YGR109C / CLB6

B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR109C / CLB6

Click on Significant Values for Screen Details ID:SGTC_50|Compound:0929-0078|FD-Score:3.79|P-value:3.84E-5 ID:SGTC_68|Compound:0986-0284|FD-Score:-3.06|P-value:6.99E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:4.24|P-value:4.68E-6 ID:SGTC_155|Compound:k072-0202|FD-Score:3.75|P-value:4.61E-5 ID:SGTC_359|Compound:0081-0058|FD-Score:3.93|P-value:2.00E-5 ID:SGTC_441|Compound:propafenone|FD-Score:-3.24|P-value:3.54E-4 ID:SGTC_531|Compound:3788-1495|FD-Score:2.98|P-value:9.20E-4 ID:SGTC_612|Compound:0302-0167|FD-Score:3.76|P-value:4.35E-5 ID:SGTC_704|Compound:1310-0270|FD-Score:4.57|P-value:8.96E-7 ID:SGTC_931|Compound:2812-0076|FD-Score:-3.20|P-value:4.13E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:3.05|P-value:7.14E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:3.71|P-value:5.41E-5 ID:SGTC_1142|Compound:3253-1408|FD-Score:4.04|P-value:1.26E-5 ID:SGTC_1280|Compound:0880-0253|FD-Score:3.20|P-value:4.16E-4 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:3.34|P-value:2.43E-4 ID:SGTC_1456|Compound:k015-0012|FD-Score:3.06|P-value:6.92E-4 ID:SGTC_1617|Compound:st002906|FD-Score:-3.54|P-value:1.08E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:-2.97|P-value:9.51E-4 ID:SGTC_1737|Compound:st035557|FD-Score:-4.21|P-value:5.40E-6 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:3.05|P-value:7.24E-4 ID:SGTC_2108|Compound:5365811|FD-Score:3.77|P-value:4.11E-5 ID:SGTC_2111|Compound:5486399|FD-Score:3.92|P-value:2.10E-5 ID:SGTC_2126|Compound:5251174|FD-Score:3.72|P-value:5.12E-5 ID:SGTC_2442|Compound:5158906|FD-Score:2.98|P-value:9.31E-4 ID:SGTC_2483|Compound:5729050|FD-Score:3.12|P-value:5.55E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-2.97|P-value:9.63E-4 ID:SGTC_2801|Compound:7907800|FD-Score:-3.08|P-value:6.28E-4 ID:SGTC_2809|Compound:7964133|FD-Score:-3.40|P-value:1.93E-4 ID:SGTC_2827|Compound:7993847|FD-Score:2.99|P-value:9.03E-4 ID:SGTC_2837|Compound:9008476|FD-Score:3.61|P-value:8.27E-5 ID:SGTC_2881|Compound:9058953|FD-Score:-3.02|P-value:7.98E-4 ID:SGTC_2942|Compound:9052777|FD-Score:-3.02|P-value:7.84E-4 ID:SGTC_2952|Compound:9073731|FD-Score:-4.00|P-value:1.43E-5 ID:SGTC_2967|Compound:9089538|FD-Score:3.43|P-value:1.72E-4 ID:SGTC_2971|Compound:9092186|FD-Score:-3.16|P-value:4.74E-4 ID:SGTC_3182|Compound:9108849|FD-Score:3.51|P-value:1.24E-4 ID:SGTC_3202|Compound:9113761|FD-Score:3.30|P-value:2.88E-4 ID:SGTC_3309|Compound:9129340|FD-Score:4.37|P-value:2.58E-6 ID:SGTC_3329|Compound:9141233|FD-Score:3.12|P-value:5.65E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:3.79|P-value:3.84E-5 ID:SGTC_68|Compound:0986-0284|FD-Score:-3.06|P-value:6.99E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:4.24|P-value:4.68E-6 ID:SGTC_155|Compound:k072-0202|FD-Score:3.75|P-value:4.61E-5 ID:SGTC_359|Compound:0081-0058|FD-Score:3.93|P-value:2.00E-5 ID:SGTC_441|Compound:propafenone|FD-Score:-3.24|P-value:3.54E-4 ID:SGTC_531|Compound:3788-1495|FD-Score:2.98|P-value:9.20E-4 ID:SGTC_612|Compound:0302-0167|FD-Score:3.76|P-value:4.35E-5 ID:SGTC_704|Compound:1310-0270|FD-Score:4.57|P-value:8.96E-7 ID:SGTC_931|Compound:2812-0076|FD-Score:-3.20|P-value:4.13E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:3.05|P-value:7.14E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:3.71|P-value:5.41E-5 ID:SGTC_1142|Compound:3253-1408|FD-Score:4.04|P-value:1.26E-5 ID:SGTC_1280|Compound:0880-0253|FD-Score:3.20|P-value:4.16E-4 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:3.34|P-value:2.43E-4 ID:SGTC_1456|Compound:k015-0012|FD-Score:3.06|P-value:6.92E-4 ID:SGTC_1617|Compound:st002906|FD-Score:-3.54|P-value:1.08E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:-2.97|P-value:9.51E-4 ID:SGTC_1737|Compound:st035557|FD-Score:-4.21|P-value:5.40E-6 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:3.05|P-value:7.24E-4 ID:SGTC_2108|Compound:5365811|FD-Score:3.77|P-value:4.11E-5 ID:SGTC_2111|Compound:5486399|FD-Score:3.92|P-value:2.10E-5 ID:SGTC_2126|Compound:5251174|FD-Score:3.72|P-value:5.12E-5 ID:SGTC_2442|Compound:5158906|FD-Score:2.98|P-value:9.31E-4 ID:SGTC_2483|Compound:5729050|FD-Score:3.12|P-value:5.55E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-2.97|P-value:9.63E-4 ID:SGTC_2801|Compound:7907800|FD-Score:-3.08|P-value:6.28E-4 ID:SGTC_2809|Compound:7964133|FD-Score:-3.40|P-value:1.93E-4 ID:SGTC_2827|Compound:7993847|FD-Score:2.99|P-value:9.03E-4 ID:SGTC_2837|Compound:9008476|FD-Score:3.61|P-value:8.27E-5 ID:SGTC_2881|Compound:9058953|FD-Score:-3.02|P-value:7.98E-4 ID:SGTC_2942|Compound:9052777|FD-Score:-3.02|P-value:7.84E-4 ID:SGTC_2952|Compound:9073731|FD-Score:-4.00|P-value:1.43E-5 ID:SGTC_2967|Compound:9089538|FD-Score:3.43|P-value:1.72E-4 ID:SGTC_2971|Compound:9092186|FD-Score:-3.16|P-value:4.74E-4 ID:SGTC_3182|Compound:9108849|FD-Score:3.51|P-value:1.24E-4 ID:SGTC_3202|Compound:9113761|FD-Score:3.30|P-value:2.88E-4 ID:SGTC_3309|Compound:9129340|FD-Score:4.37|P-value:2.58E-6 ID:SGTC_3329|Compound:9141233|FD-Score:3.12|P-value:5.65E-4

Top fitness defect scores for YGR109C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_704 1310-0270 4.57 142.0 µM 8.96E-7 24 2.40E-6
2 SGTC_3309 9129340 4.37 25.8 µM 2.58E-6 9 6.33E-6
3 SGTC_143 4032-1194 4.24 15.7 µM 4.68E-6 54 1.10E-5
4 SGTC_1142 3253-1408 4.04 9.8 µM 1.26E-5 11 2.72E-5
5 SGTC_359 0081-0058 3.93 15.9 µM 2.00E-5 60S ribosome export 44 4.18E-5
6 SGTC_2111 5486399 3.92 200.0 µM 2.10E-5 47 4.36E-5
7 SGTC_50 0929-0078 3.79 56.4 µM 3.84E-5 51 7.61E-5
8 SGTC_2108 5365811 3.77 200.0 µM 4.11E-5 18 8.10E-5
9 SGTC_612 0302-0167 3.76 22.4 µM 4.35E-5 copper-dependent oxidative stress 43 8.53E-5
10 SGTC_155 k072-0202 3.75 43.6 µM 4.61E-5 18 9.01E-5
11 SGTC_2126 5251174 3.72 33.9 µM 5.12E-5 47 9.92E-5
12 SGTC_1133 3473-0247 3.71 50.0 µM 5.41E-5 RSC complex & mRNA processing 61 1.04E-4
13 SGTC_2837 9008476 3.61 45.5 µM 8.27E-5 46 1.54E-4
14 SGTC_3182 9108849 3.51 49.5 µM 1.24E-4 RPP1 & pyrimidine depletion 22 2.24E-4
15 SGTC_2967 9089538 3.43 49.9 µM 1.72E-4 54 3.03E-4
16 SGTC_1309 pyrazolanthrone 3.34 13.4 µM 2.43E-4 42 4.16E-4
17 SGTC_3202 9113761 3.30 49.5 µM 2.88E-4 80 4.87E-4
18 SGTC_1280 0880-0253 3.20 10.1 µM 4.16E-4 41 6.84E-4
19 SGTC_2483 5729050 3.12 27.2 µM 5.55E-4 59 8.92E-4
20 SGTC_3329 9141233 3.12 27.6 µM 5.65E-4 36 9.06E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.165 7.88E-22 YOR291W YPK9 hom Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome
0.149 4.18E-18 YKL010C UFD4 hom Ubiquitin-protein ligase (E3); interacts with Rpt4p and Rpt6p, two subunits of the 19S particle of the 26S proteasome; cytoplasmic E3 involved in the degradation of ubiquitin fusion proteins; relative distribution to the nucleus increases upon DNA replication stress
0.117 1.00E-11 YOL047C_p YOL047C_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.117 1.14E-11 YHL006C SHU1 hom Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function
0.114 3.76E-11 YOR374W ALD4 hom Mitochondrial aldehyde dehydrogenase, required for growth on ethanol and conversion of acetaldehyde to acetate; phosphorylated; activity is K+ dependent; utilizes NADP+ or NAD+ equally as coenzymes; expression is glucose repressed
0.111 1.08E-10 YBL068W PRS4 hom 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS4 has a paralog, PRS2, that arose from the whole genome duplication
0.111 1.11E-10 YMR144W_p YMR144W_p hom Putative protein of unknown function; localized to the nucleus; YMR144W is not an essential gene
0.109 3.00E-10 YGR067C_p YGR067C_p hom Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p
0.106 6.61E-10 YBR144C_d YBR144C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR144C is not an essential gene
0.102 3.64E-9 YDL096C_d OPI6_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene PMT1/YDL095W; YDL096C is not essential
0.099 1.07E-8 YGL091C NBP35 het Essential iron-sulfur cluster binding protein localized in the cytoplasm; forms a complex with Cfd1p that is involved in iron-sulfur protein assembly in the cytosol; similar to P-loop NTPases
0.098 1.22E-8 YIL107C PFK26 hom 6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate; has negligible fructose-2,6-bisphosphatase activity; transcriptional regulation involves protein kinase A
0.097 1.72E-8 YDR304C CPR5 hom Peptidyl-prolyl cis-trans isomerase (cyclophilin) of the endoplasmic reticulum, catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; transcriptionally induced in response to unfolded proteins in the ER
0.097 1.76E-8 YGL010W_p YGL010W_p hom Putative protein of unknown function; YGL010W is not an essential gene
0.096 2.53E-8 YDR416W SYF1 het Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; null mutant has splicing defect and arrests in G2/M; homologs in human and C. elegans