YGR106C / VOA1

Endoplasmic reticulum protein that functions, together with other assembly factors, in assembly of the V0 sector of the vacuolar ATPase (V-ATPase); null mutation enhances the V-ATPase deficiency of a vma21 mutant impaired in ER retrieval

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR106C / VOA1

Click on Significant Values for Screen Details ID:SGTC_17|Compound:0960-0276|FD-Score:5.08|P-value:2.35E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:10.00|P-value:3.07E-16 ID:SGTC_65|Compound:0798-0905|FD-Score:13.10|P-value:1.55E-26 ID:SGTC_121|Compound:0557-0495|FD-Score:4.95|P-value:3.66E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:12.10|P-value:9.03E-23 ID:SGTC_146|Compound:3448-8650|FD-Score:4.46|P-value:1.82E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:4.10|P-value:5.35E-4 ID:SGTC_187|Compound:1488-2104|FD-Score:5.53|P-value:4.59E-6 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:4.45|P-value:1.87E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:4.31|P-value:2.87E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:-3.78|P-value:8.60E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:5.76|P-value:1.91E-6 ID:SGTC_528|Compound:3492-0019|FD-Score:6.15|P-value:3.81E-7 ID:SGTC_582|Compound:0987-0078|FD-Score:4.14|P-value:4.73E-4 ID:SGTC_621|Compound:3584-0052|FD-Score:4.16|P-value:4.46E-4 ID:SGTC_647|Compound:0140-0236|FD-Score:5.73|P-value:2.10E-6 ID:SGTC_650|Compound:1328-0195|FD-Score:5.04|P-value:2.70E-5 ID:SGTC_690|Compound:glyoxal|FD-Score:4.63|P-value:1.07E-4 ID:SGTC_703|Compound:3875-0075|FD-Score:3.96|P-value:7.87E-4 ID:SGTC_899|Compound:1083-0020|FD-Score:4.08|P-value:5.55E-4 ID:SGTC_904|Compound:1141-0088|FD-Score:5.65|P-value:2.90E-6 ID:SGTC_1039|Compound:k821-0043|FD-Score:4.16|P-value:4.43E-4 ID:SGTC_1217|Compound:1183-1422|FD-Score:3.97|P-value:7.63E-4 ID:SGTC_1254|Compound:0550-0035|FD-Score:4.29|P-value:3.05E-4 ID:SGTC_1265|Compound:0819-1001|FD-Score:5.04|P-value:2.64E-5 ID:SGTC_1445|Compound:4239-0156|FD-Score:5.39|P-value:7.81E-6 ID:SGTC_1712|Compound:st032288|FD-Score:4.48|P-value:1.72E-4 ID:SGTC_1726|Compound:st035556|FD-Score:-7.04|P-value:3.55E-9 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:4.44|P-value:1.94E-4 ID:SGTC_1901|Compound:st060216|FD-Score:4.28|P-value:3.13E-4 ID:SGTC_1912|Compound:st060209|FD-Score:6.92|P-value:1.29E-8 ID:SGTC_1921|Compound:5740136|FD-Score:-3.77|P-value:8.75E-4 ID:SGTC_2028|Compound:5153890|FD-Score:5.22|P-value:1.44E-5 ID:SGTC_2141|Compound:5621638|FD-Score:5.77|P-value:1.81E-6 ID:SGTC_2146|Compound:5545642|FD-Score:4.16|P-value:4.51E-4 ID:SGTC_2339|Compound:9000433|FD-Score:5.24|P-value:1.33E-5 ID:SGTC_2441|Compound:5730946|FD-Score:5.29|P-value:1.11E-5 ID:SGTC_2471|Compound:5466956|FD-Score:4.78|P-value:6.41E-5 ID:SGTC_2789|Compound:5281112|FD-Score:4.21|P-value:3.83E-4 ID:SGTC_2795|Compound:7780010|FD-Score:5.38|P-value:7.93E-6 ID:SGTC_2808|Compound:7946468|FD-Score:5.30|P-value:1.08E-5 ID:SGTC_2814|Compound:7977482|FD-Score:3.91|P-value:9.14E-4 ID:SGTC_2849|Compound:9019321|FD-Score:5.08|P-value:2.30E-5 ID:SGTC_2865|Compound:9030313|FD-Score:3.98|P-value:7.35E-4 ID:SGTC_2912|Compound:7964298|FD-Score:7.06|P-value:6.67E-9 ID:SGTC_2916|Compound:7875993|FD-Score:4.05|P-value:6.05E-4 ID:SGTC_2930|Compound:9013230|FD-Score:-4.72|P-value:4.79E-5 ID:SGTC_2931|Compound:9014674|FD-Score:-4.34|P-value:1.63E-4 ID:SGTC_2990|Compound:9074105|FD-Score:4.21|P-value:3.84E-4 ID:SGTC_2996|Compound:9066192|FD-Score:3.96|P-value:7.80E-4 ID:SGTC_3020|Compound:9089140|FD-Score:4.16|P-value:4.47E-4 ID:SGTC_3130|Compound:9127414|FD-Score:6.55|P-value:6.90E-8 ID:SGTC_3229|Compound:9132204|FD-Score:4.16|P-value:4.41E-4 ID:SGTC_3266|Compound:9136860|FD-Score:4.41|P-value:2.09E-4 ID:SGTC_3311|Compound:9131146|FD-Score:11.40|P-value:1.94E-20 ID:SGTC_3321|Compound:9137793|FD-Score:7.05|P-value:7.09E-9 ID:SGTC_3349|Compound:9149703|FD-Score:4.06|P-value:5.96E-4 ID:SGTC_3350|Compound:9150499|FD-Score:4.01|P-value:6.79E-4 ID:SGTC_3356|Compound:9151811|FD-Score:4.62|P-value:1.10E-4 ID:SGTC_17|Compound:0960-0276|FD-Score:5.08|P-value:2.35E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:10.00|P-value:3.07E-16 ID:SGTC_65|Compound:0798-0905|FD-Score:13.10|P-value:1.55E-26 ID:SGTC_121|Compound:0557-0495|FD-Score:4.95|P-value:3.66E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:12.10|P-value:9.03E-23 ID:SGTC_146|Compound:3448-8650|FD-Score:4.46|P-value:1.82E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:4.10|P-value:5.35E-4 ID:SGTC_187|Compound:1488-2104|FD-Score:5.53|P-value:4.59E-6 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:4.45|P-value:1.87E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:4.31|P-value:2.87E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:-3.78|P-value:8.60E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:5.76|P-value:1.91E-6 ID:SGTC_528|Compound:3492-0019|FD-Score:6.15|P-value:3.81E-7 ID:SGTC_582|Compound:0987-0078|FD-Score:4.14|P-value:4.73E-4 ID:SGTC_621|Compound:3584-0052|FD-Score:4.16|P-value:4.46E-4 ID:SGTC_647|Compound:0140-0236|FD-Score:5.73|P-value:2.10E-6 ID:SGTC_650|Compound:1328-0195|FD-Score:5.04|P-value:2.70E-5 ID:SGTC_690|Compound:glyoxal|FD-Score:4.63|P-value:1.07E-4 ID:SGTC_703|Compound:3875-0075|FD-Score:3.96|P-value:7.87E-4 ID:SGTC_899|Compound:1083-0020|FD-Score:4.08|P-value:5.55E-4 ID:SGTC_904|Compound:1141-0088|FD-Score:5.65|P-value:2.90E-6 ID:SGTC_1039|Compound:k821-0043|FD-Score:4.16|P-value:4.43E-4 ID:SGTC_1217|Compound:1183-1422|FD-Score:3.97|P-value:7.63E-4 ID:SGTC_1254|Compound:0550-0035|FD-Score:4.29|P-value:3.05E-4 ID:SGTC_1265|Compound:0819-1001|FD-Score:5.04|P-value:2.64E-5 ID:SGTC_1445|Compound:4239-0156|FD-Score:5.39|P-value:7.81E-6 ID:SGTC_1712|Compound:st032288|FD-Score:4.48|P-value:1.72E-4 ID:SGTC_1726|Compound:st035556|FD-Score:-7.04|P-value:3.55E-9 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:4.44|P-value:1.94E-4 ID:SGTC_1901|Compound:st060216|FD-Score:4.28|P-value:3.13E-4 ID:SGTC_1912|Compound:st060209|FD-Score:6.92|P-value:1.29E-8 ID:SGTC_1921|Compound:5740136|FD-Score:-3.77|P-value:8.75E-4 ID:SGTC_2028|Compound:5153890|FD-Score:5.22|P-value:1.44E-5 ID:SGTC_2141|Compound:5621638|FD-Score:5.77|P-value:1.81E-6 ID:SGTC_2146|Compound:5545642|FD-Score:4.16|P-value:4.51E-4 ID:SGTC_2339|Compound:9000433|FD-Score:5.24|P-value:1.33E-5 ID:SGTC_2441|Compound:5730946|FD-Score:5.29|P-value:1.11E-5 ID:SGTC_2471|Compound:5466956|FD-Score:4.78|P-value:6.41E-5 ID:SGTC_2789|Compound:5281112|FD-Score:4.21|P-value:3.83E-4 ID:SGTC_2795|Compound:7780010|FD-Score:5.38|P-value:7.93E-6 ID:SGTC_2808|Compound:7946468|FD-Score:5.30|P-value:1.08E-5 ID:SGTC_2814|Compound:7977482|FD-Score:3.91|P-value:9.14E-4 ID:SGTC_2849|Compound:9019321|FD-Score:5.08|P-value:2.30E-5 ID:SGTC_2865|Compound:9030313|FD-Score:3.98|P-value:7.35E-4 ID:SGTC_2912|Compound:7964298|FD-Score:7.06|P-value:6.67E-9 ID:SGTC_2916|Compound:7875993|FD-Score:4.05|P-value:6.05E-4 ID:SGTC_2930|Compound:9013230|FD-Score:-4.72|P-value:4.79E-5 ID:SGTC_2931|Compound:9014674|FD-Score:-4.34|P-value:1.63E-4 ID:SGTC_2990|Compound:9074105|FD-Score:4.21|P-value:3.84E-4 ID:SGTC_2996|Compound:9066192|FD-Score:3.96|P-value:7.80E-4 ID:SGTC_3020|Compound:9089140|FD-Score:4.16|P-value:4.47E-4 ID:SGTC_3130|Compound:9127414|FD-Score:6.55|P-value:6.90E-8 ID:SGTC_3229|Compound:9132204|FD-Score:4.16|P-value:4.41E-4 ID:SGTC_3266|Compound:9136860|FD-Score:4.41|P-value:2.09E-4 ID:SGTC_3311|Compound:9131146|FD-Score:11.40|P-value:1.94E-20 ID:SGTC_3321|Compound:9137793|FD-Score:7.05|P-value:7.09E-9 ID:SGTC_3349|Compound:9149703|FD-Score:4.06|P-value:5.96E-4 ID:SGTC_3350|Compound:9150499|FD-Score:4.01|P-value:6.79E-4 ID:SGTC_3356|Compound:9151811|FD-Score:4.62|P-value:1.10E-4

Top fitness defect scores for YGR106C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_65 0798-0905 13.10 35.0 µM 1.55E-26 calcium & mitochondrial duress 5 1.60E-39
2 SGTC_138 0850-0259 12.10 40.9 µM 9.03E-23 cell wall 27 8.12E-34
3 SGTC_3311 9131146 11.40 2.9 µM 1.94E-20 cell wall 13 2.78E-30
4 SGTC_58 0957-0393 10.00 9.0 µM 3.07E-16 cell wall 76 6.43E-24
5 SGTC_2912 7964298 7.06 10.9 µM 6.67E-9 cell wall 34 8.34E-13
6 SGTC_3321 9137793 7.05 26.8 µM 7.09E-9 cell wall 22 9.14E-13
7 SGTC_1912 st060209 6.92 90.8 µM 1.29E-8 5 2.27E-12
8 SGTC_3130 9127414 6.55 49.5 µM 6.90E-8 3 2.85E-11
9 SGTC_528 3492-0019 6.15 172.0 µM 3.81E-7 calcium & mitochondrial duress 119 3.77E-10
10 SGTC_2141 5621638 5.77 7.7 µM 1.81E-6 tubulin folding & SWR complex 13 3.99E-9
11 SGTC_514 4466-0038 5.76 2.6 nM 1.91E-6 cell wall 82 4.31E-9
12 SGTC_647 0140-0236 5.73 81.0 µM 2.10E-6 2 4.98E-9
13 SGTC_904 1141-0088 5.65 396.0 µM 2.90E-6 4 8.10E-9
14 SGTC_187 1488-2104 5.53 32.7 µM 4.59E-6 calcium & mitochondrial duress 20 1.62E-8
15 SGTC_1445 4239-0156 5.39 97.7 µM 7.81E-6 3 3.61E-8
16 SGTC_2795 7780010 5.38 54.5 µM 7.93E-6 5 3.70E-8
17 SGTC_2808 7946468 5.30 45.5 µM 1.08E-5 13 5.85E-8
18 SGTC_2441 5730946 5.29 39.1 µM 1.11E-5 6 6.14E-8
19 SGTC_2339 9000433 5.24 200.0 µM 1.33E-5 9 8.08E-8
20 SGTC_2028 5153890 5.22 36.4 µM 1.44E-5 cell wall signaling 15 9.13E-8

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.339 4.68E-91 YJL099W CHS6 hom Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication
0.310 1.24E-75 YDL203C ACK1 hom Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria
0.307 3.76E-74 YBL006C LDB7 hom Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions
0.301 3.07E-71 YDL066W IDP1 hom Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes
0.296 7.47E-69 YJR142W_p YJR142W_p hom Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member
0.282 2.99E-62 YPL115C BEM3 hom Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly
0.282 4.14E-62 YLR331C_d JIP3_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
0.281 1.24E-61 YCL005W LDB16 hom Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria
0.278 1.43E-60 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.276 7.82E-60 YKL076C_d PSY1_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C
0.271 2.20E-57 YBR023C CHS3 hom Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan
0.270 5.21E-57 YDR335W MSN5 hom Karyopherin involved in nuclear import and export of proteins, including import of replication protein A and export of Swi6p, Far1p, and Pho4p; required for re-export of mature tRNAs after their retrograde import from the cytoplasm
0.260 7.67E-53 YLL032C YLL032C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene
0.259 1.52E-52 YJR111C_p YJR111C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondria
0.258 6.27E-52 YMR124W_p YMR124W_p hom Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization