YGR114C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps 5' end of the essential gene SPT6

Zygosity: Heterozygous strain
fixedexpanded
Profile for YGR114C / YGR114C

Click on Significant Values for Screen Details ID:SGTC_100|Compound:0086-0128|FD-Score:9.25|P-value:7.06E-11 ID:SGTC_233|Compound:rapamycin|FD-Score:4.64|P-value:7.17E-4 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:5.98|P-value:1.85E-5 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:7.22|P-value:2.90E-7 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:4.64|P-value:7.08E-4 ID:SGTC_258|Compound:haloperidol|FD-Score:4.78|P-value:5.04E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:-4.60|P-value:5.36E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:8.24|P-value:5.79E-9 ID:SGTC_363|Compound:0455-0021|FD-Score:-4.76|P-value:3.60E-4 ID:SGTC_398|Compound:bronopol|FD-Score:-8.37|P-value:1.70E-9 ID:SGTC_427|Compound:1354-0053|FD-Score:4.50|P-value:9.98E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-6.60|P-value:1.49E-6 ID:SGTC_768|Compound:0384-0033|FD-Score:-4.34|P-value:9.95E-4 ID:SGTC_809|Compound:3998-0021|FD-Score:-4.43|P-value:7.99E-4 ID:SGTC_853|Compound:0419-0306|FD-Score:4.51|P-value:9.63E-4 ID:SGTC_870|Compound:0573-2213|FD-Score:4.67|P-value:6.60E-4 ID:SGTC_882|Compound:0843-0131|FD-Score:4.69|P-value:6.31E-4 ID:SGTC_966|Compound:1300-0360|FD-Score:7.32|P-value:2.04E-7 ID:SGTC_1017|Compound:4239-0030|FD-Score:5.87|P-value:2.59E-5 ID:SGTC_1026|Compound:k007-1105|FD-Score:-5.56|P-value:4.00E-5 ID:SGTC_1060|Compound:3448-7350|FD-Score:5.27|P-value:1.41E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:-4.88|P-value:2.62E-4 ID:SGTC_1171|Compound:0368-0077|FD-Score:5.73|P-value:3.86E-5 ID:SGTC_1172|Compound:0370-0043|FD-Score:4.80|P-value:4.74E-4 ID:SGTC_1201|Compound:1889-3372|FD-Score:4.51|P-value:9.60E-4 ID:SGTC_1326|Compound:1431-2094|FD-Score:-4.65|P-value:4.78E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:5.58|P-value:5.93E-5 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:-4.73|P-value:3.82E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:4.83|P-value:4.40E-4 ID:SGTC_1750|Compound:st081859|FD-Score:-4.58|P-value:5.63E-4 ID:SGTC_1754|Compound:st042065|FD-Score:-5.87|P-value:1.58E-5 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:7.91|P-value:2.14E-8 ID:SGTC_1800|Compound:st050079|FD-Score:-4.85|P-value:2.81E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-4.66|P-value:4.63E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-6.56|P-value:1.74E-6 ID:SGTC_1899|Compound:st063254|FD-Score:5.91|P-value:2.30E-5 ID:SGTC_1991|Compound:st073000|FD-Score:5.00|P-value:2.85E-4 ID:SGTC_2021|Compound:4019055|FD-Score:-4.46|P-value:7.49E-4 ID:SGTC_2061|Compound:5245884|FD-Score:4.67|P-value:6.60E-4 ID:SGTC_2085|Compound:5307070|FD-Score:4.81|P-value:4.68E-4 ID:SGTC_2114|Compound:5491910|FD-Score:4.66|P-value:6.82E-4 ID:SGTC_2290|Compound:7904846|FD-Score:5.10|P-value:2.20E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:5.59|P-value:5.75E-5 ID:SGTC_2676|Compound:harmalol|FD-Score:5.03|P-value:2.64E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-4.55|P-value:6.05E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:4.51|P-value:9.80E-4 ID:SGTC_2727|Compound:riluzole|FD-Score:4.77|P-value:5.11E-4 ID:SGTC_2821|Compound:7996764|FD-Score:5.96|P-value:1.94E-5 ID:SGTC_2841|Compound:9004761|FD-Score:4.55|P-value:8.73E-4 ID:SGTC_2854|Compound:9024559|FD-Score:4.70|P-value:6.15E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-4.52|P-value:6.52E-4 ID:SGTC_2862|Compound:9027634|FD-Score:4.58|P-value:8.23E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-6.43|P-value:2.64E-6 ID:SGTC_2980|Compound:9014342|FD-Score:5.65|P-value:4.92E-5 ID:SGTC_2991|Compound:9074669|FD-Score:-5.80|P-value:1.96E-5 ID:SGTC_2997|Compound:9067075|FD-Score:-6.19|P-value:5.81E-6 ID:SGTC_3018|Compound:9082602|FD-Score:-5.58|P-value:3.82E-5 ID:SGTC_3033|Compound:9090887|FD-Score:5.99|P-value:1.79E-5 ID:SGTC_3037|Compound:9091026|FD-Score:-6.98|P-value:3.99E-7 ID:SGTC_3131|Compound:9127911|FD-Score:5.61|P-value:5.44E-5 ID:SGTC_3152|Compound:9099253|FD-Score:-6.15|P-value:6.64E-6 ID:SGTC_3216|Compound:9129716|FD-Score:4.93|P-value:3.42E-4 ID:SGTC_3255|Compound:9139072|FD-Score:4.77|P-value:5.22E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:9.25|P-value:7.06E-11 ID:SGTC_233|Compound:rapamycin|FD-Score:4.64|P-value:7.17E-4 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:5.98|P-value:1.85E-5 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:7.22|P-value:2.90E-7 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:4.64|P-value:7.08E-4 ID:SGTC_258|Compound:haloperidol|FD-Score:4.78|P-value:5.04E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:-4.60|P-value:5.36E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:8.24|P-value:5.79E-9 ID:SGTC_363|Compound:0455-0021|FD-Score:-4.76|P-value:3.60E-4 ID:SGTC_398|Compound:bronopol|FD-Score:-8.37|P-value:1.70E-9 ID:SGTC_427|Compound:1354-0053|FD-Score:4.50|P-value:9.98E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-6.60|P-value:1.49E-6 ID:SGTC_768|Compound:0384-0033|FD-Score:-4.34|P-value:9.95E-4 ID:SGTC_809|Compound:3998-0021|FD-Score:-4.43|P-value:7.99E-4 ID:SGTC_853|Compound:0419-0306|FD-Score:4.51|P-value:9.63E-4 ID:SGTC_870|Compound:0573-2213|FD-Score:4.67|P-value:6.60E-4 ID:SGTC_882|Compound:0843-0131|FD-Score:4.69|P-value:6.31E-4 ID:SGTC_966|Compound:1300-0360|FD-Score:7.32|P-value:2.04E-7 ID:SGTC_1017|Compound:4239-0030|FD-Score:5.87|P-value:2.59E-5 ID:SGTC_1026|Compound:k007-1105|FD-Score:-5.56|P-value:4.00E-5 ID:SGTC_1060|Compound:3448-7350|FD-Score:5.27|P-value:1.41E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:-4.88|P-value:2.62E-4 ID:SGTC_1171|Compound:0368-0077|FD-Score:5.73|P-value:3.86E-5 ID:SGTC_1172|Compound:0370-0043|FD-Score:4.80|P-value:4.74E-4 ID:SGTC_1201|Compound:1889-3372|FD-Score:4.51|P-value:9.60E-4 ID:SGTC_1326|Compound:1431-2094|FD-Score:-4.65|P-value:4.78E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:5.58|P-value:5.93E-5 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:-4.73|P-value:3.82E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:4.83|P-value:4.40E-4 ID:SGTC_1750|Compound:st081859|FD-Score:-4.58|P-value:5.63E-4 ID:SGTC_1754|Compound:st042065|FD-Score:-5.87|P-value:1.58E-5 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:7.91|P-value:2.14E-8 ID:SGTC_1800|Compound:st050079|FD-Score:-4.85|P-value:2.81E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-4.66|P-value:4.63E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-6.56|P-value:1.74E-6 ID:SGTC_1899|Compound:st063254|FD-Score:5.91|P-value:2.30E-5 ID:SGTC_1991|Compound:st073000|FD-Score:5.00|P-value:2.85E-4 ID:SGTC_2021|Compound:4019055|FD-Score:-4.46|P-value:7.49E-4 ID:SGTC_2061|Compound:5245884|FD-Score:4.67|P-value:6.60E-4 ID:SGTC_2085|Compound:5307070|FD-Score:4.81|P-value:4.68E-4 ID:SGTC_2114|Compound:5491910|FD-Score:4.66|P-value:6.82E-4 ID:SGTC_2290|Compound:7904846|FD-Score:5.10|P-value:2.20E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:5.59|P-value:5.75E-5 ID:SGTC_2676|Compound:harmalol|FD-Score:5.03|P-value:2.64E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-4.55|P-value:6.05E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:4.51|P-value:9.80E-4 ID:SGTC_2727|Compound:riluzole|FD-Score:4.77|P-value:5.11E-4 ID:SGTC_2821|Compound:7996764|FD-Score:5.96|P-value:1.94E-5 ID:SGTC_2841|Compound:9004761|FD-Score:4.55|P-value:8.73E-4 ID:SGTC_2854|Compound:9024559|FD-Score:4.70|P-value:6.15E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-4.52|P-value:6.52E-4 ID:SGTC_2862|Compound:9027634|FD-Score:4.58|P-value:8.23E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-6.43|P-value:2.64E-6 ID:SGTC_2980|Compound:9014342|FD-Score:5.65|P-value:4.92E-5 ID:SGTC_2991|Compound:9074669|FD-Score:-5.80|P-value:1.96E-5 ID:SGTC_2997|Compound:9067075|FD-Score:-6.19|P-value:5.81E-6 ID:SGTC_3018|Compound:9082602|FD-Score:-5.58|P-value:3.82E-5 ID:SGTC_3033|Compound:9090887|FD-Score:5.99|P-value:1.79E-5 ID:SGTC_3037|Compound:9091026|FD-Score:-6.98|P-value:3.99E-7 ID:SGTC_3131|Compound:9127911|FD-Score:5.61|P-value:5.44E-5 ID:SGTC_3152|Compound:9099253|FD-Score:-6.15|P-value:6.64E-6 ID:SGTC_3216|Compound:9129716|FD-Score:4.93|P-value:3.42E-4 ID:SGTC_3255|Compound:9139072|FD-Score:4.77|P-value:5.22E-4

Top fitness defect scores for YGR114C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_100 0086-0128 9.25 49.6 µM 7.06E-11 copper-dependent oxidative stress 1 1.12E-20 2.17
2 SGTC_361 000s-0510 8.24 1.4 µM 5.79E-9 1 8.85E-17 2.26
3 SGTC_1785 bathophenanthroline 7.91 24.0 µM 2.14E-8 heme requiring 2 1.26E-15 0.25
4 SGTC_966 1300-0360 7.32 30.2 µM 2.04E-7 heme requiring 5 1.24E-13 2.11
5 SGTC_241 5hr heat shock (37°C) + cantharidin 7.22 155.4 µM 2.90E-7 cell wall signaling 4 2.52E-13 0.10
6 SGTC_3033 9090887 5.99 49.5 µM 1.79E-5 fatty acid desaturase (OLE1) 2 1.07E-9 0.60
7 SGTC_238 5hr heat shock (37°C) + nsc-638432 5.98 8.9 µM 1.85E-5 heat shock/prefoldin 1 1.14E-9 0.64
8 SGTC_2821 7996764 5.96 71.4 µM 1.94E-5 4 1.25E-9 1.12
9 SGTC_1899 st063254 5.91 59.6 µM 2.30E-5 1 1.76E-9 1.55
10 SGTC_1017 4239-0030 5.87 168.0 µM 2.59E-5 1 2.24E-9 2.00
11 SGTC_1171 0368-0077 5.73 21.4 µM 3.86E-5 3 5.00E-9 0.17
12 SGTC_2980 9014342 5.65 25.3 µM 4.92E-5 8 8.18E-9 0.28
13 SGTC_3131 9127911 5.61 49.5 µM 5.44E-5 2 1.00E-8 0.57
14 SGTC_2630 antimycin a 5.59 100.0 µM 5.75E-5 mitochondrial processes 3 1.12E-8 0.83
15 SGTC_1371 2421-0008 5.58 32.7 µM 5.93E-5 mitochondrial processes 10 1.19E-8 0.05
16 SGTC_1060 3448-7350 5.27 82.0 µM 1.41E-4 Golgi 10 6.76E-8 0.36
17 SGTC_2290 7904846 5.10 200.0 µM 2.20E-4 7 1.67E-7 0.24
18 SGTC_2676 harmalol 5.03 100.0 µM 2.64E-4 mitochondrial processes 3 2.41E-7 0.84
19 SGTC_1991 st073000 5.00 8.9 µM 2.85E-4 NEO1 10 2.81E-7 0.16
20 SGTC_3216 9129716 4.93 49.5 µM 3.42E-4 RPP1 & pyrimidine depletion 4 4.03E-7 0.39

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.259 2.16E-52 YGR116W SPT6 het Nucleosome remodeling protein; functions in various aspects of transcription, chromatin maintenance, and RNA processing; required for the maintenance of chromatin structure during transcription in order to inhibit transcription from promoters within the coding region
0.204 8.80E-33 YPR133C SPN1 het Protein involved in RNA polymerase II transcription; interacts genetically or physically with RNAP II, TBP, TFIIS, and chromatin remodelling factors; central domain highly conserved throughout eukaryotes; mutations confer an Spt- phenotype
0.129 6.10E-14 YOR001W RRP6 hom Nuclear exosome exonuclease component; has 3'-5' exonuclease activity; involved in RNA processing, maturation, surveillance, degradation, tethering, and export; has similarity to E. coli RNase D and to human PM-Sc1 100 (EXOSC10); mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay
0.119 4.23E-12 YGL251C HFM1 hom Meiosis specific DNA helicase involved in the conversion of double-stranded breaks to later recombination intermediates and in crossover control; catalyzes the unwinding of Holliday junctions; has ssDNA and dsDNA stimulated ATPase activity
0.113 4.94E-11 YMR282C AEP2 hom Mitochondrial protein, likely involved in translation of the mitochondrial OLI1 mRNA; exhibits genetic interaction with the OLI1 mRNA 5'-untranslated leader
0.113 5.41E-11 YLL045C RPL8B hom Ribosomal 60S subunit protein L8B; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8B has a paralog, RPL8A, that arose from the whole genome duplication
0.104 1.77E-9 YDR268W MSW1 hom Mitochondrial tryptophanyl-tRNA synthetase
0.102 3.46E-9 YDR260C SWM1 hom Subunit of the anaphase-promoting complex, which is an E3 ubiquitin ligase that regulates the metaphase-anaphase transition and exit from mitosis; required for activation of the daughter-specific gene expression and spore wall maturation
0.099 1.10E-8 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.098 1.55E-8 YIL038C NOT3 hom Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation
0.098 1.62E-8 YLR027C AAT2 hom Cytosolic aspartate aminotransferase, involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells
0.096 2.86E-8 YML061C PIF1 hom DNA helicase; exists in a nuclear form that acts as a catalytic inhibitor of telomerase; and as a mitochondrial form involved in repair and recombination of mitochondrial DNA; mutations affect zinc and iron homeostasis; regulated by Rad53p-dependent phosphorylation in rho0 cells
0.094 4.52E-8 YLR044C PDC1 hom Major of three pyruvate decarboxylase isozymes, key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde; subject to glucose-, ethanol-, and autoregulation; involved in amino acid catabolism
0.091 1.28E-7 YPL005W AEP3 hom Protein that may facilitate use of unformylated tRNA-Met in mitochondrial translation initiation; localized to the matrix face of the mitochondrial inner membrane; stabilizes the bicistronic AAP1-ATP6 mRNA
0.091 1.48E-7 YOL040C RPS15 het Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15 and bacterial S19