HIPHOP chemogenomics database

YGR119C / NUP57

FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nic96p and two other FG-nucleoproteins (Nsp1p and Nup49p)

Zygosity: Heterozygous strain

fixedexpanded
Profile for YGR119C / NUP57

Click on Significant Values for Screen Details

Top fitness defect scores for YGR119C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value	Screen Clearance
1	SGTC_1911	st060208	8.24	74.3 µM	6.50E-12		1	8.33E-17	2.35
2	SGTC_2591	skatole	6.74	100.0 µM	1.53E-8		1	7.69E-12	2.17
3	SGTC_1129	3453-1384	6.57	223.0 µM	3.41E-8		3	2.48E-11	0.59
4	SGTC_1294	1000-1494	6.40	117.0 µM	7.26E-8		4	7.54E-11	0.36
5	SGTC_1932	st074806	6.34	40.9 µM	9.52E-8		2	1.12E-10	0.67
6	SGTC_2140	5586273	5.99	200.0 µM	4.29E-7	RSC complex & mRNA processing	5	1.02E-9	0.03
7	SGTC_2718	lomofungin	5.85	53.0 µM	7.91E-7	mitochondrial processes	2	2.51E-9	1.07
8	SGTC_2663	amphotericin b	5.76	100.0 µM	1.13E-6		1	4.25E-9	0.81
9	SGTC_182	3448-4371	5.71	550.5 µM	1.37E-6		1	5.59E-9	1.28
10	SGTC_1838	st055369	5.26	84.5 µM	7.80E-6		3	7.15E-8	0.98
11	SGTC_2207	7258803	5.15	200.0 µM	1.16E-5		1	1.27E-7	1.81
12	SGTC_3201	9113999	5.09	49.5 µM	1.44E-5		2	1.76E-7	0.44
13	SGTC_1469	k284-2957	4.91	126.0 µM	2.74E-5		9	4.47E-7	0.72
14	SGTC_1583	clindamycin	4.81	39.6 µM	3.97E-5	mitochondrial processes	2	7.70E-7	0.24
15	SGTC_672	1441-0018	4.75	53.7 µM	4.80E-5		1	1.01E-6	0.48
16	SGTC_2857	9024691	4.67	58.4 µM	6.25E-5		4	1.49E-6	1.03
17	SGTC_2576	guaiol	4.65	23.1 µM	6.74E-5		6	1.67E-6	0.86
18	SGTC_1089	terbinafine	4.58	2.2 µM	8.51E-5		4	2.34E-6	0.03
19	SGTC_1204	4049-0315	4.57	18.3 µM	8.67E-5		5	2.40E-6	0.07
20	SGTC_93	0109-0045	4.55	59.2 µM	9.46E-5	DNA damage response	12	2.73E-6	0.03

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.137	1.42E-15	YGL172W	NUP49	het	FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nic96p and two other FG-nucleoproteins (Nsp1p and Nup57p)
0.131	2.75E-14	YDL207W	GLE1	het	Cytoplasmic nucleoporin required for polyadenylated RNA export; not essential for protein import; contains a nuclear export signal; when bound to inositol hexakisphosphate (IP6), functions as an activator for the Dbp5p ATPase activity at the nuclear pore complex during mRNA export
0.089	2.57E-7	YIL069C	RPS24B	hom	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S24, no bacterial homolog; RPS24B has a paralog, RPS24A, that arose from the whole genome duplication
0.086	6.93E-7	YMR312W	ELP6	hom	Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity
0.082	1.88E-6	YER177W	BMH1	hom	14-3-3 protein, major isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress
0.082	1.88E-6	YKL186C	MTR2	het	mRNA transport regulator, essential nuclear protein; Mex67p and Mtr2p form a mRNA export complex which binds to RNA
0.081	2.43E-6	YMR029C	FAR8	hom	Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p
0.080	3.15E-6	YPL169C	MEX67	het	Poly(A)RNA binding protein involved in nuclear mRNA export, component of the nuclear pore; ortholog of human TAP
0.079	5.21E-6	YOR066W	MSA1	hom	Activator of G1-specific transcription factors, MBF and SBF; involved in regulation of the timing of G1-specific gene transcription and cell cycle initiation; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation
0.078	6.05E-6	YOR224C	RPB8	het	RNA polymerase subunit ABC14.5, common to RNA polymerases I, II, and III
0.077	7.08E-6	YGL127C	SOH1	hom	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; involved in telomere maintenance; conserved with other metazoan MED31 subunits
0.077	7.59E-6	YGL184C	STR3	hom	Peroxisomal cystathionine beta-lyase, converts cystathionine into homocysteine; may be redox regulated by Gto1p
0.077	8.56E-6	YOR295W	UAF30	hom	Subunit of UAF (upstream activation factor); UAF is an RNA polymerase I specific transcription stimulatory factor composed of Uaf30p, Rrn5p, Rrn9p, Rrn10p, histones H3 and H4; deletion decreases cellular growth rate; UAF30 has a paralog, TRI1, that arose from the whole genome duplication
0.075	1.44E-5	YGR165W	MRPS35	hom	Mitochondrial ribosomal protein of the small subunit; null mutant does not grow on glycerol, is sensitive to 2,4-dichlorophenol, and accumulates large lipid droplets
0.074	1.69E-5	YOR174W	MED4	het	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation