YGR120C / COG2

Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments

Zygosity: Heterozygous strain
fixedexpanded
Profile for YGR120C / COG2

Click on Significant Values for Screen Details ID:SGTC_81|Compound:0411-0046|FD-Score:5.80|P-value:3.63E-8 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.88|P-value:2.72E-6 ID:SGTC_496|Compound:calpeptin|FD-Score:-5.23|P-value:5.34E-7 ID:SGTC_737|Compound:1950-0117|FD-Score:-3.78|P-value:2.10E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:3.46|P-value:6.67E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:4.75|P-value:5.19E-6 ID:SGTC_1111|Compound:tnp00062|FD-Score:-3.82|P-value:1.85E-4 ID:SGTC_1446|Compound:4239-0190|FD-Score:-3.51|P-value:5.26E-4 ID:SGTC_1606|Compound:st000094|FD-Score:-4.01|P-value:9.29E-5 ID:SGTC_1628|Compound:st004252|FD-Score:3.56|P-value:4.82E-4 ID:SGTC_1727|Compound:st034309|FD-Score:3.82|P-value:1.97E-4 ID:SGTC_1750|Compound:st081859|FD-Score:-3.36|P-value:8.46E-4 ID:SGTC_1843|Compound:st055809|FD-Score:4.47|P-value:1.72E-5 ID:SGTC_1851|Compound:st056236|FD-Score:-3.78|P-value:2.09E-4 ID:SGTC_1860|Compound:st056228|FD-Score:-7.48|P-value:1.59E-12 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:5.31|P-value:4.19E-7 ID:SGTC_1972|Compound:st070201|FD-Score:3.78|P-value:2.32E-4 ID:SGTC_1984|Compound:st072354|FD-Score:3.87|P-value:1.67E-4 ID:SGTC_2080|Compound:5212524|FD-Score:5.94|P-value:1.76E-8 ID:SGTC_2552|Compound:juarezic acid|FD-Score:4.03|P-value:9.32E-5 ID:SGTC_2568|Compound:diosmetin|FD-Score:-5.08|P-value:1.09E-6 ID:SGTC_2570|Compound:licareol|FD-Score:-4.07|P-value:7.31E-5 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:6.61|P-value:4.17E-10 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:-3.67|P-value:3.12E-4 ID:SGTC_2692|Compound:st077426|FD-Score:5.08|P-value:1.20E-6 ID:SGTC_2693|Compound:st077581|FD-Score:5.59|P-value:1.07E-7 ID:SGTC_2694|Compound:st077685|FD-Score:3.86|P-value:1.70E-4 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:-5.29|P-value:4.01E-7 ID:SGTC_2990|Compound:9074105|FD-Score:-3.81|P-value:1.90E-4 ID:SGTC_2992|Compound:9074591|FD-Score:-4.20|P-value:4.46E-5 ID:SGTC_3025|Compound:9087895|FD-Score:4.69|P-value:6.86E-6 ID:SGTC_3165|Compound:9101544|FD-Score:3.66|P-value:3.43E-4 ID:SGTC_3264|Compound:9137442|FD-Score:4.08|P-value:7.73E-5 ID:SGTC_3323|Compound:9138564|FD-Score:-3.42|P-value:7.04E-4 ID:SGTC_3356|Compound:9151811|FD-Score:-3.54|P-value:4.78E-4 ID:SGTC_81|Compound:0411-0046|FD-Score:5.80|P-value:3.63E-8 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.88|P-value:2.72E-6 ID:SGTC_496|Compound:calpeptin|FD-Score:-5.23|P-value:5.34E-7 ID:SGTC_737|Compound:1950-0117|FD-Score:-3.78|P-value:2.10E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:3.46|P-value:6.67E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:4.75|P-value:5.19E-6 ID:SGTC_1111|Compound:tnp00062|FD-Score:-3.82|P-value:1.85E-4 ID:SGTC_1446|Compound:4239-0190|FD-Score:-3.51|P-value:5.26E-4 ID:SGTC_1606|Compound:st000094|FD-Score:-4.01|P-value:9.29E-5 ID:SGTC_1628|Compound:st004252|FD-Score:3.56|P-value:4.82E-4 ID:SGTC_1727|Compound:st034309|FD-Score:3.82|P-value:1.97E-4 ID:SGTC_1750|Compound:st081859|FD-Score:-3.36|P-value:8.46E-4 ID:SGTC_1843|Compound:st055809|FD-Score:4.47|P-value:1.72E-5 ID:SGTC_1851|Compound:st056236|FD-Score:-3.78|P-value:2.09E-4 ID:SGTC_1860|Compound:st056228|FD-Score:-7.48|P-value:1.59E-12 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:5.31|P-value:4.19E-7 ID:SGTC_1972|Compound:st070201|FD-Score:3.78|P-value:2.32E-4 ID:SGTC_1984|Compound:st072354|FD-Score:3.87|P-value:1.67E-4 ID:SGTC_2080|Compound:5212524|FD-Score:5.94|P-value:1.76E-8 ID:SGTC_2552|Compound:juarezic acid|FD-Score:4.03|P-value:9.32E-5 ID:SGTC_2568|Compound:diosmetin|FD-Score:-5.08|P-value:1.09E-6 ID:SGTC_2570|Compound:licareol|FD-Score:-4.07|P-value:7.31E-5 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:6.61|P-value:4.17E-10 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:-3.67|P-value:3.12E-4 ID:SGTC_2692|Compound:st077426|FD-Score:5.08|P-value:1.20E-6 ID:SGTC_2693|Compound:st077581|FD-Score:5.59|P-value:1.07E-7 ID:SGTC_2694|Compound:st077685|FD-Score:3.86|P-value:1.70E-4 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:-5.29|P-value:4.01E-7 ID:SGTC_2990|Compound:9074105|FD-Score:-3.81|P-value:1.90E-4 ID:SGTC_2992|Compound:9074591|FD-Score:-4.20|P-value:4.46E-5 ID:SGTC_3025|Compound:9087895|FD-Score:4.69|P-value:6.86E-6 ID:SGTC_3165|Compound:9101544|FD-Score:3.66|P-value:3.43E-4 ID:SGTC_3264|Compound:9137442|FD-Score:4.08|P-value:7.73E-5 ID:SGTC_3323|Compound:9138564|FD-Score:-3.42|P-value:7.04E-4 ID:SGTC_3356|Compound:9151811|FD-Score:-3.54|P-value:4.78E-4

Top fitness defect scores for YGR120C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 6.61 13.2 µM 4.17E-10 1 1.90E-11 0.86
2 SGTC_2080 5212524 5.94 12.4 µM 1.76E-8 copper-dependent oxidative stress 1 1.43E-9 0.84
3 SGTC_81 0411-0046 5.80 10.0 µM 3.63E-8 21 3.29E-9 0.33
4 SGTC_2693 st077581 5.59 40.7 µM 1.07E-7 2 1.15E-8 0.93
5 SGTC_1869 3',7'-dimethoxyflavone 5.31 40.3 µM 4.19E-7 1 5.54E-8 1.62
6 SGTC_2692 st077426 5.08 47.7 µM 1.20E-6 3 1.86E-7 0.63
7 SGTC_1082 camptothecin 4.75 424.9 nM 5.19E-6 DNA damage response 13 1.01E-6 0.20
8 SGTC_3025 9087895 4.69 49.5 µM 6.86E-6 PDR1 2 1.39E-6 0.37
9 SGTC_1843 st055809 4.47 45.5 µM 1.72E-5 2 3.99E-6 0.30
10 SGTC_3264 9137442 4.08 49.5 µM 7.73E-5 4 2.26E-5 0.00
11 SGTC_2552 juarezic acid 4.03 87.0 µM 9.32E-5 TSC3-RPN4 2 2.80E-5 0.43
12 SGTC_1984 st072354 3.87 53.1 µM 1.67E-4 1 5.48E-5 0.31
13 SGTC_2694 st077685 3.86 81.9 µM 1.70E-4 endomembrane recycling 6 5.59E-5 0.02
14 SGTC_1727 st034309 3.82 9.9 µM 1.97E-4 17 6.62E-5 0.08
15 SGTC_1972 st070201 3.78 17.4 µM 2.32E-4 3 8.00E-5 0.03
16 SGTC_3165 9101544 3.66 49.5 µM 3.43E-4 5 1.25E-4 0.06
17 SGTC_1628 st004252 3.56 77.7 µM 4.82E-4 6 1.85E-4 0.12
18 SGTC_1027 k015-0025 3.46 8.7 µM 6.67E-4 8 2.69E-4 0.09
19 SGTC_2569 tetrandrine 3.32 100.0 µM 0.00105 10 4.54E-4 0.15
20 SGTC_1857 st056007 3.31 79.3 µM 0.00107 5 4.64E-4 0.25

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.111 1.21E-10 YKL221W MCH2 hom Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport
0.109 2.52E-10 YML116W ATR1 hom Multidrug efflux pump of the major facilitator superfamily; required for resistance to aminotriazole and 4-nitroquinoline-N-oxide; ATR1 has a paralog, YMR279C, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.100 6.03E-9 YMR133W REC114 hom Protein involved in early stages of meiotic recombination; possibly involved in the coordination of recombination and meiotic division; mutations lead to premature initiation of the first meiotic division
0.099 8.91E-9 YBL066C SEF1 hom Putative transcription factor, has homolog in Kluyveromyces lactis
0.095 6.50E-8 YKR099W BAS1 hom Myb-related transcription factor involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways; also involved in regulation of meiotic recombination at specific genes
0.094 4.22E-8 YJR092W BUD4 hom Anillin-like protein involved in bud-site selection; required for the axial budding pattern; localizes with septins to the bud neck in mitosis and may constitute an axial landmark for the next round of budding; required for the formation and disassembly of the double septin ring structure, and generally for septin organization; in vivo substrate of Cdc28p/Clb2p
0.085 8.42E-7 YDL174C DLD1 hom D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane
0.083 1.36E-6 YDR386W MUS81 hom Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in DNA repair, replication fork stability, and joint molecule formation/resolution during meiotic recombination; helix-hairpin-helix protein; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p
0.083 1.55E-6 YDR246W TRS23 het One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic; human homolog is TRAPPC4
0.082 1.74E-6 YPL128C TBF1 het Telobox-containing general regulatory factor; binds TTAGGG repeats within subtelomeric anti-silencing regions (STARs), blocking silent chromatin propagation; binds majority of snoRNA gene promoters, required for full snoRNA expression; caps DSB flanked by long T2AG3 repeats and blocks checkpoint activation
0.082 2.23E-6 YDR189W SLY1 het Hydrophilic protein involved in vesicle trafficking between the ER and Golgi; SM (Sec1/Munc-18) family protein that binds the tSNARE Sed5p and stimulates its assembly into a trans-SNARE membrane-protein complex
0.081 2.52E-6 YBR258C SHG1 hom Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres
0.079 4.83E-6 YDR272W GLO2 hom Cytoplasmic glyoxalase II, catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate
0.077 8.75E-6 YGL229C SAP4 hom Protein required for function of the Sit4p protein phosphatase, member of a family of similar proteins that form complexes with Sit4p, including Sap155p, Sap185p, and Sap190p
0.076 1.14E-5 YOR020W-A_p YOR020W-A_p hom Putative protein of unknown function, conserved in A. gossypii; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies