YGR128C / UTP8

Nucleolar protein required for export of tRNAs from the nucleus; also copurifies with the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA

Zygosity: Heterozygous strain
fixedexpanded
Profile for YGR128C / UTP8

Click on Significant Values for Screen Details ID:SGTC_68|Compound:0986-0284|FD-Score:3.56|P-value:7.29E-4 ID:SGTC_97|Compound:0535-0701|FD-Score:-3.62|P-value:6.02E-4 ID:SGTC_98|Compound:0074-0023|FD-Score:3.59|P-value:6.64E-4 ID:SGTC_174|Compound:3553-0389|FD-Score:3.72|P-value:4.31E-4 ID:SGTC_198|Compound:3454-2873|FD-Score:-5.01|P-value:3.64E-6 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:-3.67|P-value:5.14E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:3.74|P-value:4.04E-4 ID:SGTC_610|Compound:4215-0184|FD-Score:-3.70|P-value:4.66E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:3.48|P-value:9.36E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:3.52|P-value:8.17E-4 ID:SGTC_816|Compound:0325-0417|FD-Score:3.72|P-value:4.44E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:-4.08|P-value:1.33E-4 ID:SGTC_1009|Compound:4106-0057|FD-Score:6.50|P-value:2.98E-9 ID:SGTC_1020|Compound:4335-0961|FD-Score:4.67|P-value:1.45E-5 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.94|P-value:2.12E-4 ID:SGTC_1103|Compound:duloxetine|FD-Score:4.37|P-value:4.65E-5 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:6.16|P-value:1.80E-8 ID:SGTC_1297|Compound:1068-0111|FD-Score:-4.03|P-value:1.54E-4 ID:SGTC_1359|Compound:1582-0056|FD-Score:6.45|P-value:3.93E-9 ID:SGTC_1369|Compound:1866-0067|FD-Score:5.44|P-value:5.70E-7 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.87|P-value:2.66E-4 ID:SGTC_1466|Compound:k213-0079|FD-Score:3.47|P-value:9.55E-4 ID:SGTC_1712|Compound:st032288|FD-Score:9.14|P-value:1.44E-16 ID:SGTC_1782|Compound:st039423|FD-Score:4.42|P-value:3.85E-5 ID:SGTC_1786|Compound:berberine|FD-Score:-6.18|P-value:1.64E-8 ID:SGTC_1981|Compound:st071826|FD-Score:4.48|P-value:3.11E-5 ID:SGTC_2003|Compound:4023581|FD-Score:3.47|P-value:9.46E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:-4.66|P-value:1.56E-5 ID:SGTC_2179|Compound:6298986|FD-Score:-3.73|P-value:4.20E-4 ID:SGTC_2202|Compound:7226349|FD-Score:3.86|P-value:2.74E-4 ID:SGTC_2254|Compound:7938975|FD-Score:5.04|P-value:3.30E-6 ID:SGTC_2299|Compound:7976368|FD-Score:3.62|P-value:5.94E-4 ID:SGTC_2351|Compound:9026858|FD-Score:-4.50|P-value:2.86E-5 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:-3.48|P-value:9.19E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.55|P-value:2.33E-5 ID:SGTC_2779|Compound:methotrexate|FD-Score:5.38|P-value:7.45E-7 ID:SGTC_2781|Compound:5567276|FD-Score:5.32|P-value:9.61E-7 ID:SGTC_2887|Compound:9044784|FD-Score:4.10|P-value:1.21E-4 ID:SGTC_2896|Compound:9052656|FD-Score:6.23|P-value:1.24E-8 ID:SGTC_3049|Compound:9092223|FD-Score:4.12|P-value:1.13E-4 ID:SGTC_3108|Compound:9121785|FD-Score:3.78|P-value:3.55E-4 ID:SGTC_3204|Compound:9114183|FD-Score:4.26|P-value:6.89E-5 ID:SGTC_3205|Compound:9113483|FD-Score:4.66|P-value:1.55E-5 ID:SGTC_3208|Compound:9114115|FD-Score:4.62|P-value:1.79E-5 ID:SGTC_3210|Compound:9128157|FD-Score:-4.88|P-value:6.34E-6 ID:SGTC_3218|Compound:9131285|FD-Score:3.88|P-value:2.63E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:3.56|P-value:7.29E-4 ID:SGTC_97|Compound:0535-0701|FD-Score:-3.62|P-value:6.02E-4 ID:SGTC_98|Compound:0074-0023|FD-Score:3.59|P-value:6.64E-4 ID:SGTC_174|Compound:3553-0389|FD-Score:3.72|P-value:4.31E-4 ID:SGTC_198|Compound:3454-2873|FD-Score:-5.01|P-value:3.64E-6 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:-3.67|P-value:5.14E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:3.74|P-value:4.04E-4 ID:SGTC_610|Compound:4215-0184|FD-Score:-3.70|P-value:4.66E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:3.48|P-value:9.36E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:3.52|P-value:8.17E-4 ID:SGTC_816|Compound:0325-0417|FD-Score:3.72|P-value:4.44E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:-4.08|P-value:1.33E-4 ID:SGTC_1009|Compound:4106-0057|FD-Score:6.50|P-value:2.98E-9 ID:SGTC_1020|Compound:4335-0961|FD-Score:4.67|P-value:1.45E-5 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.94|P-value:2.12E-4 ID:SGTC_1103|Compound:duloxetine|FD-Score:4.37|P-value:4.65E-5 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:6.16|P-value:1.80E-8 ID:SGTC_1297|Compound:1068-0111|FD-Score:-4.03|P-value:1.54E-4 ID:SGTC_1359|Compound:1582-0056|FD-Score:6.45|P-value:3.93E-9 ID:SGTC_1369|Compound:1866-0067|FD-Score:5.44|P-value:5.70E-7 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.87|P-value:2.66E-4 ID:SGTC_1466|Compound:k213-0079|FD-Score:3.47|P-value:9.55E-4 ID:SGTC_1712|Compound:st032288|FD-Score:9.14|P-value:1.44E-16 ID:SGTC_1782|Compound:st039423|FD-Score:4.42|P-value:3.85E-5 ID:SGTC_1786|Compound:berberine|FD-Score:-6.18|P-value:1.64E-8 ID:SGTC_1981|Compound:st071826|FD-Score:4.48|P-value:3.11E-5 ID:SGTC_2003|Compound:4023581|FD-Score:3.47|P-value:9.46E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:-4.66|P-value:1.56E-5 ID:SGTC_2179|Compound:6298986|FD-Score:-3.73|P-value:4.20E-4 ID:SGTC_2202|Compound:7226349|FD-Score:3.86|P-value:2.74E-4 ID:SGTC_2254|Compound:7938975|FD-Score:5.04|P-value:3.30E-6 ID:SGTC_2299|Compound:7976368|FD-Score:3.62|P-value:5.94E-4 ID:SGTC_2351|Compound:9026858|FD-Score:-4.50|P-value:2.86E-5 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:-3.48|P-value:9.19E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.55|P-value:2.33E-5 ID:SGTC_2779|Compound:methotrexate|FD-Score:5.38|P-value:7.45E-7 ID:SGTC_2781|Compound:5567276|FD-Score:5.32|P-value:9.61E-7 ID:SGTC_2887|Compound:9044784|FD-Score:4.10|P-value:1.21E-4 ID:SGTC_2896|Compound:9052656|FD-Score:6.23|P-value:1.24E-8 ID:SGTC_3049|Compound:9092223|FD-Score:4.12|P-value:1.13E-4 ID:SGTC_3108|Compound:9121785|FD-Score:3.78|P-value:3.55E-4 ID:SGTC_3204|Compound:9114183|FD-Score:4.26|P-value:6.89E-5 ID:SGTC_3205|Compound:9113483|FD-Score:4.66|P-value:1.55E-5 ID:SGTC_3208|Compound:9114115|FD-Score:4.62|P-value:1.79E-5 ID:SGTC_3210|Compound:9128157|FD-Score:-4.88|P-value:6.34E-6 ID:SGTC_3218|Compound:9131285|FD-Score:3.88|P-value:2.63E-4

Top fitness defect scores for YGR128C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1712 st032288 9.14 53.4 µM 1.44E-16 calcium & mitochondrial duress 4 3.11E-20 0.36
2 SGTC_1009 4106-0057 6.50 9.9 µM 2.98E-9 2 3.95E-11 0.88
3 SGTC_1359 1582-0056 6.45 520.0 nM 3.93E-9 1 5.57E-11 1.75
4 SGTC_2896 9052656 6.23 71.4 µM 1.24E-8 endomembrane recycling 8 2.33E-10 0.16
5 SGTC_1116 jasmonic acid 6.16 1.6 µM 1.80E-8 1 3.69E-10 1.19
6 SGTC_1369 1866-0067 5.44 208.0 µM 5.70E-7 RPP1 & pyrimidine depletion 4 2.69E-8 0.23
7 SGTC_2779 methotrexate 5.38 400.0 µM 7.45E-7 7 3.74E-8 0.10
8 SGTC_2781 5567276 5.32 71.4 µM 9.61E-7 3 5.14E-8 0.05
9 SGTC_2254 7938975 5.04 95.2 µM 3.30E-6 2 2.37E-7 0.16
10 SGTC_1020 4335-0961 4.67 93.3 µM 1.45E-5 4 1.48E-6 0.21
11 SGTC_3205 9113483 4.66 49.5 µM 1.55E-5 3 1.62E-6 0.34
12 SGTC_3208 9114115 4.62 49.5 µM 1.79E-5 5 1.93E-6 0.22
13 SGTC_2688 kanamycin b 4.55 96.7 µM 2.33E-5 calcium & mitochondrial duress 13 2.67E-6 0.01
14 SGTC_1981 st071826 4.48 47.0 µM 3.11E-5 1 3.81E-6 0.27
15 SGTC_1782 st039423 4.42 80.6 µM 3.85E-5 2 4.96E-6 0.48
16 SGTC_1103 duloxetine 4.37 36.1 µM 4.65E-5 4 6.27E-6 0.18
17 SGTC_3204 9114183 4.26 49.5 µM 6.89E-5 5 1.02E-5 0.29
18 SGTC_3049 9092223 4.12 49.5 µM 1.13E-4 3 1.88E-5 0.14
19 SGTC_2887 9044784 4.10 58.4 µM 1.21E-4 fatty acid desaturase (OLE1) 18 2.05E-5 0.04
20 SGTC_1083 didemethylchlorpromazine sulfoxide 3.94 707.4 nM 2.12E-4 redox potentiating 24 4.09E-5 0.13

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.239 1.08E-44 YKL051W SFK1 hom Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
0.180 6.59E-26 YOR086C TCB1 hom Lipid-binding ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; contains three calcium and lipid binding domains; non-tagged protein also localizes to mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact
0.164 1.56E-21 YDR475C JIP4 hom Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence
0.157 6.91E-20 YOL016C CMK2 hom Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to mammalian Cam Kinase II; CMK2 has a paralog, CMK1, that arose from the whole genome duplication
0.153 3.96E-19 YDL019C OSH2 hom Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
0.151 1.60E-18 YDR467C_d YDR467C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.141 2.17E-16 YDR398W UTP5 het Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit
0.137 1.63E-15 YLL048C YBT1 hom Transporter of the ATP-binding cassette (ABC) family; involved in bile acid transport; negative regulator of vacuole fusion; regulates the release of lumenal Ca2+ stores; similar to mammalian bile transporters
0.130 3.57E-14 YDR324C UTP4 het Subunit of U3-containing 90S preribosome and Small Subunit (SSU) processome complexes involved in production of 18S rRNA and assembly of small ribosomal subunit; member of t-Utp subcomplex involved with transcription of 35S rRNA transcript
0.126 3.09E-13 YJL165C HAL5 hom Putative protein kinase; overexpression increases sodium and lithium tolerance, whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake, suggesting a role in regulation of Trk1p and/or Trk2p transporters; HAL5 has a paralog, KKQ8, that arose from the whole genome duplication
0.125 4.13E-13 YHR196W UTP9 het Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
0.124 5.47E-13 YDL085W NDE2 hom Mitochondrial external NADH dehydrogenase, catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p are involved in providing the cytosolic NADH to the mitochondrial respiratory chain
0.124 5.83E-13 YGR267C FOL2 het GTP-cyclohydrolase I, catalyzes the first step in the folic acid biosynthetic pathway
0.122 1.59E-12 YOR067C ALG8 hom Glucosyl transferase, involved in N-linked glycosylation; adds glucose to the dolichol-linked oligosaccharide precursor prior to transfer to protein during lipid-linked oligosaccharide biosynthesis; similar to Alg6p
0.121 2.20E-12 YDR491C_d YDR491C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data