YGR146C / ECL1

Protein of unknown function; mitochondrial-dependent role in the extension of chronological lifespan; overexpression increases oxygen consumption and respiratory activity while deletion results in reduced oxygen consumption under conditions of caloric restriction; induced by iron homeostasis transcription factor Aft2p; multicopy suppressor of temperature sensitive hsf1 mutant; induced by treatment with 8-methoxypsoralen and UVA irradiation

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR146C / ECL1

Click on Significant Values for Screen Details ID:SGTC_43|Compound:0570-0105|FD-Score:3.24|P-value:6.94E-4 ID:SGTC_96|Compound:0929-0093|FD-Score:3.78|P-value:9.39E-5 ID:SGTC_108|Compound:0509-0257|FD-Score:3.85|P-value:7.24E-5 ID:SGTC_113|Compound:0099-0221|FD-Score:3.17|P-value:9.02E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:3.48|P-value:3.00E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:-3.33|P-value:4.31E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:3.16|P-value:9.32E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:4.10|P-value:2.62E-5 ID:SGTC_196|Compound:k015-0023|FD-Score:4.81|P-value:9.81E-7 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:3.34|P-value:4.92E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:3.90|P-value:5.94E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:4.51|P-value:4.12E-6 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.26|P-value:6.58E-4 ID:SGTC_541|Compound:4513-1321|FD-Score:3.78|P-value:9.43E-5 ID:SGTC_545|Compound:4218-0007|FD-Score:-3.69|P-value:1.12E-4 ID:SGTC_567|Compound:1080-0542|FD-Score:4.30|P-value:1.08E-5 ID:SGTC_628|Compound:1636-0253|FD-Score:5.11|P-value:2.20E-7 ID:SGTC_695|Compound:3505-6186|FD-Score:3.77|P-value:9.71E-5 ID:SGTC_796|Compound:1234-0020|FD-Score:3.59|P-value:1.98E-4 ID:SGTC_855|Compound:0428-0020|FD-Score:3.27|P-value:6.23E-4 ID:SGTC_873|Compound:0591-4978|FD-Score:4.74|P-value:1.37E-6 ID:SGTC_917|Compound:harmaline|FD-Score:4.73|P-value:1.44E-6 ID:SGTC_1010|Compound:4112-3296|FD-Score:3.24|P-value:7.07E-4 ID:SGTC_1043|Compound:0916-0009|FD-Score:-3.17|P-value:7.62E-4 ID:SGTC_1051|Compound:3253-3903|FD-Score:4.86|P-value:7.65E-7 ID:SGTC_1118|Compound:chelidonine|FD-Score:-3.71|P-value:1.05E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:3.35|P-value:4.74E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:4.60|P-value:2.68E-6 ID:SGTC_1189|Compound:1431-2119|FD-Score:4.18|P-value:1.80E-5 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:3.67|P-value:1.47E-4 ID:SGTC_1296|Compound:1068-0102|FD-Score:3.27|P-value:6.41E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:3.55|P-value:2.34E-4 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:3.15|P-value:9.42E-4 ID:SGTC_1630|Compound:st005209|FD-Score:3.34|P-value:4.91E-4 ID:SGTC_1733|Compound:st037357|FD-Score:-3.35|P-value:4.05E-4 ID:SGTC_1804|Compound:st050076|FD-Score:3.32|P-value:5.33E-4 ID:SGTC_1846|Compound:st056244|FD-Score:3.14|P-value:9.84E-4 ID:SGTC_1941|Compound:st076221|FD-Score:3.31|P-value:5.48E-4 ID:SGTC_2064|Compound:5220758|FD-Score:4.22|P-value:1.54E-5 ID:SGTC_2411|Compound:st077133|FD-Score:3.48|P-value:3.01E-4 ID:SGTC_2415|Compound:st077333|FD-Score:3.32|P-value:5.32E-4 ID:SGTC_2417|Compound:cerulenin|FD-Score:3.65|P-value:1.55E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:3.98|P-value:4.19E-5 ID:SGTC_2424|Compound:5537928|FD-Score:-3.48|P-value:2.45E-4 ID:SGTC_2426|Compound:5582046|FD-Score:3.24|P-value:7.01E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:7.97|P-value:1.49E-15 ID:SGTC_2713|Compound:st079149|FD-Score:5.55|P-value:2.00E-8 ID:SGTC_2780|Compound:5215298|FD-Score:4.27|P-value:1.21E-5 ID:SGTC_2806|Compound:7952793|FD-Score:-5.41|P-value:3.26E-8 ID:SGTC_2812|Compound:7970281|FD-Score:3.74|P-value:1.12E-4 ID:SGTC_2813|Compound:7971799|FD-Score:3.15|P-value:9.65E-4 ID:SGTC_2896|Compound:9052656|FD-Score:3.32|P-value:5.32E-4 ID:SGTC_3004|Compound:9076122|FD-Score:4.43|P-value:5.94E-6 ID:SGTC_3225|Compound:9130819|FD-Score:3.62|P-value:1.75E-4 ID:SGTC_3252|Compound:9135871|FD-Score:4.31|P-value:1.03E-5 ID:SGTC_3276|Compound:9139060|FD-Score:-3.28|P-value:5.19E-4 ID:SGTC_3279|Compound:9140807|FD-Score:-3.59|P-value:1.65E-4 ID:SGTC_3280|Compound:9140961|FD-Score:-4.01|P-value:3.00E-5 ID:SGTC_43|Compound:0570-0105|FD-Score:3.24|P-value:6.94E-4 ID:SGTC_96|Compound:0929-0093|FD-Score:3.78|P-value:9.39E-5 ID:SGTC_108|Compound:0509-0257|FD-Score:3.85|P-value:7.24E-5 ID:SGTC_113|Compound:0099-0221|FD-Score:3.17|P-value:9.02E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:3.48|P-value:3.00E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:-3.33|P-value:4.31E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:3.16|P-value:9.32E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:4.10|P-value:2.62E-5 ID:SGTC_196|Compound:k015-0023|FD-Score:4.81|P-value:9.81E-7 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:3.34|P-value:4.92E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:3.90|P-value:5.94E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:4.51|P-value:4.12E-6 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.26|P-value:6.58E-4 ID:SGTC_541|Compound:4513-1321|FD-Score:3.78|P-value:9.43E-5 ID:SGTC_545|Compound:4218-0007|FD-Score:-3.69|P-value:1.12E-4 ID:SGTC_567|Compound:1080-0542|FD-Score:4.30|P-value:1.08E-5 ID:SGTC_628|Compound:1636-0253|FD-Score:5.11|P-value:2.20E-7 ID:SGTC_695|Compound:3505-6186|FD-Score:3.77|P-value:9.71E-5 ID:SGTC_796|Compound:1234-0020|FD-Score:3.59|P-value:1.98E-4 ID:SGTC_855|Compound:0428-0020|FD-Score:3.27|P-value:6.23E-4 ID:SGTC_873|Compound:0591-4978|FD-Score:4.74|P-value:1.37E-6 ID:SGTC_917|Compound:harmaline|FD-Score:4.73|P-value:1.44E-6 ID:SGTC_1010|Compound:4112-3296|FD-Score:3.24|P-value:7.07E-4 ID:SGTC_1043|Compound:0916-0009|FD-Score:-3.17|P-value:7.62E-4 ID:SGTC_1051|Compound:3253-3903|FD-Score:4.86|P-value:7.65E-7 ID:SGTC_1118|Compound:chelidonine|FD-Score:-3.71|P-value:1.05E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:3.35|P-value:4.74E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:4.60|P-value:2.68E-6 ID:SGTC_1189|Compound:1431-2119|FD-Score:4.18|P-value:1.80E-5 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:3.67|P-value:1.47E-4 ID:SGTC_1296|Compound:1068-0102|FD-Score:3.27|P-value:6.41E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:3.55|P-value:2.34E-4 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:3.15|P-value:9.42E-4 ID:SGTC_1630|Compound:st005209|FD-Score:3.34|P-value:4.91E-4 ID:SGTC_1733|Compound:st037357|FD-Score:-3.35|P-value:4.05E-4 ID:SGTC_1804|Compound:st050076|FD-Score:3.32|P-value:5.33E-4 ID:SGTC_1846|Compound:st056244|FD-Score:3.14|P-value:9.84E-4 ID:SGTC_1941|Compound:st076221|FD-Score:3.31|P-value:5.48E-4 ID:SGTC_2064|Compound:5220758|FD-Score:4.22|P-value:1.54E-5 ID:SGTC_2411|Compound:st077133|FD-Score:3.48|P-value:3.01E-4 ID:SGTC_2415|Compound:st077333|FD-Score:3.32|P-value:5.32E-4 ID:SGTC_2417|Compound:cerulenin|FD-Score:3.65|P-value:1.55E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:3.98|P-value:4.19E-5 ID:SGTC_2424|Compound:5537928|FD-Score:-3.48|P-value:2.45E-4 ID:SGTC_2426|Compound:5582046|FD-Score:3.24|P-value:7.01E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:7.97|P-value:1.49E-15 ID:SGTC_2713|Compound:st079149|FD-Score:5.55|P-value:2.00E-8 ID:SGTC_2780|Compound:5215298|FD-Score:4.27|P-value:1.21E-5 ID:SGTC_2806|Compound:7952793|FD-Score:-5.41|P-value:3.26E-8 ID:SGTC_2812|Compound:7970281|FD-Score:3.74|P-value:1.12E-4 ID:SGTC_2813|Compound:7971799|FD-Score:3.15|P-value:9.65E-4 ID:SGTC_2896|Compound:9052656|FD-Score:3.32|P-value:5.32E-4 ID:SGTC_3004|Compound:9076122|FD-Score:4.43|P-value:5.94E-6 ID:SGTC_3225|Compound:9130819|FD-Score:3.62|P-value:1.75E-4 ID:SGTC_3252|Compound:9135871|FD-Score:4.31|P-value:1.03E-5 ID:SGTC_3276|Compound:9139060|FD-Score:-3.28|P-value:5.19E-4 ID:SGTC_3279|Compound:9140807|FD-Score:-3.59|P-value:1.65E-4 ID:SGTC_3280|Compound:9140961|FD-Score:-4.01|P-value:3.00E-5

Top fitness defect scores for YGR146C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2597 laccaic acid a 7.97 100.0 µM 1.49E-15 2 8.13E-16
2 SGTC_2713 st079149 5.55 53.4 µM 2.00E-8 4 1.42E-8
3 SGTC_628 1636-0253 5.11 16.0 µM 2.20E-7 sphingolipid biosynthesis & PDR1 15 1.63E-7
4 SGTC_1051 3253-3903 4.86 78.0 µM 7.65E-7 5 5.78E-7
5 SGTC_196 k015-0023 4.81 18.1 µM 9.81E-7 PDR1 11 7.44E-7
6 SGTC_873 0591-4978 4.74 488.0 µM 1.37E-6 8 1.05E-6
7 SGTC_917 harmaline 4.73 728.1 nM 1.44E-6 ergosterol biosynthesis 12 1.10E-6
8 SGTC_1129 3453-1384 4.60 223.0 µM 2.68E-6 24 2.07E-6
9 SGTC_310 1273-0058 4.51 1.1 µM 4.12E-6 mitochondrial stress 209 3.21E-6
10 SGTC_3004 9076122 4.43 71.4 µM 5.94E-6 11 4.66E-6
11 SGTC_3252 9135871 4.31 49.5 µM 1.03E-5 7 8.18E-6
12 SGTC_567 1080-0542 4.30 68.4 µM 1.08E-5 11 8.53E-6
13 SGTC_2780 5215298 4.27 71.4 µM 1.21E-5 28 9.58E-6
14 SGTC_2064 5220758 4.22 200.0 µM 1.54E-5 26 1.23E-5
15 SGTC_1189 1431-2119 4.18 7.3 µM 1.80E-5 19 1.44E-5
16 SGTC_166 k072-0058 4.10 166.4 µM 2.62E-5 DNA intercalators 29 2.11E-5
17 SGTC_2420 aureobasidin a 3.98 50.0 nM 4.19E-5 44 3.40E-5
18 SGTC_270 tamoxifen 3.90 5.5 µM 5.94E-5 NEO1 30 4.85E-5
19 SGTC_108 0509-0257 3.85 621.1 µM 7.24E-5 56 5.93E-5
20 SGTC_96 0929-0093 3.78 37.3 µM 9.39E-5 calcium & mitochondrial duress 17 7.73E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.107 5.90E-10 YJR108W ABM1 hom Protein of unknown function, required for normal microtubule organization
0.105 9.91E-10 YJR088C EMC2 hom Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm Y57G7A.10/EMC-2, fly CG17556, human TTC35
0.092 1.04E-7 YNR008W LRO1 hom Acyltransferase that catalyzes diacylglycerol esterification; one of several acyltransferases that contribute to triglyceride synthesis; putative homolog of human lecithin cholesterol acyltransferase
0.088 3.66E-7 YGL194C HOS2 hom Histone deacetylase and subunit of Set3 and Rpd3L complexes; required for gene activation via specific deacetylation of lysines in H3 and H4 histone tails; subunit of the Set3 complex, a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; co-localizes with Cmr1p in nuclear foci in response to DNA damage by MMS
0.084 9.91E-7 YKL137W CMC1 hom Evolutionarily conserved copper-binding protein of the mitochondrial intermembrane space, may be involved in delivering copper from the matrix to the cytochrome c oxidase complex; contains a twin CX9C motif
0.082 1.79E-6 YDL174C DLD1 hom D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane
0.082 2.11E-6 YHR086W NAM8 hom RNA binding protein, component of the U1 snRNP protein; mutants are defective in meiotic recombination and in formation of viable spores, involved in the formation of DSBs through meiosis-specific splicing of REC107 pre-mRNA; Nam8p regulon embraces the meiotic pre-mRNAs of REC107, HFM1, AMA1 SPO22 and PCH2; the putative RNA binding domains RRM2 and RRM3 are required for Nam8p meiotic function
0.081 2.61E-6 YKR056W TRM2 hom tRNA methyltransferase, 5-methylates the uridine residue at position 54 of tRNAs and may also have a role in tRNA stabilization or maturation; endo-exonuclease with a role in DNA repair
0.081 2.71E-6 YLR196W PWP1 het Protein with WD-40 repeats involved in rRNA processing; associates with trans-acting ribosome biogenesis factors; similar to beta-transducin superfamily
0.078 6.33E-6 YLR324W PEX30 hom Peroxisomal integral membrane protein, involved in negative regulation of peroxisome number; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p
0.078 6.34E-6 YEL060C PRB1 hom Vacuolar proteinase B (yscB); serine protease of the subtilisin family; involved in protein degradation in the vacuole and required for full protein degradation during sporulation; activity inhibited by Pbi2p; protein abundance increases in response to DNA replication stress
0.078 6.84E-6 YGL225W VRG4 het Golgi GDP-mannose transporter; regulates Golgi function and glycosylation in Golgi
0.075 1.43E-5 YMR267W PPA2 hom Mitochondrial inorganic pyrophosphatase, required for mitochondrial function and possibly involved in energy generation from inorganic pyrophosphate
0.074 1.96E-5 YNL259C ATX1 hom Cytosolic copper metallochaperone that transports copper to the secretory vesicle copper transporter Ccc2p for eventual insertion into Fet3p, which is a multicopper oxidase required for high-affinity iron uptake
0.073 2.48E-5 YLR361C-A_p YLR361C-A_p hom Putative protein of unknown function