YGR141W / VPS62

Vacuolar protein sorting (VPS) protein required for cytoplasm to vacuole targeting of proteins

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR141W / VPS62

Click on Significant Values for Screen Details ID:SGTC_15|Compound:0266-0086|FD-Score:3.40|P-value:1.64E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.26|P-value:4.78E-6 ID:SGTC_118|Compound:0083-0097|FD-Score:-3.04|P-value:8.00E-4 ID:SGTC_289|Compound:k017-0060|FD-Score:3.11|P-value:5.03E-4 ID:SGTC_307|Compound:1501-1223|FD-Score:-3.04|P-value:8.08E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:-3.36|P-value:2.41E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:2.96|P-value:8.66E-4 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:3.69|P-value:5.01E-5 ID:SGTC_558|Compound:k064-0027|FD-Score:3.06|P-value:6.05E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:3.84|P-value:2.49E-5 ID:SGTC_731|Compound:3966-0296|FD-Score:-3.07|P-value:7.20E-4 ID:SGTC_798|Compound:1287-0182|FD-Score:4.08|P-value:8.31E-6 ID:SGTC_952|Compound:1185-0122|FD-Score:-3.18|P-value:4.78E-4 ID:SGTC_1321|Compound:1326-2144|FD-Score:-4.09|P-value:1.08E-5 ID:SGTC_1327|Compound:1436-0082|FD-Score:-3.57|P-value:1.04E-4 ID:SGTC_1341|Compound:1486-1360|FD-Score:4.66|P-value:4.58E-7 ID:SGTC_1445|Compound:4239-0156|FD-Score:3.12|P-value:4.82E-4 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:3.62|P-value:6.78E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:2.94|P-value:9.34E-4 ID:SGTC_1720|Compound:st037298|FD-Score:3.41|P-value:1.60E-4 ID:SGTC_1762|Compound:st045503|FD-Score:-3.04|P-value:8.01E-4 ID:SGTC_1771|Compound:st048882|FD-Score:3.30|P-value:2.46E-4 ID:SGTC_1997|Compound:st073024|FD-Score:3.38|P-value:1.78E-4 ID:SGTC_2091|Compound:4-phenylthiadiazole|FD-Score:-3.54|P-value:1.19E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-3.34|P-value:2.64E-4 ID:SGTC_2264|Compound:7948757|FD-Score:3.61|P-value:7.03E-5 ID:SGTC_2275|Compound:7947463|FD-Score:4.06|P-value:9.33E-6 ID:SGTC_2398|Compound:5228213|FD-Score:3.11|P-value:4.99E-4 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:4.11|P-value:7.35E-6 ID:SGTC_2602|Compound:kawain|FD-Score:3.88|P-value:2.10E-5 ID:SGTC_2859|Compound:9028643|FD-Score:4.47|P-value:1.26E-6 ID:SGTC_3283|Compound:9109332|FD-Score:3.86|P-value:2.30E-5 ID:SGTC_3287|Compound:9117173|FD-Score:3.58|P-value:7.77E-5 ID:SGTC_3290|Compound:9121031|FD-Score:-3.10|P-value:6.54E-4 ID:SGTC_15|Compound:0266-0086|FD-Score:3.40|P-value:1.64E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.26|P-value:4.78E-6 ID:SGTC_118|Compound:0083-0097|FD-Score:-3.04|P-value:8.00E-4 ID:SGTC_289|Compound:k017-0060|FD-Score:3.11|P-value:5.03E-4 ID:SGTC_307|Compound:1501-1223|FD-Score:-3.04|P-value:8.08E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:-3.36|P-value:2.41E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:2.96|P-value:8.66E-4 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:3.69|P-value:5.01E-5 ID:SGTC_558|Compound:k064-0027|FD-Score:3.06|P-value:6.05E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:3.84|P-value:2.49E-5 ID:SGTC_731|Compound:3966-0296|FD-Score:-3.07|P-value:7.20E-4 ID:SGTC_798|Compound:1287-0182|FD-Score:4.08|P-value:8.31E-6 ID:SGTC_952|Compound:1185-0122|FD-Score:-3.18|P-value:4.78E-4 ID:SGTC_1321|Compound:1326-2144|FD-Score:-4.09|P-value:1.08E-5 ID:SGTC_1327|Compound:1436-0082|FD-Score:-3.57|P-value:1.04E-4 ID:SGTC_1341|Compound:1486-1360|FD-Score:4.66|P-value:4.58E-7 ID:SGTC_1445|Compound:4239-0156|FD-Score:3.12|P-value:4.82E-4 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:3.62|P-value:6.78E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:2.94|P-value:9.34E-4 ID:SGTC_1720|Compound:st037298|FD-Score:3.41|P-value:1.60E-4 ID:SGTC_1762|Compound:st045503|FD-Score:-3.04|P-value:8.01E-4 ID:SGTC_1771|Compound:st048882|FD-Score:3.30|P-value:2.46E-4 ID:SGTC_1997|Compound:st073024|FD-Score:3.38|P-value:1.78E-4 ID:SGTC_2091|Compound:4-phenylthiadiazole|FD-Score:-3.54|P-value:1.19E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-3.34|P-value:2.64E-4 ID:SGTC_2264|Compound:7948757|FD-Score:3.61|P-value:7.03E-5 ID:SGTC_2275|Compound:7947463|FD-Score:4.06|P-value:9.33E-6 ID:SGTC_2398|Compound:5228213|FD-Score:3.11|P-value:4.99E-4 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:4.11|P-value:7.35E-6 ID:SGTC_2602|Compound:kawain|FD-Score:3.88|P-value:2.10E-5 ID:SGTC_2859|Compound:9028643|FD-Score:4.47|P-value:1.26E-6 ID:SGTC_3283|Compound:9109332|FD-Score:3.86|P-value:2.30E-5 ID:SGTC_3287|Compound:9117173|FD-Score:3.58|P-value:7.77E-5 ID:SGTC_3290|Compound:9121031|FD-Score:-3.10|P-value:6.54E-4

Top fitness defect scores for YGR141W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1341 1486-1360 4.66 280.0 µM 4.58E-7 7 1.59E-6
2 SGTC_2859 9028643 4.47 45.5 µM 1.26E-6 8 4.00E-6
3 SGTC_2598 perillyl alcohol 4.11 100.0 µM 7.35E-6 25 1.99E-5
4 SGTC_798 1287-0182 4.08 476.0 µM 8.31E-6 18 2.22E-5
5 SGTC_2275 7947463 4.06 200.0 µM 9.33E-6 iron homeostasis 33 2.47E-5
6 SGTC_2602 kawain 3.88 100.0 µM 2.10E-5 29 5.16E-5
7 SGTC_3283 9109332 3.86 35.8 µM 2.30E-5 DNA intercalators 20 5.61E-5
8 SGTC_684 1140-0066 3.84 328.0 µM 2.49E-5 Golgi 28 6.03E-5
9 SGTC_503 tyrphostin 8 3.69 294.0 µM 5.01E-5 TSC3-RPN4 41 1.14E-4
10 SGTC_1551 6-bromo-3'-methylflavone 3.62 63.5 µM 6.78E-5 28 1.50E-4
11 SGTC_2264 7948757 3.61 110.8 µM 7.03E-5 25 1.55E-4
12 SGTC_3287 9117173 3.58 37.1 µM 7.77E-5 60S ribosome export 8 1.70E-4
13 SGTC_1720 st037298 3.41 9.5 µM 1.60E-4 57 3.28E-4
14 SGTC_15 0266-0086 3.40 27.1 µM 1.64E-4 endomembrane recycling 90 3.35E-4
15 SGTC_1997 st073024 3.38 93.8 µM 1.78E-4 20 3.60E-4
16 SGTC_1771 st048882 3.30 4.2 µM 2.46E-4 RPP1 & pyrimidine depletion 41 4.84E-4
17 SGTC_1445 4239-0156 3.12 97.7 µM 4.82E-4 69 8.95E-4
18 SGTC_2398 5228213 3.11 48.8 µM 4.99E-4 iron homeostasis 93 9.24E-4
19 SGTC_289 k017-0060 3.11 526.0 µM 5.03E-4 15 9.30E-4
20 SGTC_558 k064-0027 3.06 21.3 µM 6.05E-4 DNA damage response 72 0.00110

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.128 9.78E-14 YBR050C REG2 hom Regulatory subunit of the Glc7p type-1 protein phosphatase; involved with Reg1p, Glc7p, and Snf1p in regulation of glucose-repressible genes, also involved in glucose-induced proteolysis of maltose permease
0.111 1.49E-10 YIR013C GAT4 hom Protein containing GATA family zinc finger motifs
0.103 2.41E-9 YGR178C PBP1 hom Component of glucose deprivation induced stress granules; involved in P-body-dependent granule assembly; similar to human ataxin-2; interacts with Pab1p to regulate mRNA polyadenylation; interacts with Mkt1p to regulate HO translation; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress
0.100 6.06E-9 YDL236W PHO13 hom Alkaline phosphatase specific for p-nitrophenyl phosphate; also has protein phosphatase activity
0.100 6.92E-9 YGR152C RSR1 hom GTP-binding protein of the ras superfamily required for bud site selection, morphological changes in response to mating pheromone, and efficient cell fusion; localized to the plasma membrane; significantly similar to mammalian Rap GTPases
0.099 9.06E-9 YEL022W GEA2 hom Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs); involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; GEA2 has a paralog, GEA1, that arose from the whole genome duplication
0.099 9.44E-9 YGR206W MVB12 hom ESCRT-I subunit required to stabilize oligomers of the ESCRT-I core complex (Stp22p, Vps28p, Srn2p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; deletion mutant is sensitive to rapamycin and nystatin
0.096 2.83E-8 YOR190W SPR1 hom Sporulation-specific exo-1,3-beta-glucanase; contributes to ascospore thermoresistance
0.091 1.44E-7 YCR067C SED4 hom Integral endoplasmic reticulum membrane protein that stimulates Sar1p GTPase activity; involved in COPII vesicle budding through disassociation of coat proteins from membranes onto liposomes; binds Sec16p; similar to Sec12p
0.085 7.82E-7 YNL260C LTO1 het Essential protein that forms a complex with Rli1p and Yae1p; ortholog of human ORAOV1, which is overexpressed in solid tumors; inviability of null mutant under standard conditions is complemented by overexpression of ORAOV1; essential for growth under standard (aerobic) conditions but not under anaerobic conditions; may have a role in protection of ribosomal assembly and function from damage due to reactive oxygen species
0.081 2.45E-6 YNR030W ALG12 hom Alpha-1,6-mannosyltransferase localized to the ER; responsible for the addition of the alpha-1,6 mannose to dolichol-linked Man7GlcNAc2, acts in the dolichol pathway for N-glycosylation
0.081 2.64E-6 YNL219C ALG9 hom Mannosyltransferase, involved in N-linked glycosylation; catalyzes both the transfer of seventh mannose residue on B-arm and ninth mannose residue on the C-arm from Dol-P-Man to lipid-linked oligosaccharides; mutation of the human ortholog causes type 1 congenital disorders of glycosylation
0.077 7.05E-6 YER034W YER034W hom Protein of unknown function; non-essential gene; expression induced upon calcium shortage; protein abundance increases in response to DNA replication stress
0.076 1.03E-5 YGR131W FHN1 hom Protein of unknown function; induced by ketoconazole; promoter region contains sterol regulatory element motif, which has been identified as a Upc2p-binding site; overexpression complements function of Nce102p in NCE102 deletion strain
0.076 1.05E-5 YHL023C NPR3 hom Subunit of SEA (Seh1-associated), Npr2/3, and Iml1p complexes; Npr2/3 complex mediates downregulation of TORC1 activity upon amino acid limitation; SEA complex is a coatomer-related complex that associates dynamically with the vacuole; Iml1p complex (Iml1p-Npr2p-Npr3p) is required for non-nitrogen-starvation (NNS)-induced autophagy; required for Npr2p phosphorylation and Iml1p-Npr2p interaction; null mutant shows delayed meiotic DNA replication and double-strand break repair