YGR145W / ENP2

Essential nucleolar protein, required for biogenesis of the small ribosomal subunit; contains WD repeats, interacts with Mpp10p and Bfr2p, and has homology to Spb1p

Zygosity: Heterozygous strain
fixedexpanded
Profile for YGR145W / ENP2

Click on Significant Values for Screen Details ID:SGTC_82|Compound:0054-0107|FD-Score:4.32|P-value:1.97E-5 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:-5.69|P-value:3.23E-8 ID:SGTC_116|Compound:0155-0182|FD-Score:-5.72|P-value:2.71E-8 ID:SGTC_289|Compound:k017-0060|FD-Score:3.88|P-value:1.09E-4 ID:SGTC_346|Compound:4513-0042|FD-Score:3.77|P-value:1.65E-4 ID:SGTC_382|Compound:3229-0966|FD-Score:3.62|P-value:2.85E-4 ID:SGTC_631|Compound:k072-0230|FD-Score:-3.31|P-value:8.24E-4 ID:SGTC_1193|Compound:1488-0126|FD-Score:3.48|P-value:4.70E-4 ID:SGTC_1489|Compound:4065-0444|FD-Score:3.30|P-value:8.56E-4 ID:SGTC_1539|Compound:benzyladenosine|FD-Score:4.83|P-value:2.16E-6 ID:SGTC_1546|Compound:5-methoxyflavanone|FD-Score:3.42|P-value:5.68E-4 ID:SGTC_1633|Compound:st005664|FD-Score:6.48|P-value:3.58E-10 ID:SGTC_1838|Compound:st055369|FD-Score:4.15|P-value:3.96E-5 ID:SGTC_1842|Compound:st055362|FD-Score:4.73|P-value:3.40E-6 ID:SGTC_1964|Compound:st076914|FD-Score:3.57|P-value:3.41E-4 ID:SGTC_2072|Compound:5231554|FD-Score:3.45|P-value:5.20E-4 ID:SGTC_2105|Compound:5350118|FD-Score:4.03|P-value:6.36E-5 ID:SGTC_2154|Compound:5570129|FD-Score:3.36|P-value:7.04E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:3.46|P-value:4.99E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:3.52|P-value:4.09E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:4.44|P-value:1.20E-5 ID:SGTC_2712|Compound:st079126|FD-Score:3.59|P-value:3.17E-4 ID:SGTC_2970|Compound:9090938|FD-Score:-3.28|P-value:9.07E-4 ID:SGTC_3127|Compound:9126946|FD-Score:-3.27|P-value:9.47E-4 ID:SGTC_82|Compound:0054-0107|FD-Score:4.32|P-value:1.97E-5 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:-5.69|P-value:3.23E-8 ID:SGTC_116|Compound:0155-0182|FD-Score:-5.72|P-value:2.71E-8 ID:SGTC_289|Compound:k017-0060|FD-Score:3.88|P-value:1.09E-4 ID:SGTC_346|Compound:4513-0042|FD-Score:3.77|P-value:1.65E-4 ID:SGTC_382|Compound:3229-0966|FD-Score:3.62|P-value:2.85E-4 ID:SGTC_631|Compound:k072-0230|FD-Score:-3.31|P-value:8.24E-4 ID:SGTC_1193|Compound:1488-0126|FD-Score:3.48|P-value:4.70E-4 ID:SGTC_1489|Compound:4065-0444|FD-Score:3.30|P-value:8.56E-4 ID:SGTC_1539|Compound:benzyladenosine|FD-Score:4.83|P-value:2.16E-6 ID:SGTC_1546|Compound:5-methoxyflavanone|FD-Score:3.42|P-value:5.68E-4 ID:SGTC_1633|Compound:st005664|FD-Score:6.48|P-value:3.58E-10 ID:SGTC_1838|Compound:st055369|FD-Score:4.15|P-value:3.96E-5 ID:SGTC_1842|Compound:st055362|FD-Score:4.73|P-value:3.40E-6 ID:SGTC_1964|Compound:st076914|FD-Score:3.57|P-value:3.41E-4 ID:SGTC_2072|Compound:5231554|FD-Score:3.45|P-value:5.20E-4 ID:SGTC_2105|Compound:5350118|FD-Score:4.03|P-value:6.36E-5 ID:SGTC_2154|Compound:5570129|FD-Score:3.36|P-value:7.04E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:3.46|P-value:4.99E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:3.52|P-value:4.09E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:4.44|P-value:1.20E-5 ID:SGTC_2712|Compound:st079126|FD-Score:3.59|P-value:3.17E-4 ID:SGTC_2970|Compound:9090938|FD-Score:-3.28|P-value:9.07E-4 ID:SGTC_3127|Compound:9126946|FD-Score:-3.27|P-value:9.47E-4

Top fitness defect scores for YGR145W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1633 st005664 6.48 67.9 µM 3.58E-10 1 4.61E-11 1.61
2 SGTC_1539 benzyladenosine 4.83 56.0 µM 2.16E-6 4 6.82E-7 0.10
3 SGTC_1842 st055362 4.73 61.2 µM 3.40E-6 1 1.12E-6 0.61
4 SGTC_2613 3',4'-dimethoxydalbergione 4.44 24.6 µM 1.20E-5 5 4.48E-6 0.42
5 SGTC_82 0054-0107 4.32 293.8 µM 1.97E-5 2 7.74E-6 0.01
6 SGTC_1838 st055369 4.15 84.5 µM 3.96E-5 5 1.67E-5 0.13
7 SGTC_2105 5350118 4.03 200.0 µM 6.36E-5 6 2.82E-5 0.26
8 SGTC_289 k017-0060 3.88 526.0 µM 1.09E-4 2 5.12E-5 0.50
9 SGTC_346 4513-0042 3.77 7.2 µM 1.65E-4 azole & statin 5 8.02E-5 0.05
10 SGTC_382 3229-0966 3.62 23.2 µM 2.85E-4 6 1.47E-4 0.17
11 SGTC_2712 st079126 3.59 47.7 µM 3.17E-4 7 1.65E-4 0.14
12 SGTC_1964 st076914 3.57 61.0 µM 3.41E-4 RPP1 & pyrimidine depletion 11 1.79E-4 0.03
13 SGTC_2592 piperlongumine 3.52 83.3 µM 4.09E-4 TSC3-RPN4 11 2.18E-4 0.07
14 SGTC_1193 1488-0126 3.48 41.5 µM 4.70E-4 6 2.54E-4 0.06
15 SGTC_2419 paclitaxel 3.46 166.5 µM 4.99E-4 8 2.72E-4 0.10
16 SGTC_2072 5231554 3.45 129.0 µM 5.20E-4 5 2.84E-4 0.02
17 SGTC_1546 5-methoxyflavanone 3.42 78.7 µM 5.68E-4 3 3.13E-4 0.11
18 SGTC_2154 5570129 3.36 200.0 µM 7.04E-4 5 3.96E-4 0.18
19 SGTC_1489 4065-0444 3.30 182.0 µM 8.56E-4 5 4.91E-4 0.04
20 SGTC_1839 st053978 3.22 48.0 µM 0.00109 3 6.40E-4 0.17

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.117 8.75E-12 YLR237W THI7 hom Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia
0.111 1.16E-10 YNL163C RIA1 het Cytoplasmic GTPase/eEF2-like factor involved in ribosomal biogenesis; with Sdo1p, promotes release of Tif6p from 60S ribosomal subunits in the cytoplasm so that they can assemble with 40S subunits to generate mature ribosomes; required for quality control check of newly made large ribosomal subunits before they are released into the pool of translating ribosomes
0.107 5.49E-10 YLR195C NMT1 het N-myristoyl transferase, catalyzes the cotranslational, covalent attachment of myristic acid to the N-terminal glycine residue of several proteins involved in cellular growth and signal transduction
0.105 9.63E-10 YDR222W_p YDR222W_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.102 3.44E-9 YDR235W PRP42 het U1 snRNP protein involved in splicing, required for U1 snRNP biogenesis; contains multiple tetriatricopeptide repeats
0.101 4.64E-9 YDL153C SAS10 het Essential subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit; disrupts silencing when overproduced; mutant has increased aneuploidy tolerance
0.101 5.24E-9 YHR019C DED81 het Cytosolic asparaginyl-tRNA synthetase, required for protein synthesis, catalyzes the specific attachment of asparagine to its cognate tRNA
0.100 7.03E-9 YKL152C GPM1 het Tetrameric phosphoglycerate mutase, mediates the conversion of 3-phosphoglycerate to 2-phosphoglycerate during glycolysis and the reverse reaction during gluconeogenesis
0.098 1.12E-8 YER043C SAH1 het S-adenosyl-L-homocysteine hydrolase, catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor
0.094 4.41E-8 YMR213W CEF1 het Essential splicing factor; associated with Prp19p and the spliceosome, contains an N-terminal c-Myb DNA binding motif necessary for cell viability but not for Prp19p association, evolutionarily conserved and homologous to S. pombe Cdc5p
0.094 4.87E-8 YKL182W FAS1 het Beta subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities
0.088 3.73E-7 YGL201C MCM6 het Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex; forms a subcomplex with Mcm4p and Mcm7p
0.088 3.73E-7 YMR222C FSH2 hom Putative serine hydrolase that localizes to the cytoplasm; sequence is similar to S. cerevisiae Fsh1p and Fsh3p and the human candidate tumor suppressor OVCA2
0.085 8.28E-7 YGL111W NSA1 het Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis
0.083 1.54E-6 YBL084C CDC27 het Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition