YGR130C

Component of the eisosome with unknown function; GFP-fusion protein localizes to the cytoplasm; specifically phosphorylated in vitro by mammalian diphosphoinositol pentakisphosphate (IP7)

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR130C / YGR130C

Click on Significant Values for Screen Details ID:SGTC_84|Compound:0443-0269|FD-Score:-4.37|P-value:2.83E-5 ID:SGTC_95|Compound:0471-0001|FD-Score:3.42|P-value:8.89E-4 ID:SGTC_99|Compound:0109-0120|FD-Score:-3.61|P-value:4.35E-4 ID:SGTC_101|Compound:0490-5701|FD-Score:-3.46|P-value:7.03E-4 ID:SGTC_108|Compound:0509-0257|FD-Score:6.14|P-value:9.28E-9 ID:SGTC_143|Compound:4032-1194|FD-Score:3.45|P-value:7.87E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:3.68|P-value:3.74E-4 ID:SGTC_196|Compound:k015-0023|FD-Score:5.85|P-value:4.10E-8 ID:SGTC_197|Compound:4544-0043|FD-Score:5.13|P-value:1.30E-6 ID:SGTC_214|Compound:4373-3496|FD-Score:3.46|P-value:7.62E-4 ID:SGTC_521|Compound:r062-0005|FD-Score:3.48|P-value:7.36E-4 ID:SGTC_737|Compound:1950-0117|FD-Score:-4.17|P-value:5.97E-5 ID:SGTC_738|Compound:1315-0003|FD-Score:3.90|P-value:1.80E-4 ID:SGTC_745|Compound:0469-0705|FD-Score:-3.55|P-value:5.40E-4 ID:SGTC_834|Compound:0312-0008|FD-Score:3.94|P-value:1.53E-4 ID:SGTC_858|Compound:0438-0351|FD-Score:4.52|P-value:1.73E-5 ID:SGTC_899|Compound:1083-0020|FD-Score:3.72|P-value:3.27E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:3.82|P-value:2.38E-4 ID:SGTC_975|Compound:1335-0046|FD-Score:3.41|P-value:9.13E-4 ID:SGTC_1121|Compound:fusaric acid|FD-Score:3.95|P-value:1.50E-4 ID:SGTC_1419|Compound:3993-2473|FD-Score:3.49|P-value:6.96E-4 ID:SGTC_1518|Compound:st038567|FD-Score:4.28|P-value:4.47E-5 ID:SGTC_1629|Compound:st005085|FD-Score:4.25|P-value:5.06E-5 ID:SGTC_1708|Compound:st033234|FD-Score:5.66|P-value:1.08E-7 ID:SGTC_1712|Compound:st032288|FD-Score:4.34|P-value:3.49E-5 ID:SGTC_1767|Compound:st044992|FD-Score:3.94|P-value:1.53E-4 ID:SGTC_1962|Compound:st076595|FD-Score:3.63|P-value:4.45E-4 ID:SGTC_2021|Compound:4019055|FD-Score:4.30|P-value:4.10E-5 ID:SGTC_2062|Compound:5245942|FD-Score:4.02|P-value:1.18E-4 ID:SGTC_2083|Compound:5306046|FD-Score:3.70|P-value:3.50E-4 ID:SGTC_2185|Compound:6113692|FD-Score:3.61|P-value:4.77E-4 ID:SGTC_2347|Compound:9049783|FD-Score:-3.62|P-value:4.18E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:-3.54|P-value:5.46E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-4.25|P-value:4.43E-5 ID:SGTC_2721|Compound:ifenprodil|FD-Score:-4.01|P-value:1.08E-4 ID:SGTC_2826|Compound:7992541|FD-Score:4.80|P-value:5.60E-6 ID:SGTC_2856|Compound:9022925|FD-Score:3.83|P-value:2.27E-4 ID:SGTC_3165|Compound:9101544|FD-Score:3.90|P-value:1.76E-4 ID:SGTC_3210|Compound:9128157|FD-Score:3.77|P-value:2.80E-4 ID:SGTC_3348|Compound:9149464|FD-Score:3.61|P-value:4.73E-4 ID:SGTC_84|Compound:0443-0269|FD-Score:-4.37|P-value:2.83E-5 ID:SGTC_95|Compound:0471-0001|FD-Score:3.42|P-value:8.89E-4 ID:SGTC_99|Compound:0109-0120|FD-Score:-3.61|P-value:4.35E-4 ID:SGTC_101|Compound:0490-5701|FD-Score:-3.46|P-value:7.03E-4 ID:SGTC_108|Compound:0509-0257|FD-Score:6.14|P-value:9.28E-9 ID:SGTC_143|Compound:4032-1194|FD-Score:3.45|P-value:7.87E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:3.68|P-value:3.74E-4 ID:SGTC_196|Compound:k015-0023|FD-Score:5.85|P-value:4.10E-8 ID:SGTC_197|Compound:4544-0043|FD-Score:5.13|P-value:1.30E-6 ID:SGTC_214|Compound:4373-3496|FD-Score:3.46|P-value:7.62E-4 ID:SGTC_521|Compound:r062-0005|FD-Score:3.48|P-value:7.36E-4 ID:SGTC_737|Compound:1950-0117|FD-Score:-4.17|P-value:5.97E-5 ID:SGTC_738|Compound:1315-0003|FD-Score:3.90|P-value:1.80E-4 ID:SGTC_745|Compound:0469-0705|FD-Score:-3.55|P-value:5.40E-4 ID:SGTC_834|Compound:0312-0008|FD-Score:3.94|P-value:1.53E-4 ID:SGTC_858|Compound:0438-0351|FD-Score:4.52|P-value:1.73E-5 ID:SGTC_899|Compound:1083-0020|FD-Score:3.72|P-value:3.27E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:3.82|P-value:2.38E-4 ID:SGTC_975|Compound:1335-0046|FD-Score:3.41|P-value:9.13E-4 ID:SGTC_1121|Compound:fusaric acid|FD-Score:3.95|P-value:1.50E-4 ID:SGTC_1419|Compound:3993-2473|FD-Score:3.49|P-value:6.96E-4 ID:SGTC_1518|Compound:st038567|FD-Score:4.28|P-value:4.47E-5 ID:SGTC_1629|Compound:st005085|FD-Score:4.25|P-value:5.06E-5 ID:SGTC_1708|Compound:st033234|FD-Score:5.66|P-value:1.08E-7 ID:SGTC_1712|Compound:st032288|FD-Score:4.34|P-value:3.49E-5 ID:SGTC_1767|Compound:st044992|FD-Score:3.94|P-value:1.53E-4 ID:SGTC_1962|Compound:st076595|FD-Score:3.63|P-value:4.45E-4 ID:SGTC_2021|Compound:4019055|FD-Score:4.30|P-value:4.10E-5 ID:SGTC_2062|Compound:5245942|FD-Score:4.02|P-value:1.18E-4 ID:SGTC_2083|Compound:5306046|FD-Score:3.70|P-value:3.50E-4 ID:SGTC_2185|Compound:6113692|FD-Score:3.61|P-value:4.77E-4 ID:SGTC_2347|Compound:9049783|FD-Score:-3.62|P-value:4.18E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:-3.54|P-value:5.46E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-4.25|P-value:4.43E-5 ID:SGTC_2721|Compound:ifenprodil|FD-Score:-4.01|P-value:1.08E-4 ID:SGTC_2826|Compound:7992541|FD-Score:4.80|P-value:5.60E-6 ID:SGTC_2856|Compound:9022925|FD-Score:3.83|P-value:2.27E-4 ID:SGTC_3165|Compound:9101544|FD-Score:3.90|P-value:1.76E-4 ID:SGTC_3210|Compound:9128157|FD-Score:3.77|P-value:2.80E-4 ID:SGTC_3348|Compound:9149464|FD-Score:3.61|P-value:4.73E-4

Top fitness defect scores for YGR130C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_108 0509-0257 6.14 621.1 µM 9.28E-9 12 4.20E-10
2 SGTC_196 k015-0023 5.85 18.1 µM 4.10E-8 PDR1 6 2.43E-9
3 SGTC_1708 st033234 5.66 31.8 µM 1.08E-7 1 7.60E-9
4 SGTC_197 4544-0043 5.13 41.6 µM 1.30E-6 endomembrane recycling 28 1.45E-7
5 SGTC_2826 7992541 4.80 19.5 µM 5.60E-6 7 8.11E-7
6 SGTC_858 0438-0351 4.52 2.8 µM 1.73E-5 copper-dependent oxidative stress 11 3.07E-6
7 SGTC_1712 st032288 4.34 53.4 µM 3.49E-5 calcium & mitochondrial duress 161 7.02E-6
8 SGTC_2021 4019055 4.30 173.0 µM 4.10E-5 endomembrane recycling 102 8.50E-6
9 SGTC_1518 st038567 4.28 90.8 µM 4.47E-5 9 9.41E-6
10 SGTC_1629 st005085 4.25 44.9 µM 5.06E-5 RPP1 & pyrimidine depletion 27 1.09E-5
11 SGTC_2062 5245942 4.02 200.0 µM 1.18E-4 17 2.97E-5
12 SGTC_1121 fusaric acid 3.95 630.5 nM 1.50E-4 34 3.92E-5
13 SGTC_1767 st044992 3.94 70.3 µM 1.53E-4 23 4.00E-5
14 SGTC_834 0312-0008 3.94 75.7 µM 1.53E-4 NEO1 37 4.02E-5
15 SGTC_3165 9101544 3.90 49.5 µM 1.76E-4 12 4.73E-5
16 SGTC_738 1315-0003 3.90 72.4 µM 1.80E-4 22 4.84E-5
17 SGTC_2856 9022925 3.83 19.5 µM 2.27E-4 21 6.37E-5
18 SGTC_955 1216-0110 3.82 33.0 µM 2.38E-4 sphingolipid biosynthesis & PDR1 70 6.74E-5
19 SGTC_3210 9128157 3.77 49.5 µM 2.80E-4 52 8.15E-5
20 SGTC_899 1083-0020 3.72 478.0 µM 3.27E-4 27 9.80E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.181 5.64E-26 YDR467C_d YDR467C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.165 7.28E-22 YFL033C RIM15 hom Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase
0.159 1.67E-20 YHR205W SCH9 hom AGC family protein kinase; functional ortholog of mammalian S6 kinase; phosphorylated by Tor1p and required for TORC1-mediated regulation of ribosome biogenesis, translation initiation, and entry into G0 phase; involved in transactivation of osmostress-responsive genes; regulates G1 progression, cAPK activity and nitrogen activation of the FGM pathway; integrates nutrient signals and stress signals from sphingolipids to regulate lifespan
0.149 3.69E-18 YDR466W PKH3 hom Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant
0.142 1.29E-16 YDR005C MAF1 hom Highly conserved negative regulator of RNA polymerase III; binds to the N-terminal domain of the Rpc160p subunit of Pol III to prevent closed-complex formation; localization and activity are regulated by phosphorylation, mediated by TORC1, protein kinase A, and Sch9p; localizes to cytoplasm during vegetative growth and translocates to the nucleus and nucleolus under stress conditions
0.127 1.54E-13 YGL151W NUT1 hom Component of the RNA polymerase II mediator complex, which is required for transcriptional activation and also has a role in basal transcription
0.118 6.87E-12 YPR149W NCE102 hom Protein of unknown function; contains transmembrane domains; involved in secretion of proteins that lack classical secretory signal sequences; component of the detergent-insoluble glycolipid-enriched complexes (DIGs)
0.118 8.35E-12 YKL051W SFK1 hom Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
0.117 1.18E-11 YDR357C_p CNL1_p hom Protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; null mutant is sensitive to drug inducing secretion of vacuolar cargo; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.113 6.11E-11 YPR091C NVJ2 hom Lipid-binding ER protein, enriched at nucleus-vacuolar junctions (NVJ); may be involved in sterol metabolism or signaling at the NVJ; contains a synaptotagmin-like-mitochondrial- lipid binding protein (SMP) domain; binds phosphatidylinositols and other lipids in a large-scale study; may interact with ribosomes, based on co-purification experiments
0.104 1.70E-9 YGL203C KEX1 hom Protease involved in the processing of killer toxin and alpha factor precursor; cleaves Lys and Arg residues from the C-terminus of peptides and proteins
0.102 3.24E-9 YGR014W MSB2 hom Mucin family member involved in signaling; functions in the Cdc42p- and MAP kinase-dependent filamentous growth signaling pathway; is processed into secreted and cell-associated forms by the aspartyl protease, Yps1p; also functions as an osmosensor in parallel to the Sho1p-mediated pathway; potential Cdc28p substrate
0.100 6.03E-9 YDL019C OSH2 hom Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
0.098 1.23E-8 YDL167C NRP1 hom Putative RNA binding protein of unknown function; localizes to stress granules induced by glucose deprivation; predicted to be involved in ribosome biogenesis
0.095 3.47E-8 YDR315C IPK1 hom Inositol 1,3,4,5,6-pentakisphosphate 2-kinase, nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviable