YGR129W / SYF2

Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; isy1 syf2 cells have defective spindles activiating cell cycle arrest

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR129W / SYF2

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:4.31|P-value:3.02E-5 ID:SGTC_18|Compound:0111-0177|FD-Score:3.48|P-value:6.29E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:4.01|P-value:9.73E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.82|P-value:1.51E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:3.40|P-value:8.10E-4 ID:SGTC_196|Compound:k015-0023|FD-Score:4.14|P-value:5.88E-5 ID:SGTC_435|Compound:c-PAF|FD-Score:3.74|P-value:2.56E-4 ID:SGTC_626|Compound:0214-0009|FD-Score:4.32|P-value:2.93E-5 ID:SGTC_869|Compound:0564-0080|FD-Score:5.31|P-value:3.81E-7 ID:SGTC_883|Compound:0850-0245|FD-Score:4.08|P-value:7.49E-5 ID:SGTC_902|Compound:1120-0002|FD-Score:3.33|P-value:9.94E-4 ID:SGTC_917|Compound:harmaline|FD-Score:4.52|P-value:1.30E-5 ID:SGTC_942|Compound:3253-1115|FD-Score:-3.42|P-value:6.05E-4 ID:SGTC_1029|Compound:k015-0030|FD-Score:3.36|P-value:9.23E-4 ID:SGTC_1034|Compound:k072-0165|FD-Score:-4.95|P-value:1.45E-6 ID:SGTC_1183|Compound:1254-0324|FD-Score:4.69|P-value:6.47E-6 ID:SGTC_1251|Compound:0490-5699|FD-Score:5.27|P-value:4.61E-7 ID:SGTC_1252|Compound:0493-0875|FD-Score:3.36|P-value:9.15E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:4.10|P-value:6.92E-5 ID:SGTC_1442|Compound:4112-3290|FD-Score:4.03|P-value:8.90E-5 ID:SGTC_1657|Compound:st012939|FD-Score:3.41|P-value:7.76E-4 ID:SGTC_1665|Compound:st014639|FD-Score:3.55|P-value:4.97E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-5.03|P-value:1.04E-6 ID:SGTC_1900|Compound:st060200|FD-Score:3.86|P-value:1.68E-4 ID:SGTC_1901|Compound:st060216|FD-Score:3.58|P-value:4.54E-4 ID:SGTC_2003|Compound:4023581|FD-Score:3.57|P-value:4.61E-4 ID:SGTC_2046|Compound:4110841|FD-Score:4.55|P-value:1.16E-5 ID:SGTC_2238|Compound:6671620|FD-Score:4.80|P-value:4.05E-6 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-3.90|P-value:1.14E-4 ID:SGTC_2283|Compound:7944793|FD-Score:-4.23|P-value:3.22E-5 ID:SGTC_2356|Compound:9061756|FD-Score:-4.22|P-value:3.29E-5 ID:SGTC_2360|Compound:9040895|FD-Score:7.20|P-value:9.31E-12 ID:SGTC_2364|Compound:9055074|FD-Score:-3.60|P-value:3.29E-4 ID:SGTC_2437|Compound:5741531|FD-Score:4.21|P-value:4.51E-5 ID:SGTC_2440|Compound:5628896|FD-Score:6.60|P-value:3.77E-10 ID:SGTC_2442|Compound:5158906|FD-Score:-5.00|P-value:1.18E-6 ID:SGTC_2447|Compound:5741742|FD-Score:5.74|P-value:4.42E-8 ID:SGTC_2453|Compound:5731132|FD-Score:5.73|P-value:4.78E-8 ID:SGTC_2461|Compound:5755302|FD-Score:4.23|P-value:4.22E-5 ID:SGTC_2471|Compound:5466956|FD-Score:4.32|P-value:2.94E-5 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:3.68|P-value:3.12E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:4.55|P-value:1.15E-5 ID:SGTC_2594|Compound:a-mangostin|FD-Score:-3.28|P-value:9.51E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-4.19|P-value:3.80E-5 ID:SGTC_2777|Compound:climbazole|FD-Score:4.54|P-value:1.19E-5 ID:SGTC_2808|Compound:7946468|FD-Score:3.68|P-value:3.21E-4 ID:SGTC_2871|Compound:9038510|FD-Score:-3.35|P-value:7.61E-4 ID:SGTC_7|Compound:0192-1582|FD-Score:4.31|P-value:3.02E-5 ID:SGTC_18|Compound:0111-0177|FD-Score:3.48|P-value:6.29E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:4.01|P-value:9.73E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.82|P-value:1.51E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:3.40|P-value:8.10E-4 ID:SGTC_196|Compound:k015-0023|FD-Score:4.14|P-value:5.88E-5 ID:SGTC_435|Compound:c-PAF|FD-Score:3.74|P-value:2.56E-4 ID:SGTC_626|Compound:0214-0009|FD-Score:4.32|P-value:2.93E-5 ID:SGTC_869|Compound:0564-0080|FD-Score:5.31|P-value:3.81E-7 ID:SGTC_883|Compound:0850-0245|FD-Score:4.08|P-value:7.49E-5 ID:SGTC_902|Compound:1120-0002|FD-Score:3.33|P-value:9.94E-4 ID:SGTC_917|Compound:harmaline|FD-Score:4.52|P-value:1.30E-5 ID:SGTC_942|Compound:3253-1115|FD-Score:-3.42|P-value:6.05E-4 ID:SGTC_1029|Compound:k015-0030|FD-Score:3.36|P-value:9.23E-4 ID:SGTC_1034|Compound:k072-0165|FD-Score:-4.95|P-value:1.45E-6 ID:SGTC_1183|Compound:1254-0324|FD-Score:4.69|P-value:6.47E-6 ID:SGTC_1251|Compound:0490-5699|FD-Score:5.27|P-value:4.61E-7 ID:SGTC_1252|Compound:0493-0875|FD-Score:3.36|P-value:9.15E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:4.10|P-value:6.92E-5 ID:SGTC_1442|Compound:4112-3290|FD-Score:4.03|P-value:8.90E-5 ID:SGTC_1657|Compound:st012939|FD-Score:3.41|P-value:7.76E-4 ID:SGTC_1665|Compound:st014639|FD-Score:3.55|P-value:4.97E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-5.03|P-value:1.04E-6 ID:SGTC_1900|Compound:st060200|FD-Score:3.86|P-value:1.68E-4 ID:SGTC_1901|Compound:st060216|FD-Score:3.58|P-value:4.54E-4 ID:SGTC_2003|Compound:4023581|FD-Score:3.57|P-value:4.61E-4 ID:SGTC_2046|Compound:4110841|FD-Score:4.55|P-value:1.16E-5 ID:SGTC_2238|Compound:6671620|FD-Score:4.80|P-value:4.05E-6 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-3.90|P-value:1.14E-4 ID:SGTC_2283|Compound:7944793|FD-Score:-4.23|P-value:3.22E-5 ID:SGTC_2356|Compound:9061756|FD-Score:-4.22|P-value:3.29E-5 ID:SGTC_2360|Compound:9040895|FD-Score:7.20|P-value:9.31E-12 ID:SGTC_2364|Compound:9055074|FD-Score:-3.60|P-value:3.29E-4 ID:SGTC_2437|Compound:5741531|FD-Score:4.21|P-value:4.51E-5 ID:SGTC_2440|Compound:5628896|FD-Score:6.60|P-value:3.77E-10 ID:SGTC_2442|Compound:5158906|FD-Score:-5.00|P-value:1.18E-6 ID:SGTC_2447|Compound:5741742|FD-Score:5.74|P-value:4.42E-8 ID:SGTC_2453|Compound:5731132|FD-Score:5.73|P-value:4.78E-8 ID:SGTC_2461|Compound:5755302|FD-Score:4.23|P-value:4.22E-5 ID:SGTC_2471|Compound:5466956|FD-Score:4.32|P-value:2.94E-5 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:3.68|P-value:3.12E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:4.55|P-value:1.15E-5 ID:SGTC_2594|Compound:a-mangostin|FD-Score:-3.28|P-value:9.51E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-4.19|P-value:3.80E-5 ID:SGTC_2777|Compound:climbazole|FD-Score:4.54|P-value:1.19E-5 ID:SGTC_2808|Compound:7946468|FD-Score:3.68|P-value:3.21E-4 ID:SGTC_2871|Compound:9038510|FD-Score:-3.35|P-value:7.61E-4

Top fitness defect scores for YGR129W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2360 9040895 7.20 200.0 µM 9.31E-12 RPP1 & pyrimidine depletion 1 3.00E-13
2 SGTC_2440 5628896 6.60 157.8 µM 3.77E-10 7 2.04E-11
3 SGTC_2447 5741742 5.74 33.8 µM 4.42E-8 6 4.68E-9
4 SGTC_2453 5731132 5.73 22.2 µM 4.78E-8 3 5.12E-9
5 SGTC_869 0564-0080 5.31 44.1 µM 3.81E-7 6 5.46E-8
6 SGTC_1251 0490-5699 5.27 265.0 µM 4.61E-7 13 6.79E-8
7 SGTC_2238 6671620 4.80 73.2 µM 4.05E-6 13 8.09E-7
8 SGTC_1183 1254-0324 4.69 198.0 µM 6.47E-6 12 1.38E-6
9 SGTC_2536 dehydroabietamide 4.55 32.0 µM 1.15E-5 18 2.67E-6
10 SGTC_2046 4110841 4.55 106.0 µM 1.16E-5 iron homeostasis 18 2.69E-6
11 SGTC_2777 climbazole 4.54 1.5 µM 1.19E-5 iron homeostasis 30 2.76E-6
12 SGTC_917 harmaline 4.52 728.1 nM 1.30E-5 ergosterol biosynthesis 14 3.04E-6
13 SGTC_626 0214-0009 4.32 33.0 µM 2.93E-5 copper-dependent oxidative stress 13 7.73E-6
14 SGTC_2471 5466956 4.32 24.8 µM 2.94E-5 mitochondrial processes 7 7.74E-6
15 SGTC_7 0192-1582 4.31 4.2 µM 3.02E-5 49 8.00E-6
16 SGTC_2461 5755302 4.23 26.1 µM 4.22E-5 27 1.17E-5
17 SGTC_2437 5741531 4.21 144.2 µM 4.51E-5 30 1.26E-5
18 SGTC_196 k015-0023 4.14 18.1 µM 5.88E-5 PDR1 15 1.71E-5
19 SGTC_1357 1503-1303 4.10 39.5 µM 6.92E-5 26 2.06E-5
20 SGTC_883 0850-0245 4.08 24.6 µM 7.49E-5 cell wall 30 2.25E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.160 1.23E-20 YFL021W GAT1 hom Transcriptional activator of genes involved in nitrogen catabolite repression; contains a GATA-1-type zinc finger DNA-binding motif; activity and localization regulated by nitrogen limitation and Ure2p
0.122 1.12E-12 YNL270C ALP1 hom Arginine transporter; expression is normally very low and it is unclear what conditions would induce significant expression; ALP1 has a paralog, CAN1, that arose from the whole genome duplication
0.104 1.63E-9 YNL135C FPR1 hom Peptidyl-prolyl cis-trans isomerase (PPIase), binds to the drugs FK506 and rapamycin; also binds to the nonhistone chromatin binding protein Hmo1p and may regulate its assembly or function
0.102 2.98E-9 YML043C RRN11 het Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p
0.098 1.35E-8 YDR067C_p OCA6_p hom Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying positive-strand RNA virus replication; null mutation confers sensitivity to tunicamycin and DTT
0.084 1.08E-6 YDR421W ARO80 hom Zinc finger transcriptional activator of the Zn2Cys6 family; activates transcription of aromatic amino acid catabolic genes in the presence of aromatic amino acids
0.082 2.25E-6 YGR051C_d YGR051C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YGR051C is not an essential gene
0.079 4.06E-6 YOL030W GAS5 hom 1,3-beta-glucanosyltransferase, has similarity to Gas1p; localizes to the cell wall
0.079 4.14E-6 YBL009W ALK2 hom Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; ALK2 has a paralog, ALK1, that arose from the whole genome duplication; similar to mammalian haspins
0.079 4.16E-6 YLR125W_p YLR125W_p hom Putative protein of unknown function; mutant has decreased Ty3 transposition; YLR125W is not an essential gene
0.079 4.36E-6 YMR132C_p JLP2_p hom Protein of unknown function, contains sequence that closely resembles a J domain (typified by the E. coli DnaJ protein)
0.079 4.76E-6 YDR422C SIP1 hom Alternate beta-subunit of the Snf1p kinase complex, may confer substrate specificity; vacuolar protein containing KIS (Kinase-Interacting Sequence) and ASC (Association with Snf1 kinase Complex) domains involved in protein interactions
0.078 6.79E-6 YFL044C OTU1 hom Deubiquitylation enzyme that binds to the chaperone-ATPase Cdc48p; may contribute to regulation of protein degradation by deubiquitylating substrates that have been ubiquitylated by Ufd2p; member of the Ovarian Tumor (OTU) family; protein abundance increases in response to DNA replication stress
0.077 7.21E-6 YNL071W LAT1 hom Dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase complex, which catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA
0.074 1.59E-5 YDL154W MSH5 hom Protein of the MutS family, forms a dimer with Msh4p that facilitates crossovers between homologs during meiosis; msh5-Y823H mutation confers tolerance to DNA alkylating agents; homologs present in C. elegans and humans