YGR101W / PCP1

Mitochondrial serine protease required for the processing of various mitochondrial proteins and maintenance of mitochondrial DNA and morphology; belongs to the rhomboid-GlpG superfamily of intramembrane peptidases

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR101W / PCP1

Click on Significant Values for Screen Details ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:3.62|P-value:3.38E-4 ID:SGTC_57|Compound:miconazole|FD-Score:-3.30|P-value:9.90E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:8.35|P-value:2.44E-15 ID:SGTC_68|Compound:0986-0284|FD-Score:6.60|P-value:3.03E-10 ID:SGTC_70|Compound:0141-0289|FD-Score:6.93|P-value:4.03E-11 ID:SGTC_87|Compound:0100-0052|FD-Score:4.88|P-value:2.35E-6 ID:SGTC_116|Compound:0155-0182|FD-Score:3.31|P-value:9.63E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:-5.22|P-value:4.79E-7 ID:SGTC_173|Compound:1273-0061|FD-Score:4.05|P-value:7.17E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:14.60|P-value:6.93E-43 ID:SGTC_275|Compound:trichlorophene|FD-Score:5.25|P-value:4.17E-7 ID:SGTC_310|Compound:1273-0058|FD-Score:9.15|P-value:4.51E-18 ID:SGTC_341|Compound:1486-1430|FD-Score:3.38|P-value:7.53E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:-3.38|P-value:7.69E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:-3.57|P-value:4.10E-4 ID:SGTC_393|Compound:acivicin|FD-Score:-3.65|P-value:3.08E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:4.94|P-value:1.82E-6 ID:SGTC_885|Compound:0865-0106|FD-Score:3.59|P-value:3.77E-4 ID:SGTC_1014|Compound:4130-3005|FD-Score:-4.66|P-value:6.21E-6 ID:SGTC_1020|Compound:4335-0961|FD-Score:3.41|P-value:6.98E-4 ID:SGTC_1024|Compound:4507-0395|FD-Score:4.71|P-value:4.92E-6 ID:SGTC_1036|Compound:k216-0215|FD-Score:3.73|P-value:2.36E-4 ID:SGTC_1148|Compound:3909-7663|FD-Score:4.19|P-value:4.27E-5 ID:SGTC_1153|Compound:4055-0057|FD-Score:4.10|P-value:5.88E-5 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.58|P-value:3.90E-4 ID:SGTC_1298|Compound:1079-1278|FD-Score:4.15|P-value:4.91E-5 ID:SGTC_1502|Compound:4534-4282|FD-Score:3.44|P-value:6.32E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.59|P-value:3.77E-4 ID:SGTC_1623|Compound:st003709|FD-Score:5.19|P-value:5.57E-7 ID:SGTC_1693|Compound:xanthone|FD-Score:4.16|P-value:4.82E-5 ID:SGTC_1707|Compound:st032323|FD-Score:-4.00|P-value:8.81E-5 ID:SGTC_1765|Compound:st044815|FD-Score:3.86|P-value:1.47E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-5.36|P-value:2.47E-7 ID:SGTC_1840|Compound:st055363|FD-Score:3.57|P-value:4.00E-4 ID:SGTC_1916|Compound:st067606|FD-Score:-3.31|P-value:9.39E-4 ID:SGTC_2086|Compound:5274770|FD-Score:4.20|P-value:4.02E-5 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:5.67|P-value:5.27E-8 ID:SGTC_2347|Compound:9049783|FD-Score:3.40|P-value:7.11E-4 ID:SGTC_2403|Compound:6032726|FD-Score:3.50|P-value:5.10E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:4.38|P-value:2.00E-5 ID:SGTC_2418|Compound:pentamidine|FD-Score:3.80|P-value:1.82E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-4.46|P-value:1.42E-5 ID:SGTC_2620|Compound:irigenin|FD-Score:-6.27|P-value:2.01E-9 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.82|P-value:3.08E-6 ID:SGTC_3071|Compound:9117417|FD-Score:-3.35|P-value:8.30E-4 ID:SGTC_3201|Compound:9113999|FD-Score:-6.49|P-value:5.69E-10 ID:SGTC_3202|Compound:9113761|FD-Score:-9.95|P-value:5.24E-21 ID:SGTC_3206|Compound:9114350|FD-Score:4.06|P-value:6.86E-5 ID:SGTC_3209|Compound:9113616|FD-Score:-9.28|P-value:1.54E-18 ID:SGTC_3284|Compound:9108171|FD-Score:-4.01|P-value:8.53E-5 ID:SGTC_3355|Compound:9151058|FD-Score:3.64|P-value:3.15E-4 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:3.62|P-value:3.38E-4 ID:SGTC_57|Compound:miconazole|FD-Score:-3.30|P-value:9.90E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:8.35|P-value:2.44E-15 ID:SGTC_68|Compound:0986-0284|FD-Score:6.60|P-value:3.03E-10 ID:SGTC_70|Compound:0141-0289|FD-Score:6.93|P-value:4.03E-11 ID:SGTC_87|Compound:0100-0052|FD-Score:4.88|P-value:2.35E-6 ID:SGTC_116|Compound:0155-0182|FD-Score:3.31|P-value:9.63E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:-5.22|P-value:4.79E-7 ID:SGTC_173|Compound:1273-0061|FD-Score:4.05|P-value:7.17E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:14.60|P-value:6.93E-43 ID:SGTC_275|Compound:trichlorophene|FD-Score:5.25|P-value:4.17E-7 ID:SGTC_310|Compound:1273-0058|FD-Score:9.15|P-value:4.51E-18 ID:SGTC_341|Compound:1486-1430|FD-Score:3.38|P-value:7.53E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:-3.38|P-value:7.69E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:-3.57|P-value:4.10E-4 ID:SGTC_393|Compound:acivicin|FD-Score:-3.65|P-value:3.08E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:4.94|P-value:1.82E-6 ID:SGTC_885|Compound:0865-0106|FD-Score:3.59|P-value:3.77E-4 ID:SGTC_1014|Compound:4130-3005|FD-Score:-4.66|P-value:6.21E-6 ID:SGTC_1020|Compound:4335-0961|FD-Score:3.41|P-value:6.98E-4 ID:SGTC_1024|Compound:4507-0395|FD-Score:4.71|P-value:4.92E-6 ID:SGTC_1036|Compound:k216-0215|FD-Score:3.73|P-value:2.36E-4 ID:SGTC_1148|Compound:3909-7663|FD-Score:4.19|P-value:4.27E-5 ID:SGTC_1153|Compound:4055-0057|FD-Score:4.10|P-value:5.88E-5 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.58|P-value:3.90E-4 ID:SGTC_1298|Compound:1079-1278|FD-Score:4.15|P-value:4.91E-5 ID:SGTC_1502|Compound:4534-4282|FD-Score:3.44|P-value:6.32E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.59|P-value:3.77E-4 ID:SGTC_1623|Compound:st003709|FD-Score:5.19|P-value:5.57E-7 ID:SGTC_1693|Compound:xanthone|FD-Score:4.16|P-value:4.82E-5 ID:SGTC_1707|Compound:st032323|FD-Score:-4.00|P-value:8.81E-5 ID:SGTC_1765|Compound:st044815|FD-Score:3.86|P-value:1.47E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-5.36|P-value:2.47E-7 ID:SGTC_1840|Compound:st055363|FD-Score:3.57|P-value:4.00E-4 ID:SGTC_1916|Compound:st067606|FD-Score:-3.31|P-value:9.39E-4 ID:SGTC_2086|Compound:5274770|FD-Score:4.20|P-value:4.02E-5 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:5.67|P-value:5.27E-8 ID:SGTC_2347|Compound:9049783|FD-Score:3.40|P-value:7.11E-4 ID:SGTC_2403|Compound:6032726|FD-Score:3.50|P-value:5.10E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:4.38|P-value:2.00E-5 ID:SGTC_2418|Compound:pentamidine|FD-Score:3.80|P-value:1.82E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-4.46|P-value:1.42E-5 ID:SGTC_2620|Compound:irigenin|FD-Score:-6.27|P-value:2.01E-9 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.82|P-value:3.08E-6 ID:SGTC_3071|Compound:9117417|FD-Score:-3.35|P-value:8.30E-4 ID:SGTC_3201|Compound:9113999|FD-Score:-6.49|P-value:5.69E-10 ID:SGTC_3202|Compound:9113761|FD-Score:-9.95|P-value:5.24E-21 ID:SGTC_3206|Compound:9114350|FD-Score:4.06|P-value:6.86E-5 ID:SGTC_3209|Compound:9113616|FD-Score:-9.28|P-value:1.54E-18 ID:SGTC_3284|Compound:9108171|FD-Score:-4.01|P-value:8.53E-5 ID:SGTC_3355|Compound:9151058|FD-Score:3.64|P-value:3.15E-4

Top fitness defect scores for YGR101W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 14.60 5.3 µM 6.93E-43 107 1.94E-48
2 SGTC_310 1273-0058 9.15 1.1 µM 4.51E-18 mitochondrial stress 62 2.82E-20
3 SGTC_63 0099-0242 8.35 26.7 µM 2.44E-15 mitochondrial stress 7 3.55E-17
4 SGTC_70 0141-0289 6.93 43.3 µM 4.03E-11 mitochondrial stress 53 2.14E-12
5 SGTC_68 0986-0284 6.60 82.8 µM 3.03E-10 15 2.11E-11
6 SGTC_2232 chlorophetanol 5.67 41.5 µM 5.27E-8 TRP & mitochondrial translation 48 7.27E-9
7 SGTC_275 trichlorophene 5.25 5.7 µM 4.17E-7 mitochondrial stress 154 7.55E-8
8 SGTC_1623 st003709 5.19 20.3 µM 5.57E-7 calcium & mitochondrial duress 24 1.05E-7
9 SGTC_832 4083-0019 4.94 164.0 µM 1.82E-6 translation 45 3.98E-7
10 SGTC_87 0100-0052 4.88 35.5 µM 2.35E-6 59 5.33E-7
11 SGTC_2688 kanamycin b 4.82 96.7 µM 3.08E-6 calcium & mitochondrial duress 263 7.25E-7
12 SGTC_1024 4507-0395 4.71 26.0 µM 4.92E-6 TSC3-RPN4 16 1.23E-6
13 SGTC_2405 ticlatone 4.38 3.5 µM 2.00E-5 51 6.01E-6
14 SGTC_2086 5274770 4.20 176.6 µM 4.02E-5 18 1.32E-5
15 SGTC_1148 3909-7663 4.19 27.7 µM 4.27E-5 10 1.41E-5
16 SGTC_1693 xanthone 4.16 101.9 µM 4.82E-5 DNA damage response 13 1.62E-5
17 SGTC_1298 1079-1278 4.15 263.0 µM 4.91E-5 DNA damage response 12 1.65E-5
18 SGTC_1153 4055-0057 4.10 267.0 µM 5.88E-5 23 2.03E-5
19 SGTC_3206 9114350 4.06 49.5 µM 6.86E-5 16 2.41E-5
20 SGTC_173 1273-0061 4.05 2.7 µM 7.17E-5 mitochondrial stress 182 2.54E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.439 1.21E-157 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.421 2.56E-144 YGR171C MSM1 hom Mitochondrial methionyl-tRNA synthetase (MetRS), functions as a monomer in mitochondrial protein synthesis; functions similarly to cytoplasmic MetRS although the cytoplasmic form contains a zinc-binding domain not found in Msm1p
0.397 6.91E-127 YIL070C MAM33 hom Acidic protein of the mitochondrial matrix involved in oxidative phosphorylation; related to the human complement receptor gC1q-R
0.394 3.25E-125 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.390 8.80E-122 YLR260W LCB5 hom Minor sphingoid long-chain base kinase, paralog of Lcb4p responsible for few percent of the total activity, possibly involved in synthesis of long-chain base phosphates, which function as signaling molecules
0.389 1.39E-121 YER028C MIG3 hom Transcriptional regulator; partially nonfunctional in S288C strains but has a major role in catabolite repression and ethanol response in some other strains; involved in response to toxic agents; phosphorylation by Snf1p or the Mec1p pathway inactivates Mig3p, allowing induction of damage response genes; MIG3 has a paralog, MIG2, that arose from the whole genome duplication
0.386 1.88E-119 YPL078C ATP4 hom Subunit b of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; contributes to the oligomerization of the complex; phosphorylated
0.381 1.80E-116 YDR332W IRC3 hom Putative RNA helicase of the DEAH/D-box family; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion
0.379 2.35E-115 YGR220C MRPL9 hom Mitochondrial ribosomal protein of the large subunit
0.379 4.15E-115 YLL033W IRC19 hom Putative protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52p foci
0.376 7.08E-113 YGR215W RSM27 hom Mitochondrial ribosomal protein of the small subunit
0.374 1.31E-111 YNL005C MRP7 hom Mitochondrial ribosomal protein of the large subunit
0.369 6.53E-109 YPL040C ISM1 hom Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
0.367 1.04E-107 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.366 3.19E-107 YLR439W MRPL4 hom Mitochondrial ribosomal protein of the large subunit, homolog of prokaryotic L29 ribosomal protein; located at the ribosomal tunnel exit