YGR103W / NOP7

Component of several different pre-ribosomal particles; forms a complex with Ytm1p and Erb1p that is required for maturation of the large ribosomal subunit; required for exit from G0 and the initiation of cell proliferation

Zygosity: Heterozygous strain
fixedexpanded
Profile for YGR103W / NOP7

Click on Significant Values for Screen Details ID:SGTC_132|Compound:0417-1715|FD-Score:3.18|P-value:4.26E-4 ID:SGTC_252|Compound:miconazole|FD-Score:3.07|P-value:6.55E-4 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:3.37|P-value:2.00E-4 ID:SGTC_416|Compound:estradiol valerate|FD-Score:-4.20|P-value:2.86E-6 ID:SGTC_440|Compound:fluspirilene|FD-Score:3.21|P-value:3.80E-4 ID:SGTC_493|Compound:zm226600|FD-Score:-4.18|P-value:3.17E-6 ID:SGTC_540|Compound:1187-0821|FD-Score:3.15|P-value:4.84E-4 ID:SGTC_572|Compound:0960-0087|FD-Score:2.96|P-value:9.65E-4 ID:SGTC_814|Compound:3342-0569|FD-Score:3.15|P-value:4.74E-4 ID:SGTC_846|Compound:0335-0850|FD-Score:-3.64|P-value:4.07E-5 ID:SGTC_1170|Compound:0310-0127|FD-Score:3.22|P-value:3.69E-4 ID:SGTC_1379|Compound:2144-0755|FD-Score:-3.42|P-value:1.03E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:3.06|P-value:6.86E-4 ID:SGTC_1628|Compound:st004252|FD-Score:3.28|P-value:2.96E-4 ID:SGTC_1648|Compound:st011736|FD-Score:3.57|P-value:8.93E-5 ID:SGTC_1674|Compound:st016616|FD-Score:5.37|P-value:7.02E-9 ID:SGTC_1683|Compound:st010134|FD-Score:3.22|P-value:3.64E-4 ID:SGTC_1722|Compound:st034304|FD-Score:3.36|P-value:2.10E-4 ID:SGTC_1825|Compound:st052143|FD-Score:-3.01|P-value:5.34E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.23|P-value:2.31E-4 ID:SGTC_2035|Compound:5154463|FD-Score:-3.37|P-value:1.30E-4 ID:SGTC_2085|Compound:5307070|FD-Score:5.06|P-value:4.71E-8 ID:SGTC_2136|Compound:5328288|FD-Score:3.75|P-value:4.13E-5 ID:SGTC_2236|Compound:dapsone|FD-Score:3.14|P-value:5.00E-4 ID:SGTC_2370|Compound:9071495|FD-Score:3.26|P-value:3.20E-4 ID:SGTC_2395|Compound:5646831|FD-Score:3.22|P-value:3.73E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:-3.09|P-value:4.01E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:3.18|P-value:4.36E-4 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:-3.39|P-value:1.17E-4 ID:SGTC_2681|Compound:menadione|FD-Score:2.99|P-value:8.61E-4 ID:SGTC_2821|Compound:7996764|FD-Score:3.31|P-value:2.59E-4 ID:SGTC_2823|Compound:7987624|FD-Score:3.84|P-value:2.71E-5 ID:SGTC_2960|Compound:9079389|FD-Score:-2.90|P-value:8.04E-4 ID:SGTC_2961|Compound:9083290|FD-Score:-2.99|P-value:5.82E-4 ID:SGTC_3009|Compound:9080819|FD-Score:4.32|P-value:2.74E-6 ID:SGTC_3322|Compound:9139058|FD-Score:-2.86|P-value:9.34E-4 ID:SGTC_132|Compound:0417-1715|FD-Score:3.18|P-value:4.26E-4 ID:SGTC_252|Compound:miconazole|FD-Score:3.07|P-value:6.55E-4 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:3.37|P-value:2.00E-4 ID:SGTC_416|Compound:estradiol valerate|FD-Score:-4.20|P-value:2.86E-6 ID:SGTC_440|Compound:fluspirilene|FD-Score:3.21|P-value:3.80E-4 ID:SGTC_493|Compound:zm226600|FD-Score:-4.18|P-value:3.17E-6 ID:SGTC_540|Compound:1187-0821|FD-Score:3.15|P-value:4.84E-4 ID:SGTC_572|Compound:0960-0087|FD-Score:2.96|P-value:9.65E-4 ID:SGTC_814|Compound:3342-0569|FD-Score:3.15|P-value:4.74E-4 ID:SGTC_846|Compound:0335-0850|FD-Score:-3.64|P-value:4.07E-5 ID:SGTC_1170|Compound:0310-0127|FD-Score:3.22|P-value:3.69E-4 ID:SGTC_1379|Compound:2144-0755|FD-Score:-3.42|P-value:1.03E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:3.06|P-value:6.86E-4 ID:SGTC_1628|Compound:st004252|FD-Score:3.28|P-value:2.96E-4 ID:SGTC_1648|Compound:st011736|FD-Score:3.57|P-value:8.93E-5 ID:SGTC_1674|Compound:st016616|FD-Score:5.37|P-value:7.02E-9 ID:SGTC_1683|Compound:st010134|FD-Score:3.22|P-value:3.64E-4 ID:SGTC_1722|Compound:st034304|FD-Score:3.36|P-value:2.10E-4 ID:SGTC_1825|Compound:st052143|FD-Score:-3.01|P-value:5.34E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.23|P-value:2.31E-4 ID:SGTC_2035|Compound:5154463|FD-Score:-3.37|P-value:1.30E-4 ID:SGTC_2085|Compound:5307070|FD-Score:5.06|P-value:4.71E-8 ID:SGTC_2136|Compound:5328288|FD-Score:3.75|P-value:4.13E-5 ID:SGTC_2236|Compound:dapsone|FD-Score:3.14|P-value:5.00E-4 ID:SGTC_2370|Compound:9071495|FD-Score:3.26|P-value:3.20E-4 ID:SGTC_2395|Compound:5646831|FD-Score:3.22|P-value:3.73E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:-3.09|P-value:4.01E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:3.18|P-value:4.36E-4 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:-3.39|P-value:1.17E-4 ID:SGTC_2681|Compound:menadione|FD-Score:2.99|P-value:8.61E-4 ID:SGTC_2821|Compound:7996764|FD-Score:3.31|P-value:2.59E-4 ID:SGTC_2823|Compound:7987624|FD-Score:3.84|P-value:2.71E-5 ID:SGTC_2960|Compound:9079389|FD-Score:-2.90|P-value:8.04E-4 ID:SGTC_2961|Compound:9083290|FD-Score:-2.99|P-value:5.82E-4 ID:SGTC_3009|Compound:9080819|FD-Score:4.32|P-value:2.74E-6 ID:SGTC_3322|Compound:9139058|FD-Score:-2.86|P-value:9.34E-4

Top fitness defect scores for YGR103W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1674 st016616 5.37 23.6 µM 7.02E-9 1 3.86E-8 0.42
2 SGTC_2085 5307070 5.06 144.1 µM 4.71E-8 superoxide 2 2.11E-7 0.06
3 SGTC_3009 9080819 4.32 71.4 µM 2.74E-6 6 7.92E-6 0.14
4 SGTC_2823 7987624 3.84 58.4 µM 2.71E-5 14 6.15E-5 0.03
5 SGTC_2136 5328288 3.75 199.3 µM 4.13E-5 10 8.98E-5 0.01
6 SGTC_1648 st011736 3.57 69.8 µM 8.93E-5 PDR1 3 1.79E-4 0.25
7 SGTC_402 epigallocatechin gallate 3.37 10.0 µM 2.00E-4 8 3.69E-4 0.02
8 SGTC_1722 st034304 3.36 3.6 µM 2.10E-4 mitochondrial processes 17 3.86E-4 0.02
9 SGTC_2821 7996764 3.31 71.4 µM 2.59E-4 15 4.66E-4 0.05
10 SGTC_1628 st004252 3.28 77.7 µM 2.96E-4 11 5.27E-4 0.18
11 SGTC_2370 9071495 3.26 200.0 µM 3.20E-4 mitochondrial processes 17 5.65E-4 0.03
12 SGTC_1683 st010134 3.22 710.0 nM 3.64E-4 8 6.34E-4 0.03
13 SGTC_1170 0310-0127 3.22 64.8 µM 3.69E-4 21 6.42E-4 0.03
14 SGTC_2395 5646831 3.22 180.2 µM 3.73E-4 7 6.48E-4 0.11
15 SGTC_440 fluspirilene 3.21 35.1 µM 3.80E-4 5 6.60E-4 0.02
16 SGTC_132 0417-1715 3.18 25.8 µM 4.26E-4 RPP1 & pyrimidine depletion 14 7.30E-4 0.01
17 SGTC_2620 irigenin 3.18 100.0 µM 4.36E-4 23 7.45E-4 0.03
18 SGTC_814 3342-0569 3.15 96.0 µM 4.74E-4 11 8.03E-4 0.05
19 SGTC_540 1187-0821 3.15 17.3 µM 4.84E-4 16 8.19E-4 0.16
20 SGTC_2236 dapsone 3.14 200.0 µM 5.00E-4 6 8.44E-4 0.24

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.176 8.67E-25 YMR173W DDR48 hom DNA damage-responsive protein; expression is increased in response to heat-shock stress or treatments that produce DNA lesions; contains multiple repeats of the amino acid sequence NNNDSYGS; protein abundance increases in response to DNA replication stress
0.123 9.07E-13 YBR186W PCH2 hom Nucleolar component of the pachytene checkpoint, which prevents chromosome segregation when recombination and chromosome synapsis are defective; also represses meiotic interhomolog recombination in the rDNA; required for meiotic double-stranded break formation
0.115 1.98E-11 YJR046W TAH11 het DNA replication licensing factor, required for pre-replication complex assembly
0.115 2.15E-11 YDR536W STL1 hom Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock
0.103 1.87E-9 YMR117C SPC24 het Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering
0.098 1.17E-8 YHR024C MAS2 het Larger subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins
0.098 1.52E-8 YFR031C SMC2 het Subunit of the condensin complex; essential SMC chromosomal ATPase family member that forms a complex with Smc4p to form the active ATPase; Smc2p/Smc4p complex binds DNA; required for clustering of tRNA genes at the nucleolus
0.096 2.42E-8 YHR035W_p YHR035W_p hom Putative protein of unknown function; not an essential gene
0.096 2.90E-8 YOR283W YOR283W hom Phosphatase with a broad substrate specificity and some similarity to GPM1/YKL152C, a phosphoglycerate mutase; YOR283W is not an essential gene
0.095 3.31E-8 YNL260C LTO1 het Essential protein that forms a complex with Rli1p and Yae1p; ortholog of human ORAOV1, which is overexpressed in solid tumors; inviability of null mutant under standard conditions is complemented by overexpression of ORAOV1; essential for growth under standard (aerobic) conditions but not under anaerobic conditions; may have a role in protection of ribosomal assembly and function from damage due to reactive oxygen species
0.093 7.63E-8 YFR003C YPI1 het Regulatory subunit of the type I protein phosphatase (PP1) Glc7p; Glc7p participates in the regulation of a variety of metabolic processes including mitosis and glycogen metabolism; in vitro evidence suggests Ypi1p is an inhibitor of Glc7p while in vivo evidence suggests it is an activator; overproduction causes decreased cellular content of glycogen; partial depletion causes lithium sensitivity, while overproduction confers lithium-tolerance
0.090 1.88E-7 YLR141W RRN5 het Protein involved in transcription of rDNA by RNA polymerase I; transcription factor, member of UAF (upstream activation factor) family along with Rrn9p and Rrn10p
0.087 4.01E-7 YMR094W CTF13 het Subunit of the CBF3 complex, which binds to the CDE III element of centromeres, bending the DNA upon binding, and may be involved in sister chromatid cohesion during mitosis
0.087 4.89E-7 YMR191W SPG5 hom Protein required for proteasome assembly during quiescence; binds to base of the proteasome regulartory particle; required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
0.083 1.47E-6 YLL005C SPO75 hom Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis