HIPHOP chemogenomics database

YGR107W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain

fixedexpanded
Profile for YGR107W / YGR107W

Click on Significant Values for Screen Details

Top fitness defect scores for YGR107W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_444	curcumin	5.73	90.4 µM	3.62E-9	iron homeostasis	8	4.89E-9
2	SGTC_456	gingerol	5.27	170.0 µM	5.27E-8		5	6.73E-8
3	SGTC_2243	6634756	4.88	200.0 µM	4.29E-7		6	5.23E-7
4	SGTC_907	3448-6986	4.83	75.5 µM	5.65E-7		9	6.87E-7
5	SGTC_264	promethazine	4.79	12.5 mM	6.89E-7	DNA intercalators	35	8.34E-7
6	SGTC_2967	9089538	4.36	49.9 µM	5.72E-6		23	6.63E-6
7	SGTC_729	4092-0585	4.28	94.1 µM	8.22E-6		20	9.46E-6
8	SGTC_2009	4012297	4.14	12.1 µM	1.55E-5	cell wall signaling	55	1.76E-5
9	SGTC_814	3342-0569	4.06	96.0 µM	2.18E-5		17	2.46E-5
10	SGTC_3281	9140613	4.05	49.5 µM	2.25E-5	RPP1 & pyrimidine depletion	18	2.54E-5
11	SGTC_1427	4048-4900	3.92	550.0 nM	3.91E-5		28	4.37E-5
12	SGTC_457	grayanotoxin iii	3.85	135.0 µM	5.25E-5		73	5.83E-5
13	SGTC_1729	st035615	3.83	46.0 µM	5.83E-5		40	6.45E-5
14	SGTC_2398	5228213	3.79	48.8 µM	6.92E-5	iron homeostasis	43	7.64E-5
15	SGTC_922	1866-0035	3.74	480.0 µM	8.20E-5	excess fatty acid	70	9.03E-5
16	SGTC_1852	st056254	3.69	31.4 µM	1.02E-4		15	1.12E-4
17	SGTC_1873	rapamycin	3.58	2.0 nM	1.57E-4		84	1.70E-4
18	SGTC_112	phenothiazine	3.58	287.2 µM	1.57E-4	unfolded protein response	19	1.71E-4
19	SGTC_2851	9015922	3.55	71.4 µM	1.79E-4		58	1.94E-4
20	SGTC_2002	4023503	3.53	131.0 µM	1.88E-4	mitochondrial processes	53	2.04E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.131	2.75E-14	YHL039W	EFM1	hom	Lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.128	8.79E-14	YOR133W	EFT1	hom	Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT1 has a paralog, EFT2, that arose from the whole genome duplication
0.126	2.19E-13	YMR289W	ABZ2	hom	Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase), catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis
0.117	1.30E-11	YGR065C	VHT1	het	High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin
0.109	2.08E-10	YPL157W	TGS1	hom	Trimethyl guanosine synthase, conserved nucleolar methyl transferase that converts the m(7)G cap structure of snRNAs, snoRNAs, and telomerase TLC1 RNA to m(2,2,7)G; also required for nucleolar assembly and splicing of meiotic pre-mRNAs
0.109	2.61E-10	YKL140W	TGL1	hom	Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes
0.105	9.18E-10	YMR166C_p	YMR166C_p	hom	Predicted transporter of the mitochondrial inner membrane; has similarity to human mitochondrial ATP-Mg/Pi carriers; YMR166C is not an essential gene
0.103	1.91E-9	YDR409W	SIZ1	hom	SUMO/Smt3 ligase that promotes the attachment of sumo (Smt3p; small ubiquitin-related modifier) to proteins; binds Ubc9p and may bind septins; specifically required for sumoylation of septins in vivo; localized to the septin ring
0.103	1.94E-9	YDR391C_p	YDR391C_p	hom	Putative protein of unknown function, possibly involved in zinc homeostasis; Bdf1p-dependent transcription induced by salt stress; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
0.103	2.11E-9	YJL025W	RRN7	het	Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p
0.099	8.56E-9	YJR075W	HOC1	hom	Alpha-1,6-mannosyltransferase involved in cell wall mannan biosynthesis; subunit of a Golgi-localized complex that also contains Anp1p, Mnn9p, Mnn11p, and Mnn10p; identified as a suppressor of a cell lysis sensitive pkc1-371 allele
0.099	9.68E-9	YDL223C	HBT1	hom	Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis
0.098	1.54E-8	YOR053W_d	YOR053W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VHS3/YOR054C
0.094	4.96E-8	YGL041C_d	YGL041C_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.089	2.75E-7	YBR170C	NPL4	hom	Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; assists Cdc48p in the dislocation of misfolded, polyubiquitinated ERAD substrates that are subsequently delivered to the proteasome for degradation; also involved in the regulated destruction of resident ER membrane proteins, such as HMG-CoA reductase (Hmg1/2p) and cytoplasmic proteins (Fbp1p); role in mobilizing membrane bound transcription factors by regulated ubiquitin/proteasome-dependent processing (RUP)