YGR150C / CCM1

Mitochondrial 15s rRNA-binding protein; required for intron removal of COB and COX1 pre-mRNAs; contains pentatricopeptide repeat (PPR) motifs; mutant is respiratory deficient and has defective plasma membrane electron transport

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR150C / CCM1

Click on Significant Values for Screen Details ID:SGTC_70|Compound:0141-0289|FD-Score:3.96|P-value:1.62E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:6.24|P-value:7.74E-9 ID:SGTC_100|Compound:0086-0128|FD-Score:3.69|P-value:4.09E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:4.18|P-value:7.57E-5 ID:SGTC_134|Compound:0269-0018|FD-Score:14.00|P-value:3.56E-37 ID:SGTC_173|Compound:1273-0061|FD-Score:8.47|P-value:8.91E-15 ID:SGTC_214|Compound:4373-3496|FD-Score:4.54|P-value:1.91E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:16.70|P-value:4.14E-52 ID:SGTC_275|Compound:trichlorophene|FD-Score:10.20|P-value:1.44E-20 ID:SGTC_310|Compound:1273-0058|FD-Score:5.73|P-value:1.05E-7 ID:SGTC_339|Compound:3091-4833|FD-Score:-3.49|P-value:8.43E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:7.01|P-value:1.10E-10 ID:SGTC_386|Compound:1509-0011|FD-Score:11.30|P-value:4.75E-25 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-6.49|P-value:2.35E-9 ID:SGTC_456|Compound:gingerol|FD-Score:3.89|P-value:2.08E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-4.39|P-value:3.81E-5 ID:SGTC_520|Compound:3584-0023|FD-Score:3.46|P-value:8.54E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:-3.95|P-value:1.89E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:-3.50|P-value:8.12E-4 ID:SGTC_663|Compound:1486-0733|FD-Score:-4.18|P-value:8.33E-5 ID:SGTC_745|Compound:0469-0705|FD-Score:5.68|P-value:1.31E-7 ID:SGTC_793|Compound:0488-0545|FD-Score:3.98|P-value:1.55E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:5.23|P-value:1.08E-6 ID:SGTC_971|Compound:1315-0384|FD-Score:-4.06|P-value:1.26E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:4.01|P-value:1.40E-4 ID:SGTC_1047|Compound:2043-3044|FD-Score:-4.27|P-value:5.89E-5 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:5.36|P-value:5.95E-7 ID:SGTC_1072|Compound:oxiconazole|FD-Score:-4.46|P-value:2.88E-5 ID:SGTC_1085|Compound:doxorubicin|FD-Score:4.65|P-value:1.27E-5 ID:SGTC_1168|Compound:k815-0004|FD-Score:3.56|P-value:6.29E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:7.26|P-value:2.41E-11 ID:SGTC_1336|Compound:1486-0901|FD-Score:4.20|P-value:7.00E-5 ID:SGTC_1353|Compound:1498-1206|FD-Score:4.38|P-value:3.56E-5 ID:SGTC_1369|Compound:1866-0067|FD-Score:3.90|P-value:2.02E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:4.34|P-value:4.19E-5 ID:SGTC_1388|Compound:3346-4487|FD-Score:3.54|P-value:6.66E-4 ID:SGTC_1389|Compound:3405-0187|FD-Score:-3.70|P-value:4.28E-4 ID:SGTC_1400|Compound:3771-8998|FD-Score:4.22|P-value:6.56E-5 ID:SGTC_1401|Compound:3807-4679|FD-Score:-3.97|P-value:1.76E-4 ID:SGTC_1403|Compound:3909-7815|FD-Score:-4.60|P-value:1.70E-5 ID:SGTC_1418|Compound:3966-3099|FD-Score:3.46|P-value:8.57E-4 ID:SGTC_1478|Compound:0453-0656|FD-Score:6.98|P-value:1.30E-10 ID:SGTC_1625|Compound:st003711|FD-Score:9.43|P-value:7.10E-18 ID:SGTC_1627|Compound:st003713|FD-Score:4.80|P-value:6.69E-6 ID:SGTC_1629|Compound:st005085|FD-Score:5.61|P-value:1.87E-7 ID:SGTC_1635|Compound:st007035|FD-Score:16.30|P-value:3.05E-49 ID:SGTC_1646|Compound:st011709|FD-Score:4.25|P-value:5.83E-5 ID:SGTC_1656|Compound:st012921|FD-Score:-4.69|P-value:1.18E-5 ID:SGTC_1658|Compound:st012944|FD-Score:-4.06|P-value:1.28E-4 ID:SGTC_1730|Compound:st033808|FD-Score:3.66|P-value:4.49E-4 ID:SGTC_1732|Compound:st034308|FD-Score:3.91|P-value:1.96E-4 ID:SGTC_1742|Compound:st038235|FD-Score:7.38|P-value:1.21E-11 ID:SGTC_1787|Compound:fluconazole|FD-Score:-7.87|P-value:6.31E-13 ID:SGTC_1922|Compound:5578187|FD-Score:3.44|P-value:9.08E-4 ID:SGTC_2147|Compound:5545932|FD-Score:3.63|P-value:4.95E-4 ID:SGTC_2165|Compound:5727197|FD-Score:4.55|P-value:1.84E-5 ID:SGTC_2274|Compound:7947094|FD-Score:-3.95|P-value:1.84E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:4.53|P-value:2.01E-5 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:3.79|P-value:2.89E-4 ID:SGTC_2825|Compound:7998094|FD-Score:-3.70|P-value:4.34E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-4.29|P-value:5.58E-5 ID:SGTC_3123|Compound:9126162|FD-Score:4.42|P-value:3.06E-5 ID:SGTC_3135|Compound:9127742|FD-Score:3.57|P-value:5.97E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:3.96|P-value:1.62E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:6.24|P-value:7.74E-9 ID:SGTC_100|Compound:0086-0128|FD-Score:3.69|P-value:4.09E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:4.18|P-value:7.57E-5 ID:SGTC_134|Compound:0269-0018|FD-Score:14.00|P-value:3.56E-37 ID:SGTC_173|Compound:1273-0061|FD-Score:8.47|P-value:8.91E-15 ID:SGTC_214|Compound:4373-3496|FD-Score:4.54|P-value:1.91E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:16.70|P-value:4.14E-52 ID:SGTC_275|Compound:trichlorophene|FD-Score:10.20|P-value:1.44E-20 ID:SGTC_310|Compound:1273-0058|FD-Score:5.73|P-value:1.05E-7 ID:SGTC_339|Compound:3091-4833|FD-Score:-3.49|P-value:8.43E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:7.01|P-value:1.10E-10 ID:SGTC_386|Compound:1509-0011|FD-Score:11.30|P-value:4.75E-25 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-6.49|P-value:2.35E-9 ID:SGTC_456|Compound:gingerol|FD-Score:3.89|P-value:2.08E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-4.39|P-value:3.81E-5 ID:SGTC_520|Compound:3584-0023|FD-Score:3.46|P-value:8.54E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:-3.95|P-value:1.89E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:-3.50|P-value:8.12E-4 ID:SGTC_663|Compound:1486-0733|FD-Score:-4.18|P-value:8.33E-5 ID:SGTC_745|Compound:0469-0705|FD-Score:5.68|P-value:1.31E-7 ID:SGTC_793|Compound:0488-0545|FD-Score:3.98|P-value:1.55E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:5.23|P-value:1.08E-6 ID:SGTC_971|Compound:1315-0384|FD-Score:-4.06|P-value:1.26E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:4.01|P-value:1.40E-4 ID:SGTC_1047|Compound:2043-3044|FD-Score:-4.27|P-value:5.89E-5 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:5.36|P-value:5.95E-7 ID:SGTC_1072|Compound:oxiconazole|FD-Score:-4.46|P-value:2.88E-5 ID:SGTC_1085|Compound:doxorubicin|FD-Score:4.65|P-value:1.27E-5 ID:SGTC_1168|Compound:k815-0004|FD-Score:3.56|P-value:6.29E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:7.26|P-value:2.41E-11 ID:SGTC_1336|Compound:1486-0901|FD-Score:4.20|P-value:7.00E-5 ID:SGTC_1353|Compound:1498-1206|FD-Score:4.38|P-value:3.56E-5 ID:SGTC_1369|Compound:1866-0067|FD-Score:3.90|P-value:2.02E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:4.34|P-value:4.19E-5 ID:SGTC_1388|Compound:3346-4487|FD-Score:3.54|P-value:6.66E-4 ID:SGTC_1389|Compound:3405-0187|FD-Score:-3.70|P-value:4.28E-4 ID:SGTC_1400|Compound:3771-8998|FD-Score:4.22|P-value:6.56E-5 ID:SGTC_1401|Compound:3807-4679|FD-Score:-3.97|P-value:1.76E-4 ID:SGTC_1403|Compound:3909-7815|FD-Score:-4.60|P-value:1.70E-5 ID:SGTC_1418|Compound:3966-3099|FD-Score:3.46|P-value:8.57E-4 ID:SGTC_1478|Compound:0453-0656|FD-Score:6.98|P-value:1.30E-10 ID:SGTC_1625|Compound:st003711|FD-Score:9.43|P-value:7.10E-18 ID:SGTC_1627|Compound:st003713|FD-Score:4.80|P-value:6.69E-6 ID:SGTC_1629|Compound:st005085|FD-Score:5.61|P-value:1.87E-7 ID:SGTC_1635|Compound:st007035|FD-Score:16.30|P-value:3.05E-49 ID:SGTC_1646|Compound:st011709|FD-Score:4.25|P-value:5.83E-5 ID:SGTC_1656|Compound:st012921|FD-Score:-4.69|P-value:1.18E-5 ID:SGTC_1658|Compound:st012944|FD-Score:-4.06|P-value:1.28E-4 ID:SGTC_1730|Compound:st033808|FD-Score:3.66|P-value:4.49E-4 ID:SGTC_1732|Compound:st034308|FD-Score:3.91|P-value:1.96E-4 ID:SGTC_1742|Compound:st038235|FD-Score:7.38|P-value:1.21E-11 ID:SGTC_1787|Compound:fluconazole|FD-Score:-7.87|P-value:6.31E-13 ID:SGTC_1922|Compound:5578187|FD-Score:3.44|P-value:9.08E-4 ID:SGTC_2147|Compound:5545932|FD-Score:3.63|P-value:4.95E-4 ID:SGTC_2165|Compound:5727197|FD-Score:4.55|P-value:1.84E-5 ID:SGTC_2274|Compound:7947094|FD-Score:-3.95|P-value:1.84E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:4.53|P-value:2.01E-5 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:3.79|P-value:2.89E-4 ID:SGTC_2825|Compound:7998094|FD-Score:-3.70|P-value:4.34E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-4.29|P-value:5.58E-5 ID:SGTC_3123|Compound:9126162|FD-Score:4.42|P-value:3.06E-5 ID:SGTC_3135|Compound:9127742|FD-Score:3.57|P-value:5.97E-4

Top fitness defect scores for YGR150C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 16.70 5.3 µM 4.14E-52 81 3.33E-63
2 SGTC_1635 st007035 16.30 42.4 µM 3.05E-49 31 1.06E-59
3 SGTC_134 0269-0018 14.00 6.9 µM 3.56E-37 22 5.86E-45
4 SGTC_386 1509-0011 11.30 3.1 µM 4.75E-25 38 3.73E-30
5 SGTC_275 trichlorophene 10.20 5.7 µM 1.44E-20 mitochondrial stress 44 1.09E-24
6 SGTC_1625 st003711 9.43 30.1 µM 7.10E-18 calcium & mitochondrial duress 2 2.11E-21
7 SGTC_173 1273-0061 8.47 2.7 µM 8.91E-15 mitochondrial stress 58 1.26E-17
8 SGTC_1742 st038235 7.38 28.9 µM 1.21E-11 mitochondrial stress 23 8.19E-14
9 SGTC_1188 1403-0014 7.26 4.6 µM 2.41E-11 mitochondrial stress 9 1.91E-13
10 SGTC_365 0121-0052 7.01 13.6 µM 1.10E-10 mitochondrial response to ROS 11 1.21E-12
11 SGTC_1478 0453-0656 6.98 35.7 µM 1.30E-10 2 1.49E-12
12 SGTC_87 0100-0052 6.24 35.5 µM 7.74E-9 28 2.13E-10
13 SGTC_310 1273-0058 5.73 1.1 µM 1.05E-7 mitochondrial stress 151 5.03E-9
14 SGTC_745 0469-0705 5.68 296.0 µM 1.31E-7 mitochondrial processes 4 6.64E-9
15 SGTC_1629 st005085 5.61 44.9 µM 1.87E-7 RPP1 & pyrimidine depletion 9 1.02E-8
16 SGTC_1069 diphenylcyclopropenone 5.36 8.5 µM 5.95E-7 12 4.15E-8
17 SGTC_908 3448-7491 5.23 47.7 µM 1.08E-6 mitochondrial stress 70 8.57E-8
18 SGTC_1627 st003713 4.80 25.6 µM 6.69E-6 calcium & mitochondrial duress 44 7.79E-7
19 SGTC_1085 doxorubicin 4.65 7.7 µM 1.27E-5 anthracycline transcription coupled DNA repair 8 1.70E-6
20 SGTC_2165 5727197 4.55 32.1 µM 1.84E-5 24 2.65E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.569 6.61E-287 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.565 2.93E-282 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.559 2.31E-274 YNL213C RRG9 hom Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.555 1.00E-269 YNL252C MRPL17 hom Mitochondrial ribosomal protein of the large subunit
0.550 1.61E-263 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.549 3.10E-263 YGR220C MRPL9 hom Mitochondrial ribosomal protein of the large subunit
0.546 2.53E-259 YDR079W PET100 hom Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme
0.535 3.58E-247 YDR237W MRPL7 hom Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein
0.533 3.17E-245 YKL155C RSM22 hom Mitochondrial ribosomal protein of the small subunit; also predicted to be an S-adenosylmethionine-dependent methyltransferase
0.528 5.17E-240 YDR231C COX20 hom Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase
0.525 7.54E-237 YKL194C MST1 hom Mitochondrial threonyl-tRNA synthetase; aminoacylates both the canonical threonine tRNA tT(UGU)Q1 and the unusual threonine tRNA tT(XXX)Q2 in vitro
0.525 2.92E-236 YPL132W COX11 hom Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
0.522 8.10E-234 YNR045W PET494 hom Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane
0.521 6.57E-233 YML129C COX14 hom Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes
0.521 6.14E-232 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases