YGR108W / CLB1

B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR108W / CLB1

Click on Significant Values for Screen Details ID:SGTC_178|Compound:4092-0806|FD-Score:-4.00|P-value:2.62E-5 ID:SGTC_212|Compound:3807-4682|FD-Score:3.14|P-value:5.59E-4 ID:SGTC_214|Compound:4373-3496|FD-Score:3.87|P-value:3.08E-5 ID:SGTC_373|Compound:0844-0104|FD-Score:3.47|P-value:1.65E-4 ID:SGTC_588|Compound:3970-1144|FD-Score:3.24|P-value:3.98E-4 ID:SGTC_636|Compound:0kpi-0074|FD-Score:3.17|P-value:5.00E-4 ID:SGTC_703|Compound:3875-0075|FD-Score:3.85|P-value:3.37E-5 ID:SGTC_910|Compound:3454-3003|FD-Score:-3.09|P-value:9.32E-4 ID:SGTC_929|Compound:2805-0021|FD-Score:3.74|P-value:5.55E-5 ID:SGTC_1108|Compound:betulinic acid|FD-Score:3.01|P-value:9.09E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:5.15|P-value:5.36E-8 ID:SGTC_1213|Compound:1315-0166|FD-Score:3.24|P-value:3.97E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:-3.26|P-value:4.98E-4 ID:SGTC_1446|Compound:4239-0190|FD-Score:6.51|P-value:1.05E-11 ID:SGTC_1457|Compound:k015-0032|FD-Score:5.74|P-value:1.65E-9 ID:SGTC_1465|Compound:k213-0056|FD-Score:-4.68|P-value:1.07E-6 ID:SGTC_1483|Compound:3453-0561|FD-Score:3.82|P-value:3.90E-5 ID:SGTC_1506|Compound:4226-2149|FD-Score:3.96|P-value:2.14E-5 ID:SGTC_1874|Compound:staurosporine|FD-Score:3.65|P-value:7.77E-5 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:3.88|P-value:3.04E-5 ID:SGTC_1935|Compound:st074532|FD-Score:-3.33|P-value:3.86E-4 ID:SGTC_1956|Compound:st077085|FD-Score:4.41|P-value:2.61E-6 ID:SGTC_1962|Compound:st076595|FD-Score:3.70|P-value:6.39E-5 ID:SGTC_1969|Compound:st069479|FD-Score:3.24|P-value:3.89E-4 ID:SGTC_2056|Compound:5235370|FD-Score:6.11|P-value:1.58E-10 ID:SGTC_2087|Compound:5276107|FD-Score:3.96|P-value:2.11E-5 ID:SGTC_2109|Compound:5483026|FD-Score:4.60|P-value:1.03E-6 ID:SGTC_2183|Compound:6420625|FD-Score:-3.11|P-value:8.52E-4 ID:SGTC_2202|Compound:7226349|FD-Score:-3.23|P-value:5.60E-4 ID:SGTC_2265|Compound:7929201|FD-Score:-3.09|P-value:9.25E-4 ID:SGTC_2266|Compound:7929956|FD-Score:-3.11|P-value:8.54E-4 ID:SGTC_2270|Compound:7924575|FD-Score:-3.27|P-value:4.85E-4 ID:SGTC_2327|Compound:6189656|FD-Score:3.17|P-value:5.11E-4 ID:SGTC_2521|Compound:angolensin|FD-Score:3.25|P-value:3.85E-4 ID:SGTC_2608|Compound:thymoquinone|FD-Score:-3.45|P-value:2.44E-4 ID:SGTC_2713|Compound:st079149|FD-Score:4.65|P-value:7.73E-7 ID:SGTC_3281|Compound:9140613|FD-Score:3.92|P-value:2.56E-5 ID:SGTC_3285|Compound:9112818|FD-Score:3.63|P-value:8.71E-5 ID:SGTC_3289|Compound:9119912|FD-Score:3.84|P-value:3.54E-5 ID:SGTC_3290|Compound:9121031|FD-Score:3.48|P-value:1.59E-4 ID:SGTC_3293|Compound:9120939|FD-Score:5.14|P-value:5.78E-8 ID:SGTC_178|Compound:4092-0806|FD-Score:-4.00|P-value:2.62E-5 ID:SGTC_212|Compound:3807-4682|FD-Score:3.14|P-value:5.59E-4 ID:SGTC_214|Compound:4373-3496|FD-Score:3.87|P-value:3.08E-5 ID:SGTC_373|Compound:0844-0104|FD-Score:3.47|P-value:1.65E-4 ID:SGTC_588|Compound:3970-1144|FD-Score:3.24|P-value:3.98E-4 ID:SGTC_636|Compound:0kpi-0074|FD-Score:3.17|P-value:5.00E-4 ID:SGTC_703|Compound:3875-0075|FD-Score:3.85|P-value:3.37E-5 ID:SGTC_910|Compound:3454-3003|FD-Score:-3.09|P-value:9.32E-4 ID:SGTC_929|Compound:2805-0021|FD-Score:3.74|P-value:5.55E-5 ID:SGTC_1108|Compound:betulinic acid|FD-Score:3.01|P-value:9.09E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:5.15|P-value:5.36E-8 ID:SGTC_1213|Compound:1315-0166|FD-Score:3.24|P-value:3.97E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:-3.26|P-value:4.98E-4 ID:SGTC_1446|Compound:4239-0190|FD-Score:6.51|P-value:1.05E-11 ID:SGTC_1457|Compound:k015-0032|FD-Score:5.74|P-value:1.65E-9 ID:SGTC_1465|Compound:k213-0056|FD-Score:-4.68|P-value:1.07E-6 ID:SGTC_1483|Compound:3453-0561|FD-Score:3.82|P-value:3.90E-5 ID:SGTC_1506|Compound:4226-2149|FD-Score:3.96|P-value:2.14E-5 ID:SGTC_1874|Compound:staurosporine|FD-Score:3.65|P-value:7.77E-5 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:3.88|P-value:3.04E-5 ID:SGTC_1935|Compound:st074532|FD-Score:-3.33|P-value:3.86E-4 ID:SGTC_1956|Compound:st077085|FD-Score:4.41|P-value:2.61E-6 ID:SGTC_1962|Compound:st076595|FD-Score:3.70|P-value:6.39E-5 ID:SGTC_1969|Compound:st069479|FD-Score:3.24|P-value:3.89E-4 ID:SGTC_2056|Compound:5235370|FD-Score:6.11|P-value:1.58E-10 ID:SGTC_2087|Compound:5276107|FD-Score:3.96|P-value:2.11E-5 ID:SGTC_2109|Compound:5483026|FD-Score:4.60|P-value:1.03E-6 ID:SGTC_2183|Compound:6420625|FD-Score:-3.11|P-value:8.52E-4 ID:SGTC_2202|Compound:7226349|FD-Score:-3.23|P-value:5.60E-4 ID:SGTC_2265|Compound:7929201|FD-Score:-3.09|P-value:9.25E-4 ID:SGTC_2266|Compound:7929956|FD-Score:-3.11|P-value:8.54E-4 ID:SGTC_2270|Compound:7924575|FD-Score:-3.27|P-value:4.85E-4 ID:SGTC_2327|Compound:6189656|FD-Score:3.17|P-value:5.11E-4 ID:SGTC_2521|Compound:angolensin|FD-Score:3.25|P-value:3.85E-4 ID:SGTC_2608|Compound:thymoquinone|FD-Score:-3.45|P-value:2.44E-4 ID:SGTC_2713|Compound:st079149|FD-Score:4.65|P-value:7.73E-7 ID:SGTC_3281|Compound:9140613|FD-Score:3.92|P-value:2.56E-5 ID:SGTC_3285|Compound:9112818|FD-Score:3.63|P-value:8.71E-5 ID:SGTC_3289|Compound:9119912|FD-Score:3.84|P-value:3.54E-5 ID:SGTC_3290|Compound:9121031|FD-Score:3.48|P-value:1.59E-4 ID:SGTC_3293|Compound:9120939|FD-Score:5.14|P-value:5.78E-8

Top fitness defect scores for YGR108W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1446 4239-0190 6.51 62.0 µM 1.05E-11 6 3.84E-11
2 SGTC_2056 5235370 6.11 200.0 µM 1.58E-10 12 5.06E-10
3 SGTC_1457 k015-0032 5.74 57.3 µM 1.65E-9 9 4.71E-9
4 SGTC_1130 3454-2858 5.15 15.9 µM 5.36E-8 NEO1 55 1.29E-7
5 SGTC_3293 9120939 5.14 62.0 µM 5.78E-8 4 1.38E-7
6 SGTC_2713 st079149 4.65 53.4 µM 7.73E-7 11 1.62E-6
7 SGTC_2109 5483026 4.60 200.0 µM 1.03E-6 RSC complex & mRNA processing 14 2.12E-6
8 SGTC_1956 st077085 4.41 54.0 µM 2.61E-6 11 5.15E-6
9 SGTC_2087 5276107 3.96 200.0 µM 2.11E-5 16 3.74E-5
10 SGTC_1506 4226-2149 3.96 212.0 µM 2.14E-5 31 3.79E-5
11 SGTC_3281 9140613 3.92 49.5 µM 2.56E-5 RPP1 & pyrimidine depletion 20 4.49E-5
12 SGTC_1928 4'-methoxychalcone 3.88 40.3 µM 3.04E-5 14 5.29E-5
13 SGTC_214 4373-3496 3.87 70.0 µM 3.08E-5 58 5.35E-5
14 SGTC_703 3875-0075 3.85 71.8 µM 3.37E-5 10 5.83E-5
15 SGTC_3289 9119912 3.84 71.4 µM 3.54E-5 20 6.11E-5
16 SGTC_1483 3453-0561 3.82 55.9 µM 3.90E-5 23 6.70E-5
17 SGTC_929 2805-0021 3.74 398.0 µM 5.55E-5 16 9.37E-5
18 SGTC_1962 st076595 3.70 64.5 µM 6.39E-5 redox potentiating 32 1.07E-4
19 SGTC_1874 staurosporine 3.65 7.6 µM 7.77E-5 cell wall signaling 35 1.29E-4
20 SGTC_3285 9112818 3.63 20.9 µM 8.71E-5 cell wall 40 1.44E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.123 1.05E-12 YDR259C YAP6 hom Basic leucine zipper (bZIP) transcription factor; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; overexpression increases sodium and lithium tolerance; computational analysis suggests a role in regulation of expression of genes involved in carbohydrate metabolism; YAP6 has a paralog, CIN5, that arose from the whole genome duplication
0.122 1.41E-12 YDR087C RRP1 het Essential evolutionarily conserved nucleolar protein necessary for biogenesis of 60S ribosomal subunits and processing of pre-rRNAs to mature rRNAs, associated with several distinct 66S pre-ribosomal particles
0.099 9.53E-9 YPR096C YPR096C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments
0.098 1.38E-8 YKL189W HYM1 het Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with Kic1p and Sog2p, localizes to sites of polarized growth during budding and during the mating response
0.093 6.04E-8 YGR094W VAS1 het Mitochondrial and cytoplasmic valyl-tRNA synthetase
0.092 1.10E-7 YDR440W DOT1 hom Nucleosomal histone H3-Lys79 methylase; methylation is required for telomeric silencing, meiotic checkpoint control, and DNA damage response
0.091 1.14E-7 YOR019W YOR019W hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments
0.085 8.80E-7 YGR085C RPL11B hom Ribosomal 60S subunit protein L11B; expressed at half the level of Rpl11Ap; involved in ribosomal assembly; depletion causes degradation of 60S proteins and RNA; homologous to mammalian ribosomal protein L11 and bacterial L5; RPL11B has a paralog, RPL11A, that arose from the whole genome duplication
0.084 1.20E-6 YLL023C POM33 hom Transmembrane nucleoporin; involved in nuclear pore complex (NPC) distribution, assembly or stabilization; highly conserved across species, orthologous to human TMEM33 and paralogous to Per33p; protein abundance increases in response to DNA replication stress
0.083 1.32E-6 YNL120C_d YNL120C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; deletion enhances replication of Brome mosaic virus in S. cerevisiae, but likely due to effects on the overlapping gene
0.083 1.44E-6 YDR249C_p YDR249C_p hom Putative protein of unknown function
0.081 2.60E-6 YJL075C_d APQ13_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the verified gene NET1; null mutant is sensitive to sorbate
0.080 3.92E-6 YJR048W CYC1 hom Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration; CYC1 has a paralog, CYC7, that arose from the whole genome duplication
0.078 5.37E-6 YGL112C TAF6 het Subunit (60 kDa) of TFIID and SAGA complexes, involved in transcription initiation of RNA polymerase II and in chromatin modification, similar to histone H4
0.077 7.52E-6 YBL034C STU1 het Component of the mitotic spindle that binds to interpolar microtubules via its association with beta-tubulin (Tub2p); required for interpolar microtubules to provide an outward force on the spindle poles