YGR102C / GTF1

Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR102C / GTF1

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:4.05|P-value:3.16E-5 ID:SGTC_19|Compound:0279-0214|FD-Score:3.80|P-value:8.89E-5 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:3.41|P-value:3.76E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:3.54|P-value:2.32E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:3.93|P-value:5.27E-5 ID:SGTC_119|Compound:0121-0043|FD-Score:3.94|P-value:4.97E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:-4.00|P-value:4.18E-5 ID:SGTC_161|Compound:4065-0411|FD-Score:3.65|P-value:1.59E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:13.80|P-value:1.68E-42 ID:SGTC_218|Compound:alverine citrate|FD-Score:3.17|P-value:8.63E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:16.30|P-value:2.25E-58 ID:SGTC_275|Compound:trichlorophene|FD-Score:8.45|P-value:4.12E-17 ID:SGTC_310|Compound:1273-0058|FD-Score:9.42|P-value:7.83E-21 ID:SGTC_314|Compound:1671-0008|FD-Score:8.05|P-value:1.02E-15 ID:SGTC_324|Compound:1315-0088|FD-Score:3.20|P-value:7.90E-4 ID:SGTC_327|Compound:1273-0057|FD-Score:4.08|P-value:2.82E-5 ID:SGTC_330|Compound:1488-0319|FD-Score:5.68|P-value:1.03E-8 ID:SGTC_339|Compound:3091-4833|FD-Score:-6.43|P-value:1.25E-10 ID:SGTC_340|Compound:k038-0059|FD-Score:-3.46|P-value:3.41E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:4.01|P-value:3.74E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:-3.91|P-value:6.16E-5 ID:SGTC_520|Compound:3584-0023|FD-Score:3.35|P-value:4.76E-4 ID:SGTC_609|Compound:0986-0026|FD-Score:3.28|P-value:5.94E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:4.70|P-value:1.73E-6 ID:SGTC_767|Compound:0929-0023|FD-Score:4.54|P-value:3.77E-6 ID:SGTC_862|Compound:0452-0056|FD-Score:3.25|P-value:6.74E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:6.66|P-value:2.63E-11 ID:SGTC_969|Compound:1313-0238|FD-Score:4.06|P-value:3.05E-5 ID:SGTC_1188|Compound:1403-0014|FD-Score:7.10|P-value:1.30E-12 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.20|P-value:7.85E-4 ID:SGTC_1262|Compound:0737-0114|FD-Score:-3.22|P-value:7.79E-4 ID:SGTC_1318|Compound:1280-3875|FD-Score:4.41|P-value:6.73E-6 ID:SGTC_1319|Compound:1306-0155|FD-Score:3.51|P-value:2.67E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:4.51|P-value:4.34E-6 ID:SGTC_1456|Compound:k015-0012|FD-Score:3.46|P-value:3.20E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:3.40|P-value:3.91E-4 ID:SGTC_1658|Compound:st012944|FD-Score:-4.10|P-value:2.76E-5 ID:SGTC_1707|Compound:st032323|FD-Score:-4.11|P-value:2.65E-5 ID:SGTC_1742|Compound:st038235|FD-Score:9.40|P-value:9.56E-21 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-3.34|P-value:5.27E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-7.81|P-value:7.62E-15 ID:SGTC_1800|Compound:st050079|FD-Score:-4.06|P-value:3.32E-5 ID:SGTC_1818|Compound:st052136|FD-Score:-3.32|P-value:5.54E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-5.30|P-value:9.30E-8 ID:SGTC_1858|Compound:4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione|FD-Score:3.21|P-value:7.53E-4 ID:SGTC_1882|Compound:5615643|FD-Score:3.65|P-value:1.56E-4 ID:SGTC_1921|Compound:5740136|FD-Score:3.39|P-value:4.09E-4 ID:SGTC_1922|Compound:5578187|FD-Score:4.04|P-value:3.38E-5 ID:SGTC_1925|Compound:st057770|FD-Score:-3.25|P-value:7.14E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.60|P-value:2.03E-4 ID:SGTC_1935|Compound:st074532|FD-Score:3.77|P-value:9.86E-5 ID:SGTC_1999|Compound:st074831|FD-Score:3.13|P-value:9.98E-4 ID:SGTC_2038|Compound:4100038|FD-Score:-4.83|P-value:1.03E-6 ID:SGTC_2092|Compound:5303694|FD-Score:-3.72|P-value:1.30E-4 ID:SGTC_2139|Compound:5578692|FD-Score:4.03|P-value:3.51E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.20|P-value:1.67E-5 ID:SGTC_2291|Compound:7917025|FD-Score:-6.21|P-value:5.23E-10 ID:SGTC_2344|Compound:7990960|FD-Score:3.88|P-value:6.47E-5 ID:SGTC_2361|Compound:9034121|FD-Score:5.05|P-value:3.18E-7 ID:SGTC_2368|Compound:9071271|FD-Score:3.24|P-value:6.89E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:-4.99|P-value:4.74E-7 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:-3.32|P-value:5.59E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:8.68|P-value:5.77E-18 ID:SGTC_2611|Compound:pyromycin|FD-Score:3.79|P-value:9.28E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:-3.45|P-value:3.47E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-4.69|P-value:2.07E-6 ID:SGTC_2702|Compound:st077768|FD-Score:3.20|P-value:7.90E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-4.08|P-value:3.09E-5 ID:SGTC_2858|Compound:9025781|FD-Score:-4.16|P-value:2.21E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-4.91|P-value:7.07E-7 ID:SGTC_2905|Compound:7799065|FD-Score:-3.78|P-value:1.04E-4 ID:SGTC_2923|Compound:7992654|FD-Score:-4.73|P-value:1.68E-6 ID:SGTC_2928|Compound:9011484|FD-Score:3.20|P-value:7.79E-4 ID:SGTC_2971|Compound:9092186|FD-Score:4.05|P-value:3.22E-5 ID:SGTC_3006|Compound:9075424|FD-Score:3.29|P-value:5.87E-4 ID:SGTC_3152|Compound:9099253|FD-Score:4.17|P-value:1.97E-5 ID:SGTC_3346|Compound:9158254|FD-Score:3.25|P-value:6.54E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:4.05|P-value:3.16E-5 ID:SGTC_19|Compound:0279-0214|FD-Score:3.80|P-value:8.89E-5 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:3.41|P-value:3.76E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:3.54|P-value:2.32E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:3.93|P-value:5.27E-5 ID:SGTC_119|Compound:0121-0043|FD-Score:3.94|P-value:4.97E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:-4.00|P-value:4.18E-5 ID:SGTC_161|Compound:4065-0411|FD-Score:3.65|P-value:1.59E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:13.80|P-value:1.68E-42 ID:SGTC_218|Compound:alverine citrate|FD-Score:3.17|P-value:8.63E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:16.30|P-value:2.25E-58 ID:SGTC_275|Compound:trichlorophene|FD-Score:8.45|P-value:4.12E-17 ID:SGTC_310|Compound:1273-0058|FD-Score:9.42|P-value:7.83E-21 ID:SGTC_314|Compound:1671-0008|FD-Score:8.05|P-value:1.02E-15 ID:SGTC_324|Compound:1315-0088|FD-Score:3.20|P-value:7.90E-4 ID:SGTC_327|Compound:1273-0057|FD-Score:4.08|P-value:2.82E-5 ID:SGTC_330|Compound:1488-0319|FD-Score:5.68|P-value:1.03E-8 ID:SGTC_339|Compound:3091-4833|FD-Score:-6.43|P-value:1.25E-10 ID:SGTC_340|Compound:k038-0059|FD-Score:-3.46|P-value:3.41E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:4.01|P-value:3.74E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:-3.91|P-value:6.16E-5 ID:SGTC_520|Compound:3584-0023|FD-Score:3.35|P-value:4.76E-4 ID:SGTC_609|Compound:0986-0026|FD-Score:3.28|P-value:5.94E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:4.70|P-value:1.73E-6 ID:SGTC_767|Compound:0929-0023|FD-Score:4.54|P-value:3.77E-6 ID:SGTC_862|Compound:0452-0056|FD-Score:3.25|P-value:6.74E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:6.66|P-value:2.63E-11 ID:SGTC_969|Compound:1313-0238|FD-Score:4.06|P-value:3.05E-5 ID:SGTC_1188|Compound:1403-0014|FD-Score:7.10|P-value:1.30E-12 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.20|P-value:7.85E-4 ID:SGTC_1262|Compound:0737-0114|FD-Score:-3.22|P-value:7.79E-4 ID:SGTC_1318|Compound:1280-3875|FD-Score:4.41|P-value:6.73E-6 ID:SGTC_1319|Compound:1306-0155|FD-Score:3.51|P-value:2.67E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:4.51|P-value:4.34E-6 ID:SGTC_1456|Compound:k015-0012|FD-Score:3.46|P-value:3.20E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:3.40|P-value:3.91E-4 ID:SGTC_1658|Compound:st012944|FD-Score:-4.10|P-value:2.76E-5 ID:SGTC_1707|Compound:st032323|FD-Score:-4.11|P-value:2.65E-5 ID:SGTC_1742|Compound:st038235|FD-Score:9.40|P-value:9.56E-21 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-3.34|P-value:5.27E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-7.81|P-value:7.62E-15 ID:SGTC_1800|Compound:st050079|FD-Score:-4.06|P-value:3.32E-5 ID:SGTC_1818|Compound:st052136|FD-Score:-3.32|P-value:5.54E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-5.30|P-value:9.30E-8 ID:SGTC_1858|Compound:4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione|FD-Score:3.21|P-value:7.53E-4 ID:SGTC_1882|Compound:5615643|FD-Score:3.65|P-value:1.56E-4 ID:SGTC_1921|Compound:5740136|FD-Score:3.39|P-value:4.09E-4 ID:SGTC_1922|Compound:5578187|FD-Score:4.04|P-value:3.38E-5 ID:SGTC_1925|Compound:st057770|FD-Score:-3.25|P-value:7.14E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.60|P-value:2.03E-4 ID:SGTC_1935|Compound:st074532|FD-Score:3.77|P-value:9.86E-5 ID:SGTC_1999|Compound:st074831|FD-Score:3.13|P-value:9.98E-4 ID:SGTC_2038|Compound:4100038|FD-Score:-4.83|P-value:1.03E-6 ID:SGTC_2092|Compound:5303694|FD-Score:-3.72|P-value:1.30E-4 ID:SGTC_2139|Compound:5578692|FD-Score:4.03|P-value:3.51E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.20|P-value:1.67E-5 ID:SGTC_2291|Compound:7917025|FD-Score:-6.21|P-value:5.23E-10 ID:SGTC_2344|Compound:7990960|FD-Score:3.88|P-value:6.47E-5 ID:SGTC_2361|Compound:9034121|FD-Score:5.05|P-value:3.18E-7 ID:SGTC_2368|Compound:9071271|FD-Score:3.24|P-value:6.89E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:-4.99|P-value:4.74E-7 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:-3.32|P-value:5.59E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:8.68|P-value:5.77E-18 ID:SGTC_2611|Compound:pyromycin|FD-Score:3.79|P-value:9.28E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:-3.45|P-value:3.47E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-4.69|P-value:2.07E-6 ID:SGTC_2702|Compound:st077768|FD-Score:3.20|P-value:7.90E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-4.08|P-value:3.09E-5 ID:SGTC_2858|Compound:9025781|FD-Score:-4.16|P-value:2.21E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-4.91|P-value:7.07E-7 ID:SGTC_2905|Compound:7799065|FD-Score:-3.78|P-value:1.04E-4 ID:SGTC_2923|Compound:7992654|FD-Score:-4.73|P-value:1.68E-6 ID:SGTC_2928|Compound:9011484|FD-Score:3.20|P-value:7.79E-4 ID:SGTC_2971|Compound:9092186|FD-Score:4.05|P-value:3.22E-5 ID:SGTC_3006|Compound:9075424|FD-Score:3.29|P-value:5.87E-4 ID:SGTC_3152|Compound:9099253|FD-Score:4.17|P-value:1.97E-5 ID:SGTC_3346|Compound:9158254|FD-Score:3.25|P-value:6.54E-4

Top fitness defect scores for YGR102C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 16.30 5.3 µM 2.25E-58 84 4.67E-60
2 SGTC_173 1273-0061 13.80 2.7 µM 1.68E-42 mitochondrial stress 10 1.06E-43
3 SGTC_310 1273-0058 9.42 1.1 µM 7.83E-21 mitochondrial stress 54 2.21E-21
4 SGTC_1742 st038235 9.40 28.9 µM 9.56E-21 mitochondrial stress 14 2.71E-21
5 SGTC_2582 agaric acid 8.68 100.0 µM 5.77E-18 redox potentiating 91 1.98E-18
6 SGTC_275 trichlorophene 8.45 5.7 µM 4.12E-17 mitochondrial stress 64 1.50E-17
7 SGTC_314 1671-0008 8.05 2.7 µM 1.02E-15 1 4.06E-16
8 SGTC_1188 1403-0014 7.10 4.6 µM 1.30E-12 mitochondrial stress 10 6.39E-13
9 SGTC_908 3448-7491 6.66 47.7 µM 2.63E-11 mitochondrial stress 34 1.42E-11
10 SGTC_330 1488-0319 5.68 80.1 µM 1.03E-8 RPP1 & pyrimidine depletion 1 6.61E-9
11 SGTC_2361 9034121 5.05 116.0 µM 3.18E-7 RSC complex & mRNA processing 6 2.24E-7
12 SGTC_748 0136-0228 4.70 77.9 µM 1.73E-6 redox potentiating 54 1.28E-6
13 SGTC_767 0929-0023 4.54 86.0 µM 3.77E-6 TRP & mitochondrial translation 51 2.84E-6
14 SGTC_1371 2421-0008 4.51 32.7 µM 4.34E-6 mitochondrial processes 21 3.29E-6
15 SGTC_1318 1280-3875 4.41 124.0 µM 6.73E-6 17 5.17E-6
16 SGTC_2250 alverine citrate 4.20 130.0 µM 1.67E-5 139 1.32E-5
17 SGTC_3152 9099253 4.17 49.5 µM 1.97E-5 NEO1-PIK1 118 1.56E-5
18 SGTC_327 1273-0057 4.08 4.0 µM 2.82E-5 azole & statin 31 2.25E-5
19 SGTC_969 1313-0238 4.06 134.0 µM 3.05E-5 mitochondrial processes 22 2.44E-5
20 SGTC_10 0279-0212 4.05 42.6 µM 3.16E-5 TRP & mitochondrial translation 113 2.53E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.579 5.55E-299 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.536 1.40E-247 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.533 3.65E-245 YMR098C ATP25 hom Mitochondrial protein required for the stability of Oli1p (Atp9p) mRNA and for the Oli1p ring formation; YMR098C is not an essential gene
0.523 3.45E-235 YNL252C MRPL17 hom Mitochondrial ribosomal protein of the large subunit
0.518 2.24E-229 YDR237W MRPL7 hom Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein
0.513 7.34E-225 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.500 1.71E-211 YDR268W MSW1 hom Mitochondrial tryptophanyl-tRNA synthetase
0.497 5.33E-209 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.494 7.70E-206 YGR220C MRPL9 hom Mitochondrial ribosomal protein of the large subunit
0.492 1.88E-203 YPR166C MRP2 hom Mitochondrial ribosomal protein of the small subunit
0.491 6.18E-203 YER087W AIM10 hom Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays elevated frequency of mitochondrial genome loss
0.491 1.04E-202 YNL184C_p YNL184C_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.490 3.49E-202 YGL064C MRH4 hom Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function
0.489 7.95E-201 YMR072W ABF2 hom Mitochondrial DNA-binding protein involved in mitochondrial DNA replication and recombination, member of HMG1 DNA-binding protein family; activity may be regulated by protein kinase A phosphorylation
0.477 9.18E-190 YNL177C MRPL22 hom Mitochondrial ribosomal protein of the large subunit