YGR125W_p

Putative protein of unknown function; deletion mutant has decreased rapamycin resistance but normal wormannin resistance; green fluorescent protein (GFP)-fusion protein localizes to the vacuole

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR125W / YGR125W

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:3.14|P-value:9.50E-4 ID:SGTC_15|Compound:0266-0086|FD-Score:3.48|P-value:2.83E-4 ID:SGTC_24|Compound:0417-1663|FD-Score:-3.36|P-value:4.98E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.56|P-value:3.79E-6 ID:SGTC_61|Compound:0978-8327|FD-Score:3.50|P-value:2.61E-4 ID:SGTC_77|Compound:0828-0286|FD-Score:3.13|P-value:9.60E-4 ID:SGTC_83|Compound:0170-0301|FD-Score:5.04|P-value:3.08E-7 ID:SGTC_93|Compound:0109-0045|FD-Score:4.25|P-value:1.31E-5 ID:SGTC_96|Compound:0929-0093|FD-Score:3.16|P-value:8.71E-4 ID:SGTC_122|Compound:0236-0016|FD-Score:3.55|P-value:2.17E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:3.57|P-value:2.05E-4 ID:SGTC_162|Compound:k030-0015|FD-Score:3.76|P-value:9.88E-5 ID:SGTC_170|Compound:4197-0004|FD-Score:3.15|P-value:8.92E-4 ID:SGTC_271|Compound:rotenone|FD-Score:3.88|P-value:6.21E-5 ID:SGTC_321|Compound:4534-3890|FD-Score:-3.66|P-value:1.61E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:3.29|P-value:5.69E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:-3.40|P-value:4.18E-4 ID:SGTC_570|Compound:0987-0065|FD-Score:3.77|P-value:9.36E-5 ID:SGTC_582|Compound:0987-0078|FD-Score:3.16|P-value:8.80E-4 ID:SGTC_731|Compound:3966-0296|FD-Score:4.79|P-value:1.11E-6 ID:SGTC_737|Compound:1950-0117|FD-Score:4.17|P-value:1.89E-5 ID:SGTC_740|Compound:k014-0057|FD-Score:5.20|P-value:1.35E-7 ID:SGTC_766|Compound:1391-0721|FD-Score:3.53|P-value:2.37E-4 ID:SGTC_809|Compound:3998-0021|FD-Score:4.85|P-value:7.94E-7 ID:SGTC_858|Compound:0438-0351|FD-Score:-3.18|P-value:9.05E-4 ID:SGTC_904|Compound:1141-0088|FD-Score:3.24|P-value:6.59E-4 ID:SGTC_917|Compound:harmaline|FD-Score:5.55|P-value:2.07E-8 ID:SGTC_1330|Compound:1469-0054|FD-Score:3.95|P-value:4.60E-5 ID:SGTC_1333|Compound:1482-0047|FD-Score:-3.73|P-value:1.27E-4 ID:SGTC_1336|Compound:1486-0901|FD-Score:3.81|P-value:8.22E-5 ID:SGTC_1403|Compound:3909-7815|FD-Score:4.39|P-value:6.93E-6 ID:SGTC_1433|Compound:4060-0023|FD-Score:-3.33|P-value:5.52E-4 ID:SGTC_1449|Compound:4112-4002|FD-Score:3.24|P-value:6.65E-4 ID:SGTC_1468|Compound:k284-1086|FD-Score:4.55|P-value:3.40E-6 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:3.67|P-value:1.38E-4 ID:SGTC_1591|Compound:genipin|FD-Score:-4.17|P-value:2.07E-5 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:3.66|P-value:1.46E-4 ID:SGTC_1740|Compound:st038286|FD-Score:3.39|P-value:3.88E-4 ID:SGTC_1812|Compound:st052057|FD-Score:3.42|P-value:3.49E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:3.45|P-value:3.13E-4 ID:SGTC_2011|Compound:4012611|FD-Score:4.40|P-value:6.86E-6 ID:SGTC_2113|Compound:5491891|FD-Score:3.25|P-value:6.34E-4 ID:SGTC_2377|Compound:9073351|FD-Score:4.11|P-value:2.43E-5 ID:SGTC_2382|Compound:9035899|FD-Score:3.90|P-value:5.63E-5 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-5.18|P-value:1.78E-7 ID:SGTC_2533|Compound:agelasine|FD-Score:-4.43|P-value:6.78E-6 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:-6.09|P-value:1.09E-9 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:3.83|P-value:7.61E-5 ID:SGTC_2618|Compound:avocadyne|FD-Score:3.46|P-value:3.04E-4 ID:SGTC_2689|Compound:tacrolimus|FD-Score:3.45|P-value:3.20E-4 ID:SGTC_2692|Compound:st077426|FD-Score:-4.16|P-value:2.25E-5 ID:SGTC_2771|Compound:fluoxetine|FD-Score:3.40|P-value:3.85E-4 ID:SGTC_2825|Compound:7998094|FD-Score:-4.59|P-value:3.29E-6 ID:SGTC_3141|Compound:9094609|FD-Score:3.19|P-value:7.78E-4 ID:SGTC_3254|Compound:9136651|FD-Score:3.26|P-value:6.19E-4 ID:SGTC_3296|Compound:9122258|FD-Score:3.46|P-value:3.10E-4 ID:SGTC_3334|Compound:9142812|FD-Score:4.28|P-value:1.15E-5 ID:SGTC_8|Compound:0354-0001|FD-Score:3.14|P-value:9.50E-4 ID:SGTC_15|Compound:0266-0086|FD-Score:3.48|P-value:2.83E-4 ID:SGTC_24|Compound:0417-1663|FD-Score:-3.36|P-value:4.98E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.56|P-value:3.79E-6 ID:SGTC_61|Compound:0978-8327|FD-Score:3.50|P-value:2.61E-4 ID:SGTC_77|Compound:0828-0286|FD-Score:3.13|P-value:9.60E-4 ID:SGTC_83|Compound:0170-0301|FD-Score:5.04|P-value:3.08E-7 ID:SGTC_93|Compound:0109-0045|FD-Score:4.25|P-value:1.31E-5 ID:SGTC_96|Compound:0929-0093|FD-Score:3.16|P-value:8.71E-4 ID:SGTC_122|Compound:0236-0016|FD-Score:3.55|P-value:2.17E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:3.57|P-value:2.05E-4 ID:SGTC_162|Compound:k030-0015|FD-Score:3.76|P-value:9.88E-5 ID:SGTC_170|Compound:4197-0004|FD-Score:3.15|P-value:8.92E-4 ID:SGTC_271|Compound:rotenone|FD-Score:3.88|P-value:6.21E-5 ID:SGTC_321|Compound:4534-3890|FD-Score:-3.66|P-value:1.61E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:3.29|P-value:5.69E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:-3.40|P-value:4.18E-4 ID:SGTC_570|Compound:0987-0065|FD-Score:3.77|P-value:9.36E-5 ID:SGTC_582|Compound:0987-0078|FD-Score:3.16|P-value:8.80E-4 ID:SGTC_731|Compound:3966-0296|FD-Score:4.79|P-value:1.11E-6 ID:SGTC_737|Compound:1950-0117|FD-Score:4.17|P-value:1.89E-5 ID:SGTC_740|Compound:k014-0057|FD-Score:5.20|P-value:1.35E-7 ID:SGTC_766|Compound:1391-0721|FD-Score:3.53|P-value:2.37E-4 ID:SGTC_809|Compound:3998-0021|FD-Score:4.85|P-value:7.94E-7 ID:SGTC_858|Compound:0438-0351|FD-Score:-3.18|P-value:9.05E-4 ID:SGTC_904|Compound:1141-0088|FD-Score:3.24|P-value:6.59E-4 ID:SGTC_917|Compound:harmaline|FD-Score:5.55|P-value:2.07E-8 ID:SGTC_1330|Compound:1469-0054|FD-Score:3.95|P-value:4.60E-5 ID:SGTC_1333|Compound:1482-0047|FD-Score:-3.73|P-value:1.27E-4 ID:SGTC_1336|Compound:1486-0901|FD-Score:3.81|P-value:8.22E-5 ID:SGTC_1403|Compound:3909-7815|FD-Score:4.39|P-value:6.93E-6 ID:SGTC_1433|Compound:4060-0023|FD-Score:-3.33|P-value:5.52E-4 ID:SGTC_1449|Compound:4112-4002|FD-Score:3.24|P-value:6.65E-4 ID:SGTC_1468|Compound:k284-1086|FD-Score:4.55|P-value:3.40E-6 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:3.67|P-value:1.38E-4 ID:SGTC_1591|Compound:genipin|FD-Score:-4.17|P-value:2.07E-5 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:3.66|P-value:1.46E-4 ID:SGTC_1740|Compound:st038286|FD-Score:3.39|P-value:3.88E-4 ID:SGTC_1812|Compound:st052057|FD-Score:3.42|P-value:3.49E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:3.45|P-value:3.13E-4 ID:SGTC_2011|Compound:4012611|FD-Score:4.40|P-value:6.86E-6 ID:SGTC_2113|Compound:5491891|FD-Score:3.25|P-value:6.34E-4 ID:SGTC_2377|Compound:9073351|FD-Score:4.11|P-value:2.43E-5 ID:SGTC_2382|Compound:9035899|FD-Score:3.90|P-value:5.63E-5 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-5.18|P-value:1.78E-7 ID:SGTC_2533|Compound:agelasine|FD-Score:-4.43|P-value:6.78E-6 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:-6.09|P-value:1.09E-9 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:3.83|P-value:7.61E-5 ID:SGTC_2618|Compound:avocadyne|FD-Score:3.46|P-value:3.04E-4 ID:SGTC_2689|Compound:tacrolimus|FD-Score:3.45|P-value:3.20E-4 ID:SGTC_2692|Compound:st077426|FD-Score:-4.16|P-value:2.25E-5 ID:SGTC_2771|Compound:fluoxetine|FD-Score:3.40|P-value:3.85E-4 ID:SGTC_2825|Compound:7998094|FD-Score:-4.59|P-value:3.29E-6 ID:SGTC_3141|Compound:9094609|FD-Score:3.19|P-value:7.78E-4 ID:SGTC_3254|Compound:9136651|FD-Score:3.26|P-value:6.19E-4 ID:SGTC_3296|Compound:9122258|FD-Score:3.46|P-value:3.10E-4 ID:SGTC_3334|Compound:9142812|FD-Score:4.28|P-value:1.15E-5

Top fitness defect scores for YGR125W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_917 harmaline 5.55 728.1 nM 2.07E-8 ergosterol biosynthesis 8 1.44E-8
2 SGTC_740 k014-0057 5.20 261.0 µM 1.35E-7 6 9.84E-8
3 SGTC_83 0170-0301 5.04 39.0 µM 3.08E-7 endomembrane recycling 2 2.29E-7
4 SGTC_809 3998-0021 4.85 90.0 µM 7.94E-7 RNA processing & uracil transport 6 6.04E-7
5 SGTC_731 3966-0296 4.79 387.0 µM 1.11E-6 5 8.50E-7
6 SGTC_1468 k284-1086 4.55 134.0 µM 3.40E-6 DNA intercalators 18 2.68E-6
7 SGTC_2011 4012611 4.40 177.0 µM 6.86E-6 mitochondrial processes 18 5.51E-6
8 SGTC_1403 3909-7815 4.39 62.9 µM 6.93E-6 12 5.57E-6
9 SGTC_3334 9142812 4.28 21.9 µM 1.15E-5 22 9.36E-6
10 SGTC_93 0109-0045 4.25 59.2 µM 1.31E-5 DNA damage response 31 1.07E-5
11 SGTC_737 1950-0117 4.17 57.9 µM 1.89E-5 21 1.55E-5
12 SGTC_2377 9073351 4.11 62.6 µM 2.43E-5 ergosterol biosynthesis 21 2.02E-5
13 SGTC_1330 1469-0054 3.95 61.8 µM 4.60E-5 iron homeostasis 17 3.87E-5
14 SGTC_2382 9035899 3.90 200.0 µM 5.63E-5 60S ribosome export 15 4.76E-5
15 SGTC_271 rotenone 3.88 740.0 µM 6.21E-5 26 5.27E-5
16 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 3.83 15.3 µM 7.61E-5 36 6.48E-5
17 SGTC_1336 1486-0901 3.81 104.0 µM 8.22E-5 24 7.02E-5
18 SGTC_570 0987-0065 3.77 62.6 µM 9.36E-5 60S ribosome export 9 8.02E-5
19 SGTC_162 k030-0015 3.76 37.8 µM 9.88E-5 iron homeostasis 25 8.47E-5
20 SGTC_1584 6-fluoro-dl-tryptophan 3.67 90.0 µM 1.38E-4 mitochondrial processes 22 1.19E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.117 1.27E-11 YHR072W ERG7 het Lanosterol synthase, an essential enzyme that catalyzes the cyclization of squalene 2,3-epoxide, a step in ergosterol biosynthesis
0.106 7.67E-10 YMR305C SCW10 hom Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on mutant phenotype and its regulation by Ste12p
0.098 1.09E-8 YDR482C CWC21 hom Protein involved in RNA splicing by the spliceosome; component of a complex containing Cef1p; interacts genetically with ISY1 and BUD13; may bind RNA; has similarity to S. pombe Cwf21p
0.088 3.08E-7 YGR008C STF2 hom Protein involved in resistance to dessication stress; Stf2p exhibits antioxidant properties, and its overexpression prevents ROS accumulation and apoptosis; binds to the F0 sector of mitochondrial F1F0 ATPase in vitro and is proposed to modulate the inhibitory action of Inh1p and Stf1p; protein abundance increases in response to DNA replication stress
0.088 3.28E-7 YOL153C YOL153C hom Hypothetical protein
0.086 6.13E-7 YGR055W MUP1 hom High affinity methionine permease, integral membrane protein with 13 putative membrane-spanning regions; also involved in cysteine uptake
0.084 1.26E-6 YDL180W_p YDL180W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
0.082 2.10E-6 YBR030W RKM3 hom Ribosomal lysine methyltransferase specific for monomethylation of Rpl42ap and Rpl42bp (lysine 40); nuclear SET domain containing protein
0.081 2.75E-6 YOR002W ALG6 hom Alpha 1,3 glucosyltransferase, involved in transfer of oligosaccharides from dolichyl pyrophosphate to asparagine residues of proteins during N-linked protein glycosylation; mutations in human ortholog are associated with disease
0.081 3.02E-6 YDR297W SUR2 hom Sphinganine C4-hydroxylase, catalyses the conversion of sphinganine to phytosphingosine in sphingolipid biosyntheis
0.080 3.13E-6 YOR067C ALG8 hom Glucosyl transferase, involved in N-linked glycosylation; adds glucose to the dolichol-linked oligosaccharide precursor prior to transfer to protein during lipid-linked oligosaccharide biosynthesis; similar to Alg6p
0.072 2.69E-5 YDR446W ECM11 hom Non-essential protein apparently involved in meiosis, GFP fusion protein is present in discrete clusters in the nucleus throughout mitosis; may be involved in maintaining chromatin structure
0.071 3.70E-5 YDR067C_p OCA6_p hom Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying positive-strand RNA virus replication; null mutation confers sensitivity to tunicamycin and DTT
0.070 5.02E-5 YNL067W RPL9B hom Ribosomal 60S subunit protein L9B; nearly identical to paralog Rpl9Ap; homologous to mammalian ribosomal protein L9 and bacterial L6
0.070 5.50E-5 YGR168C_p YGR168C_p hom Putative protein of unknown function; YGR168C is not an essential gene