YGR095C / RRP46

Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp46p (EXOSC5)

Zygosity: Heterozygous strain
fixedexpanded
Profile for YGR095C / RRP46

Click on Significant Values for Screen Details ID:SGTC_53|Compound:0973-0023|FD-Score:5.02|P-value:4.04E-6 ID:SGTC_118|Compound:0083-0097|FD-Score:6.36|P-value:7.95E-9 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:9.66|P-value:5.04E-18 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:4.68|P-value:1.58E-5 ID:SGTC_274|Compound:sirtinol|FD-Score:3.78|P-value:3.81E-4 ID:SGTC_371|Compound:0195-0006|FD-Score:3.76|P-value:4.00E-4 ID:SGTC_389|Compound:tpck|FD-Score:4.53|P-value:2.81E-5 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:10.30|P-value:2.06E-20 ID:SGTC_490|Compound:phenamil|FD-Score:-4.67|P-value:1.94E-5 ID:SGTC_610|Compound:4215-0184|FD-Score:5.44|P-value:6.52E-7 ID:SGTC_617|Compound:3770-0098|FD-Score:8.98|P-value:7.89E-16 ID:SGTC_756|Compound:0508-1999|FD-Score:3.83|P-value:3.21E-4 ID:SGTC_770|Compound:0389-1121|FD-Score:4.19|P-value:9.38E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:5.09|P-value:3.01E-6 ID:SGTC_872|Compound:0588-0139|FD-Score:-3.76|P-value:4.63E-4 ID:SGTC_895|Compound:0964-0006|FD-Score:5.23|P-value:1.61E-6 ID:SGTC_903|Compound:1134-0042|FD-Score:4.40|P-value:4.41E-5 ID:SGTC_917|Compound:harmaline|FD-Score:-3.52|P-value:9.70E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:-5.10|P-value:3.47E-6 ID:SGTC_953|Compound:1188-0045|FD-Score:-3.52|P-value:9.74E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:5.39|P-value:8.32E-7 ID:SGTC_1035|Compound:k081-0041|FD-Score:3.47|P-value:9.78E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:-5.27|P-value:1.66E-6 ID:SGTC_1037|Compound:k284-1091|FD-Score:4.51|P-value:3.00E-5 ID:SGTC_1044|Compound:1222-0021|FD-Score:-4.30|P-value:7.71E-5 ID:SGTC_1052|Compound:3253-3998|FD-Score:5.03|P-value:3.79E-6 ID:SGTC_1054|Compound:3429-0080|FD-Score:-3.77|P-value:4.56E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:-3.67|P-value:6.26E-4 ID:SGTC_1056|Compound:3448-1962|FD-Score:4.90|P-value:6.41E-6 ID:SGTC_1057|Compound:3448-5381|FD-Score:-4.97|P-value:5.95E-6 ID:SGTC_1074|Compound:carmofur|FD-Score:4.40|P-value:4.39E-5 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:6.66|P-value:1.64E-9 ID:SGTC_1136|Compound:pergolide|FD-Score:3.50|P-value:9.00E-4 ID:SGTC_1232|Compound:0279-0259|FD-Score:3.57|P-value:7.26E-4 ID:SGTC_1269|Compound:0831-0796|FD-Score:-4.11|P-value:1.45E-4 ID:SGTC_1275|Compound:0867-0008|FD-Score:3.75|P-value:4.11E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:4.49|P-value:3.22E-5 ID:SGTC_1424|Compound:4048-1941|FD-Score:4.21|P-value:8.73E-5 ID:SGTC_1456|Compound:k015-0012|FD-Score:5.60|P-value:3.19E-7 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:3.80|P-value:3.55E-4 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:-3.82|P-value:3.84E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:-4.30|P-value:7.61E-5 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:6.72|P-value:1.19E-9 ID:SGTC_1737|Compound:st035557|FD-Score:4.10|P-value:1.29E-4 ID:SGTC_1786|Compound:berberine|FD-Score:-3.84|P-value:3.61E-4 ID:SGTC_1827|Compound:berberine|FD-Score:-3.91|P-value:2.88E-4 ID:SGTC_2047|Compound:4141938|FD-Score:3.69|P-value:4.99E-4 ID:SGTC_2065|Compound:5221596|FD-Score:4.49|P-value:3.26E-5 ID:SGTC_2066|Compound:5222451|FD-Score:-3.88|P-value:3.15E-4 ID:SGTC_2087|Compound:5276107|FD-Score:3.98|P-value:1.97E-4 ID:SGTC_2100|Compound:5377183|FD-Score:-4.07|P-value:1.68E-4 ID:SGTC_2112|Compound:5488546|FD-Score:4.73|P-value:1.30E-5 ID:SGTC_2113|Compound:5491891|FD-Score:4.13|P-value:1.18E-4 ID:SGTC_2115|Compound:tiliquinol|FD-Score:3.91|P-value:2.47E-4 ID:SGTC_2290|Compound:7904846|FD-Score:7.83|P-value:1.78E-12 ID:SGTC_2313|Compound:7726885|FD-Score:3.78|P-value:3.76E-4 ID:SGTC_2358|Compound:9037157|FD-Score:8.03|P-value:4.88E-13 ID:SGTC_2367|Compound:9070478|FD-Score:-5.81|P-value:1.46E-7 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:3.93|P-value:2.32E-4 ID:SGTC_2722|Compound:naftopidil|FD-Score:-3.64|P-value:6.81E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:-4.23|P-value:9.87E-5 ID:SGTC_2785|Compound:7756463|FD-Score:4.31|P-value:6.21E-5 ID:SGTC_2834|Compound:9001755|FD-Score:4.93|P-value:5.64E-6 ID:SGTC_2835|Compound:9006588|FD-Score:3.75|P-value:4.18E-4 ID:SGTC_2908|Compound:7930301|FD-Score:-4.26|P-value:8.67E-5 ID:SGTC_2913|Compound:7966556|FD-Score:-3.75|P-value:4.82E-4 ID:SGTC_2980|Compound:9014342|FD-Score:-3.95|P-value:2.52E-4 ID:SGTC_3002|Compound:9075603|FD-Score:4.33|P-value:5.77E-5 ID:SGTC_3003|Compound:9075612|FD-Score:3.75|P-value:4.11E-4 ID:SGTC_3007|Compound:9078383|FD-Score:4.07|P-value:1.44E-4 ID:SGTC_3030|Compound:9087619|FD-Score:3.53|P-value:8.23E-4 ID:SGTC_3032|Compound:9089427|FD-Score:-3.72|P-value:5.26E-4 ID:SGTC_3126|Compound:9127922|FD-Score:-3.51|P-value:9.94E-4 ID:SGTC_3127|Compound:9126946|FD-Score:3.74|P-value:4.32E-4 ID:SGTC_3128|Compound:9127691|FD-Score:3.70|P-value:4.95E-4 ID:SGTC_3143|Compound:9086658|FD-Score:-3.84|P-value:3.66E-4 ID:SGTC_3222|Compound:9128301|FD-Score:-5.00|P-value:5.24E-6 ID:SGTC_3249|Compound:9135183|FD-Score:-4.00|P-value:2.16E-4 ID:SGTC_3250|Compound:9135583|FD-Score:3.92|P-value:2.37E-4 ID:SGTC_53|Compound:0973-0023|FD-Score:5.02|P-value:4.04E-6 ID:SGTC_118|Compound:0083-0097|FD-Score:6.36|P-value:7.95E-9 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:9.66|P-value:5.04E-18 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:4.68|P-value:1.58E-5 ID:SGTC_274|Compound:sirtinol|FD-Score:3.78|P-value:3.81E-4 ID:SGTC_371|Compound:0195-0006|FD-Score:3.76|P-value:4.00E-4 ID:SGTC_389|Compound:tpck|FD-Score:4.53|P-value:2.81E-5 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:10.30|P-value:2.06E-20 ID:SGTC_490|Compound:phenamil|FD-Score:-4.67|P-value:1.94E-5 ID:SGTC_610|Compound:4215-0184|FD-Score:5.44|P-value:6.52E-7 ID:SGTC_617|Compound:3770-0098|FD-Score:8.98|P-value:7.89E-16 ID:SGTC_756|Compound:0508-1999|FD-Score:3.83|P-value:3.21E-4 ID:SGTC_770|Compound:0389-1121|FD-Score:4.19|P-value:9.38E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:5.09|P-value:3.01E-6 ID:SGTC_872|Compound:0588-0139|FD-Score:-3.76|P-value:4.63E-4 ID:SGTC_895|Compound:0964-0006|FD-Score:5.23|P-value:1.61E-6 ID:SGTC_903|Compound:1134-0042|FD-Score:4.40|P-value:4.41E-5 ID:SGTC_917|Compound:harmaline|FD-Score:-3.52|P-value:9.70E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:-5.10|P-value:3.47E-6 ID:SGTC_953|Compound:1188-0045|FD-Score:-3.52|P-value:9.74E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:5.39|P-value:8.32E-7 ID:SGTC_1035|Compound:k081-0041|FD-Score:3.47|P-value:9.78E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:-5.27|P-value:1.66E-6 ID:SGTC_1037|Compound:k284-1091|FD-Score:4.51|P-value:3.00E-5 ID:SGTC_1044|Compound:1222-0021|FD-Score:-4.30|P-value:7.71E-5 ID:SGTC_1052|Compound:3253-3998|FD-Score:5.03|P-value:3.79E-6 ID:SGTC_1054|Compound:3429-0080|FD-Score:-3.77|P-value:4.56E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:-3.67|P-value:6.26E-4 ID:SGTC_1056|Compound:3448-1962|FD-Score:4.90|P-value:6.41E-6 ID:SGTC_1057|Compound:3448-5381|FD-Score:-4.97|P-value:5.95E-6 ID:SGTC_1074|Compound:carmofur|FD-Score:4.40|P-value:4.39E-5 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:6.66|P-value:1.64E-9 ID:SGTC_1136|Compound:pergolide|FD-Score:3.50|P-value:9.00E-4 ID:SGTC_1232|Compound:0279-0259|FD-Score:3.57|P-value:7.26E-4 ID:SGTC_1269|Compound:0831-0796|FD-Score:-4.11|P-value:1.45E-4 ID:SGTC_1275|Compound:0867-0008|FD-Score:3.75|P-value:4.11E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:4.49|P-value:3.22E-5 ID:SGTC_1424|Compound:4048-1941|FD-Score:4.21|P-value:8.73E-5 ID:SGTC_1456|Compound:k015-0012|FD-Score:5.60|P-value:3.19E-7 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:3.80|P-value:3.55E-4 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:-3.82|P-value:3.84E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:-4.30|P-value:7.61E-5 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:6.72|P-value:1.19E-9 ID:SGTC_1737|Compound:st035557|FD-Score:4.10|P-value:1.29E-4 ID:SGTC_1786|Compound:berberine|FD-Score:-3.84|P-value:3.61E-4 ID:SGTC_1827|Compound:berberine|FD-Score:-3.91|P-value:2.88E-4 ID:SGTC_2047|Compound:4141938|FD-Score:3.69|P-value:4.99E-4 ID:SGTC_2065|Compound:5221596|FD-Score:4.49|P-value:3.26E-5 ID:SGTC_2066|Compound:5222451|FD-Score:-3.88|P-value:3.15E-4 ID:SGTC_2087|Compound:5276107|FD-Score:3.98|P-value:1.97E-4 ID:SGTC_2100|Compound:5377183|FD-Score:-4.07|P-value:1.68E-4 ID:SGTC_2112|Compound:5488546|FD-Score:4.73|P-value:1.30E-5 ID:SGTC_2113|Compound:5491891|FD-Score:4.13|P-value:1.18E-4 ID:SGTC_2115|Compound:tiliquinol|FD-Score:3.91|P-value:2.47E-4 ID:SGTC_2290|Compound:7904846|FD-Score:7.83|P-value:1.78E-12 ID:SGTC_2313|Compound:7726885|FD-Score:3.78|P-value:3.76E-4 ID:SGTC_2358|Compound:9037157|FD-Score:8.03|P-value:4.88E-13 ID:SGTC_2367|Compound:9070478|FD-Score:-5.81|P-value:1.46E-7 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:3.93|P-value:2.32E-4 ID:SGTC_2722|Compound:naftopidil|FD-Score:-3.64|P-value:6.81E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:-4.23|P-value:9.87E-5 ID:SGTC_2785|Compound:7756463|FD-Score:4.31|P-value:6.21E-5 ID:SGTC_2834|Compound:9001755|FD-Score:4.93|P-value:5.64E-6 ID:SGTC_2835|Compound:9006588|FD-Score:3.75|P-value:4.18E-4 ID:SGTC_2908|Compound:7930301|FD-Score:-4.26|P-value:8.67E-5 ID:SGTC_2913|Compound:7966556|FD-Score:-3.75|P-value:4.82E-4 ID:SGTC_2980|Compound:9014342|FD-Score:-3.95|P-value:2.52E-4 ID:SGTC_3002|Compound:9075603|FD-Score:4.33|P-value:5.77E-5 ID:SGTC_3003|Compound:9075612|FD-Score:3.75|P-value:4.11E-4 ID:SGTC_3007|Compound:9078383|FD-Score:4.07|P-value:1.44E-4 ID:SGTC_3030|Compound:9087619|FD-Score:3.53|P-value:8.23E-4 ID:SGTC_3032|Compound:9089427|FD-Score:-3.72|P-value:5.26E-4 ID:SGTC_3126|Compound:9127922|FD-Score:-3.51|P-value:9.94E-4 ID:SGTC_3127|Compound:9126946|FD-Score:3.74|P-value:4.32E-4 ID:SGTC_3128|Compound:9127691|FD-Score:3.70|P-value:4.95E-4 ID:SGTC_3143|Compound:9086658|FD-Score:-3.84|P-value:3.66E-4 ID:SGTC_3222|Compound:9128301|FD-Score:-5.00|P-value:5.24E-6 ID:SGTC_3249|Compound:9135183|FD-Score:-4.00|P-value:2.16E-4 ID:SGTC_3250|Compound:9135583|FD-Score:3.92|P-value:2.37E-4

Top fitness defect scores for YGR095C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_423 5-fluorouracil 10.30 457.0 µM 2.06E-20 exosome 6 2.15E-25 2.32
2 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 9.66 4.6 µM 5.04E-18 heat shock/prefoldin 5 2.30E-22 0.26
3 SGTC_617 3770-0098 8.98 35.0 µM 7.89E-16 exosome 6 1.40E-19 0.37
4 SGTC_2358 9037157 8.03 4.0 µM 4.88E-13 1 4.81E-16 1.48
5 SGTC_2290 7904846 7.83 200.0 µM 1.78E-12 3 2.47E-15 1.17
6 SGTC_1698 5-fluorocytosine 6.72 1.1 µM 1.19E-9 exosome 7 9.32E-12 0.60
7 SGTC_1077 5-fluorocytosine 6.66 377.0 nM 1.64E-9 exosome 10 1.39E-11 0.96
8 SGTC_118 0083-0097 6.36 135.3 µM 7.95E-9 translation 4 1.02E-10 0.71
9 SGTC_1456 k015-0012 5.60 13.0 µM 3.19E-7 2 1.08E-8 0.71
10 SGTC_610 4215-0184 5.44 155.0 µM 6.52E-7 exosome 15 2.65E-8 0.16
11 SGTC_1027 k015-0025 5.39 8.7 µM 8.32E-7 1 3.61E-8 1.15
12 SGTC_895 0964-0006 5.23 13.7 µM 1.61E-6 4 8.30E-8 0.18
13 SGTC_800 3448-7362 5.09 155.0 µM 3.01E-6 translation 31 1.82E-7 0.11
14 SGTC_1052 3253-3998 5.03 198.0 µM 3.79E-6 2 2.43E-7 0.56
15 SGTC_53 0973-0023 5.02 40.0 µM 4.04E-6 RNA processing & uracil transport 5 2.64E-7 0.41
16 SGTC_2834 9001755 4.93 58.4 µM 5.64E-6 2 4.01E-7 0.15
17 SGTC_1056 3448-1962 4.90 115.0 µM 6.41E-6 amide catabolism 1 4.72E-7 0.40
18 SGTC_2112 5488546 4.73 200.0 µM 1.30E-5 TSC3-RPN4 4 1.15E-6 0.41
19 SGTC_261 5-fluorouridine 4.68 15.4 µM 1.58E-5 exosome 7 1.46E-6 0.12
20 SGTC_389 tpck 4.53 16.7 µM 2.81E-5 6 3.01E-6 0.05

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.378 2.10E-114 YOL021C DIS3 het Exosome core complex catalytic subunit; possesses both endonuclease and 3'-5' exonuclease activity; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase R and to human DIS3; protein abundance increases in response to DNA replication stress
0.359 9.51E-103 YGR158C MTR3 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hMtr3p (EXOSC6)
0.357 1.72E-101 YGR195W SKI6 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp41p (EXOSC4)
0.353 4.05E-99 YDL111C RRP42 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp42p (EXOSC7)
0.305 6.17E-73 YDR280W RRP45 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp45p (PM/SCL-75, EXOSC9); protein abundance increases in response to DNA replication stress
0.269 1.28E-56 YPL044C_d YPL044C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP4/YPL043W
0.254 1.48E-50 YPL043W NOP4 het Nucleolar protein, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; contains four RNA recognition motifs (RRMs)
0.247 7.69E-48 YHR069C RRP4 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain RNA binding domains; has similarity to human hRrp4p (EXOSC2)
0.246 2.04E-47 YKL172W EBP2 het Required for 25S rRNA maturation and 60S ribosomal subunit assembly; localizes to the nucleolus and in foci along nuclear periphery; constituent of 66S pre-ribosomal particles; cooperates with Rrs1p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering
0.240 3.98E-45 YNL232W CSL4 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain an S1 RNA binding domain; has similarity to human hCsl4p (EXOSC1)
0.240 4.37E-45 YNL061W NOP2 het Probable RNA m(5)C methyltransferase, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; localized to the nucleolus; constituent of 66S pre-ribosomal particles
0.206 1.49E-33 YPR142C_d YPR142C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RRP15, which is required for ribosomal RNA processing
0.201 9.01E-32 YPR137W RRP9 het Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein
0.195 3.44E-30 YHL015W RPS20 het Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; homologous to mammalian ribosomal protein S20 and bacterial S10
0.191 7.08E-29 YPR136C_d YPR136C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF RRP9