YGR099W / TEL2

Subunit of the ASTRA complex, involved in chromatin remodeling; subunit of the telomere cap complex DNA-binding protein specific to single-stranded yeast telomeric DNA repeats, required for telomere length regulation and telomere position effect; involved in the stability or biogenesis of PIKKs such as TORC1

Zygosity: Heterozygous strain
fixedexpanded
Profile for YGR099W / TEL2

Click on Significant Values for Screen Details ID:SGTC_82|Compound:0054-0107|FD-Score:3.72|P-value:5.28E-4 ID:SGTC_128|Compound:0906-2981|FD-Score:4.26|P-value:8.57E-5 ID:SGTC_147|Compound:4466-0538|FD-Score:3.72|P-value:5.21E-4 ID:SGTC_315|Compound:k915-0449|FD-Score:3.87|P-value:3.20E-4 ID:SGTC_317|Compound:4495-0002|FD-Score:4.57|P-value:2.73E-5 ID:SGTC_362|Compound:0310-0100|FD-Score:4.13|P-value:1.35E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:5.80|P-value:1.50E-7 ID:SGTC_364|Compound:0083-0097|FD-Score:4.10|P-value:1.51E-4 ID:SGTC_368|Compound:fentichlor|FD-Score:-3.57|P-value:7.08E-4 ID:SGTC_508|Compound:roscovitine|FD-Score:5.09|P-value:3.55E-6 ID:SGTC_510|Compound:ag-490|FD-Score:3.78|P-value:4.28E-4 ID:SGTC_521|Compound:r062-0005|FD-Score:3.99|P-value:2.17E-4 ID:SGTC_904|Compound:1141-0088|FD-Score:5.95|P-value:7.17E-8 ID:SGTC_1152|Compound:3909-8331|FD-Score:4.77|P-value:1.26E-5 ID:SGTC_1156|Compound:4092-0367|FD-Score:-3.53|P-value:8.03E-4 ID:SGTC_1158|Compound:4092-0494|FD-Score:-3.84|P-value:2.97E-4 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:3.86|P-value:3.36E-4 ID:SGTC_1431|Compound:4049-0260|FD-Score:4.82|P-value:1.05E-5 ID:SGTC_1439|Compound:4092-1168|FD-Score:3.53|P-value:9.42E-4 ID:SGTC_1477|Compound:0139-0234|FD-Score:4.67|P-value:1.85E-5 ID:SGTC_1549|Compound:4'-methoxyflavonol|FD-Score:4.57|P-value:2.76E-5 ID:SGTC_1563|Compound:conessine|FD-Score:3.81|P-value:3.96E-4 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:4.40|P-value:5.16E-5 ID:SGTC_1739|Compound:st037196|FD-Score:-4.61|P-value:1.92E-5 ID:SGTC_1743|Compound:st037606|FD-Score:3.82|P-value:3.82E-4 ID:SGTC_1750|Compound:st081859|FD-Score:-3.65|P-value:5.39E-4 ID:SGTC_1900|Compound:st060200|FD-Score:-3.55|P-value:7.50E-4 ID:SGTC_2155|Compound:5570423|FD-Score:3.91|P-value:2.81E-4 ID:SGTC_2425|Compound:5628681|FD-Score:4.11|P-value:1.48E-4 ID:SGTC_2427|Compound:5545055|FD-Score:5.15|P-value:2.75E-6 ID:SGTC_2581|Compound:avocatin a|FD-Score:-4.07|P-value:1.40E-4 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:-5.82|P-value:1.05E-7 ID:SGTC_2786|Compound:7743617|FD-Score:3.83|P-value:3.74E-4 ID:SGTC_2970|Compound:9090938|FD-Score:-3.67|P-value:5.08E-4 ID:SGTC_2986|Compound:9022445|FD-Score:-3.46|P-value:9.77E-4 ID:SGTC_3296|Compound:9122258|FD-Score:3.85|P-value:3.41E-4 ID:SGTC_3302|Compound:9125395|FD-Score:7.88|P-value:1.59E-12 ID:SGTC_3305|Compound:9127027|FD-Score:-4.88|P-value:6.63E-6 ID:SGTC_3309|Compound:9129340|FD-Score:4.12|P-value:1.38E-4 ID:SGTC_82|Compound:0054-0107|FD-Score:3.72|P-value:5.28E-4 ID:SGTC_128|Compound:0906-2981|FD-Score:4.26|P-value:8.57E-5 ID:SGTC_147|Compound:4466-0538|FD-Score:3.72|P-value:5.21E-4 ID:SGTC_315|Compound:k915-0449|FD-Score:3.87|P-value:3.20E-4 ID:SGTC_317|Compound:4495-0002|FD-Score:4.57|P-value:2.73E-5 ID:SGTC_362|Compound:0310-0100|FD-Score:4.13|P-value:1.35E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:5.80|P-value:1.50E-7 ID:SGTC_364|Compound:0083-0097|FD-Score:4.10|P-value:1.51E-4 ID:SGTC_368|Compound:fentichlor|FD-Score:-3.57|P-value:7.08E-4 ID:SGTC_508|Compound:roscovitine|FD-Score:5.09|P-value:3.55E-6 ID:SGTC_510|Compound:ag-490|FD-Score:3.78|P-value:4.28E-4 ID:SGTC_521|Compound:r062-0005|FD-Score:3.99|P-value:2.17E-4 ID:SGTC_904|Compound:1141-0088|FD-Score:5.95|P-value:7.17E-8 ID:SGTC_1152|Compound:3909-8331|FD-Score:4.77|P-value:1.26E-5 ID:SGTC_1156|Compound:4092-0367|FD-Score:-3.53|P-value:8.03E-4 ID:SGTC_1158|Compound:4092-0494|FD-Score:-3.84|P-value:2.97E-4 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:3.86|P-value:3.36E-4 ID:SGTC_1431|Compound:4049-0260|FD-Score:4.82|P-value:1.05E-5 ID:SGTC_1439|Compound:4092-1168|FD-Score:3.53|P-value:9.42E-4 ID:SGTC_1477|Compound:0139-0234|FD-Score:4.67|P-value:1.85E-5 ID:SGTC_1549|Compound:4'-methoxyflavonol|FD-Score:4.57|P-value:2.76E-5 ID:SGTC_1563|Compound:conessine|FD-Score:3.81|P-value:3.96E-4 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:4.40|P-value:5.16E-5 ID:SGTC_1739|Compound:st037196|FD-Score:-4.61|P-value:1.92E-5 ID:SGTC_1743|Compound:st037606|FD-Score:3.82|P-value:3.82E-4 ID:SGTC_1750|Compound:st081859|FD-Score:-3.65|P-value:5.39E-4 ID:SGTC_1900|Compound:st060200|FD-Score:-3.55|P-value:7.50E-4 ID:SGTC_2155|Compound:5570423|FD-Score:3.91|P-value:2.81E-4 ID:SGTC_2425|Compound:5628681|FD-Score:4.11|P-value:1.48E-4 ID:SGTC_2427|Compound:5545055|FD-Score:5.15|P-value:2.75E-6 ID:SGTC_2581|Compound:avocatin a|FD-Score:-4.07|P-value:1.40E-4 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:-5.82|P-value:1.05E-7 ID:SGTC_2786|Compound:7743617|FD-Score:3.83|P-value:3.74E-4 ID:SGTC_2970|Compound:9090938|FD-Score:-3.67|P-value:5.08E-4 ID:SGTC_2986|Compound:9022445|FD-Score:-3.46|P-value:9.77E-4 ID:SGTC_3296|Compound:9122258|FD-Score:3.85|P-value:3.41E-4 ID:SGTC_3302|Compound:9125395|FD-Score:7.88|P-value:1.59E-12 ID:SGTC_3305|Compound:9127027|FD-Score:-4.88|P-value:6.63E-6 ID:SGTC_3309|Compound:9129340|FD-Score:4.12|P-value:1.38E-4

Top fitness defect scores for YGR099W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_3302 9125395 7.88 16.4 µM 1.59E-12 1 1.65E-15 2.52
2 SGTC_904 1141-0088 5.95 396.0 µM 7.17E-8 1 1.31E-9 2.20
3 SGTC_363 0455-0021 5.80 3.1 µM 1.50E-7 azole & statin 10 3.33E-9 0.88
4 SGTC_2427 5545055 5.15 42.8 µM 2.75E-6 3 1.32E-7 0.67
5 SGTC_508 roscovitine 5.09 141.0 µM 3.55E-6 1 1.82E-7 1.66
6 SGTC_1431 4049-0260 4.82 9.1 µM 1.05E-5 1 7.14E-7 1.06
7 SGTC_1152 3909-8331 4.77 15.9 µM 1.26E-5 3 9.00E-7 0.55
8 SGTC_1477 0139-0234 4.67 16.0 µM 1.85E-5 1 1.47E-6 0.53
9 SGTC_317 4495-0002 4.57 170.0 µM 2.73E-5 1 2.40E-6 0.36
10 SGTC_1549 4'-methoxyflavonol 4.57 74.6 µM 2.76E-5 1 2.43E-6 1.34
11 SGTC_1572 epiandrosterone 4.40 68.9 µM 5.16E-5 1 5.36E-6 0.76
12 SGTC_128 0906-2981 4.26 13.4 µM 8.57E-5 5 1.02E-5 0.38
13 SGTC_362 0310-0100 4.13 9.0 µM 1.35E-4 RPP1 & pyrimidine depletion 8 1.81E-5 0.27
14 SGTC_3309 9129340 4.12 25.8 µM 1.38E-4 1 1.86E-5 0.52
15 SGTC_2425 5628681 4.11 7.8 µM 1.48E-4 4 2.02E-5 0.12
16 SGTC_364 0083-0097 4.10 67.7 µM 1.51E-4 7 2.07E-5 0.10
17 SGTC_521 r062-0005 3.99 13.8 µM 2.17E-4 2 3.28E-5 0.33
18 SGTC_2155 5570423 3.91 76.0 µM 2.81E-4 ergosterol biosynthesis 5 4.54E-5 0.36
19 SGTC_315 k915-0449 3.87 187.0 µM 3.20E-4 9 5.35E-5 0.51
20 SGTC_1292 0kpi-0043 3.86 232.0 µM 3.36E-4 2 5.68E-5 0.05

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.127 1.64E-13 YDR222W_p YDR222W_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.127 1.67E-13 YGR014W MSB2 hom Mucin family member involved in signaling; functions in the Cdc42p- and MAP kinase-dependent filamentous growth signaling pathway; is processed into secreted and cell-associated forms by the aspartyl protease, Yps1p; also functions as an osmosensor in parallel to the Sho1p-mediated pathway; potential Cdc28p substrate
0.114 3.73E-11 YDR068W DOS2 hom Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.112 6.87E-11 YGL207W SPT16 het Subunit of the heterodimeric FACT complex (Spt16p-Pob3p), which associates with chromatin via interaction with Nhp6Ap and Nhp6Bp, and reorganizes nucleosomes to facilitate access to DNA by RNA and DNA polymerases; some mutations cause reduced nucleosome occupancy over highly transcribed regions of the yeast genome
0.108 4.05E-10 YLR352W_p YLR352W_p hom Putative protein of unknown function with similarity to F-box proteins; interacts with Skp1p and Cdc53p; YLR352W is not an essential gene
0.107 5.80E-10 YGR070W ROM1 hom GDP/GTP exchange protein (GEP) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP
0.103 2.01E-9 YNR013C PHO91 hom Low-affinity phosphate transporter of the vacuolar membrane; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth
0.098 1.30E-8 YDR234W LYS4 hom Homoaconitase, catalyzes the conversion of homocitrate to homoisocitrate, which is a step in the lysine biosynthesis pathway
0.097 1.76E-8 YMR004W MVP1 hom Protein required for sorting proteins to the vacuole; Mvp1p and Vps1p act in concert to promote membrane traffic to the vacuole; participates in transcription initiation and/or early elongation of specific genes; interacts with foot domain of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions; protein abundance increases in response to DNA replication stress
0.094 5.24E-8 YGL203C KEX1 hom Protease involved in the processing of killer toxin and alpha factor precursor; cleaves Lys and Arg residues from the C-terminus of peptides and proteins
0.093 6.23E-8 YFL008W SMC1 het Subunit of the multiprotein cohesin complex, essential protein involved in chromosome segregation and in double-strand DNA break repair; SMC chromosomal ATPase family member, binds DNA with a preference for DNA with secondary structure
0.092 9.47E-8 YGR046W TAM41 het Mitochondrial protein required for cardiolipin biosynthesis; viability of null mutant is strain-dependent; mRNA is targeted to the bud; mutant displays defect in mitochondrial protein import, likely due to altered membrane lipid composition
0.089 2.35E-7 YOR225W_d YOR225W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.087 3.89E-7 YLR128W DCN1 hom Scaffold-type E3 ligase required for cullin neddylation and ubiquitin ligase activation; contains a ubiquitin-binding domain (UBA) for ubiquitin and Nedd8 (Rub1p) interaction and a PONY domain involved in cullin binding and neddylation
0.086 5.28E-7 YGL170C SPO74 hom Component of the meiotic outer plaque of the spindle pole body, involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation