YGR146C-A_p

Putative protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR146C-A / YGR146C-A

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:3.19|P-value:6.74E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:3.71|P-value:9.63E-5 ID:SGTC_147|Compound:4466-0538|FD-Score:3.67|P-value:1.13E-4 ID:SGTC_198|Compound:3454-2873|FD-Score:3.13|P-value:8.25E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:4.65|P-value:1.49E-6 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:3.25|P-value:5.50E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:3.27|P-value:5.14E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:3.11|P-value:8.77E-4 ID:SGTC_687|Compound:k029-0044|FD-Score:3.82|P-value:6.22E-5 ID:SGTC_763|Compound:3453-1109|FD-Score:3.85|P-value:5.61E-5 ID:SGTC_966|Compound:1300-0360|FD-Score:-3.81|P-value:7.21E-5 ID:SGTC_1016|Compound:4226-1401|FD-Score:4.34|P-value:6.46E-6 ID:SGTC_1056|Compound:3448-1962|FD-Score:-3.12|P-value:9.28E-4 ID:SGTC_1064|Compound:honokiol|FD-Score:-3.21|P-value:6.98E-4 ID:SGTC_1070|Compound:indatraline|FD-Score:-3.47|P-value:2.74E-4 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:-3.13|P-value:9.07E-4 ID:SGTC_1166|Compound:k206-0078|FD-Score:3.58|P-value:1.62E-4 ID:SGTC_1180|Compound:1193-0155|FD-Score:3.19|P-value:6.66E-4 ID:SGTC_1181|Compound:1222-0449|FD-Score:3.11|P-value:8.97E-4 ID:SGTC_1324|Compound:1418-0026|FD-Score:3.44|P-value:2.77E-4 ID:SGTC_1460|Compound:k062-0059|FD-Score:3.99|P-value:3.09E-5 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:-4.52|P-value:3.20E-6 ID:SGTC_1975|Compound:st070967|FD-Score:-3.11|P-value:9.67E-4 ID:SGTC_2050|Compound:5263056|FD-Score:4.93|P-value:3.74E-7 ID:SGTC_2059|Compound:5238311|FD-Score:-3.86|P-value:5.86E-5 ID:SGTC_2095|Compound:5432005|FD-Score:-3.61|P-value:1.56E-4 ID:SGTC_2099|Compound:5377090|FD-Score:3.89|P-value:4.58E-5 ID:SGTC_2126|Compound:5251174|FD-Score:-3.15|P-value:8.52E-4 ID:SGTC_2127|Compound:5253358|FD-Score:3.14|P-value:8.03E-4 ID:SGTC_2132|Compound:5317594|FD-Score:-3.39|P-value:3.57E-4 ID:SGTC_2176|Compound:5809774|FD-Score:3.35|P-value:3.78E-4 ID:SGTC_2290|Compound:7904846|FD-Score:3.18|P-value:7.05E-4 ID:SGTC_2294|Compound:7971431|FD-Score:3.09|P-value:9.51E-4 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:-3.32|P-value:4.70E-4 ID:SGTC_2966|Compound:9084041|FD-Score:-4.28|P-value:9.57E-6 ID:SGTC_2969|Compound:9091408|FD-Score:3.34|P-value:3.89E-4 ID:SGTC_3047|Compound:9092122|FD-Score:3.56|P-value:1.73E-4 ID:SGTC_3147|Compound:9097027|FD-Score:-3.29|P-value:5.23E-4 ID:SGTC_3307|Compound:9126885|FD-Score:3.34|P-value:4.01E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:3.19|P-value:6.74E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:3.71|P-value:9.63E-5 ID:SGTC_147|Compound:4466-0538|FD-Score:3.67|P-value:1.13E-4 ID:SGTC_198|Compound:3454-2873|FD-Score:3.13|P-value:8.25E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:4.65|P-value:1.49E-6 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:3.25|P-value:5.50E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:3.27|P-value:5.14E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:3.11|P-value:8.77E-4 ID:SGTC_687|Compound:k029-0044|FD-Score:3.82|P-value:6.22E-5 ID:SGTC_763|Compound:3453-1109|FD-Score:3.85|P-value:5.61E-5 ID:SGTC_966|Compound:1300-0360|FD-Score:-3.81|P-value:7.21E-5 ID:SGTC_1016|Compound:4226-1401|FD-Score:4.34|P-value:6.46E-6 ID:SGTC_1056|Compound:3448-1962|FD-Score:-3.12|P-value:9.28E-4 ID:SGTC_1064|Compound:honokiol|FD-Score:-3.21|P-value:6.98E-4 ID:SGTC_1070|Compound:indatraline|FD-Score:-3.47|P-value:2.74E-4 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:-3.13|P-value:9.07E-4 ID:SGTC_1166|Compound:k206-0078|FD-Score:3.58|P-value:1.62E-4 ID:SGTC_1180|Compound:1193-0155|FD-Score:3.19|P-value:6.66E-4 ID:SGTC_1181|Compound:1222-0449|FD-Score:3.11|P-value:8.97E-4 ID:SGTC_1324|Compound:1418-0026|FD-Score:3.44|P-value:2.77E-4 ID:SGTC_1460|Compound:k062-0059|FD-Score:3.99|P-value:3.09E-5 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:-4.52|P-value:3.20E-6 ID:SGTC_1975|Compound:st070967|FD-Score:-3.11|P-value:9.67E-4 ID:SGTC_2050|Compound:5263056|FD-Score:4.93|P-value:3.74E-7 ID:SGTC_2059|Compound:5238311|FD-Score:-3.86|P-value:5.86E-5 ID:SGTC_2095|Compound:5432005|FD-Score:-3.61|P-value:1.56E-4 ID:SGTC_2099|Compound:5377090|FD-Score:3.89|P-value:4.58E-5 ID:SGTC_2126|Compound:5251174|FD-Score:-3.15|P-value:8.52E-4 ID:SGTC_2127|Compound:5253358|FD-Score:3.14|P-value:8.03E-4 ID:SGTC_2132|Compound:5317594|FD-Score:-3.39|P-value:3.57E-4 ID:SGTC_2176|Compound:5809774|FD-Score:3.35|P-value:3.78E-4 ID:SGTC_2290|Compound:7904846|FD-Score:3.18|P-value:7.05E-4 ID:SGTC_2294|Compound:7971431|FD-Score:3.09|P-value:9.51E-4 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:-3.32|P-value:4.70E-4 ID:SGTC_2966|Compound:9084041|FD-Score:-4.28|P-value:9.57E-6 ID:SGTC_2969|Compound:9091408|FD-Score:3.34|P-value:3.89E-4 ID:SGTC_3047|Compound:9092122|FD-Score:3.56|P-value:1.73E-4 ID:SGTC_3147|Compound:9097027|FD-Score:-3.29|P-value:5.23E-4 ID:SGTC_3307|Compound:9126885|FD-Score:3.34|P-value:4.01E-4

Top fitness defect scores for YGR146C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2050 5263056 4.93 171.0 µM 3.74E-7 fatty acid desaturase (OLE1) 27 4.10E-7
2 SGTC_236 1509-0011 4.65 5.3 µM 1.49E-6 346 1.62E-6
3 SGTC_1016 4226-1401 4.34 38.0 µM 6.46E-6 RNA pol III & RNase P/MRP 12 7.00E-6
4 SGTC_1460 k062-0059 3.99 9.2 µM 3.09E-5 Golgi 12 3.32E-5
5 SGTC_2099 5377090 3.89 177.4 µM 4.58E-5 24 4.91E-5
6 SGTC_763 3453-1109 3.85 128.0 µM 5.61E-5 20 6.01E-5
7 SGTC_687 k029-0044 3.82 34.9 µM 6.22E-5 PDR1 17 6.66E-5
8 SGTC_87 0100-0052 3.71 35.5 µM 9.63E-5 129 1.03E-4
9 SGTC_147 4466-0538 3.67 29.2 µM 1.13E-4 ergosterol biosynthesis 31 1.21E-4
10 SGTC_1166 k206-0078 3.58 225.0 µM 1.62E-4 32 1.73E-4
11 SGTC_3047 9092122 3.56 49.5 µM 1.73E-4 33 1.84E-4
12 SGTC_1324 1418-0026 3.44 34.4 µM 2.77E-4 28 2.95E-4
13 SGTC_2176 5809774 3.35 34.0 µM 3.78E-4 mitochondrial processes 30 4.01E-4
14 SGTC_2969 9091408 3.34 28.7 µM 3.89E-4 54 4.13E-4
15 SGTC_3307 9126885 3.34 69.3 µM 4.01E-4 51 4.25E-4
16 SGTC_304 1310-0298 3.27 97.0 µM 5.14E-4 cell wall 95 5.45E-4
17 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 3.25 4.6 µM 5.50E-4 heat shock/prefoldin 65 5.82E-4
18 SGTC_1180 1193-0155 3.19 285.0 µM 6.66E-4 47 7.05E-4
19 SGTC_58 0957-0393 3.19 9.0 µM 6.74E-4 cell wall 471 7.14E-4
20 SGTC_2290 7904846 3.18 200.0 µM 7.05E-4 61 7.46E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.167 2.08E-22 YGL107C RMD9 hom Mitochondrial protein required for respiratory growth; mutant phenotype and genetic interactions suggest a role in delivering mt mRNAs to ribosomes; located on matrix face of the inner membrane and loosely associated with mitoribosomes
0.160 1.12E-20 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.159 2.71E-20 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.157 6.71E-20 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.153 5.32E-19 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.152 9.55E-19 YOR065W CYT1 hom Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
0.152 1.07E-18 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.149 5.09E-18 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.146 1.64E-17 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.145 2.94E-17 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.141 1.99E-16 YKL109W HAP4 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
0.141 2.59E-16 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.139 5.60E-16 YKL016C ATP7 hom Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
0.136 3.22E-15 YKL087C CYT2 hom Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1
0.135 4.87E-15 YMR286W MRPL33 hom Mitochondrial ribosomal protein of the large subunit