YGR121C / MEP1

Ammonium permease; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR121C / MEP1

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:-3.85|P-value:6.27E-5 ID:SGTC_70|Compound:0141-0289|FD-Score:3.31|P-value:3.70E-4 ID:SGTC_77|Compound:0828-0286|FD-Score:3.18|P-value:5.88E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:5.39|P-value:2.13E-8 ID:SGTC_153|Compound:4077-0274|FD-Score:-3.24|P-value:6.44E-4 ID:SGTC_293|Compound:4049-0273|FD-Score:4.25|P-value:7.75E-6 ID:SGTC_531|Compound:3788-1495|FD-Score:-3.20|P-value:7.38E-4 ID:SGTC_687|Compound:k029-0044|FD-Score:5.96|P-value:7.12E-10 ID:SGTC_869|Compound:0564-0080|FD-Score:3.19|P-value:5.59E-4 ID:SGTC_917|Compound:harmaline|FD-Score:3.36|P-value:3.03E-4 ID:SGTC_921|Compound:1561-0023|FD-Score:-3.29|P-value:5.25E-4 ID:SGTC_1094|Compound:duloxetine|FD-Score:3.57|P-value:1.38E-4 ID:SGTC_1298|Compound:1079-1278|FD-Score:3.70|P-value:8.11E-5 ID:SGTC_1303|Compound:1160-0052|FD-Score:3.69|P-value:8.32E-5 ID:SGTC_1308|Compound:1187-1617|FD-Score:3.68|P-value:8.64E-5 ID:SGTC_1338|Compound:1486-1223|FD-Score:3.57|P-value:1.33E-4 ID:SGTC_1385|Compound:3091-4834|FD-Score:4.08|P-value:1.60E-5 ID:SGTC_1514|Compound:1189-1591|FD-Score:3.40|P-value:2.65E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:-3.19|P-value:7.46E-4 ID:SGTC_1543|Compound:azetidyl-2-carboxylic acid|FD-Score:-3.14|P-value:8.94E-4 ID:SGTC_1549|Compound:4'-methoxyflavonol|FD-Score:-4.16|P-value:1.70E-5 ID:SGTC_1602|Compound:st001878|FD-Score:-3.55|P-value:2.05E-4 ID:SGTC_1674|Compound:st016616|FD-Score:3.32|P-value:3.53E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:3.53|P-value:1.58E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:3.17|P-value:6.10E-4 ID:SGTC_1835|Compound:st008666|FD-Score:4.58|P-value:1.55E-6 ID:SGTC_1913|Compound:st060213|FD-Score:-3.66|P-value:1.32E-4 ID:SGTC_2004|Compound:4023728|FD-Score:-3.48|P-value:2.67E-4 ID:SGTC_2022|Compound:5136654|FD-Score:3.37|P-value:2.92E-4 ID:SGTC_2284|Compound:7945075|FD-Score:-3.44|P-value:3.05E-4 ID:SGTC_2359|Compound:9039622|FD-Score:-3.89|P-value:5.36E-5 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:3.91|P-value:3.34E-5 ID:SGTC_2408|Compound:sulbentine|FD-Score:-3.61|P-value:1.63E-4 ID:SGTC_2416|Compound:tofa|FD-Score:3.04|P-value:9.54E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:-3.77|P-value:8.47E-5 ID:SGTC_2452|Compound:5863136|FD-Score:3.33|P-value:3.41E-4 ID:SGTC_2481|Compound:5478948|FD-Score:3.07|P-value:8.59E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:-4.35|P-value:7.17E-6 ID:SGTC_2537|Compound:larixol|FD-Score:-7.41|P-value:5.46E-14 ID:SGTC_2558|Compound:carylophyllene oxide|FD-Score:3.06|P-value:8.88E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:3.36|P-value:3.08E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-3.40|P-value:3.64E-4 ID:SGTC_2770|Compound:toltrazuril|FD-Score:-3.49|P-value:2.57E-4 ID:SGTC_2862|Compound:9027634|FD-Score:4.22|P-value:8.64E-6 ID:SGTC_2869|Compound:9037858|FD-Score:3.90|P-value:3.52E-5 ID:SGTC_2871|Compound:9038510|FD-Score:3.22|P-value:5.03E-4 ID:SGTC_2876|Compound:9059903|FD-Score:-3.22|P-value:6.71E-4 ID:SGTC_2909|Compound:7941780|FD-Score:-9.01|P-value:7.65E-20 ID:SGTC_2914|Compound:7968218|FD-Score:-3.72|P-value:1.05E-4 ID:SGTC_2933|Compound:9026794|FD-Score:3.46|P-value:2.10E-4 ID:SGTC_2934|Compound:9036370|FD-Score:-4.37|P-value:6.58E-6 ID:SGTC_2936|Compound:9038235|FD-Score:3.10|P-value:7.76E-4 ID:SGTC_2949|Compound:9072542|FD-Score:3.20|P-value:5.41E-4 ID:SGTC_2959|Compound:9079155|FD-Score:-3.93|P-value:4.45E-5 ID:SGTC_2963|Compound:9082507|FD-Score:-3.90|P-value:5.01E-5 ID:SGTC_3006|Compound:9075424|FD-Score:-3.92|P-value:4.71E-5 ID:SGTC_3008|Compound:9078912|FD-Score:3.64|P-value:1.02E-4 ID:SGTC_3100|Compound:9120536|FD-Score:-3.25|P-value:6.23E-4 ID:SGTC_3104|Compound:9120930|FD-Score:-5.61|P-value:1.03E-8 ID:SGTC_3106|Compound:9121286|FD-Score:3.05|P-value:9.09E-4 ID:SGTC_3107|Compound:9121808|FD-Score:-4.96|P-value:3.62E-7 ID:SGTC_3112|Compound:9123419|FD-Score:3.87|P-value:3.93E-5 ID:SGTC_3119|Compound:9125183|FD-Score:-3.15|P-value:8.76E-4 ID:SGTC_3124|Compound:9127567|FD-Score:-3.66|P-value:1.35E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.85|P-value:6.27E-5 ID:SGTC_70|Compound:0141-0289|FD-Score:3.31|P-value:3.70E-4 ID:SGTC_77|Compound:0828-0286|FD-Score:3.18|P-value:5.88E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:5.39|P-value:2.13E-8 ID:SGTC_153|Compound:4077-0274|FD-Score:-3.24|P-value:6.44E-4 ID:SGTC_293|Compound:4049-0273|FD-Score:4.25|P-value:7.75E-6 ID:SGTC_531|Compound:3788-1495|FD-Score:-3.20|P-value:7.38E-4 ID:SGTC_687|Compound:k029-0044|FD-Score:5.96|P-value:7.12E-10 ID:SGTC_869|Compound:0564-0080|FD-Score:3.19|P-value:5.59E-4 ID:SGTC_917|Compound:harmaline|FD-Score:3.36|P-value:3.03E-4 ID:SGTC_921|Compound:1561-0023|FD-Score:-3.29|P-value:5.25E-4 ID:SGTC_1094|Compound:duloxetine|FD-Score:3.57|P-value:1.38E-4 ID:SGTC_1298|Compound:1079-1278|FD-Score:3.70|P-value:8.11E-5 ID:SGTC_1303|Compound:1160-0052|FD-Score:3.69|P-value:8.32E-5 ID:SGTC_1308|Compound:1187-1617|FD-Score:3.68|P-value:8.64E-5 ID:SGTC_1338|Compound:1486-1223|FD-Score:3.57|P-value:1.33E-4 ID:SGTC_1385|Compound:3091-4834|FD-Score:4.08|P-value:1.60E-5 ID:SGTC_1514|Compound:1189-1591|FD-Score:3.40|P-value:2.65E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:-3.19|P-value:7.46E-4 ID:SGTC_1543|Compound:azetidyl-2-carboxylic acid|FD-Score:-3.14|P-value:8.94E-4 ID:SGTC_1549|Compound:4'-methoxyflavonol|FD-Score:-4.16|P-value:1.70E-5 ID:SGTC_1602|Compound:st001878|FD-Score:-3.55|P-value:2.05E-4 ID:SGTC_1674|Compound:st016616|FD-Score:3.32|P-value:3.53E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:3.53|P-value:1.58E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:3.17|P-value:6.10E-4 ID:SGTC_1835|Compound:st008666|FD-Score:4.58|P-value:1.55E-6 ID:SGTC_1913|Compound:st060213|FD-Score:-3.66|P-value:1.32E-4 ID:SGTC_2004|Compound:4023728|FD-Score:-3.48|P-value:2.67E-4 ID:SGTC_2022|Compound:5136654|FD-Score:3.37|P-value:2.92E-4 ID:SGTC_2284|Compound:7945075|FD-Score:-3.44|P-value:3.05E-4 ID:SGTC_2359|Compound:9039622|FD-Score:-3.89|P-value:5.36E-5 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:3.91|P-value:3.34E-5 ID:SGTC_2408|Compound:sulbentine|FD-Score:-3.61|P-value:1.63E-4 ID:SGTC_2416|Compound:tofa|FD-Score:3.04|P-value:9.54E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:-3.77|P-value:8.47E-5 ID:SGTC_2452|Compound:5863136|FD-Score:3.33|P-value:3.41E-4 ID:SGTC_2481|Compound:5478948|FD-Score:3.07|P-value:8.59E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:-4.35|P-value:7.17E-6 ID:SGTC_2537|Compound:larixol|FD-Score:-7.41|P-value:5.46E-14 ID:SGTC_2558|Compound:carylophyllene oxide|FD-Score:3.06|P-value:8.88E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:3.36|P-value:3.08E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-3.40|P-value:3.64E-4 ID:SGTC_2770|Compound:toltrazuril|FD-Score:-3.49|P-value:2.57E-4 ID:SGTC_2862|Compound:9027634|FD-Score:4.22|P-value:8.64E-6 ID:SGTC_2869|Compound:9037858|FD-Score:3.90|P-value:3.52E-5 ID:SGTC_2871|Compound:9038510|FD-Score:3.22|P-value:5.03E-4 ID:SGTC_2876|Compound:9059903|FD-Score:-3.22|P-value:6.71E-4 ID:SGTC_2909|Compound:7941780|FD-Score:-9.01|P-value:7.65E-20 ID:SGTC_2914|Compound:7968218|FD-Score:-3.72|P-value:1.05E-4 ID:SGTC_2933|Compound:9026794|FD-Score:3.46|P-value:2.10E-4 ID:SGTC_2934|Compound:9036370|FD-Score:-4.37|P-value:6.58E-6 ID:SGTC_2936|Compound:9038235|FD-Score:3.10|P-value:7.76E-4 ID:SGTC_2949|Compound:9072542|FD-Score:3.20|P-value:5.41E-4 ID:SGTC_2959|Compound:9079155|FD-Score:-3.93|P-value:4.45E-5 ID:SGTC_2963|Compound:9082507|FD-Score:-3.90|P-value:5.01E-5 ID:SGTC_3006|Compound:9075424|FD-Score:-3.92|P-value:4.71E-5 ID:SGTC_3008|Compound:9078912|FD-Score:3.64|P-value:1.02E-4 ID:SGTC_3100|Compound:9120536|FD-Score:-3.25|P-value:6.23E-4 ID:SGTC_3104|Compound:9120930|FD-Score:-5.61|P-value:1.03E-8 ID:SGTC_3106|Compound:9121286|FD-Score:3.05|P-value:9.09E-4 ID:SGTC_3107|Compound:9121808|FD-Score:-4.96|P-value:3.62E-7 ID:SGTC_3112|Compound:9123419|FD-Score:3.87|P-value:3.93E-5 ID:SGTC_3119|Compound:9125183|FD-Score:-3.15|P-value:8.76E-4 ID:SGTC_3124|Compound:9127567|FD-Score:-3.66|P-value:1.35E-4

Top fitness defect scores for YGR121C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_687 k029-0044 5.96 34.9 µM 7.12E-10 PDR1 5 1.24E-9
2 SGTC_143 4032-1194 5.39 15.7 µM 2.13E-8 24 3.45E-8
3 SGTC_1835 st008666 4.58 49.2 µM 1.55E-6 15 2.27E-6
4 SGTC_293 4049-0273 4.25 38.5 µM 7.75E-6 12 1.09E-5
5 SGTC_2862 9027634 4.22 71.4 µM 8.64E-6 ERG2 24 1.22E-5
6 SGTC_1385 3091-4834 4.08 14.1 µM 1.60E-5 RPP1 & pyrimidine depletion 18 2.22E-5
7 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 3.91 200.0 µM 3.34E-5 14 4.55E-5
8 SGTC_2869 9037858 3.90 32.5 µM 3.52E-5 13 4.79E-5
9 SGTC_3112 9123419 3.87 49.5 µM 3.93E-5 RPP1 & pyrimidine depletion 16 5.34E-5
10 SGTC_1298 1079-1278 3.70 263.0 µM 8.11E-5 DNA damage response 24 1.08E-4
11 SGTC_1303 1160-0052 3.69 261.0 µM 8.32E-5 11 1.11E-4
12 SGTC_1308 1187-1617 3.68 41.4 µM 8.64E-5 fatty acid desaturase (OLE1) 51 1.15E-4
13 SGTC_3008 9078912 3.64 71.4 µM 1.02E-4 26 1.35E-4
14 SGTC_1338 1486-1223 3.57 76.0 µM 1.33E-4 32 1.75E-4
15 SGTC_1094 duloxetine 3.57 25.4 µM 1.38E-4 RPP1 & pyrimidine depletion 29 1.81E-4
16 SGTC_1680 diphenhydramine 3.53 100.0 µM 1.58E-4 NEO1 44 2.07E-4
17 SGTC_2933 9026794 3.46 32.5 µM 2.10E-4 42 2.73E-4
18 SGTC_1514 1189-1591 3.40 158.0 µM 2.65E-4 63 3.43E-4
19 SGTC_2022 5136654 3.37 200.0 µM 2.92E-4 42 3.77E-4
20 SGTC_917 harmaline 3.36 728.1 nM 3.03E-4 ergosterol biosynthesis 49 3.91E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.116 1.48E-11 YGR173W RBG2 hom Protein with a role in translation; forms a complex with Gir2p; has similarity to mammalian developmentally regulated GTP-binding protein
0.112 6.73E-11 YGR143W SKN1 hom Protein involved in sphingolipid biosynthesis; type II membrane protein with similarity to Kre6p
0.110 1.86E-10 YHL042W_p YHL042W_p hom Putative protein of unknown function; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
0.109 2.40E-10 YCR027C RHB1 hom Putative Rheb-related GTPase involved in regulating canavanine resistance and arginine uptake; member of the Ras superfamily of G-proteins
0.107 4.45E-10 YPL140C MKK2 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk1p; MKK2 has a paralog, MKK1, that arose from the whole genome duplication
0.097 2.10E-8 YDR055W PST1 hom Cell wall protein that contains a putative GPI-attachment site; secreted by regenerating protoplasts; up-regulated by activation of the cell integrity pathway, as mediated by Rlm1p; upregulated by cell wall damage via disruption of FKS1
0.091 1.35E-7 YLR078C BOS1 het v-SNARE (vesicle specific SNAP receptor), localized to the endoplasmic reticulum membrane and necessary for vesicular transport from the ER to the Golgi
0.089 2.17E-7 YER152C YER152C hom Protein with 2-aminoadipate transaminase activity; shares amino acid similarity with the aminotransferases Aro8p and Aro9p; YER152C is not an essential gene
0.089 2.23E-7 YKL065C YET1 hom Endoplasmic reticulum transmembrane protein; may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein
0.089 2.38E-7 YDR015C_d YDR015C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene HED1/YDR014W-A
0.087 4.46E-7 YFL021W GAT1 hom Transcriptional activator of genes involved in nitrogen catabolite repression; contains a GATA-1-type zinc finger DNA-binding motif; activity and localization regulated by nitrogen limitation and Ure2p
0.080 3.90E-6 YJL142C_d IRC9_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene YJL141C; null mutant displays increased levels of spontaneous Rad52p foci
0.079 4.63E-6 YDL096C_d OPI6_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene PMT1/YDL095W; YDL096C is not essential
0.073 2.60E-5 YIL011W TIR3 hom Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth
0.071 3.49E-5 YKR088C TVP38 hom Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; required for asymmetric localization of Kar9p during mitosis; GFP-fusion protein localizes to the cytoplasm in a punctate pattern