YGR107W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR107W / YGR107W

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:-3.09|P-value:7.89E-4 ID:SGTC_112|Compound:phenothiazine|FD-Score:3.58|P-value:1.57E-4 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:-3.18|P-value:5.81E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:-3.56|P-value:1.42E-4 ID:SGTC_230|Compound:MPP+|FD-Score:3.22|P-value:5.99E-4 ID:SGTC_264|Compound:promethazine|FD-Score:4.79|P-value:6.89E-7 ID:SGTC_381|Compound:3461-2219|FD-Score:3.18|P-value:7.01E-4 ID:SGTC_444|Compound:curcumin|FD-Score:5.73|P-value:3.62E-9 ID:SGTC_456|Compound:gingerol|FD-Score:5.27|P-value:5.27E-8 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.85|P-value:5.25E-5 ID:SGTC_673|Compound:1082-0474|FD-Score:-3.42|P-value:2.41E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:-4.41|P-value:3.48E-6 ID:SGTC_729|Compound:4092-0585|FD-Score:4.28|P-value:8.22E-6 ID:SGTC_814|Compound:3342-0569|FD-Score:4.06|P-value:2.18E-5 ID:SGTC_867|Compound:0518-0118|FD-Score:3.52|P-value:2.00E-4 ID:SGTC_907|Compound:3448-6986|FD-Score:4.83|P-value:5.65E-7 ID:SGTC_919|Compound:tnp00227|FD-Score:-4.57|P-value:1.59E-6 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:-4.22|P-value:8.56E-6 ID:SGTC_922|Compound:1866-0035|FD-Score:3.74|P-value:8.20E-5 ID:SGTC_950|Compound:1165-0508|FD-Score:-3.76|P-value:6.31E-5 ID:SGTC_1174|Compound:0739-0097|FD-Score:3.18|P-value:7.03E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:-3.37|P-value:2.88E-4 ID:SGTC_1408|Compound:3909-7976|FD-Score:-3.30|P-value:3.72E-4 ID:SGTC_1417|Compound:3966-0327|FD-Score:-4.26|P-value:6.92E-6 ID:SGTC_1427|Compound:4048-4900|FD-Score:3.92|P-value:3.91E-5 ID:SGTC_1461|Compound:k072-0203|FD-Score:3.13|P-value:8.25E-4 ID:SGTC_1519|Compound:esterone|FD-Score:3.46|P-value:2.49E-4 ID:SGTC_1666|Compound:st014829|FD-Score:-3.07|P-value:8.44E-4 ID:SGTC_1729|Compound:st035615|FD-Score:3.83|P-value:5.83E-5 ID:SGTC_1852|Compound:st056254|FD-Score:3.69|P-value:1.02E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:3.58|P-value:1.57E-4 ID:SGTC_1938|Compound:st074717|FD-Score:-3.99|P-value:2.34E-5 ID:SGTC_1943|Compound:st076331|FD-Score:3.21|P-value:6.19E-4 ID:SGTC_1954|Compound:st077032|FD-Score:-3.42|P-value:2.44E-4 ID:SGTC_2002|Compound:4023503|FD-Score:3.53|P-value:1.88E-4 ID:SGTC_2005|Compound:4024620|FD-Score:-3.05|P-value:9.07E-4 ID:SGTC_2009|Compound:4012297|FD-Score:4.14|P-value:1.55E-5 ID:SGTC_2012|Compound:4023501|FD-Score:-4.27|P-value:6.68E-6 ID:SGTC_2025|Compound:5147754|FD-Score:-4.93|P-value:2.60E-7 ID:SGTC_2057|Compound:5236571|FD-Score:3.20|P-value:6.40E-4 ID:SGTC_2127|Compound:5253358|FD-Score:-5.14|P-value:8.20E-8 ID:SGTC_2133|Compound:5320837|FD-Score:-5.45|P-value:1.46E-8 ID:SGTC_2135|Compound:5326629|FD-Score:-4.98|P-value:1.93E-7 ID:SGTC_2241|Compound:6772625|FD-Score:-3.07|P-value:8.52E-4 ID:SGTC_2242|Compound:6630449|FD-Score:3.12|P-value:8.59E-4 ID:SGTC_2243|Compound:6634756|FD-Score:4.88|P-value:4.29E-7 ID:SGTC_2328|Compound:6201408|FD-Score:-3.63|P-value:1.06E-4 ID:SGTC_2398|Compound:5228213|FD-Score:3.79|P-value:6.92E-5 ID:SGTC_2400|Compound:5203494|FD-Score:-3.64|P-value:1.01E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:-4.44|P-value:3.01E-6 ID:SGTC_2851|Compound:9015922|FD-Score:3.55|P-value:1.79E-4 ID:SGTC_2967|Compound:9089538|FD-Score:4.36|P-value:5.72E-6 ID:SGTC_3272|Compound:9137413|FD-Score:-3.56|P-value:1.38E-4 ID:SGTC_3281|Compound:9140613|FD-Score:4.05|P-value:2.25E-5 ID:SGTC_3293|Compound:9120939|FD-Score:-3.09|P-value:8.01E-4 ID:SGTC_3310|Compound:9130229|FD-Score:3.18|P-value:7.07E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.09|P-value:7.89E-4 ID:SGTC_112|Compound:phenothiazine|FD-Score:3.58|P-value:1.57E-4 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:-3.18|P-value:5.81E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:-3.56|P-value:1.42E-4 ID:SGTC_230|Compound:MPP+|FD-Score:3.22|P-value:5.99E-4 ID:SGTC_264|Compound:promethazine|FD-Score:4.79|P-value:6.89E-7 ID:SGTC_381|Compound:3461-2219|FD-Score:3.18|P-value:7.01E-4 ID:SGTC_444|Compound:curcumin|FD-Score:5.73|P-value:3.62E-9 ID:SGTC_456|Compound:gingerol|FD-Score:5.27|P-value:5.27E-8 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.85|P-value:5.25E-5 ID:SGTC_673|Compound:1082-0474|FD-Score:-3.42|P-value:2.41E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:-4.41|P-value:3.48E-6 ID:SGTC_729|Compound:4092-0585|FD-Score:4.28|P-value:8.22E-6 ID:SGTC_814|Compound:3342-0569|FD-Score:4.06|P-value:2.18E-5 ID:SGTC_867|Compound:0518-0118|FD-Score:3.52|P-value:2.00E-4 ID:SGTC_907|Compound:3448-6986|FD-Score:4.83|P-value:5.65E-7 ID:SGTC_919|Compound:tnp00227|FD-Score:-4.57|P-value:1.59E-6 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:-4.22|P-value:8.56E-6 ID:SGTC_922|Compound:1866-0035|FD-Score:3.74|P-value:8.20E-5 ID:SGTC_950|Compound:1165-0508|FD-Score:-3.76|P-value:6.31E-5 ID:SGTC_1174|Compound:0739-0097|FD-Score:3.18|P-value:7.03E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:-3.37|P-value:2.88E-4 ID:SGTC_1408|Compound:3909-7976|FD-Score:-3.30|P-value:3.72E-4 ID:SGTC_1417|Compound:3966-0327|FD-Score:-4.26|P-value:6.92E-6 ID:SGTC_1427|Compound:4048-4900|FD-Score:3.92|P-value:3.91E-5 ID:SGTC_1461|Compound:k072-0203|FD-Score:3.13|P-value:8.25E-4 ID:SGTC_1519|Compound:esterone|FD-Score:3.46|P-value:2.49E-4 ID:SGTC_1666|Compound:st014829|FD-Score:-3.07|P-value:8.44E-4 ID:SGTC_1729|Compound:st035615|FD-Score:3.83|P-value:5.83E-5 ID:SGTC_1852|Compound:st056254|FD-Score:3.69|P-value:1.02E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:3.58|P-value:1.57E-4 ID:SGTC_1938|Compound:st074717|FD-Score:-3.99|P-value:2.34E-5 ID:SGTC_1943|Compound:st076331|FD-Score:3.21|P-value:6.19E-4 ID:SGTC_1954|Compound:st077032|FD-Score:-3.42|P-value:2.44E-4 ID:SGTC_2002|Compound:4023503|FD-Score:3.53|P-value:1.88E-4 ID:SGTC_2005|Compound:4024620|FD-Score:-3.05|P-value:9.07E-4 ID:SGTC_2009|Compound:4012297|FD-Score:4.14|P-value:1.55E-5 ID:SGTC_2012|Compound:4023501|FD-Score:-4.27|P-value:6.68E-6 ID:SGTC_2025|Compound:5147754|FD-Score:-4.93|P-value:2.60E-7 ID:SGTC_2057|Compound:5236571|FD-Score:3.20|P-value:6.40E-4 ID:SGTC_2127|Compound:5253358|FD-Score:-5.14|P-value:8.20E-8 ID:SGTC_2133|Compound:5320837|FD-Score:-5.45|P-value:1.46E-8 ID:SGTC_2135|Compound:5326629|FD-Score:-4.98|P-value:1.93E-7 ID:SGTC_2241|Compound:6772625|FD-Score:-3.07|P-value:8.52E-4 ID:SGTC_2242|Compound:6630449|FD-Score:3.12|P-value:8.59E-4 ID:SGTC_2243|Compound:6634756|FD-Score:4.88|P-value:4.29E-7 ID:SGTC_2328|Compound:6201408|FD-Score:-3.63|P-value:1.06E-4 ID:SGTC_2398|Compound:5228213|FD-Score:3.79|P-value:6.92E-5 ID:SGTC_2400|Compound:5203494|FD-Score:-3.64|P-value:1.01E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:-4.44|P-value:3.01E-6 ID:SGTC_2851|Compound:9015922|FD-Score:3.55|P-value:1.79E-4 ID:SGTC_2967|Compound:9089538|FD-Score:4.36|P-value:5.72E-6 ID:SGTC_3272|Compound:9137413|FD-Score:-3.56|P-value:1.38E-4 ID:SGTC_3281|Compound:9140613|FD-Score:4.05|P-value:2.25E-5 ID:SGTC_3293|Compound:9120939|FD-Score:-3.09|P-value:8.01E-4 ID:SGTC_3310|Compound:9130229|FD-Score:3.18|P-value:7.07E-4

Top fitness defect scores for YGR107W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_444 curcumin 5.73 90.4 µM 3.62E-9 iron homeostasis 8 4.89E-9
2 SGTC_456 gingerol 5.27 170.0 µM 5.27E-8 5 6.73E-8
3 SGTC_2243 6634756 4.88 200.0 µM 4.29E-7 6 5.23E-7
4 SGTC_907 3448-6986 4.83 75.5 µM 5.65E-7 9 6.87E-7
5 SGTC_264 promethazine 4.79 12.5 mM 6.89E-7 DNA intercalators 35 8.34E-7
6 SGTC_2967 9089538 4.36 49.9 µM 5.72E-6 23 6.63E-6
7 SGTC_729 4092-0585 4.28 94.1 µM 8.22E-6 20 9.46E-6
8 SGTC_2009 4012297 4.14 12.1 µM 1.55E-5 cell wall signaling 55 1.76E-5
9 SGTC_814 3342-0569 4.06 96.0 µM 2.18E-5 17 2.46E-5
10 SGTC_3281 9140613 4.05 49.5 µM 2.25E-5 RPP1 & pyrimidine depletion 18 2.54E-5
11 SGTC_1427 4048-4900 3.92 550.0 nM 3.91E-5 28 4.37E-5
12 SGTC_457 grayanotoxin iii 3.85 135.0 µM 5.25E-5 73 5.83E-5
13 SGTC_1729 st035615 3.83 46.0 µM 5.83E-5 40 6.45E-5
14 SGTC_2398 5228213 3.79 48.8 µM 6.92E-5 iron homeostasis 43 7.64E-5
15 SGTC_922 1866-0035 3.74 480.0 µM 8.20E-5 excess fatty acid 70 9.03E-5
16 SGTC_1852 st056254 3.69 31.4 µM 1.02E-4 15 1.12E-4
17 SGTC_1873 rapamycin 3.58 2.0 nM 1.57E-4 84 1.70E-4
18 SGTC_112 phenothiazine 3.58 287.2 µM 1.57E-4 unfolded protein response 19 1.71E-4
19 SGTC_2851 9015922 3.55 71.4 µM 1.79E-4 58 1.94E-4
20 SGTC_2002 4023503 3.53 131.0 µM 1.88E-4 mitochondrial processes 53 2.04E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.131 2.75E-14 YHL039W EFM1 hom Lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.128 8.79E-14 YOR133W EFT1 hom Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT1 has a paralog, EFT2, that arose from the whole genome duplication
0.126 2.19E-13 YMR289W ABZ2 hom Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase), catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis
0.117 1.30E-11 YGR065C VHT1 het High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin
0.109 2.08E-10 YPL157W TGS1 hom Trimethyl guanosine synthase, conserved nucleolar methyl transferase that converts the m(7)G cap structure of snRNAs, snoRNAs, and telomerase TLC1 RNA to m(2,2,7)G; also required for nucleolar assembly and splicing of meiotic pre-mRNAs
0.109 2.61E-10 YKL140W TGL1 hom Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes
0.105 9.18E-10 YMR166C_p YMR166C_p hom Predicted transporter of the mitochondrial inner membrane; has similarity to human mitochondrial ATP-Mg/Pi carriers; YMR166C is not an essential gene
0.103 1.91E-9 YDR409W SIZ1 hom SUMO/Smt3 ligase that promotes the attachment of sumo (Smt3p; small ubiquitin-related modifier) to proteins; binds Ubc9p and may bind septins; specifically required for sumoylation of septins in vivo; localized to the septin ring
0.103 1.94E-9 YDR391C_p YDR391C_p hom Putative protein of unknown function, possibly involved in zinc homeostasis; Bdf1p-dependent transcription induced by salt stress; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
0.103 2.11E-9 YJL025W RRN7 het Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p
0.099 8.56E-9 YJR075W HOC1 hom Alpha-1,6-mannosyltransferase involved in cell wall mannan biosynthesis; subunit of a Golgi-localized complex that also contains Anp1p, Mnn9p, Mnn11p, and Mnn10p; identified as a suppressor of a cell lysis sensitive pkc1-371 allele
0.099 9.68E-9 YDL223C HBT1 hom Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis
0.098 1.54E-8 YOR053W_d YOR053W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VHS3/YOR054C
0.094 4.96E-8 YGL041C_d YGL041C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.089 2.75E-7 YBR170C NPL4 hom Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; assists Cdc48p in the dislocation of misfolded, polyubiquitinated ERAD substrates that are subsequently delivered to the proteasome for degradation; also involved in the regulated destruction of resident ER membrane proteins, such as HMG-CoA reductase (Hmg1/2p) and cytoplasmic proteins (Fbp1p); role in mobilizing membrane bound transcription factors by regulated ubiquitin/proteasome-dependent processing (RUP)