YGR137W_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR137W / YGR137W

Click on Significant Values for Screen Details ID:SGTC_1|Compound:0258-0098|FD-Score:3.11|P-value:6.25E-4 ID:SGTC_41|Compound:0478-0632|FD-Score:-3.45|P-value:1.65E-4 ID:SGTC_181|Compound:1447-1644|FD-Score:3.47|P-value:1.58E-4 ID:SGTC_302|Compound:1094-0063|FD-Score:3.28|P-value:3.33E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:3.18|P-value:4.79E-4 ID:SGTC_419|Compound:nsc-638432|FD-Score:4.23|P-value:5.57E-6 ID:SGTC_698|Compound:k064-0052|FD-Score:4.62|P-value:8.14E-7 ID:SGTC_709|Compound:3807-1509|FD-Score:3.70|P-value:6.19E-5 ID:SGTC_815|Compound:1582-0027|FD-Score:4.01|P-value:1.60E-5 ID:SGTC_1023|Compound:4482-3888|FD-Score:3.74|P-value:5.25E-5 ID:SGTC_1210|Compound:3013-0140|FD-Score:-3.28|P-value:3.12E-4 ID:SGTC_1256|Compound:0570-0116|FD-Score:-3.70|P-value:5.91E-5 ID:SGTC_1283|Compound:0922-0125|FD-Score:3.16|P-value:5.16E-4 ID:SGTC_1336|Compound:1486-0901|FD-Score:-3.13|P-value:5.49E-4 ID:SGTC_1359|Compound:1582-0056|FD-Score:3.74|P-value:5.20E-5 ID:SGTC_1447|Compound:4239-0816|FD-Score:-2.97|P-value:9.76E-4 ID:SGTC_1526|Compound:st051518|FD-Score:4.46|P-value:1.83E-6 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:-3.21|P-value:4.09E-4 ID:SGTC_1583|Compound:clindamycin|FD-Score:3.20|P-value:4.44E-4 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:-3.14|P-value:5.35E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-3.09|P-value:6.37E-4 ID:SGTC_1743|Compound:st037606|FD-Score:3.18|P-value:4.79E-4 ID:SGTC_2110|Compound:5483698|FD-Score:-3.99|P-value:1.65E-5 ID:SGTC_2116|Compound:5511452|FD-Score:5.52|P-value:5.00E-9 ID:SGTC_2120|Compound:5538279|FD-Score:3.02|P-value:8.64E-4 ID:SGTC_2124|Compound:5246320|FD-Score:3.13|P-value:5.93E-4 ID:SGTC_2316|Compound:5844804|FD-Score:3.40|P-value:2.10E-4 ID:SGTC_2327|Compound:6189656|FD-Score:-3.07|P-value:6.94E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:-4.61|P-value:7.95E-7 ID:SGTC_2602|Compound:kawain|FD-Score:-3.11|P-value:6.05E-4 ID:SGTC_2978|Compound:9011784|FD-Score:3.43|P-value:1.85E-4 ID:SGTC_3108|Compound:9121785|FD-Score:3.23|P-value:4.01E-4 ID:SGTC_3333|Compound:9141820|FD-Score:3.87|P-value:2.92E-5 ID:SGTC_3352|Compound:9151559|FD-Score:5.37|P-value:1.23E-8 ID:SGTC_1|Compound:0258-0098|FD-Score:3.11|P-value:6.25E-4 ID:SGTC_41|Compound:0478-0632|FD-Score:-3.45|P-value:1.65E-4 ID:SGTC_181|Compound:1447-1644|FD-Score:3.47|P-value:1.58E-4 ID:SGTC_302|Compound:1094-0063|FD-Score:3.28|P-value:3.33E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:3.18|P-value:4.79E-4 ID:SGTC_419|Compound:nsc-638432|FD-Score:4.23|P-value:5.57E-6 ID:SGTC_698|Compound:k064-0052|FD-Score:4.62|P-value:8.14E-7 ID:SGTC_709|Compound:3807-1509|FD-Score:3.70|P-value:6.19E-5 ID:SGTC_815|Compound:1582-0027|FD-Score:4.01|P-value:1.60E-5 ID:SGTC_1023|Compound:4482-3888|FD-Score:3.74|P-value:5.25E-5 ID:SGTC_1210|Compound:3013-0140|FD-Score:-3.28|P-value:3.12E-4 ID:SGTC_1256|Compound:0570-0116|FD-Score:-3.70|P-value:5.91E-5 ID:SGTC_1283|Compound:0922-0125|FD-Score:3.16|P-value:5.16E-4 ID:SGTC_1336|Compound:1486-0901|FD-Score:-3.13|P-value:5.49E-4 ID:SGTC_1359|Compound:1582-0056|FD-Score:3.74|P-value:5.20E-5 ID:SGTC_1447|Compound:4239-0816|FD-Score:-2.97|P-value:9.76E-4 ID:SGTC_1526|Compound:st051518|FD-Score:4.46|P-value:1.83E-6 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:-3.21|P-value:4.09E-4 ID:SGTC_1583|Compound:clindamycin|FD-Score:3.20|P-value:4.44E-4 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:-3.14|P-value:5.35E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-3.09|P-value:6.37E-4 ID:SGTC_1743|Compound:st037606|FD-Score:3.18|P-value:4.79E-4 ID:SGTC_2110|Compound:5483698|FD-Score:-3.99|P-value:1.65E-5 ID:SGTC_2116|Compound:5511452|FD-Score:5.52|P-value:5.00E-9 ID:SGTC_2120|Compound:5538279|FD-Score:3.02|P-value:8.64E-4 ID:SGTC_2124|Compound:5246320|FD-Score:3.13|P-value:5.93E-4 ID:SGTC_2316|Compound:5844804|FD-Score:3.40|P-value:2.10E-4 ID:SGTC_2327|Compound:6189656|FD-Score:-3.07|P-value:6.94E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:-4.61|P-value:7.95E-7 ID:SGTC_2602|Compound:kawain|FD-Score:-3.11|P-value:6.05E-4 ID:SGTC_2978|Compound:9011784|FD-Score:3.43|P-value:1.85E-4 ID:SGTC_3108|Compound:9121785|FD-Score:3.23|P-value:4.01E-4 ID:SGTC_3333|Compound:9141820|FD-Score:3.87|P-value:2.92E-5 ID:SGTC_3352|Compound:9151559|FD-Score:5.37|P-value:1.23E-8

Top fitness defect scores for YGR137W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2116 5511452 5.52 16.9 µM 5.00E-9 2 1.71E-8
2 SGTC_3352 9151559 5.37 45.6 µM 1.23E-8 3 3.93E-8
3 SGTC_698 k064-0052 4.62 127.0 µM 8.14E-7 DNA damage response 1 1.93E-6
4 SGTC_1526 st051518 4.46 75.0 µM 1.83E-6 13 4.11E-6
5 SGTC_419 nsc-638432 4.23 893.0 µM 5.57E-6 DNA damage response 8 1.15E-5
6 SGTC_815 1582-0027 4.01 36.9 µM 1.60E-5 25 3.08E-5
7 SGTC_3333 9141820 3.87 12.1 µM 2.92E-5 15 5.39E-5
8 SGTC_1359 1582-0056 3.74 520.0 nM 5.20E-5 24 9.22E-5
9 SGTC_1023 4482-3888 3.74 16.0 µM 5.25E-5 TSC3-RPN4 24 9.30E-5
10 SGTC_709 3807-1509 3.70 243.0 µM 6.19E-5 RSC complex & mRNA processing 20 1.08E-4
11 SGTC_181 1447-1644 3.47 8.1 µM 1.58E-4 endomembrane recycling 48 2.59E-4
12 SGTC_2978 9011784 3.43 43.0 µM 1.85E-4 51 3.00E-4
13 SGTC_2316 5844804 3.40 197.4 µM 2.10E-4 62 3.37E-4
14 SGTC_302 1094-0063 3.28 18.9 µM 3.33E-4 28 5.20E-4
15 SGTC_3108 9121785 3.23 49.5 µM 4.01E-4 39 6.17E-4
16 SGTC_1583 clindamycin 3.20 39.6 µM 4.44E-4 mitochondrial processes 38 6.79E-4
17 SGTC_1743 st037606 3.18 46.4 µM 4.79E-4 56 7.29E-4
18 SGTC_359 0081-0058 3.18 15.9 µM 4.79E-4 60S ribosome export 89 7.29E-4
19 SGTC_1283 0922-0125 3.16 16.4 µM 5.16E-4 51 7.80E-4
20 SGTC_2124 5246320 3.13 200.0 µM 5.93E-4 heme biosynthesis & mitochondrial translocase 52 8.88E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.119 5.14E-12 YDR396W_d YDR396W_d het Dubious open reading frame unlikely to encode a functional protein; extensively overlaps essential NCB2 gene encoding the beta subunit of the NC2 dimeric histone-fold complex
0.102 3.60E-9 YDR517W GRH1 hom Acetylated cis-Golgi protein, involved in ER to Golgi transport; homolog of human GRASP65; forms a complex with the coiled-coil protein Bug1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes; protein abundance increases in response to DNA replication stress
0.099 8.91E-9 YGR201C_p YGR201C_p hom Putative protein of unknown function
0.092 1.10E-7 YJR015W_p YJR015W_p hom Putative protein of unknown function; localizes to the endoplasmic reticulum and cytoplasm; predicted to encode a membrane transporter based on phylogenetic analysis; YJR015W is a non-essential gene
0.090 1.60E-7 YDL046W NPC2 hom Functional homolog of human NPC2/He1, which is a cholesterol-binding protein whose deficiency causes Niemann-Pick type C2 disease involving retention of cholesterol in lysosomes
0.090 1.96E-7 YLR206W ENT2 hom Epsin-like protein required for endocytosis and actin patch assembly and functionally redundant with Ent1p; contains clathrin-binding motif at C-terminus
0.088 3.20E-7 YOR300W_d YOR300W_d hom Dubious open reading frame, unlikely to encode a protein; overlaps with verified gene BUD7/YOR299W; mutation affects bipolar budding and bud site selection, though phenotype could be due to the mutation's effects on BUD7
0.088 3.83E-7 YBR299W MAL32 hom Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL3 complex locus; functional in genomic reference strain S288C; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose
0.085 8.35E-7 YBR084W MIS1 hom Mitochondrial C1-tetrahydrofolate synthase, involved in interconversion between different oxidation states of tetrahydrofolate (THF); provides activities of formyl-THF synthetase, methenyl-THF cyclohydrolase, and methylene-THF dehydrogenase
0.085 8.91E-7 YDR394W RPT3 het One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; substrate of N-acetyltransferase B
0.084 1.21E-6 YOL154W ZPS1 hom Putative GPI-anchored protein; transcription is induced under low-zinc conditions, as mediated by the Zap1p transcription factor, and at alkaline pH
0.083 1.29E-6 YMR106C YKU80 hom Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair
0.083 1.39E-6 YFL007W BLM10 hom Proteasome activator; binds the core proteasome and stimulates proteasome-mediated protein degradation by inducing gate opening; required for resistance to bleomycin, may be involved in protecting against oxidative damage; similar to mammalian PA200
0.079 4.87E-6 YMR088C VBA1 hom Permease of basic amino acids in the vacuolar membrane
0.079 4.77E-6 YOR126C IAH1 hom Isoamyl acetate-hydrolyzing esterase, required in balance with alcohol acetyltransferase to maintain optimal amounts of isoamyl acetate, which is particularly important in sake brewing