HIPHOP chemogenomics database

YGR099W / TEL2

Subunit of the ASTRA complex, involved in chromatin remodeling; subunit of the telomere cap complex DNA-binding protein specific to single-stranded yeast telomeric DNA repeats, required for telomere length regulation and telomere position effect; involved in the stability or biogenesis of PIKKs such as TORC1

Zygosity: Heterozygous strain

fixedexpanded
Profile for YGR099W / TEL2

Click on Significant Values for Screen Details

Top fitness defect scores for YGR099W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value	Screen Clearance
1	SGTC_3302	9125395	7.88	16.4 µM	1.59E-12		1	1.65E-15	2.52
2	SGTC_904	1141-0088	5.95	396.0 µM	7.17E-8		1	1.31E-9	2.20
3	SGTC_363	0455-0021	5.80	3.1 µM	1.50E-7	azole & statin	10	3.33E-9	0.88
4	SGTC_2427	5545055	5.15	42.8 µM	2.75E-6		3	1.32E-7	0.67
5	SGTC_508	roscovitine	5.09	141.0 µM	3.55E-6		1	1.82E-7	1.66
6	SGTC_1431	4049-0260	4.82	9.1 µM	1.05E-5		1	7.14E-7	1.06
7	SGTC_1152	3909-8331	4.77	15.9 µM	1.26E-5		3	9.00E-7	0.55
8	SGTC_1477	0139-0234	4.67	16.0 µM	1.85E-5		1	1.47E-6	0.53
9	SGTC_317	4495-0002	4.57	170.0 µM	2.73E-5		1	2.40E-6	0.36
10	SGTC_1549	4'-methoxyflavonol	4.57	74.6 µM	2.76E-5		1	2.43E-6	1.34
11	SGTC_1572	epiandrosterone	4.40	68.9 µM	5.16E-5		1	5.36E-6	0.76
12	SGTC_128	0906-2981	4.26	13.4 µM	8.57E-5		5	1.02E-5	0.38
13	SGTC_362	0310-0100	4.13	9.0 µM	1.35E-4	RPP1 & pyrimidine depletion	8	1.81E-5	0.27
14	SGTC_3309	9129340	4.12	25.8 µM	1.38E-4		1	1.86E-5	0.52
15	SGTC_2425	5628681	4.11	7.8 µM	1.48E-4		4	2.02E-5	0.12
16	SGTC_364	0083-0097	4.10	67.7 µM	1.51E-4		7	2.07E-5	0.10
17	SGTC_521	r062-0005	3.99	13.8 µM	2.17E-4		2	3.28E-5	0.33
18	SGTC_2155	5570423	3.91	76.0 µM	2.81E-4	ergosterol biosynthesis	5	4.54E-5	0.36
19	SGTC_315	k915-0449	3.87	187.0 µM	3.20E-4		9	5.35E-5	0.51
20	SGTC_1292	0kpi-0043	3.86	232.0 µM	3.36E-4		2	5.68E-5	0.05

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.127	1.64E-13	YDR222W_p	YDR222W_p	hom	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.127	1.67E-13	YGR014W	MSB2	hom	Mucin family member involved in signaling; functions in the Cdc42p- and MAP kinase-dependent filamentous growth signaling pathway; is processed into secreted and cell-associated forms by the aspartyl protease, Yps1p; also functions as an osmosensor in parallel to the Sho1p-mediated pathway; potential Cdc28p substrate
0.114	3.73E-11	YDR068W	DOS2	hom	Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.112	6.87E-11	YGL207W	SPT16	het	Subunit of the heterodimeric FACT complex (Spt16p-Pob3p), which associates with chromatin via interaction with Nhp6Ap and Nhp6Bp, and reorganizes nucleosomes to facilitate access to DNA by RNA and DNA polymerases; some mutations cause reduced nucleosome occupancy over highly transcribed regions of the yeast genome
0.108	4.05E-10	YLR352W_p	YLR352W_p	hom	Putative protein of unknown function with similarity to F-box proteins; interacts with Skp1p and Cdc53p; YLR352W is not an essential gene
0.107	5.80E-10	YGR070W	ROM1	hom	GDP/GTP exchange protein (GEP) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP
0.103	2.01E-9	YNR013C	PHO91	hom	Low-affinity phosphate transporter of the vacuolar membrane; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth
0.098	1.30E-8	YDR234W	LYS4	hom	Homoaconitase, catalyzes the conversion of homocitrate to homoisocitrate, which is a step in the lysine biosynthesis pathway
0.097	1.76E-8	YMR004W	MVP1	hom	Protein required for sorting proteins to the vacuole; Mvp1p and Vps1p act in concert to promote membrane traffic to the vacuole; participates in transcription initiation and/or early elongation of specific genes; interacts with foot domain of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions; protein abundance increases in response to DNA replication stress
0.094	5.24E-8	YGL203C	KEX1	hom	Protease involved in the processing of killer toxin and alpha factor precursor; cleaves Lys and Arg residues from the C-terminus of peptides and proteins
0.093	6.23E-8	YFL008W	SMC1	het	Subunit of the multiprotein cohesin complex, essential protein involved in chromosome segregation and in double-strand DNA break repair; SMC chromosomal ATPase family member, binds DNA with a preference for DNA with secondary structure
0.092	9.47E-8	YGR046W	TAM41	het	Mitochondrial protein required for cardiolipin biosynthesis; viability of null mutant is strain-dependent; mRNA is targeted to the bud; mutant displays defect in mitochondrial protein import, likely due to altered membrane lipid composition
0.089	2.35E-7	YOR225W_d	YOR225W_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.087	3.89E-7	YLR128W	DCN1	hom	Scaffold-type E3 ligase required for cullin neddylation and ubiquitin ligase activation; contains a ubiquitin-binding domain (UBA) for ubiquitin and Nedd8 (Rub1p) interaction and a PONY domain involved in cullin binding and neddylation
0.086	5.28E-7	YGL170C	SPO74	hom	Component of the meiotic outer plaque of the spindle pole body, involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation