YGR147C / NAT2

Protein with an apparent role in acetylation of N-terminal methionine residues

Zygosity: Heterozygous strain
fixedexpanded
Profile for YGR147C / NAT2

Click on Significant Values for Screen Details ID:SGTC_97|Compound:0535-0701|FD-Score:3.16|P-value:9.75E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:4.16|P-value:2.25E-5 ID:SGTC_167|Compound:3672-0051|FD-Score:4.54|P-value:4.23E-6 ID:SGTC_177|Compound:1327-0068|FD-Score:3.19|P-value:8.83E-4 ID:SGTC_228|Compound:caffeine|FD-Score:3.93|P-value:5.90E-5 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:3.36|P-value:5.00E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:-5.14|P-value:2.40E-7 ID:SGTC_558|Compound:k064-0027|FD-Score:4.56|P-value:4.02E-6 ID:SGTC_561|Compound:1550-0330|FD-Score:3.71|P-value:1.37E-4 ID:SGTC_609|Compound:0986-0026|FD-Score:3.23|P-value:7.86E-4 ID:SGTC_776|Compound:4476-4378|FD-Score:5.19|P-value:1.87E-7 ID:SGTC_1019|Compound:4262-0212|FD-Score:4.08|P-value:3.20E-5 ID:SGTC_1030|Compound:k029-0042|FD-Score:3.72|P-value:1.32E-4 ID:SGTC_1040|Compound:k898-0338|FD-Score:-3.80|P-value:9.96E-5 ID:SGTC_1068|Compound:loratadine|FD-Score:3.96|P-value:5.22E-5 ID:SGTC_1130|Compound:3454-2858|FD-Score:3.57|P-value:2.31E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:-4.14|P-value:2.54E-5 ID:SGTC_1185|Compound:1319-0113|FD-Score:3.99|P-value:4.68E-5 ID:SGTC_1200|Compound:1643-0193|FD-Score:4.89|P-value:8.38E-7 ID:SGTC_1211|Compound:1056-0033|FD-Score:-4.23|P-value:1.71E-5 ID:SGTC_1310|Compound:1188-0297|FD-Score:3.51|P-value:2.95E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:3.16|P-value:9.68E-4 ID:SGTC_1501|Compound:4491-0275|FD-Score:-3.83|P-value:8.67E-5 ID:SGTC_1503|Compound:4585-0012|FD-Score:3.59|P-value:2.20E-4 ID:SGTC_1518|Compound:st038567|FD-Score:4.72|P-value:1.90E-6 ID:SGTC_1616|Compound:st002734|FD-Score:3.34|P-value:5.38E-4 ID:SGTC_1666|Compound:st014829|FD-Score:3.49|P-value:3.14E-4 ID:SGTC_1668|Compound:st014914|FD-Score:3.19|P-value:8.96E-4 ID:SGTC_1735|Compound:st034310|FD-Score:-3.51|P-value:2.93E-4 ID:SGTC_1741|Compound:st038134|FD-Score:3.18|P-value:9.25E-4 ID:SGTC_1768|Compound:st044301|FD-Score:3.55|P-value:2.53E-4 ID:SGTC_1786|Compound:berberine|FD-Score:3.31|P-value:5.84E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:5.12|P-value:2.61E-7 ID:SGTC_1840|Compound:st055363|FD-Score:-3.59|P-value:2.15E-4 ID:SGTC_1903|Compound:st060211|FD-Score:-4.39|P-value:8.61E-6 ID:SGTC_1904|Compound:st060225|FD-Score:-3.34|P-value:5.38E-4 ID:SGTC_1925|Compound:st057770|FD-Score:3.20|P-value:8.57E-4 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:-5.88|P-value:4.20E-9 ID:SGTC_1932|Compound:st074806|FD-Score:6.60|P-value:4.86E-11 ID:SGTC_1981|Compound:st071826|FD-Score:3.23|P-value:7.81E-4 ID:SGTC_2161|Compound:5662504|FD-Score:-4.09|P-value:3.07E-5 ID:SGTC_2313|Compound:7726885|FD-Score:5.52|P-value:3.15E-8 ID:SGTC_2314|Compound:7727897|FD-Score:3.46|P-value:3.45E-4 ID:SGTC_2467|Compound:5474540|FD-Score:-3.16|P-value:9.72E-4 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:-3.20|P-value:8.61E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:4.68|P-value:2.27E-6 ID:SGTC_2534|Compound:helenine|FD-Score:-3.66|P-value:1.72E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:4.63|P-value:2.89E-6 ID:SGTC_2607|Compound:solasodine|FD-Score:4.47|P-value:5.87E-6 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:4.46|P-value:6.29E-6 ID:SGTC_2739|Compound:tacrine|FD-Score:3.93|P-value:5.82E-5 ID:SGTC_2763|Compound:lisinopril|FD-Score:3.97|P-value:4.98E-5 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:-3.29|P-value:6.41E-4 ID:SGTC_2832|Compound:7992762|FD-Score:3.96|P-value:5.31E-5 ID:SGTC_2928|Compound:9011484|FD-Score:3.17|P-value:9.34E-4 ID:SGTC_3067|Compound:9117431|FD-Score:4.75|P-value:1.64E-6 ID:SGTC_3124|Compound:9127567|FD-Score:-3.44|P-value:3.76E-4 ID:SGTC_3145|Compound:9085516|FD-Score:3.15|P-value:9.95E-4 ID:SGTC_3181|Compound:9108277|FD-Score:3.50|P-value:3.04E-4 ID:SGTC_3185|Compound:9108267|FD-Score:3.30|P-value:6.17E-4 ID:SGTC_97|Compound:0535-0701|FD-Score:3.16|P-value:9.75E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:4.16|P-value:2.25E-5 ID:SGTC_167|Compound:3672-0051|FD-Score:4.54|P-value:4.23E-6 ID:SGTC_177|Compound:1327-0068|FD-Score:3.19|P-value:8.83E-4 ID:SGTC_228|Compound:caffeine|FD-Score:3.93|P-value:5.90E-5 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:3.36|P-value:5.00E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:-5.14|P-value:2.40E-7 ID:SGTC_558|Compound:k064-0027|FD-Score:4.56|P-value:4.02E-6 ID:SGTC_561|Compound:1550-0330|FD-Score:3.71|P-value:1.37E-4 ID:SGTC_609|Compound:0986-0026|FD-Score:3.23|P-value:7.86E-4 ID:SGTC_776|Compound:4476-4378|FD-Score:5.19|P-value:1.87E-7 ID:SGTC_1019|Compound:4262-0212|FD-Score:4.08|P-value:3.20E-5 ID:SGTC_1030|Compound:k029-0042|FD-Score:3.72|P-value:1.32E-4 ID:SGTC_1040|Compound:k898-0338|FD-Score:-3.80|P-value:9.96E-5 ID:SGTC_1068|Compound:loratadine|FD-Score:3.96|P-value:5.22E-5 ID:SGTC_1130|Compound:3454-2858|FD-Score:3.57|P-value:2.31E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:-4.14|P-value:2.54E-5 ID:SGTC_1185|Compound:1319-0113|FD-Score:3.99|P-value:4.68E-5 ID:SGTC_1200|Compound:1643-0193|FD-Score:4.89|P-value:8.38E-7 ID:SGTC_1211|Compound:1056-0033|FD-Score:-4.23|P-value:1.71E-5 ID:SGTC_1310|Compound:1188-0297|FD-Score:3.51|P-value:2.95E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:3.16|P-value:9.68E-4 ID:SGTC_1501|Compound:4491-0275|FD-Score:-3.83|P-value:8.67E-5 ID:SGTC_1503|Compound:4585-0012|FD-Score:3.59|P-value:2.20E-4 ID:SGTC_1518|Compound:st038567|FD-Score:4.72|P-value:1.90E-6 ID:SGTC_1616|Compound:st002734|FD-Score:3.34|P-value:5.38E-4 ID:SGTC_1666|Compound:st014829|FD-Score:3.49|P-value:3.14E-4 ID:SGTC_1668|Compound:st014914|FD-Score:3.19|P-value:8.96E-4 ID:SGTC_1735|Compound:st034310|FD-Score:-3.51|P-value:2.93E-4 ID:SGTC_1741|Compound:st038134|FD-Score:3.18|P-value:9.25E-4 ID:SGTC_1768|Compound:st044301|FD-Score:3.55|P-value:2.53E-4 ID:SGTC_1786|Compound:berberine|FD-Score:3.31|P-value:5.84E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:5.12|P-value:2.61E-7 ID:SGTC_1840|Compound:st055363|FD-Score:-3.59|P-value:2.15E-4 ID:SGTC_1903|Compound:st060211|FD-Score:-4.39|P-value:8.61E-6 ID:SGTC_1904|Compound:st060225|FD-Score:-3.34|P-value:5.38E-4 ID:SGTC_1925|Compound:st057770|FD-Score:3.20|P-value:8.57E-4 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:-5.88|P-value:4.20E-9 ID:SGTC_1932|Compound:st074806|FD-Score:6.60|P-value:4.86E-11 ID:SGTC_1981|Compound:st071826|FD-Score:3.23|P-value:7.81E-4 ID:SGTC_2161|Compound:5662504|FD-Score:-4.09|P-value:3.07E-5 ID:SGTC_2313|Compound:7726885|FD-Score:5.52|P-value:3.15E-8 ID:SGTC_2314|Compound:7727897|FD-Score:3.46|P-value:3.45E-4 ID:SGTC_2467|Compound:5474540|FD-Score:-3.16|P-value:9.72E-4 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:-3.20|P-value:8.61E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:4.68|P-value:2.27E-6 ID:SGTC_2534|Compound:helenine|FD-Score:-3.66|P-value:1.72E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:4.63|P-value:2.89E-6 ID:SGTC_2607|Compound:solasodine|FD-Score:4.47|P-value:5.87E-6 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:4.46|P-value:6.29E-6 ID:SGTC_2739|Compound:tacrine|FD-Score:3.93|P-value:5.82E-5 ID:SGTC_2763|Compound:lisinopril|FD-Score:3.97|P-value:4.98E-5 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:-3.29|P-value:6.41E-4 ID:SGTC_2832|Compound:7992762|FD-Score:3.96|P-value:5.31E-5 ID:SGTC_2928|Compound:9011484|FD-Score:3.17|P-value:9.34E-4 ID:SGTC_3067|Compound:9117431|FD-Score:4.75|P-value:1.64E-6 ID:SGTC_3124|Compound:9127567|FD-Score:-3.44|P-value:3.76E-4 ID:SGTC_3145|Compound:9085516|FD-Score:3.15|P-value:9.95E-4 ID:SGTC_3181|Compound:9108277|FD-Score:3.50|P-value:3.04E-4 ID:SGTC_3185|Compound:9108267|FD-Score:3.30|P-value:6.17E-4

Top fitness defect scores for YGR147C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1932 st074806 6.60 40.9 µM 4.86E-11 1 1.99E-11 0.67
2 SGTC_2313 7726885 5.52 200.0 µM 3.15E-8 RPP1 & pyrimidine depletion 2 1.68E-8 0.71
3 SGTC_776 4476-4378 5.19 112.0 µM 1.87E-7 ERG2 1 1.07E-7 0.68
4 SGTC_1787 fluconazole 5.12 80.0 µM 2.61E-7 iron homeostasis 5 1.52E-7 0.27
5 SGTC_1200 1643-0193 4.89 18.4 µM 8.38E-7 2 5.11E-7 0.72
6 SGTC_3067 9117431 4.75 49.5 µM 1.64E-6 1 1.03E-6 0.32
7 SGTC_1518 st038567 4.72 90.8 µM 1.90E-6 2 1.19E-6 0.82
8 SGTC_2531 methyl deoxycholate 4.68 70.1 µM 2.27E-6 3 1.44E-6 0.31
9 SGTC_2536 dehydroabietamide 4.63 32.0 µM 2.89E-6 5 1.85E-6 0.56
10 SGTC_558 k064-0027 4.56 21.3 µM 4.02E-6 DNA damage response 8 2.61E-6 0.54
11 SGTC_167 3672-0051 4.54 66.2 µM 4.23E-6 5 2.75E-6 0.07
12 SGTC_2607 solasodine 4.47 47.4 µM 5.87E-6 9 3.86E-6 0.30
13 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 4.46 70.0 µM 6.29E-6 redox potentiating 7 4.15E-6 0.35
14 SGTC_166 k072-0058 4.16 166.4 µM 2.25E-5 DNA intercalators 5 1.56E-5 0.08
15 SGTC_1019 4262-0212 4.08 3.4 µM 3.20E-5 ergosterol depletion effects on membrane 11 2.26E-5 0.01
16 SGTC_1185 1319-0113 3.99 81.3 µM 4.68E-5 DNA damage response 4 3.35E-5 0.30
17 SGTC_2763 lisinopril 3.97 49.3 µM 4.98E-5 4 3.58E-5 0.52
18 SGTC_1068 loratadine 3.96 26.9 µM 5.22E-5 5 3.75E-5 0.02
19 SGTC_2832 7992762 3.96 52.0 µM 5.31E-5 6 3.82E-5 0.19
20 SGTC_2739 tacrine 3.93 100.9 µM 5.82E-5 heme requiring 6 4.20E-5 0.04

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.088 3.55E-7 YHR193C EGD2 hom Alpha subunit of the heteromeric nascent polypeptide-associated complex (NAC) involved in protein sorting and translocation, associated with cytoplasmic ribosomes
0.077 7.00E-6 YML114C TAF8 het TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
0.071 3.98E-5 YPR200C ARR2 hom Arsenate reductase required for arsenate resistance; converts arsenate to arsenite which can then be exported from cells by Arr3p
0.071 4.18E-5 YER137C_p YER137C_p hom Putative protein of unknown function
0.067 9.73E-5 YNR053C NOG2 het Putative GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation
0.066 1.21E-4 YLR193C UPS1 hom Phosphatidic acid transfer protein; plays a role in phospholipid metabolism by transporting phosphatidic acid from the outer to the inner mitochondrial membrane; localizes to the mitochondrial intermembrane space; null mutant has altered cardiolipin and phosphatidic acid levels; ortholog of human PRELI
0.066 1.38E-4 YGR148C RPL24B hom Ribosomal 60S subunit protein L24B; not essential for translation but may be required for normal translation rate; homologous to mammalian ribosomal protein L24, no bacterial homolog; RPL24B has a paralog, RPL24A, that arose from the whole genome duplication
0.065 1.55E-4 YML049C RSE1 het Protein involved in pre-mRNA splicing; component of the pre-spliceosome; associates with U2 snRNA; involved in ER to Golgi transport
0.063 2.37E-4 YDL070W BDF2 hom Protein involved in transcription initiation; acts at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf1p; protein abundance increases in response to DNA replication stress
0.063 2.80E-4 YAL065C_p YAL065C_p hom Putative protein of unknown function; has homology to FLO1; possible pseudogene
0.062 3.00E-4 YPL257W_p YPL257W_p hom Putative protein of unknown function; homozygous diploid deletion strain exhibits low budding index; physically interacts with Hsp82p; YPL257W is not an essential gene
0.062 3.31E-4 YOR274W MOD5 hom Delta 2-isopentenyl pyrophosphate:tRNA isopentenyl transferase; required for biosynthesis of the modified base isopentenyladenosine in mitochondrial and cytoplasmic tRNAs; gene is nuclear and encodes two isozymic forms; converts to a prion form, and prion conversion contributes to azole antifungal resistance by upregulating ergosterol biosynthesis
0.061 3.85E-4 YMR105W-A_p YMR105W-A_p hom Putative protein of unknown function
0.061 3.94E-4 YML021C UNG1 hom Uracil-DNA glycosylase, required for repair of uracil in DNA formed by spontaneous cytosine deamination, not required for strand-specific mismatch repair, cell-cycle regulated, expressed in late G1, localizes to mitochondria and nucleus
0.060 4.85E-4 YDR341C YDR341C het Arginyl-tRNA synthetase, proposed to be cytoplasmic but the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies