YGR111W_p

Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR111W / YGR111W

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:4.40|P-value:3.19E-5 ID:SGTC_129|Compound:0088-0017|FD-Score:3.46|P-value:8.53E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:3.67|P-value:4.35E-4 ID:SGTC_188|Compound:3229-0966|FD-Score:4.11|P-value:9.32E-5 ID:SGTC_207|Compound:4185-0010|FD-Score:4.23|P-value:6.10E-5 ID:SGTC_214|Compound:4373-3496|FD-Score:3.72|P-value:3.72E-4 ID:SGTC_250|Compound:brefeldin a|FD-Score:-3.93|P-value:1.32E-4 ID:SGTC_251|Compound:melphalan|FD-Score:-3.34|P-value:9.43E-4 ID:SGTC_336|Compound:4111-0029|FD-Score:3.46|P-value:8.67E-4 ID:SGTC_338|Compound:4055-0136|FD-Score:4.65|P-value:1.15E-5 ID:SGTC_429|Compound:1112-0049|FD-Score:5.51|P-value:2.63E-7 ID:SGTC_432|Compound:NS 1619|FD-Score:-3.90|P-value:1.44E-4 ID:SGTC_440|Compound:fluspirilene|FD-Score:-3.77|P-value:2.28E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:4.99|P-value:2.86E-6 ID:SGTC_697|Compound:0508-1955|FD-Score:5.01|P-value:2.60E-6 ID:SGTC_703|Compound:3875-0075|FD-Score:5.83|P-value:5.33E-8 ID:SGTC_704|Compound:1310-0270|FD-Score:4.20|P-value:6.83E-5 ID:SGTC_833|Compound:3852-0053|FD-Score:4.82|P-value:5.76E-6 ID:SGTC_992|Compound:3909-8734|FD-Score:5.35|P-value:5.65E-7 ID:SGTC_993|Compound:3909-8757|FD-Score:4.51|P-value:2.09E-5 ID:SGTC_1136|Compound:pergolide|FD-Score:4.75|P-value:7.75E-6 ID:SGTC_1364|Compound:1653-0028|FD-Score:6.75|P-value:3.69E-10 ID:SGTC_1471|Compound:k673-0312|FD-Score:3.51|P-value:7.39E-4 ID:SGTC_1735|Compound:st034310|FD-Score:3.63|P-value:4.98E-4 ID:SGTC_1795|Compound:st049545|FD-Score:3.68|P-value:4.22E-4 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:3.74|P-value:3.48E-4 ID:SGTC_2116|Compound:5511452|FD-Score:3.59|P-value:5.65E-4 ID:SGTC_2152|Compound:5568786|FD-Score:3.96|P-value:1.63E-4 ID:SGTC_2155|Compound:5570423|FD-Score:3.48|P-value:8.07E-4 ID:SGTC_2393|Compound:9031399|FD-Score:3.59|P-value:5.75E-4 ID:SGTC_2523|Compound:spermine|FD-Score:-3.81|P-value:2.01E-4 ID:SGTC_2524|Compound:avocatin b|FD-Score:-4.12|P-value:6.43E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:-3.69|P-value:2.96E-4 ID:SGTC_2707|Compound:st078556|FD-Score:-3.79|P-value:2.15E-4 ID:SGTC_2767|Compound:sibutramine|FD-Score:-3.86|P-value:1.64E-4 ID:SGTC_2848|Compound:9016370|FD-Score:3.42|P-value:9.60E-4 ID:SGTC_2853|Compound:9015042|FD-Score:4.11|P-value:9.34E-5 ID:SGTC_2855|Compound:9016525|FD-Score:4.84|P-value:5.42E-6 ID:SGTC_2953|Compound:9074162|FD-Score:5.03|P-value:2.31E-6 ID:SGTC_2985|Compound:9022375|FD-Score:-3.43|P-value:6.97E-4 ID:SGTC_3025|Compound:9087895|FD-Score:3.97|P-value:1.55E-4 ID:SGTC_3033|Compound:9090887|FD-Score:-4.02|P-value:9.44E-5 ID:SGTC_3106|Compound:9121286|FD-Score:-3.72|P-value:2.72E-4 ID:SGTC_3117|Compound:9124945|FD-Score:-4.33|P-value:2.95E-5 ID:SGTC_3146|Compound:9095609|FD-Score:4.11|P-value:9.45E-5 ID:SGTC_3212|Compound:9128307|FD-Score:3.46|P-value:8.69E-4 ID:SGTC_3231|Compound:9132313|FD-Score:-3.63|P-value:3.72E-4 ID:SGTC_3240|Compound:9133527|FD-Score:-3.78|P-value:2.21E-4 ID:SGTC_3257|Compound:9139206|FD-Score:3.77|P-value:3.09E-4 ID:SGTC_3339|Compound:9145883|FD-Score:-4.07|P-value:7.72E-5 ID:SGTC_3341|Compound:9147222|FD-Score:4.16|P-value:7.88E-5 ID:SGTC_8|Compound:0354-0001|FD-Score:4.40|P-value:3.19E-5 ID:SGTC_129|Compound:0088-0017|FD-Score:3.46|P-value:8.53E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:3.67|P-value:4.35E-4 ID:SGTC_188|Compound:3229-0966|FD-Score:4.11|P-value:9.32E-5 ID:SGTC_207|Compound:4185-0010|FD-Score:4.23|P-value:6.10E-5 ID:SGTC_214|Compound:4373-3496|FD-Score:3.72|P-value:3.72E-4 ID:SGTC_250|Compound:brefeldin a|FD-Score:-3.93|P-value:1.32E-4 ID:SGTC_251|Compound:melphalan|FD-Score:-3.34|P-value:9.43E-4 ID:SGTC_336|Compound:4111-0029|FD-Score:3.46|P-value:8.67E-4 ID:SGTC_338|Compound:4055-0136|FD-Score:4.65|P-value:1.15E-5 ID:SGTC_429|Compound:1112-0049|FD-Score:5.51|P-value:2.63E-7 ID:SGTC_432|Compound:NS 1619|FD-Score:-3.90|P-value:1.44E-4 ID:SGTC_440|Compound:fluspirilene|FD-Score:-3.77|P-value:2.28E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:4.99|P-value:2.86E-6 ID:SGTC_697|Compound:0508-1955|FD-Score:5.01|P-value:2.60E-6 ID:SGTC_703|Compound:3875-0075|FD-Score:5.83|P-value:5.33E-8 ID:SGTC_704|Compound:1310-0270|FD-Score:4.20|P-value:6.83E-5 ID:SGTC_833|Compound:3852-0053|FD-Score:4.82|P-value:5.76E-6 ID:SGTC_992|Compound:3909-8734|FD-Score:5.35|P-value:5.65E-7 ID:SGTC_993|Compound:3909-8757|FD-Score:4.51|P-value:2.09E-5 ID:SGTC_1136|Compound:pergolide|FD-Score:4.75|P-value:7.75E-6 ID:SGTC_1364|Compound:1653-0028|FD-Score:6.75|P-value:3.69E-10 ID:SGTC_1471|Compound:k673-0312|FD-Score:3.51|P-value:7.39E-4 ID:SGTC_1735|Compound:st034310|FD-Score:3.63|P-value:4.98E-4 ID:SGTC_1795|Compound:st049545|FD-Score:3.68|P-value:4.22E-4 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:3.74|P-value:3.48E-4 ID:SGTC_2116|Compound:5511452|FD-Score:3.59|P-value:5.65E-4 ID:SGTC_2152|Compound:5568786|FD-Score:3.96|P-value:1.63E-4 ID:SGTC_2155|Compound:5570423|FD-Score:3.48|P-value:8.07E-4 ID:SGTC_2393|Compound:9031399|FD-Score:3.59|P-value:5.75E-4 ID:SGTC_2523|Compound:spermine|FD-Score:-3.81|P-value:2.01E-4 ID:SGTC_2524|Compound:avocatin b|FD-Score:-4.12|P-value:6.43E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:-3.69|P-value:2.96E-4 ID:SGTC_2707|Compound:st078556|FD-Score:-3.79|P-value:2.15E-4 ID:SGTC_2767|Compound:sibutramine|FD-Score:-3.86|P-value:1.64E-4 ID:SGTC_2848|Compound:9016370|FD-Score:3.42|P-value:9.60E-4 ID:SGTC_2853|Compound:9015042|FD-Score:4.11|P-value:9.34E-5 ID:SGTC_2855|Compound:9016525|FD-Score:4.84|P-value:5.42E-6 ID:SGTC_2953|Compound:9074162|FD-Score:5.03|P-value:2.31E-6 ID:SGTC_2985|Compound:9022375|FD-Score:-3.43|P-value:6.97E-4 ID:SGTC_3025|Compound:9087895|FD-Score:3.97|P-value:1.55E-4 ID:SGTC_3033|Compound:9090887|FD-Score:-4.02|P-value:9.44E-5 ID:SGTC_3106|Compound:9121286|FD-Score:-3.72|P-value:2.72E-4 ID:SGTC_3117|Compound:9124945|FD-Score:-4.33|P-value:2.95E-5 ID:SGTC_3146|Compound:9095609|FD-Score:4.11|P-value:9.45E-5 ID:SGTC_3212|Compound:9128307|FD-Score:3.46|P-value:8.69E-4 ID:SGTC_3231|Compound:9132313|FD-Score:-3.63|P-value:3.72E-4 ID:SGTC_3240|Compound:9133527|FD-Score:-3.78|P-value:2.21E-4 ID:SGTC_3257|Compound:9139206|FD-Score:3.77|P-value:3.09E-4 ID:SGTC_3339|Compound:9145883|FD-Score:-4.07|P-value:7.72E-5 ID:SGTC_3341|Compound:9147222|FD-Score:4.16|P-value:7.88E-5

Top fitness defect scores for YGR111W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1364 1653-0028 6.75 37.6 µM 3.69E-10 2 7.37E-12
2 SGTC_703 3875-0075 5.83 71.8 µM 5.33E-8 2 2.73E-9
3 SGTC_429 1112-0049 5.51 25.5 µM 2.63E-7 DNA damage response 15 1.82E-8
4 SGTC_992 3909-8734 5.35 162.0 µM 5.65E-7 3 4.50E-8
5 SGTC_2953 9074162 5.03 66.5 µM 2.31E-6 9 2.40E-7
6 SGTC_697 0508-1955 5.01 564.0 µM 2.60E-6 9 2.76E-7
7 SGTC_517 1365-0151 4.99 113.0 µM 2.86E-6 17 3.09E-7
8 SGTC_2855 9016525 4.84 58.4 µM 5.42E-6 9 6.61E-7
9 SGTC_833 3852-0053 4.82 558.0 µM 5.76E-6 8 7.11E-7
10 SGTC_1136 pergolide 4.75 1.1 µM 7.75E-6 20 1.01E-6
11 SGTC_338 4055-0136 4.65 114.0 µM 1.15E-5 2 1.62E-6
12 SGTC_993 3909-8757 4.51 62.7 µM 2.09E-5 15 3.29E-6
13 SGTC_8 0354-0001 4.40 70.0 µM 3.19E-5 59 5.42E-6
14 SGTC_207 4185-0010 4.23 4.5 µM 6.10E-5 endomembrane recycling 81 1.17E-5
15 SGTC_704 1310-0270 4.20 142.0 µM 6.83E-5 27 1.34E-5
16 SGTC_3341 9147222 4.16 25.9 µM 7.88E-5 RNA processing & uracil transport 12 1.59E-5
17 SGTC_188 3229-0966 4.11 278.5 µM 9.32E-5 25 1.94E-5
18 SGTC_2853 9015042 4.11 58.4 µM 9.34E-5 20 1.94E-5
19 SGTC_3146 9095609 4.11 49.5 µM 9.45E-5 12 1.97E-5
20 SGTC_3025 9087895 3.97 49.5 µM 1.55E-4 PDR1 40 3.55E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.102 3.38E-9 YDR278C_d YDR278C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.084 1.20E-6 YER106W MAM1 hom Monopolin, kinetochore associated protein involved in chromosome attachment to meiotic spindle
0.079 4.98E-6 YGR034W RPL26B hom Ribosomal 60S subunit protein L26B; binds to 5.8S rRNA; homologous to mammalian ribosomal protein L26 and bacterial L24; RPL26B has a paralog, RPL26A, that arose from the whole genome duplication
0.072 2.75E-5 YDR448W ADA2 hom Transcription coactivator, component of the ADA and SAGA transcriptional adaptor/HAT (histone acetyltransferase) complexes
0.071 3.49E-5 YOL075C_p YOL075C_p hom Putative ABC transporter
0.070 4.61E-5 YEL007W MIT1 hom Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1
0.070 4.82E-5 YLR441C RPS1A hom Ribosomal protein 10 (rp10) of the small (40S) subunit; homologous to mammalian ribosomal protein S3A, no bacterial homolog; RPS1A has a paralog, RPS1B, that arose from the whole genome duplication
0.067 9.45E-5 YBR021W FUR4 hom Plasma membrane localized uracil permease; expression is tightly regulated by uracil levels and environmental cues; conformational alterations induced by unfolding or substrate binding result in Rsp5p-mediated ubiquitination and degradation
0.067 9.96E-5 YHL003C LAG1 hom Ceramide synthase component; involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p; forms ER foci upon DNA replication stress
0.066 1.40E-4 YLR014C PPR1 hom Zinc finger transcription factor containing a Zn(2)-Cys(6) binuclear cluster domain, positively regulates transcription of URA1, URA3, URA4, and URA10, which are involved in de novo pyrimidine biosynthesis, in response to pyrimidine starvation; activity may be modulated by interaction with Tup1p
0.065 1.79E-4 YBR197C YBR197C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR197C is not an essential gene; relative distribution to the nucleus increases upon DNA replication stress; YBR197C has a paralog, YPL077C, that arose from the whole genome duplication
0.064 2.01E-4 YHR139C SPS100 hom Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall; expression also induced in cells treated with the mycotoxin patulin
0.063 2.49E-4 YGL121C GPG1 hom Proposed gamma subunit of the heterotrimeric G protein that interacts with the receptor Gpr1p; involved in regulation of pseudohyphal growth; requires Gpb1p or Gpb2p to interact with Gpa2p; overproduction causes prion curing
0.062 2.94E-4 YBR195C MSI1 hom Subunit of chromatin assembly factor I (CAF-1); chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; and chromatin dynamics during transcription; Msi1p localizes to both nucleus and cytoplasm and has an independent role as a negative regulator of the RAS/cAMP pathway via sequestration of Npr1p kinase
0.062 3.52E-4 YLL044W_d YLL044W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YLL044W and the overlapping gene RPL8B is reduced in the gcr1 null mutant