YGR142W / BTN2

v-SNARE binding protein; facilitates specific protein retrieval from a late endosome to the Golgi; modulates arginine uptake, possible role in mediating pH homeostasis between the vacuole and plasma membrane H(+)-ATPase; BTN2 has a paralog, CUR1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR142W / BTN2

Click on Significant Values for Screen Details ID:SGTC_46|Compound:0329-0187a|FD-Score:3.40|P-value:2.80E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.23|P-value:5.05E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:4.02|P-value:2.30E-5 ID:SGTC_214|Compound:4373-3496|FD-Score:3.76|P-value:6.79E-5 ID:SGTC_346|Compound:4513-0042|FD-Score:3.83|P-value:5.00E-5 ID:SGTC_349|Compound:k015-0014|FD-Score:3.76|P-value:6.85E-5 ID:SGTC_357|Compound:1325-0123|FD-Score:-3.10|P-value:7.82E-4 ID:SGTC_440|Compound:fluspirilene|FD-Score:3.30|P-value:4.09E-4 ID:SGTC_608|Compound:k048-0125|FD-Score:3.27|P-value:4.58E-4 ID:SGTC_651|Compound:3253-0966|FD-Score:-3.24|P-value:4.72E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:4.11|P-value:1.53E-5 ID:SGTC_785|Compound:1270-0111|FD-Score:5.32|P-value:3.25E-8 ID:SGTC_787|Compound:4152-0075|FD-Score:-4.15|P-value:1.18E-5 ID:SGTC_790|Compound:1575-0012|FD-Score:-3.29|P-value:4.06E-4 ID:SGTC_869|Compound:0564-0080|FD-Score:3.20|P-value:5.92E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:3.82|P-value:5.37E-5 ID:SGTC_971|Compound:1315-0384|FD-Score:4.90|P-value:3.24E-7 ID:SGTC_978|Compound:1416-0512|FD-Score:3.42|P-value:2.65E-4 ID:SGTC_1031|Compound:k035-0009|FD-Score:3.36|P-value:3.25E-4 ID:SGTC_1051|Compound:3253-3903|FD-Score:4.56|P-value:1.84E-6 ID:SGTC_1235|Compound:benzylparaben|FD-Score:3.67|P-value:9.75E-5 ID:SGTC_1420|Compound:4'-methoxyflavone|FD-Score:4.04|P-value:2.04E-5 ID:SGTC_1690|Compound:st023502|FD-Score:3.19|P-value:6.09E-4 ID:SGTC_1728|Compound:st035614|FD-Score:5.38|P-value:2.35E-8 ID:SGTC_1768|Compound:st044301|FD-Score:-3.29|P-value:3.95E-4 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:3.39|P-value:2.88E-4 ID:SGTC_1950|Compound:st077106|FD-Score:3.51|P-value:1.81E-4 ID:SGTC_2001|Compound:4023502|FD-Score:3.20|P-value:5.95E-4 ID:SGTC_2008|Compound:4012253|FD-Score:5.99|P-value:5.85E-10 ID:SGTC_2011|Compound:4012611|FD-Score:4.36|P-value:4.77E-6 ID:SGTC_2034|Compound:5197015|FD-Score:-3.93|P-value:3.14E-5 ID:SGTC_2037|Compound:5169046|FD-Score:-3.57|P-value:1.40E-4 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:3.15|P-value:6.90E-4 ID:SGTC_2467|Compound:5474540|FD-Score:3.58|P-value:1.43E-4 ID:SGTC_2807|Compound:7945238|FD-Score:3.95|P-value:2.99E-5 ID:SGTC_2814|Compound:7977482|FD-Score:4.28|P-value:7.08E-6 ID:SGTC_2988|Compound:9073640|FD-Score:3.07|P-value:9.32E-4 ID:SGTC_3041|Compound:9091929|FD-Score:4.24|P-value:8.40E-6 ID:SGTC_3065|Compound:9113888|FD-Score:4.71|P-value:8.65E-7 ID:SGTC_3066|Compound:9117245|FD-Score:-3.24|P-value:4.80E-4 ID:SGTC_3070|Compound:9117005|FD-Score:-4.28|P-value:6.46E-6 ID:SGTC_3077|Compound:9117319|FD-Score:-5.22|P-value:5.40E-8 ID:SGTC_3301|Compound:9125354|FD-Score:3.45|P-value:2.29E-4 ID:SGTC_3315|Compound:9136395|FD-Score:5.09|P-value:1.21E-7 ID:SGTC_46|Compound:0329-0187a|FD-Score:3.40|P-value:2.80E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.23|P-value:5.05E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:4.02|P-value:2.30E-5 ID:SGTC_214|Compound:4373-3496|FD-Score:3.76|P-value:6.79E-5 ID:SGTC_346|Compound:4513-0042|FD-Score:3.83|P-value:5.00E-5 ID:SGTC_349|Compound:k015-0014|FD-Score:3.76|P-value:6.85E-5 ID:SGTC_357|Compound:1325-0123|FD-Score:-3.10|P-value:7.82E-4 ID:SGTC_440|Compound:fluspirilene|FD-Score:3.30|P-value:4.09E-4 ID:SGTC_608|Compound:k048-0125|FD-Score:3.27|P-value:4.58E-4 ID:SGTC_651|Compound:3253-0966|FD-Score:-3.24|P-value:4.72E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:4.11|P-value:1.53E-5 ID:SGTC_785|Compound:1270-0111|FD-Score:5.32|P-value:3.25E-8 ID:SGTC_787|Compound:4152-0075|FD-Score:-4.15|P-value:1.18E-5 ID:SGTC_790|Compound:1575-0012|FD-Score:-3.29|P-value:4.06E-4 ID:SGTC_869|Compound:0564-0080|FD-Score:3.20|P-value:5.92E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:3.82|P-value:5.37E-5 ID:SGTC_971|Compound:1315-0384|FD-Score:4.90|P-value:3.24E-7 ID:SGTC_978|Compound:1416-0512|FD-Score:3.42|P-value:2.65E-4 ID:SGTC_1031|Compound:k035-0009|FD-Score:3.36|P-value:3.25E-4 ID:SGTC_1051|Compound:3253-3903|FD-Score:4.56|P-value:1.84E-6 ID:SGTC_1235|Compound:benzylparaben|FD-Score:3.67|P-value:9.75E-5 ID:SGTC_1420|Compound:4'-methoxyflavone|FD-Score:4.04|P-value:2.04E-5 ID:SGTC_1690|Compound:st023502|FD-Score:3.19|P-value:6.09E-4 ID:SGTC_1728|Compound:st035614|FD-Score:5.38|P-value:2.35E-8 ID:SGTC_1768|Compound:st044301|FD-Score:-3.29|P-value:3.95E-4 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:3.39|P-value:2.88E-4 ID:SGTC_1950|Compound:st077106|FD-Score:3.51|P-value:1.81E-4 ID:SGTC_2001|Compound:4023502|FD-Score:3.20|P-value:5.95E-4 ID:SGTC_2008|Compound:4012253|FD-Score:5.99|P-value:5.85E-10 ID:SGTC_2011|Compound:4012611|FD-Score:4.36|P-value:4.77E-6 ID:SGTC_2034|Compound:5197015|FD-Score:-3.93|P-value:3.14E-5 ID:SGTC_2037|Compound:5169046|FD-Score:-3.57|P-value:1.40E-4 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:3.15|P-value:6.90E-4 ID:SGTC_2467|Compound:5474540|FD-Score:3.58|P-value:1.43E-4 ID:SGTC_2807|Compound:7945238|FD-Score:3.95|P-value:2.99E-5 ID:SGTC_2814|Compound:7977482|FD-Score:4.28|P-value:7.08E-6 ID:SGTC_2988|Compound:9073640|FD-Score:3.07|P-value:9.32E-4 ID:SGTC_3041|Compound:9091929|FD-Score:4.24|P-value:8.40E-6 ID:SGTC_3065|Compound:9113888|FD-Score:4.71|P-value:8.65E-7 ID:SGTC_3066|Compound:9117245|FD-Score:-3.24|P-value:4.80E-4 ID:SGTC_3070|Compound:9117005|FD-Score:-4.28|P-value:6.46E-6 ID:SGTC_3077|Compound:9117319|FD-Score:-5.22|P-value:5.40E-8 ID:SGTC_3301|Compound:9125354|FD-Score:3.45|P-value:2.29E-4 ID:SGTC_3315|Compound:9136395|FD-Score:5.09|P-value:1.21E-7

Top fitness defect scores for YGR142W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2008 4012253 5.99 172.0 µM 5.85E-10 2 1.04E-9
2 SGTC_1728 st035614 5.38 33.8 µM 2.35E-8 14 3.73E-8
3 SGTC_785 1270-0111 5.32 65.3 µM 3.25E-8 5 5.10E-8
4 SGTC_3315 9136395 5.09 68.5 µM 1.21E-7 2 1.83E-7
5 SGTC_971 1315-0384 4.90 26.7 µM 3.24E-7 cell wall signaling 11 4.74E-7
6 SGTC_3065 9113888 4.71 49.5 µM 8.65E-7 14 1.23E-6
7 SGTC_1051 3253-3903 4.56 78.0 µM 1.84E-6 11 2.56E-6
8 SGTC_2011 4012611 4.36 177.0 µM 4.77E-6 mitochondrial processes 19 6.45E-6
9 SGTC_2814 7977482 4.28 43.0 µM 7.08E-6 40 9.45E-6
10 SGTC_3041 9091929 4.24 49.5 µM 8.40E-6 redox potentiating 17 1.12E-5
11 SGTC_778 3456-2434 4.11 196.0 µM 1.53E-5 mitochondrial response to ROS 69 2.00E-5
12 SGTC_1420 4'-methoxyflavone 4.04 42.0 µM 2.04E-5 15 2.64E-5
13 SGTC_212 3807-4682 4.02 38.8 µM 2.30E-5 tubulin folding & SWR complex 67 2.97E-5
14 SGTC_2807 7945238 3.95 52.0 µM 2.99E-5 22 3.83E-5
15 SGTC_346 4513-0042 3.83 7.2 µM 5.00E-5 azole & statin 46 6.30E-5
16 SGTC_948 3448-0295 3.82 75.3 µM 5.37E-5 29 6.75E-5
17 SGTC_214 4373-3496 3.76 70.0 µM 6.79E-5 69 8.49E-5
18 SGTC_349 k015-0014 3.76 24.0 µM 6.85E-5 22 8.56E-5
19 SGTC_1235 benzylparaben 3.67 21.5 µM 9.75E-5 17 1.21E-4
20 SGTC_2467 5474540 3.58 200.0 µM 1.43E-4 26 1.74E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.154 3.90E-19 YLR097C HRT3 hom Putative SCF-ubiquitin ligase F-box protein, based on both genetic and physical interactions and sequence similarity; identified in association with Cdc53p, Skp1p and Ubi4 in large and small-scale studies
0.121 1.90E-12 YGR276C RNH70 hom 3'-5' exoribonuclease; required for maturation of 3' ends of 5S rRNA and tRNA-Arg3 from dicistronic transcripts
0.115 2.62E-11 YML064C TEM1 het GTP-binding protein of the ras superfamily involved in termination of M-phase; controls actomyosin and septin dynamics during cytokinesis
0.100 7.45E-9 YPL208W RKM1 hom SET-domain lysine-N-methyltransferase, catalyzes the formation of dimethyllysine residues on the large ribsomal subunit proteins L23a (Rpl23Ap and Rpl23Bp) and L18 (Rps18Ap and Rps18Bp)
0.097 1.59E-8 YDL127W PCL2 hom Cyclin, interacts with cyclin-dependent kinase Pho85p; member of the Pcl1,2-like subfamily, involved in the regulation of polarized growth and morphogenesis and progression through the cell cycle; localizes to sites of polarized cell growth
0.097 1.97E-8 YMR171C EAR1 hom Specificity factor required for Rsp5p-dependent ubiquitination and sorting of specific cargo proteins at the multivesicular body; mRNA is targeted to the bud via the mRNA transport system involving She2p
0.092 1.01E-7 YJR075W HOC1 hom Alpha-1,6-mannosyltransferase involved in cell wall mannan biosynthesis; subunit of a Golgi-localized complex that also contains Anp1p, Mnn9p, Mnn11p, and Mnn10p; identified as a suppressor of a cell lysis sensitive pkc1-371 allele
0.090 2.06E-7 YGR206W MVB12 hom ESCRT-I subunit required to stabilize oligomers of the ESCRT-I core complex (Stp22p, Vps28p, Srn2p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; deletion mutant is sensitive to rapamycin and nystatin
0.087 4.41E-7 YDL224C WHI4 hom Putative RNA binding protein; regulates the cell size requirement for passage through Start and commitment to cell division; WHI4 has a paralog, WHI3, that arose from the whole genome duplication
0.087 4.76E-7 YOL162W_p YOL162W_p hom Putative protein of unknown function; member of the Dal5p subfamily of the major facilitator family
0.084 1.02E-6 YDR030C RAD28 hom Protein involved in DNA repair, related to the human CSA protein that is involved in transcription-coupled repair nucleotide excision repair
0.083 1.36E-6 YKR016W FCJ1 hom Mitochondrial inner membrane protein, ortholog of mammalian mitofilin; involved in import of intermembrane space (IMS) proteins, probably by positioning Mia40p relative to the TOM complex to receive incoming proteins; also has an essential role in the maintenance of crista junctions and inner membrane architecture, as a component of the mitochondrial inner membrane organizing system (MICOS, MitOS or MINOS), a scaffold-like structure on the IMS side of the inner membrane
0.082 2.17E-6 YOL107W_p YOL107W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and colocalizes in a punctate pattern with the early golgi/COPI vesicles; YOL107W is not an essential protein
0.080 4.03E-6 YMR318C ADH6 hom NADPH-dependent medium chain alcohol dehydrogenase; has broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance; protein abundance increases in response to DNA replication stress
0.079 4.64E-6 YBL034C STU1 het Component of the mitotic spindle that binds to interpolar microtubules via its association with beta-tubulin (Tub2p); required for interpolar microtubules to provide an outward force on the spindle poles