YGR138C / TPO2

Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; specific for spermine; localizes to the plasma membrane; transcription of TPO2 is regulated by Haa1p; TPO2 has a paralog, TPO3, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR138C / TPO2

Click on Significant Values for Screen Details ID:SGTC_65|Compound:0798-0905|FD-Score:4.36|P-value:6.38E-8 ID:SGTC_144|Compound:4161-2749|FD-Score:-3.23|P-value:6.19E-5 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:-2.66|P-value:7.91E-4 ID:SGTC_251|Compound:melphalan|FD-Score:2.99|P-value:1.39E-4 ID:SGTC_357|Compound:1325-0123|FD-Score:2.74|P-value:4.27E-4 ID:SGTC_591|Compound:4299-0174|FD-Score:-2.63|P-value:9.21E-4 ID:SGTC_592|Compound:k241-0073|FD-Score:3.16|P-value:6.16E-5 ID:SGTC_602|Compound:3130-1533|FD-Score:2.83|P-value:2.93E-4 ID:SGTC_604|Compound:1000-0114|FD-Score:2.72|P-value:4.64E-4 ID:SGTC_613|Compound:3914-0030|FD-Score:-2.65|P-value:8.49E-4 ID:SGTC_631|Compound:k072-0230|FD-Score:2.60|P-value:7.85E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:2.56|P-value:9.21E-4 ID:SGTC_739|Compound:1486-1183|FD-Score:2.65|P-value:6.25E-4 ID:SGTC_784|Compound:4579-0127|FD-Score:2.90|P-value:2.12E-4 ID:SGTC_818|Compound:4072-2707|FD-Score:-3.60|P-value:9.25E-6 ID:SGTC_842|Compound:0271-0008|FD-Score:2.73|P-value:4.49E-4 ID:SGTC_872|Compound:0588-0139|FD-Score:-2.82|P-value:4.14E-4 ID:SGTC_874|Compound:0599-0792|FD-Score:2.94|P-value:1.78E-4 ID:SGTC_877|Compound:0771-0151|FD-Score:-2.77|P-value:4.99E-4 ID:SGTC_904|Compound:1141-0088|FD-Score:-3.01|P-value:1.79E-4 ID:SGTC_959|Compound:1222-0044|FD-Score:3.05|P-value:1.09E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:2.62|P-value:7.26E-4 ID:SGTC_969|Compound:1313-0238|FD-Score:2.56|P-value:9.25E-4 ID:SGTC_988|Compound:1497-1057|FD-Score:2.60|P-value:7.74E-4 ID:SGTC_1086|Compound:cerivastatin|FD-Score:2.73|P-value:4.43E-4 ID:SGTC_1154|Compound:4088-0362|FD-Score:-2.62|P-value:9.63E-4 ID:SGTC_1613|Compound:st002381|FD-Score:-3.33|P-value:3.79E-5 ID:SGTC_1691|Compound:st019933|FD-Score:3.54|P-value:8.81E-6 ID:SGTC_1700|Compound:st030840|FD-Score:2.61|P-value:7.51E-4 ID:SGTC_1742|Compound:st038235|FD-Score:2.72|P-value:4.75E-4 ID:SGTC_1780|Compound:st038448|FD-Score:2.79|P-value:3.49E-4 ID:SGTC_2029|Compound:5175081|FD-Score:-3.28|P-value:4.93E-5 ID:SGTC_2034|Compound:5197015|FD-Score:4.90|P-value:1.52E-9 ID:SGTC_2037|Compound:5169046|FD-Score:-3.18|P-value:7.68E-5 ID:SGTC_2057|Compound:5236571|FD-Score:2.95|P-value:1.67E-4 ID:SGTC_2121|Compound:5257820|FD-Score:2.72|P-value:4.65E-4 ID:SGTC_2285|Compound:7945142|FD-Score:3.22|P-value:4.58E-5 ID:SGTC_2293|Compound:7624732|FD-Score:-3.99|P-value:1.02E-6 ID:SGTC_2298|Compound:7976326|FD-Score:2.81|P-value:3.17E-4 ID:SGTC_2300|Compound:7976697|FD-Score:-3.57|P-value:1.06E-5 ID:SGTC_2334|Compound:9017922|FD-Score:-2.89|P-value:3.02E-4 ID:SGTC_2339|Compound:9000433|FD-Score:-2.62|P-value:9.56E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:-2.69|P-value:7.13E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:-2.68|P-value:7.24E-4 ID:SGTC_2480|Compound:5767542|FD-Score:-2.68|P-value:7.46E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:3.38|P-value:2.07E-5 ID:SGTC_2907|Compound:7721985|FD-Score:-3.14|P-value:9.45E-5 ID:SGTC_2956|Compound:9076196|FD-Score:-2.65|P-value:8.49E-4 ID:SGTC_2960|Compound:9079389|FD-Score:3.79|P-value:2.20E-6 ID:SGTC_3027|Compound:9089541|FD-Score:3.44|P-value:1.52E-5 ID:SGTC_3157|Compound:9099274|FD-Score:2.66|P-value:6.19E-4 ID:SGTC_3211|Compound:9128781|FD-Score:-4.04|P-value:7.52E-7 ID:SGTC_3226|Compound:9131256|FD-Score:2.67|P-value:5.72E-4 ID:SGTC_3249|Compound:9135183|FD-Score:-2.70|P-value:6.83E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:4.36|P-value:6.38E-8 ID:SGTC_144|Compound:4161-2749|FD-Score:-3.23|P-value:6.19E-5 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:-2.66|P-value:7.91E-4 ID:SGTC_251|Compound:melphalan|FD-Score:2.99|P-value:1.39E-4 ID:SGTC_357|Compound:1325-0123|FD-Score:2.74|P-value:4.27E-4 ID:SGTC_591|Compound:4299-0174|FD-Score:-2.63|P-value:9.21E-4 ID:SGTC_592|Compound:k241-0073|FD-Score:3.16|P-value:6.16E-5 ID:SGTC_602|Compound:3130-1533|FD-Score:2.83|P-value:2.93E-4 ID:SGTC_604|Compound:1000-0114|FD-Score:2.72|P-value:4.64E-4 ID:SGTC_613|Compound:3914-0030|FD-Score:-2.65|P-value:8.49E-4 ID:SGTC_631|Compound:k072-0230|FD-Score:2.60|P-value:7.85E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:2.56|P-value:9.21E-4 ID:SGTC_739|Compound:1486-1183|FD-Score:2.65|P-value:6.25E-4 ID:SGTC_784|Compound:4579-0127|FD-Score:2.90|P-value:2.12E-4 ID:SGTC_818|Compound:4072-2707|FD-Score:-3.60|P-value:9.25E-6 ID:SGTC_842|Compound:0271-0008|FD-Score:2.73|P-value:4.49E-4 ID:SGTC_872|Compound:0588-0139|FD-Score:-2.82|P-value:4.14E-4 ID:SGTC_874|Compound:0599-0792|FD-Score:2.94|P-value:1.78E-4 ID:SGTC_877|Compound:0771-0151|FD-Score:-2.77|P-value:4.99E-4 ID:SGTC_904|Compound:1141-0088|FD-Score:-3.01|P-value:1.79E-4 ID:SGTC_959|Compound:1222-0044|FD-Score:3.05|P-value:1.09E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:2.62|P-value:7.26E-4 ID:SGTC_969|Compound:1313-0238|FD-Score:2.56|P-value:9.25E-4 ID:SGTC_988|Compound:1497-1057|FD-Score:2.60|P-value:7.74E-4 ID:SGTC_1086|Compound:cerivastatin|FD-Score:2.73|P-value:4.43E-4 ID:SGTC_1154|Compound:4088-0362|FD-Score:-2.62|P-value:9.63E-4 ID:SGTC_1613|Compound:st002381|FD-Score:-3.33|P-value:3.79E-5 ID:SGTC_1691|Compound:st019933|FD-Score:3.54|P-value:8.81E-6 ID:SGTC_1700|Compound:st030840|FD-Score:2.61|P-value:7.51E-4 ID:SGTC_1742|Compound:st038235|FD-Score:2.72|P-value:4.75E-4 ID:SGTC_1780|Compound:st038448|FD-Score:2.79|P-value:3.49E-4 ID:SGTC_2029|Compound:5175081|FD-Score:-3.28|P-value:4.93E-5 ID:SGTC_2034|Compound:5197015|FD-Score:4.90|P-value:1.52E-9 ID:SGTC_2037|Compound:5169046|FD-Score:-3.18|P-value:7.68E-5 ID:SGTC_2057|Compound:5236571|FD-Score:2.95|P-value:1.67E-4 ID:SGTC_2121|Compound:5257820|FD-Score:2.72|P-value:4.65E-4 ID:SGTC_2285|Compound:7945142|FD-Score:3.22|P-value:4.58E-5 ID:SGTC_2293|Compound:7624732|FD-Score:-3.99|P-value:1.02E-6 ID:SGTC_2298|Compound:7976326|FD-Score:2.81|P-value:3.17E-4 ID:SGTC_2300|Compound:7976697|FD-Score:-3.57|P-value:1.06E-5 ID:SGTC_2334|Compound:9017922|FD-Score:-2.89|P-value:3.02E-4 ID:SGTC_2339|Compound:9000433|FD-Score:-2.62|P-value:9.56E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:-2.69|P-value:7.13E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:-2.68|P-value:7.24E-4 ID:SGTC_2480|Compound:5767542|FD-Score:-2.68|P-value:7.46E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:3.38|P-value:2.07E-5 ID:SGTC_2907|Compound:7721985|FD-Score:-3.14|P-value:9.45E-5 ID:SGTC_2956|Compound:9076196|FD-Score:-2.65|P-value:8.49E-4 ID:SGTC_2960|Compound:9079389|FD-Score:3.79|P-value:2.20E-6 ID:SGTC_3027|Compound:9089541|FD-Score:3.44|P-value:1.52E-5 ID:SGTC_3157|Compound:9099274|FD-Score:2.66|P-value:6.19E-4 ID:SGTC_3211|Compound:9128781|FD-Score:-4.04|P-value:7.52E-7 ID:SGTC_3226|Compound:9131256|FD-Score:2.67|P-value:5.72E-4 ID:SGTC_3249|Compound:9135183|FD-Score:-2.70|P-value:6.83E-4

Top fitness defect scores for YGR138C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2034 5197015 4.90 53.1 µM 1.52E-9 SWF1 & branched chain AA biosynthesis 12 4.71E-7
2 SGTC_65 0798-0905 4.36 35.0 µM 6.38E-8 calcium & mitochondrial duress 70 6.38E-6
3 SGTC_2960 9079389 3.79 6.0 µM 2.20E-6 32 7.57E-5
4 SGTC_1691 st019933 3.54 84.6 µM 8.81E-6 21 2.00E-4
5 SGTC_3027 9089541 3.44 49.5 µM 1.52E-5 fatty acid desaturase (OLE1) 36 2.93E-4
6 SGTC_2563 tomatine 3.38 8.5 µM 2.07E-5 80 3.63E-4
7 SGTC_2285 7945142 3.22 200.0 µM 4.58E-5 47 6.34E-4
8 SGTC_592 k241-0073 3.16 46.5 µM 6.16E-5 44 7.80E-4
9 SGTC_959 1222-0044 3.05 107.0 µM 1.09E-4 60 0.00116
10 SGTC_251 melphalan 2.99 456.5 µM 1.39E-4 DNA damage response 75 0.00138
11 SGTC_2057 5236571 2.95 38.3 µM 1.67E-4 RPP1 & pyrimidine depletion 94 0.00157
12 SGTC_874 0599-0792 2.94 117.0 µM 1.78E-4 85 0.00165
13 SGTC_784 4579-0127 2.90 173.0 µM 2.12E-4 68 0.00186
14 SGTC_602 3130-1533 2.83 38.1 µM 2.93E-4 72 0.00234
15 SGTC_2298 7976326 2.81 193.8 µM 3.17E-4 42 0.00247
16 SGTC_1780 st038448 2.79 24.5 µM 3.49E-4 iron homeostasis 84 0.00264
17 SGTC_357 1325-0123 2.74 420.0 µM 4.27E-4 53 0.00305
18 SGTC_1086 cerivastatin 2.73 2.2 µM 4.43E-4 azole & statin 51 0.00312
19 SGTC_842 0271-0008 2.73 11.1 µM 4.49E-4 heme biosynthesis & mitochondrial translocase 71 0.00316
20 SGTC_604 1000-0114 2.72 314.0 µM 4.64E-4 90 0.00323

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.177 6.05E-25 YBR139W YBR139W hom Putative serine type carboxypeptidase with a role in phytochelatin synthesis; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner
0.150 2.84E-18 YGR217W CCH1 hom Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together
0.148 5.40E-18 YIL010W DOT5 hom Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth
0.139 6.43E-16 YBR169C SSE2 hom Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; SSE2 has a paralog, SSE1, that arose from the whole genome duplication
0.128 9.48E-14 YMR118C_p SHH3_p hom Putative mitochondrial inner membrane protein of unknown function; although similar to Sdh3p, Shh3p is not a stoichiometric subunit of either succinate dehydrogenase or of the TIM22 translocase
0.123 7.52E-13 YOR071C NRT1 hom High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; shares sequence similarity with Thi7p and Thi72p; proposed to be involved in 5-fluorocytosine sensitivity
0.122 1.39E-12 YBR165W UBS1 hom Ubiquitin-conjugating enzyme suppressor that functions as a general positive regulator of Cdc34p activity; nuclear protein that may represent a link between nucleocytoplasmic transport and ubiquitin ligase activity
0.111 1.15E-10 YJL136W-A_p YJL136W-A_p hom Putative protein of unknown function; identified by SAGE
0.110 1.55E-10 YNR032C-A HUB1 hom Ubiquitin-like protein modifier; promotes alternative splicing of SRC1 pre-mRNA; binds non-covalently to the HIND domain of Snu66, may function in modification of Sph1p and Hbt1p, functionally complemented by the human or S. pombe ortholog; mechanism of Hub1p adduct formation not yet clear
0.110 2.04E-10 YLR004C THI73 hom Putative plasma membrane permease proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs
0.108 3.50E-10 YKR086W PRP16 het DEAH-box RNA helicase involved in second catalytic step of splicing; exhibits ATP-dependent RNA unwinding activity; mediates the release of Yju2p and Cwc25p in the second step; in the absence of ATP, stabilizes the binding of Cwc25p to the spliceosome in the first catalytic step
0.106 7.81E-10 YOL141W PPM2 hom AdoMet-dependent tRNA methyltransferase also involved in methoxycarbonylation; required for the synthesis of wybutosine (yW), a modified guanosine found at the 3'-position adjacent to the anticodon of phe-tRNA; similarity to Ppm1p
0.105 9.49E-10 YNL212W VID27 hom Cytoplasmic protein of unknown function; possibly involved in vacuolar protein degradation; not essential for proteasome-dependent degradation of fructose-1,6-bisphosphatase (FBPase); null mutants exhibit normal growth
0.102 3.39E-9 YML100W-A_p YML100W-A_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.102 3.41E-9 YPL027W SMA1 hom Protein of unknown function involved in the assembly of the prospore membrane during sporulation; interacts with Spo14p