.68E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:-3.89|P-value:1.47E-5 ID:SGTC_1130|Compound:3454-2858|FD-Score:5.05|P-value:7.43E-8 ID:SGTC_1169|Compound:aniline yellow|FD-Score:3.25|P-value:4.03E-4 ID:SGTC_1194|Compound:1488-0194|FD-Score:3.69|P-value:6.82E-5 ID:SGTC_1199|Compound:1638-0010|FD-Score:-3.06|P-value:4.92E-4 ID:SGTC_1259|Compound:0671-0132|FD-Score:3.76|P-value:4.93E-5 ID:SGTC_1353|Compound:1498-1206|FD-Score:-4.10|P-value:5.54E-6 ID:SGTC_1721|Compound:st082152|FD-Score:3.02|P-value:9.17E-4 ID:SGTC_1956|Compound:st077085|FD-Score:3.21|P-value:4.54E-4 ID:SGTC_2044|Compound:5102272|FD-Score:-4.30|P-value:2.06E-6 ID:SGTC_2114|Compound:5491910|FD-Score:3.58|P-value:1.05E-4 ID:SGTC_2120|Compound:5538279|FD-Score:-3.37|P-value:1.44E-4 ID:SGTC_2311|Compound:7694451|FD-Score:3.07|P-value:7.79E-4 ID:SGTC_2313|Compound:7726885|FD-Score:3.03|P-value:9.09E-4 ID:SGTC_2412|Compound:st077135|FD-Score:4.23|P-value:5.72E-6 ID:SGTC_2474|Compound:5321570|FD-Score:3.69|P-value:6.54E-5 ID:SGTC_2504|Compound:purpurogallin|FD-Score:3.22|P-value:4.50E-4 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:3.18|P-value:5.09E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:-3.02|P-value:5.66E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:3.89|P-value:2.75E-5 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:6.21|P-value:4.54E-11 ID:SGTC_2691|Compound:st077356|FD-Score:6.29|P-value:2.64E-11 ID:SGTC_2693|Compound:st077581|FD-Score:4.66|P-value:6.32E-7 ID:SGTC_2799|Compound:7812892|FD-Score:-2.92|P-value:8.07E-4 ID:SGTC_2814|Compound:7977482|FD-Score:3.88|P-value:2.95E-5 ID:SGTC_2922|Compound:7999257|FD-Score:-2.95|P-value:7.34E-4 ID:SGTC_3201|Compound:9113999|FD-Score:-2.91|P-value:8.28E-4 ID:SGTC_3202|Compound:9113761|FD-Score:5.01|P-value:9.31E-8 ID:SGTC_31|Compound:0508-1974|FD-Score:-3.02|P-value:5.63E-4 ID:SGTC_112|Compound:phenothiazine|FD-Score:-4.01|P-value:8.59E-6 ID:SGTC_168|Compound:3970-0862|FD-Score:-3.24|P-value:2.47E-4 ID:SGTC_500|Compound:h-89|FD-Score:3.55|P-value:1.21E-4 ID:SGTC_507|Compound:nimesulide|FD-Score:-3.89|P-value:1.46E-5 ID:SGTC_572|Compound:0960-0087|FD-Score:4.71|P-value:4.92E-7 ID:SGTC_575|Compound:k072-0246|FD-Score:4.32|P-value:3.70E-6 ID:SGTC_579|Compound:4491-1009|FD-Score:3.64|P-value:8.39E-5 ID:SGTC_585|Compound:0kpi-0023|FD-Score:-5.72|P-value:5.19E-10 ID:SGTC_622|Compound:1348-1566|FD-Score:3.46|P-value:1.75E-4 ID:SGTC_703|Compound:3875-0075|FD-Score:4.39|P-value:2.58E-6 ID:SGTC_946|Compound:3434-1334|FD-Score:3.54|P-value:1.26E-4 ID:SGTC_950|Compound:1165-0508|FD-Score:4.08|P-value:1.17E-5 ID:SGTC_977|Compound:1348-1378|FD-Score:3.42|P-value:2.03E-4 ID:SGTC_1111|Compound:tnp00062|FD-Score:-2.90|P-value:8.81E-4 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:-3.33|P-value:1.68E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:-3.89|P-value:1.47E-5 ID:SGTC_1130|Compound:3454-2858|FD-Score:5.05|P-value:7.43E-8 ID:SGTC_1169|Compound:aniline yellow|FD-Score:3.25|P-value:4.03E-4 ID:SGTC_1194|Compound:1488-0194|FD-Score:3.69|P-value:6.82E-5 ID:SGTC_1199|Compound:1638-0010|FD-Score:-3.06|P-value:4.92E-4 ID:SGTC_1259|Compound:0671-0132|FD-Score:3.76|P-value:4.93E-5 ID:SGTC_1353|Compound:1498-1206|FD-Score:-4.10|P-value:5.54E-6 ID:SGTC_1721|Compound:st082152|FD-Score:3.02|P-value:9.17E-4 ID:SGTC_1956|Compound:st077085|FD-Score:3.21|P-value:4.54E-4 ID:SGTC_2044|Compound:5102272|FD-Score:-4.30|P-value:2.06E-6 ID:SGTC_2114|Compound:5491910|FD-Score:3.58|P-value:1.05E-4 ID:SGTC_2120|Compound:5538279|FD-Score:-3.37|P-value:1.44E-4 ID:SGTC_2311|Compound:7694451|FD-Score:3.07|P-value:7.79E-4 ID:SGTC_2313|Compound:7726885|FD-Score:3.03|P-value:9.09E-4 ID:SGTC_2412|Compound:st077135|FD-Score:4.23|P-value:5.72E-6 ID:SGTC_2474|Compound:5321570|FD-Score:3.69|P-value:6.54E-5 ID:SGTC_2504|Compound:purpurogallin|FD-Score:3.22|P-value:4.50E-4 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:3.18|P-value:5.09E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:-3.02|P-value:5.66E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:3.89|P-value:2.75E-5 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:6.21|P-value:4.54E-11 ID:SGTC_2691|Compound:st077356|FD-Score:6.29|P-value:2.64E-11 ID:SGTC_2693|Compound:st077581|FD-Score:4.66|P-value:6.32E-7 ID:SGTC_2799|Compound:7812892|FD-Score:-2.92|P-value:8.07E-4 ID:SGTC_2814|Compound:7977482|FD-Score:3.88|P-value:2.95E-5 ID:SGTC_2922|Compound:7999257|FD-Score:-2.95|P-value:7.34E-4 ID:SGTC_3201|Compound:9113999|FD-Score:-2.91|P-value:8.28E-4 ID:SGTC_3202|Compound:9113761|FD-Score:5.01|P-value:9.31E-8

Top fitness defect scores for YGR094W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2691 st077356 6.29 60.2 µM 2.64E-11 3 1.58E-10 1.04
2 SGTC_2604 4'-hydroxychalcone 6.21 11.3 µM 4.54E-11 1 2.59E-10 0.68
3 SGTC_1130 3454-2858 5.05 15.9 µM 7.43E-8 NEO1 6 2.21E-7 0.44
4 SGTC_3202 9113761 5.01 49.5 µM 9.31E-8 4 2.71E-7 0.35
5 SGTC_572 0960-0087 4.71 17.7 µM 4.92E-7 5 1.24E-6 0.01
6 SGTC_2693 st077581 4.66 40.7 µM 6.32E-7 3 1.56E-6 0.39
7 SGTC_703 3875-0075 4.39 71.8 µM 2.58E-6 3 5.66E-6 0.32
8 SGTC_575 k072-0246 4.32 11.9 µM 3.70E-6 3 7.87E-6 0.31
9 SGTC_2412 st077135 4.23 33.4 µM 5.72E-6 6 1.17E-5 0.59
10 SGTC_950 1165-0508 4.08 94.1 µM 1.17E-5 3 2.26E-5 0.04
11 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 3.89 15.3 µM 2.75E-5 5 4.97E-5 0.41
12 SGTC_2814 7977482 3.88 43.0 µM 2.95E-5 12 5.29E-5 0.06
13 SGTC_1259 0671-0132 3.76 43.0 µM 4.93E-5 5 8.48E-5 0.02
14 SGTC_2474 5321570 3.69 43.3 µM 6.54E-5 5 1.10E-4 0.02
15 SGTC_1194 1488-0194 3.69 225.0 µM 6.82E-5 5 1.14E-4 0.12
16 SGTC_579 4491-1009 3.64 110.0 µM 8.39E-5 60S ribosome export 10 1.38E-4 0.14
17 SGTC_2114 5491910 3.58 81.2 µM 1.05E-4 7 1.70E-4 0.11
18 SGTC_500 h-89 3.55 112.0 µM 1.21E-4 cell wall signaling 13 1.94E-4 0.07
19 SGTC_946 3434-1334 3.54 87.4 µM 1.26E-4 14 2.00E-4 0.13
20 SGTC_622 1348-1566 3.46 26.3 µM 1.75E-4 6 2.72E-4 0.06

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.151 1.58E-18 YMR133W REC114 hom Protein involved in early stages of meiotic recombination; possibly involved in the coordination of recombination and meiotic division; mutations lead to premature initiation of the first meiotic division
0.121 2.06E-12 YLR097C HRT3 hom Putative SCF-ubiquitin ligase F-box protein, based on both genetic and physical interactions and sequence similarity; identified in association with Cdc53p, Skp1p and Ubi4 in large and small-scale studies
0.112 7.13E-11 YOR291W YPK9 hom Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome
0.110 2.01E-10 YBR138C_p YBR138C_p hom Cytoplasmic protein of unknown function, potentially phosphorylated by Cdc28p; YBR138C is not an essential gene
0.108 3.05E-10 YCR012W PGK1 het 3-phosphoglycerate kinase, catalyzes transfer of high-energy phosphoryl groups from the acyl phosphate of 1,3-bisphosphoglycerate to ADP to produce ATP; key enzyme in glycolysis and gluconeogenesis
0.101 4.11E-9 YOR329C SCD5 het Protein required for normal actin organization and endocytosis; targeting subunit for protein phosphatase type 1; undergoes Crm1p-dependent nuclear-cytoplasmic shuttling; multicopy suppressor of clathrin deficiency
0.093 6.04E-8 YGR108W CLB1 hom B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
0.090 1.87E-7 YJR041C URB2 het Nucleolar protein required for normal metabolism of the rRNA primary transcript, proposed to be involved in ribosome biogenesis
0.086 6.83E-7 YJL212C OPT1 hom Proton-coupled oligopeptide transporter of the plasma membrane; also transports glutathione and phytochelatin; member of the OPT family
0.085 9.14E-7 YDL017W CDC7 het DDK (Dbf4-dependent kinase) catalytic subunit required for origin firing and replication fork progression in mitotic S phase through phosphorylation of Mcm2-7p complexes and Cdc45p; kinase activity correlates with cyclical DBF4 expression; required for pre-meiotic DNA replication, meiotic DSB formation, recruitment of the monopolin complex to kinetochores during meiosis I and as a gene-specific regulator of the meiosis-specific transcription factor Ndt80p
0.084 9.50E-7 YHR118C ORC6 het Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; phosphorylated by Cdc28p
0.084 1.12E-6 YKL096W-A CWP2 hom Covalently linked cell wall mannoprotein, major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored
0.082 1.80E-6 YFR030W MET10 hom Subunit alpha of assimilatory sulfite reductase, which converts sulfite into sulfide
0.079 4.31E-6 YER148W SPT15 het TATA-binding protein, general transcription factor that interacts with other factors to form the preinitiation complex at promoters, essential for viability
0.078 5.49E-6 YMR251W-A HOR7 hom Protein of unknown function; overexpression suppresses Ca2+ sensitivity of mutants lacking inositol phosphorylceramide mannosyltransferases Csg1p and Csh1p; transcription is induced under hyperosmotic stress and repressed by alpha factor; HOR7 has a paralog, DDR2, that arose from the whole genome duplication