YGR126W_p

Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR126W / YGR126W

Click on Significant Values for Screen Details ID:SGTC_2|Compound:0422-0095|FD-Score:-3.58|P-value:8.17E-5 ID:SGTC_15|Compound:0266-0086|FD-Score:3.22|P-value:3.34E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:-2.99|P-value:8.10E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:-3.43|P-value:1.50E-4 ID:SGTC_196|Compound:k015-0023|FD-Score:3.96|P-value:1.43E-5 ID:SGTC_264|Compound:promethazine|FD-Score:-3.14|P-value:4.73E-4 ID:SGTC_464|Compound:bw-b 70c|FD-Score:-3.12|P-value:5.14E-4 ID:SGTC_491|Compound:tetrandrine|FD-Score:3.38|P-value:1.76E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:-2.98|P-value:8.49E-4 ID:SGTC_521|Compound:r062-0005|FD-Score:3.33|P-value:2.18E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:2.96|P-value:8.78E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:-3.33|P-value:2.31E-4 ID:SGTC_654|Compound:1124-0271|FD-Score:3.45|P-value:1.32E-4 ID:SGTC_793|Compound:0488-0545|FD-Score:4.12|P-value:6.81E-6 ID:SGTC_801|Compound:0866-0028|FD-Score:-4.57|P-value:7.48E-7 ID:SGTC_807|Compound:1315-0151|FD-Score:3.41|P-value:1.54E-4 ID:SGTC_834|Compound:0312-0008|FD-Score:4.05|P-value:9.20E-6 ID:SGTC_843|Compound:0310-0051|FD-Score:4.52|P-value:9.00E-7 ID:SGTC_850|Compound:0388-0143|FD-Score:3.18|P-value:3.84E-4 ID:SGTC_943|Compound:3253-1379|FD-Score:4.56|P-value:7.45E-7 ID:SGTC_1063|Compound:disulfiram|FD-Score:3.56|P-value:8.55E-5 ID:SGTC_1190|Compound:1486-1332|FD-Score:-3.65|P-value:5.96E-5 ID:SGTC_1194|Compound:1488-0194|FD-Score:-3.20|P-value:3.72E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:3.47|P-value:1.23E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:3.51|P-value:1.06E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.04|P-value:6.50E-4 ID:SGTC_1333|Compound:1482-0047|FD-Score:-3.54|P-value:9.68E-5 ID:SGTC_1357|Compound:1503-1303|FD-Score:-3.51|P-value:1.10E-4 ID:SGTC_1375|Compound:2910-0797|FD-Score:-2.95|P-value:9.63E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.02|P-value:7.45E-4 ID:SGTC_1467|Compound:k284-1082|FD-Score:4.36|P-value:2.06E-6 ID:SGTC_1658|Compound:st012944|FD-Score:3.29|P-value:2.58E-4 ID:SGTC_1675|Compound:st018485|FD-Score:2.93|P-value:9.68E-4 ID:SGTC_1755|Compound:st041960|FD-Score:-2.99|P-value:8.23E-4 ID:SGTC_1758|Compound:st042942|FD-Score:3.50|P-value:1.10E-4 ID:SGTC_1764|Compound:st044502|FD-Score:-3.36|P-value:2.05E-4 ID:SGTC_2015|Compound:5119600|FD-Score:3.91|P-value:1.79E-5 ID:SGTC_2020|Compound:4017018|FD-Score:3.41|P-value:1.57E-4 ID:SGTC_2061|Compound:5245884|FD-Score:-3.49|P-value:1.17E-4 ID:SGTC_2065|Compound:5221596|FD-Score:-5.16|P-value:2.74E-8 ID:SGTC_2071|Compound:5230951|FD-Score:-2.97|P-value:8.82E-4 ID:SGTC_2073|Compound:5212005|FD-Score:2.97|P-value:8.41E-4 ID:SGTC_2076|Compound:5212012|FD-Score:-2.99|P-value:8.24E-4 ID:SGTC_2115|Compound:tiliquinol|FD-Score:-3.65|P-value:6.00E-5 ID:SGTC_2165|Compound:5727197|FD-Score:4.47|P-value:1.19E-6 ID:SGTC_2301|Compound:7769476|FD-Score:3.21|P-value:3.47E-4 ID:SGTC_2334|Compound:9017922|FD-Score:4.40|P-value:1.71E-6 ID:SGTC_2402|Compound:5553605|FD-Score:3.30|P-value:2.43E-4 ID:SGTC_2424|Compound:5537928|FD-Score:2.96|P-value:8.67E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-3.40|P-value:1.71E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:3.06|P-value:6.13E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:3.27|P-value:2.76E-4 ID:SGTC_2902|Compound:5787006|FD-Score:3.00|P-value:7.46E-4 ID:SGTC_2903|Compound:5923464|FD-Score:3.32|P-value:2.26E-4 ID:SGTC_2906|Compound:7926292|FD-Score:-3.37|P-value:1.96E-4 ID:SGTC_2968|Compound:9090663|FD-Score:3.30|P-value:2.46E-4 ID:SGTC_2974|Compound:9094440|FD-Score:-2.97|P-value:8.88E-4 ID:SGTC_3198|Compound:9112019|FD-Score:3.71|P-value:4.38E-5 ID:SGTC_3275|Compound:9138069|FD-Score:3.73|P-value:4.00E-5 ID:SGTC_3306|Compound:9127676|FD-Score:-4.03|P-value:1.12E-5 ID:SGTC_2|Compound:0422-0095|FD-Score:-3.58|P-value:8.17E-5 ID:SGTC_15|Compound:0266-0086|FD-Score:3.22|P-value:3.34E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:-2.99|P-value:8.10E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:-3.43|P-value:1.50E-4 ID:SGTC_196|Compound:k015-0023|FD-Score:3.96|P-value:1.43E-5 ID:SGTC_264|Compound:promethazine|FD-Score:-3.14|P-value:4.73E-4 ID:SGTC_464|Compound:bw-b 70c|FD-Score:-3.12|P-value:5.14E-4 ID:SGTC_491|Compound:tetrandrine|FD-Score:3.38|P-value:1.76E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:-2.98|P-value:8.49E-4 ID:SGTC_521|Compound:r062-0005|FD-Score:3.33|P-value:2.18E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:2.96|P-value:8.78E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:-3.33|P-value:2.31E-4 ID:SGTC_654|Compound:1124-0271|FD-Score:3.45|P-value:1.32E-4 ID:SGTC_793|Compound:0488-0545|FD-Score:4.12|P-value:6.81E-6 ID:SGTC_801|Compound:0866-0028|FD-Score:-4.57|P-value:7.48E-7 ID:SGTC_807|Compound:1315-0151|FD-Score:3.41|P-value:1.54E-4 ID:SGTC_834|Compound:0312-0008|FD-Score:4.05|P-value:9.20E-6 ID:SGTC_843|Compound:0310-0051|FD-Score:4.52|P-value:9.00E-7 ID:SGTC_850|Compound:0388-0143|FD-Score:3.18|P-value:3.84E-4 ID:SGTC_943|Compound:3253-1379|FD-Score:4.56|P-value:7.45E-7 ID:SGTC_1063|Compound:disulfiram|FD-Score:3.56|P-value:8.55E-5 ID:SGTC_1190|Compound:1486-1332|FD-Score:-3.65|P-value:5.96E-5 ID:SGTC_1194|Compound:1488-0194|FD-Score:-3.20|P-value:3.72E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:3.47|P-value:1.23E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:3.51|P-value:1.06E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.04|P-value:6.50E-4 ID:SGTC_1333|Compound:1482-0047|FD-Score:-3.54|P-value:9.68E-5 ID:SGTC_1357|Compound:1503-1303|FD-Score:-3.51|P-value:1.10E-4 ID:SGTC_1375|Compound:2910-0797|FD-Score:-2.95|P-value:9.63E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.02|P-value:7.45E-4 ID:SGTC_1467|Compound:k284-1082|FD-Score:4.36|P-value:2.06E-6 ID:SGTC_1658|Compound:st012944|FD-Score:3.29|P-value:2.58E-4 ID:SGTC_1675|Compound:st018485|FD-Score:2.93|P-value:9.68E-4 ID:SGTC_1755|Compound:st041960|FD-Score:-2.99|P-value:8.23E-4 ID:SGTC_1758|Compound:st042942|FD-Score:3.50|P-value:1.10E-4 ID:SGTC_1764|Compound:st044502|FD-Score:-3.36|P-value:2.05E-4 ID:SGTC_2015|Compound:5119600|FD-Score:3.91|P-value:1.79E-5 ID:SGTC_2020|Compound:4017018|FD-Score:3.41|P-value:1.57E-4 ID:SGTC_2061|Compound:5245884|FD-Score:-3.49|P-value:1.17E-4 ID:SGTC_2065|Compound:5221596|FD-Score:-5.16|P-value:2.74E-8 ID:SGTC_2071|Compound:5230951|FD-Score:-2.97|P-value:8.82E-4 ID:SGTC_2073|Compound:5212005|FD-Score:2.97|P-value:8.41E-4 ID:SGTC_2076|Compound:5212012|FD-Score:-2.99|P-value:8.24E-4 ID:SGTC_2115|Compound:tiliquinol|FD-Score:-3.65|P-value:6.00E-5 ID:SGTC_2165|Compound:5727197|FD-Score:4.47|P-value:1.19E-6 ID:SGTC_2301|Compound:7769476|FD-Score:3.21|P-value:3.47E-4 ID:SGTC_2334|Compound:9017922|FD-Score:4.40|P-value:1.71E-6 ID:SGTC_2402|Compound:5553605|FD-Score:3.30|P-value:2.43E-4 ID:SGTC_2424|Compound:5537928|FD-Score:2.96|P-value:8.67E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-3.40|P-value:1.71E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:3.06|P-value:6.13E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:3.27|P-value:2.76E-4 ID:SGTC_2902|Compound:5787006|FD-Score:3.00|P-value:7.46E-4 ID:SGTC_2903|Compound:5923464|FD-Score:3.32|P-value:2.26E-4 ID:SGTC_2906|Compound:7926292|FD-Score:-3.37|P-value:1.96E-4 ID:SGTC_2968|Compound:9090663|FD-Score:3.30|P-value:2.46E-4 ID:SGTC_2974|Compound:9094440|FD-Score:-2.97|P-value:8.88E-4 ID:SGTC_3198|Compound:9112019|FD-Score:3.71|P-value:4.38E-5 ID:SGTC_3275|Compound:9138069|FD-Score:3.73|P-value:4.00E-5 ID:SGTC_3306|Compound:9127676|FD-Score:-4.03|P-value:1.12E-5

Top fitness defect scores for YGR126W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_943 3253-1379 4.56 105.0 µM 7.45E-7 15 2.60E-6
2 SGTC_843 0310-0051 4.52 143.0 µM 9.00E-7 6 3.09E-6
3 SGTC_2165 5727197 4.47 32.1 µM 1.19E-6 28 3.96E-6
4 SGTC_2334 9017922 4.40 200.0 µM 1.71E-6 16 5.51E-6
5 SGTC_1467 k284-1082 4.36 293.0 µM 2.06E-6 8 6.50E-6
6 SGTC_793 0488-0545 4.12 106.0 µM 6.81E-6 12 1.91E-5
7 SGTC_834 0312-0008 4.05 75.7 µM 9.20E-6 NEO1 29 2.51E-5
8 SGTC_196 k015-0023 3.96 18.1 µM 1.43E-5 PDR1 19 3.74E-5
9 SGTC_2015 5119600 3.91 184.0 µM 1.79E-5 32 4.58E-5
10 SGTC_3275 9138069 3.73 49.5 µM 4.00E-5 7 9.45E-5
11 SGTC_3198 9112019 3.71 49.5 µM 4.38E-5 mitochondrial processes 23 1.02E-4
12 SGTC_1063 disulfiram 3.56 1.8 µM 8.55E-5 36 1.88E-4
13 SGTC_1205 4161-2785 3.51 76.0 µM 1.06E-4 49 2.28E-4
14 SGTC_1758 st042942 3.50 75.2 µM 1.10E-4 33 2.36E-4
15 SGTC_1203 3992-3522 3.47 103.0 µM 1.23E-4 59 2.60E-4
16 SGTC_654 1124-0271 3.45 80.9 µM 1.32E-4 44 2.78E-4
17 SGTC_807 1315-0151 3.41 48.0 µM 1.54E-4 48 3.19E-4
18 SGTC_2020 4017018 3.41 200.0 µM 1.57E-4 40 3.25E-4
19 SGTC_491 tetrandrine 3.38 80.3 µM 1.76E-4 19 3.60E-4
20 SGTC_521 r062-0005 3.33 13.8 µM 2.18E-4 31 4.37E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.126 2.33E-13 YPR149W NCE102 hom Protein of unknown function; contains transmembrane domains; involved in secretion of proteins that lack classical secretory signal sequences; component of the detergent-insoluble glycolipid-enriched complexes (DIGs)
0.121 2.28E-12 YGR205W TDA10 hom ATP-binding protein of unknown function; crystal structure resembles that of E.coli pantothenate kinase and other small kinases; null mutant is sensitive to expression of the top1-T722A allele
0.095 3.32E-8 YML026C RPS18B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S18 and bacterial S13; RPS18B has a paralog, RPS18A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.078 6.87E-6 YKL142W MRP8 hom Protein of unknown function; undergoes sumoylation; transcription induced under cell wall stress; protein levels are reduced under anaerobic conditions; protein abundance increases in response to DNA replication stress; originally thought to be a mitochondrial ribosomal protein based on sequence analysis
0.074 1.95E-5 YML005W TRM12 hom S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; required for wybutosine formation in phenylalanine-accepting tRNA
0.074 1.99E-5 YPL164C MLH3 hom Protein involved in DNA mismatch repair and crossing-over during meiotic recombination; forms a complex with Mlh1p; mammalian homolog is implicated mammalian microsatellite instability
0.069 6.27E-5 YNL270C ALP1 hom Arginine transporter; expression is normally very low and it is unclear what conditions would induce significant expression; ALP1 has a paralog, CAN1, that arose from the whole genome duplication
0.069 6.62E-5 YNR063W_p YNR063W_p hom Putative zinc-cluster protein of unknown function
0.069 6.84E-5 YGR130C YGR130C hom Component of the eisosome with unknown function; GFP-fusion protein localizes to the cytoplasm; specifically phosphorylated in vitro by mammalian diphosphoinositol pentakisphosphate (IP7)
0.067 9.39E-5 YPR170C_d YPR170C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORFs YPR169W-A and YPR170W-B
0.067 9.73E-5 YGL004C RPN14 hom Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasome regulatory particle (RP); null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; interacts with Rpt5p
0.067 1.12E-4 YGR096W TPC1 hom Mitochondrial membrane transporter that mediates uptake of the essential cofactor thiamine pyrophosphate (ThPP) into mitochondria; expression appears to be regulated by carbon source; member of the mitochondrial carrier family
0.065 1.57E-4 YDR044W HEM13 het Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; transcription is repressed by oxygen and heme (via Rox1p and Hap1p)
0.065 1.78E-4 YDR163W CWC15 hom Non-essential protein involved in pre-mRNA splicing, component of a complex containing Cef1p; has similarity to S. pombe Cwf15p
0.064 1.90E-4 YPR001W CIT3 hom Dual specificity mitochondrial citrate and methylcitrate synthase; catalyzes the condensation of acetyl-CoA and oxaloacetate to form citrate and that of propionyl-CoA and oxaloacetate to form 2-methylcitrate