YGR115C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified and essential ORF SPT6/YGR115C

Zygosity: Heterozygous strain
fixedexpanded
Profile for YGR115C / YGR115C

Click on Significant Values for Screen Details ID:SGTC_16|Compound:erodoxin|FD-Score:4.47|P-value:1.40E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:6.45|P-value:8.07E-8 ID:SGTC_77|Compound:0828-0286|FD-Score:4.22|P-value:3.07E-4 ID:SGTC_78|Compound:0336-0123|FD-Score:5.49|P-value:4.14E-6 ID:SGTC_79|Compound:0052-0007|FD-Score:4.08|P-value:4.60E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:11.00|P-value:1.37E-19 ID:SGTC_161|Compound:4065-0411|FD-Score:4.72|P-value:6.43E-5 ID:SGTC_178|Compound:4092-0806|FD-Score:-7.26|P-value:1.60E-9 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:4.61|P-value:9.21E-5 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:7.04|P-value:5.21E-9 ID:SGTC_312|Compound:4092-0653|FD-Score:-5.58|P-value:2.61E-6 ID:SGTC_320|Compound:4092-0846|FD-Score:-4.97|P-value:2.53E-5 ID:SGTC_348|Compound:k064-0012|FD-Score:-4.08|P-value:4.35E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:-4.03|P-value:4.96E-4 ID:SGTC_356|Compound:1634-0012|FD-Score:3.88|P-value:8.20E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-6.96|P-value:6.98E-9 ID:SGTC_442|Compound:cape|FD-Score:4.12|P-value:4.15E-4 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:5.71|P-value:1.74E-6 ID:SGTC_488|Compound:nitrendipine|FD-Score:-4.00|P-value:5.52E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-4.25|P-value:2.61E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:8.51|P-value:2.35E-12 ID:SGTC_580|Compound:1123-0028|FD-Score:5.42|P-value:5.41E-6 ID:SGTC_673|Compound:1082-0474|FD-Score:9.29|P-value:2.19E-14 ID:SGTC_708|Compound:3448-5400|FD-Score:4.99|P-value:2.53E-5 ID:SGTC_764|Compound:1951-2361|FD-Score:3.84|P-value:9.12E-4 ID:SGTC_770|Compound:0389-1121|FD-Score:3.94|P-value:6.89E-4 ID:SGTC_828|Compound:2074-0507|FD-Score:5.82|P-value:1.13E-6 ID:SGTC_829|Compound:1635-0120|FD-Score:6.21|P-value:2.24E-7 ID:SGTC_878|Compound:0828-0289|FD-Score:9.33|P-value:1.70E-14 ID:SGTC_882|Compound:0843-0131|FD-Score:4.20|P-value:3.23E-4 ID:SGTC_894|Compound:0960-0238|FD-Score:4.73|P-value:6.18E-5 ID:SGTC_897|Compound:1000-0139|FD-Score:3.91|P-value:7.60E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:4.83|P-value:4.37E-5 ID:SGTC_971|Compound:1315-0384|FD-Score:4.60|P-value:9.48E-5 ID:SGTC_972|Compound:1319-0219|FD-Score:5.06|P-value:2.01E-5 ID:SGTC_1026|Compound:k007-1105|FD-Score:-4.59|P-value:9.07E-5 ID:SGTC_1044|Compound:1222-0021|FD-Score:4.93|P-value:3.16E-5 ID:SGTC_1063|Compound:disulfiram|FD-Score:4.09|P-value:4.51E-4 ID:SGTC_1072|Compound:oxiconazole|FD-Score:-4.16|P-value:3.40E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:-4.19|P-value:3.08E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:-4.22|P-value:2.89E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:-6.31|P-value:1.34E-7 ID:SGTC_1136|Compound:pergolide|FD-Score:5.50|P-value:4.02E-6 ID:SGTC_1161|Compound:k007-0610|FD-Score:-3.88|P-value:7.64E-4 ID:SGTC_1187|Compound:1391-0724|FD-Score:4.19|P-value:3.32E-4 ID:SGTC_1207|Compound:2099-0101|FD-Score:3.83|P-value:9.47E-4 ID:SGTC_1211|Compound:1056-0033|FD-Score:4.46|P-value:1.45E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:3.83|P-value:9.38E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:4.19|P-value:3.35E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:7.59|P-value:3.43E-10 ID:SGTC_1257|Compound:0669-0121|FD-Score:-3.86|P-value:8.19E-4 ID:SGTC_1266|Compound:0828-0227|FD-Score:4.65|P-value:8.03E-5 ID:SGTC_1268|Compound:0828-0275|FD-Score:4.88|P-value:3.71E-5 ID:SGTC_1306|Compound:1185-0270|FD-Score:-4.28|P-value:2.35E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:7.80|P-value:1.14E-10 ID:SGTC_1327|Compound:1436-0082|FD-Score:4.36|P-value:2.00E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.97|P-value:6.37E-4 ID:SGTC_1493|Compound:4348-0038|FD-Score:7.83|P-value:9.87E-11 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:-4.03|P-value:5.04E-4 ID:SGTC_1652|Compound:st011932|FD-Score:6.29|P-value:1.61E-7 ID:SGTC_1727|Compound:st034309|FD-Score:4.17|P-value:3.60E-4 ID:SGTC_1749|Compound:st037932|FD-Score:3.89|P-value:7.98E-4 ID:SGTC_1750|Compound:st081859|FD-Score:-5.03|P-value:1.99E-5 ID:SGTC_1772|Compound:st048439|FD-Score:6.60|P-value:4.03E-8 ID:SGTC_1786|Compound:berberine|FD-Score:5.18|P-value:1.28E-5 ID:SGTC_1915|Compound:st067105|FD-Score:4.33|P-value:2.20E-4 ID:SGTC_1959|Compound:st077091|FD-Score:5.69|P-value:1.86E-6 ID:SGTC_2004|Compound:4023728|FD-Score:8.79|P-value:4.43E-13 ID:SGTC_2025|Compound:5147754|FD-Score:3.86|P-value:8.59E-4 ID:SGTC_2038|Compound:4100038|FD-Score:-4.84|P-value:3.91E-5 ID:SGTC_2041|Compound:5107442|FD-Score:6.90|P-value:1.02E-8 ID:SGTC_2109|Compound:5483026|FD-Score:5.56|P-value:3.15E-6 ID:SGTC_2111|Compound:5486399|FD-Score:6.81|P-value:1.55E-8 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:4.34|P-value:2.14E-4 ID:SGTC_2177|Compound:5811945|FD-Score:4.25|P-value:2.83E-4 ID:SGTC_2186|Compound:6124449|FD-Score:5.56|P-value:3.18E-6 ID:SGTC_2248|Compound:tofa|FD-Score:5.29|P-value:8.71E-6 ID:SGTC_2270|Compound:7924575|FD-Score:-4.18|P-value:3.24E-4 ID:SGTC_2277|Compound:7947813|FD-Score:5.66|P-value:2.13E-6 ID:SGTC_2322|Compound:7413319|FD-Score:-3.87|P-value:7.80E-4 ID:SGTC_2330|Compound:7979373|FD-Score:4.25|P-value:2.83E-4 ID:SGTC_2348|Compound:9022543|FD-Score:8.82|P-value:3.66E-13 ID:SGTC_2361|Compound:9034121|FD-Score:3.83|P-value:9.44E-4 ID:SGTC_2399|Compound:5884133|FD-Score:6.26|P-value:1.79E-7 ID:SGTC_2430|Compound:5571206|FD-Score:4.35|P-value:2.09E-4 ID:SGTC_2440|Compound:5628896|FD-Score:-3.79|P-value:9.96E-4 ID:SGTC_2456|Compound:5770359|FD-Score:4.28|P-value:2.56E-4 ID:SGTC_2466|Compound:5983409|FD-Score:4.24|P-value:2.90E-4 ID:SGTC_2482|Compound:5981709|FD-Score:-6.45|P-value:7.12E-8 ID:SGTC_2533|Compound:agelasine|FD-Score:4.01|P-value:5.75E-4 ID:SGTC_2544|Compound:sphondin|FD-Score:4.74|P-value:6.01E-5 ID:SGTC_2563|Compound:tomatine|FD-Score:4.55|P-value:1.12E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.89|P-value:8.02E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:-4.28|P-value:2.38E-4 ID:SGTC_2639|Compound:lactacystin|FD-Score:5.77|P-value:1.39E-6 ID:SGTC_2679|Compound:rapamycin|FD-Score:6.47|P-value:7.42E-8 ID:SGTC_2724|Compound:maprotiline|FD-Score:3.89|P-value:8.03E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:8.98|P-value:1.43E-13 ID:SGTC_2759|Compound:disulfiram|FD-Score:6.30|P-value:1.50E-7 ID:SGTC_2858|Compound:9025781|FD-Score:-4.58|P-value:9.14E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-4.36|P-value:1.85E-4 ID:SGTC_2972|Compound:9093619|FD-Score:-5.18|P-value:1.20E-5 ID:SGTC_2991|Compound:9074669|FD-Score:-4.63|P-value:7.98E-5 ID:SGTC_2993|Compound:9054257|FD-Score:-4.39|P-value:1.71E-4 ID:SGTC_3108|Compound:9121785|FD-Score:-4.29|P-value:2.27E-4 ID:SGTC_3154|Compound:9100113|FD-Score:4.19|P-value:3.36E-4 ID:SGTC_3244|Compound:9134489|FD-Score:-4.54|P-value:1.04E-4 ID:SGTC_3247|Compound:9135149|FD-Score:4.85|P-value:4.10E-5 ID:SGTC_3249|Compound:9135183|FD-Score:4.26|P-value:2.74E-4 ID:SGTC_3315|Compound:9136395|FD-Score:4.07|P-value:4.78E-4 ID:SGTC_3328|Compound:9140624|FD-Score:3.82|P-value:9.55E-4 ID:SGTC_16|Compound:erodoxin|FD-Score:4.47|P-value:1.40E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:6.45|P-value:8.07E-8 ID:SGTC_77|Compound:0828-0286|FD-Score:4.22|P-value:3.07E-4 ID:SGTC_78|Compound:0336-0123|FD-Score:5.49|P-value:4.14E-6 ID:SGTC_79|Compound:0052-0007|FD-Score:4.08|P-value:4.60E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:11.00|P-value:1.37E-19 ID:SGTC_161|Compound:4065-0411|FD-Score:4.72|P-value:6.43E-5 ID:SGTC_178|Compound:4092-0806|FD-Score:-7.26|P-value:1.60E-9 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:4.61|P-value:9.21E-5 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:7.04|P-value:5.21E-9 ID:SGTC_312|Compound:4092-0653|FD-Score:-5.58|P-value:2.61E-6 ID:SGTC_320|Compound:4092-0846|FD-Score:-4.97|P-value:2.53E-5 ID:SGTC_348|Compound:k064-0012|FD-Score:-4.08|P-value:4.35E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:-4.03|P-value:4.96E-4 ID:SGTC_356|Compound:1634-0012|FD-Score:3.88|P-value:8.20E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-6.96|P-value:6.98E-9 ID:SGTC_442|Compound:cape|FD-Score:4.12|P-value:4.15E-4 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:5.71|P-value:1.74E-6 ID:SGTC_488|Compound:nitrendipine|FD-Score:-4.00|P-value:5.52E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-4.25|P-value:2.61E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:8.51|P-value:2.35E-12 ID:SGTC_580|Compound:1123-0028|FD-Score:5.42|P-value:5.41E-6 ID:SGTC_673|Compound:1082-0474|FD-Score:9.29|P-value:2.19E-14 ID:SGTC_708|Compound:3448-5400|FD-Score:4.99|P-value:2.53E-5 ID:SGTC_764|Compound:1951-2361|FD-Score:3.84|P-value:9.12E-4 ID:SGTC_770|Compound:0389-1121|FD-Score:3.94|P-value:6.89E-4 ID:SGTC_828|Compound:2074-0507|FD-Score:5.82|P-value:1.13E-6 ID:SGTC_829|Compound:1635-0120|FD-Score:6.21|P-value:2.24E-7 ID:SGTC_878|Compound:0828-0289|FD-Score:9.33|P-value:1.70E-14 ID:SGTC_882|Compound:0843-0131|FD-Score:4.20|P-value:3.23E-4 ID:SGTC_894|Compound:0960-0238|FD-Score:4.73|P-value:6.18E-5 ID:SGTC_897|Compound:1000-0139|FD-Score:3.91|P-value:7.60E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:4.83|P-value:4.37E-5 ID:SGTC_971|Compound:1315-0384|FD-Score:4.60|P-value:9.48E-5 ID:SGTC_972|Compound:1319-0219|FD-Score:5.06|P-value:2.01E-5 ID:SGTC_1026|Compound:k007-1105|FD-Score:-4.59|P-value:9.07E-5 ID:SGTC_1044|Compound:1222-0021|FD-Score:4.93|P-value:3.16E-5 ID:SGTC_1063|Compound:disulfiram|FD-Score:4.09|P-value:4.51E-4 ID:SGTC_1072|Compound:oxiconazole|FD-Score:-4.16|P-value:3.40E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:-4.19|P-value:3.08E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:-4.22|P-value:2.89E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:-6.31|P-value:1.34E-7 ID:SGTC_1136|Compound:pergolide|FD-Score:5.50|P-value:4.02E-6 ID:SGTC_1161|Compound:k007-0610|FD-Score:-3.88|P-value:7.64E-4 ID:SGTC_1187|Compound:1391-0724|FD-Score:4.19|P-value:3.32E-4 ID:SGTC_1207|Compound:2099-0101|FD-Score:3.83|P-value:9.47E-4 ID:SGTC_1211|Compound:1056-0033|FD-Score:4.46|P-value:1.45E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:3.83|P-value:9.38E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:4.19|P-value:3.35E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:7.59|P-value:3.43E-10 ID:SGTC_1257|Compound:0669-0121|FD-Score:-3.86|P-value:8.19E-4 ID:SGTC_1266|Compound:0828-0227|FD-Score:4.65|P-value:8.03E-5 ID:SGTC_1268|Compound:0828-0275|FD-Score:4.88|P-value:3.71E-5 ID:SGTC_1306|Compound:1185-0270|FD-Score:-4.28|P-value:2.35E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:7.80|P-value:1.14E-10 ID:SGTC_1327|Compound:1436-0082|FD-Score:4.36|P-value:2.00E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.97|P-value:6.37E-4 ID:SGTC_1493|Compound:4348-0038|FD-Score:7.83|P-value:9.87E-11 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:-4.03|P-value:5.04E-4 ID:SGTC_1652|Compound:st011932|FD-Score:6.29|P-value:1.61E-7 ID:SGTC_1727|Compound:st034309|FD-Score:4.17|P-value:3.60E-4 ID:SGTC_1749|Compound:st037932|FD-Score:3.89|P-value:7.98E-4 ID:SGTC_1750|Compound:st081859|FD-Score:-5.03|P-value:1.99E-5 ID:SGTC_1772|Compound:st048439|FD-Score:6.60|P-value:4.03E-8 ID:SGTC_1786|Compound:berberine|FD-Score:5.18|P-value:1.28E-5 ID:SGTC_1915|Compound:st067105|FD-Score:4.33|P-value:2.20E-4 ID:SGTC_1959|Compound:st077091|FD-Score:5.69|P-value:1.86E-6 ID:SGTC_2004|Compound:4023728|FD-Score:8.79|P-value:4.43E-13 ID:SGTC_2025|Compound:5147754|FD-Score:3.86|P-value:8.59E-4 ID:SGTC_2038|Compound:4100038|FD-Score:-4.84|P-value:3.91E-5 ID:SGTC_2041|Compound:5107442|FD-Score:6.90|P-value:1.02E-8 ID:SGTC_2109|Compound:5483026|FD-Score:5.56|P-value:3.15E-6 ID:SGTC_2111|Compound:5486399|FD-Score:6.81|P-value:1.55E-8 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:4.34|P-value:2.14E-4 ID:SGTC_2177|Compound:5811945|FD-Score:4.25|P-value:2.83E-4 ID:SGTC_2186|Compound:6124449|FD-Score:5.56|P-value:3.18E-6 ID:SGTC_2248|Compound:tofa|FD-Score:5.29|P-value:8.71E-6 ID:SGTC_2270|Compound:7924575|FD-Score:-4.18|P-value:3.24E-4 ID:SGTC_2277|Compound:7947813|FD-Score:5.66|P-value:2.13E-6 ID:SGTC_2322|Compound:7413319|FD-Score:-3.87|P-value:7.80E-4 ID:SGTC_2330|Compound:7979373|FD-Score:4.25|P-value:2.83E-4 ID:SGTC_2348|Compound:9022543|FD-Score:8.82|P-value:3.66E-13 ID:SGTC_2361|Compound:9034121|FD-Score:3.83|P-value:9.44E-4 ID:SGTC_2399|Compound:5884133|FD-Score:6.26|P-value:1.79E-7 ID:SGTC_2430|Compound:5571206|FD-Score:4.35|P-value:2.09E-4 ID:SGTC_2440|Compound:5628896|FD-Score:-3.79|P-value:9.96E-4 ID:SGTC_2456|Compound:5770359|FD-Score:4.28|P-value:2.56E-4 ID:SGTC_2466|Compound:5983409|FD-Score:4.24|P-value:2.90E-4 ID:SGTC_2482|Compound:5981709|FD-Score:-6.45|P-value:7.12E-8 ID:SGTC_2533|Compound:agelasine|FD-Score:4.01|P-value:5.75E-4 ID:SGTC_2544|Compound:sphondin|FD-Score:4.74|P-value:6.01E-5 ID:SGTC_2563|Compound:tomatine|FD-Score:4.55|P-value:1.12E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.89|P-value:8.02E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:-4.28|P-value:2.38E-4 ID:SGTC_2639|Compound:lactacystin|FD-Score:5.77|P-value:1.39E-6 ID:SGTC_2679|Compound:rapamycin|FD-Score:6.47|P-value:7.42E-8 ID:SGTC_2724|Compound:maprotiline|FD-Score:3.89|P-value:8.03E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:8.98|P-value:1.43E-13 ID:SGTC_2759|Compound:disulfiram|FD-Score:6.30|P-value:1.50E-7 ID:SGTC_2858|Compound:9025781|FD-Score:-4.58|P-value:9.14E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-4.36|P-value:1.85E-4 ID:SGTC_2972|Compound:9093619|FD-Score:-5.18|P-value:1.20E-5 ID:SGTC_2991|Compound:9074669|FD-Score:-4.63|P-value:7.98E-5 ID:SGTC_2993|Compound:9054257|FD-Score:-4.39|P-value:1.71E-4 ID:SGTC_3108|Compound:9121785|FD-Score:-4.29|P-value:2.27E-4 ID:SGTC_3154|Compound:9100113|FD-Score:4.19|P-value:3.36E-4 ID:SGTC_3244|Compound:9134489|FD-Score:-4.54|P-value:1.04E-4 ID:SGTC_3247|Compound:9135149|FD-Score:4.85|P-value:4.10E-5 ID:SGTC_3249|Compound:9135183|FD-Score:4.26|P-value:2.74E-4 ID:SGTC_3315|Compound:9136395|FD-Score:4.07|P-value:4.78E-4 ID:SGTC_3328|Compound:9140624|FD-Score:3.82|P-value:9.55E-4

Top fitness defect scores for YGR115C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_87 0100-0052 11.00 35.5 µM 1.37E-19 3 1.22E-28 1.12
2 SGTC_878 0828-0289 9.33 13.7 µM 1.70E-14 6 5.51E-21 1.38
3 SGTC_673 1082-0474 9.29 110.0 µM 2.19E-14 RSC complex & mRNA processing 15 8.07E-21 0.10
4 SGTC_2756 carbadox 8.98 75.1 µM 1.43E-13 3 1.36E-19 0.47
5 SGTC_2348 9022543 8.82 33.4 µM 3.66E-13 mitochondrial processes 9 5.56E-19 1.35
6 SGTC_2004 4023728 8.79 41.9 µM 4.43E-13 7 7.41E-19 0.01
7 SGTC_576 1073-0113 8.51 22.7 µM 2.35E-12 redox potentiating 8 9.04E-18 0.39
8 SGTC_1493 4348-0038 7.83 111.0 µM 9.87E-11 RSC complex & mRNA processing 7 2.47E-15 0.01
9 SGTC_1317 1273-0028 7.80 910.0 nM 1.14E-10 azole & statin 4 3.05E-15 0.60
10 SGTC_1239 0337-0584 7.59 35.4 µM 3.43E-10 unfolded protein response 7 1.60E-14 2.55E-4
11 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 7.04 4.6 µM 5.21E-9 heat shock/prefoldin 7 9.42E-13 0.40
12 SGTC_2041 5107442 6.90 45.3 µM 1.02E-8 RSC complex & mRNA processing 14 2.58E-12 0.13
13 SGTC_2111 5486399 6.81 200.0 µM 1.55E-8 12 4.81E-12 0.38
14 SGTC_1772 st048439 6.60 82.2 µM 4.03E-8 4 2.01E-11 1.78
15 SGTC_2679 rapamycin 6.47 1.0 nM 7.42E-8 25 5.02E-11 0.06
16 SGTC_69 0096-0274 6.45 206.7 µM 8.07E-8 mitochondrial processes 18 5.69E-11 0.08
17 SGTC_2759 disulfiram 6.30 3.4 µM 1.50E-7 7 1.44E-10 0.41
18 SGTC_1652 st011932 6.29 78.0 µM 1.61E-7 RSC complex & mRNA processing 24 1.60E-10 0.11
19 SGTC_2399 5884133 6.26 200.0 µM 1.79E-7 cell wall signaling 6 1.87E-10 0.49
20 SGTC_829 1635-0120 6.21 117.0 µM 2.24E-7 DNA damage response 26 2.62E-10 0.55

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.277 3.96E-60 YER165W PAB1 het Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G
0.217 3.87E-37 YNR016C ACC1 het Acetyl-CoA carboxylase, biotin containing enzyme; catalyzes the carboxylation of cytosolic acetyl-CoA to form malonyl-CoA and regulates histone acetylation by regulating the availablity of acetyl-CoA; required for de novo biosynthesis of long-chain fatty acids;
0.212 1.85E-35 YFL002C SPB4 het Putative ATP-dependent RNA helicase, nucleolar protein required for synthesis of 60S ribosomal subunits at a late step in the pathway; sediments with 66S pre-ribosomes in sucrose gradients
0.206 1.82E-33 YPR034W ARP7 het Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation
0.206 1.88E-33 YOR236W DFR1 het Dihydrofolate reductase involved in tetrahydrofolate biosynthesis; required for respiratory metabolism
0.200 1.85E-31 YLR033W RSC58 het Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance
0.196 1.74E-30 YML127W RSC9 het Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway
0.195 5.95E-30 YFR037C RSC8 het Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters
0.175 2.13E-24 YLR321C SFH1 het Component of the RSC chromatin remodeling complex; essential gene required for cell cycle progression and maintenance of proper ploidy; phosphorylated in the G1 phase of the cell cycle; Snf5p paralog
0.167 1.79E-22 YBL026W LSM2 het Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
0.164 1.43E-21 YBL092W RPL32 het Ribosomal 60S subunit protein L32; overexpression disrupts telomeric silencing; homologous to mammalian ribosomal protein L32, no bacterial homolog
0.158 4.23E-20 YBR091C TIM12 het Essential protein of the inner mitochondrial membrane, peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins
0.154 2.93E-19 YDR527W RBA50 het Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1
0.154 3.79E-19 YIL126W STH1 het ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; essential helicase-related protein homologous to Snf2p
0.152 8.75E-19 YMR033W ARP9 het Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation