YGR151C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF RSR1/BUD1/YGR152C; relative distribution to the nucleus increases upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR151C / YGR151C

Click on Significant Values for Screen Details ID:SGTC_142|Compound:0335-0849|FD-Score:-4.28|P-value:1.03E-5 ID:SGTC_143|Compound:4032-1194|FD-Score:4.18|P-value:1.48E-5 ID:SGTC_145|Compound:3737-0113|FD-Score:3.10|P-value:9.74E-4 ID:SGTC_196|Compound:k015-0023|FD-Score:3.87|P-value:5.64E-5 ID:SGTC_230|Compound:MPP+|FD-Score:3.19|P-value:7.11E-4 ID:SGTC_247|Compound:mechlorethamine|FD-Score:3.38|P-value:3.68E-4 ID:SGTC_355|Compound:1311-2252|FD-Score:3.22|P-value:6.38E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:3.22|P-value:6.47E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:-3.84|P-value:6.57E-5 ID:SGTC_531|Compound:3788-1495|FD-Score:-3.16|P-value:8.31E-4 ID:SGTC_538|Compound:2922-0838|FD-Score:3.76|P-value:8.68E-5 ID:SGTC_542|Compound:3381-0244|FD-Score:4.01|P-value:3.14E-5 ID:SGTC_599|Compound:1935-0052|FD-Score:-3.19|P-value:7.66E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:3.87|P-value:5.63E-5 ID:SGTC_786|Compound:4544-0069|FD-Score:3.88|P-value:5.34E-5 ID:SGTC_902|Compound:1120-0002|FD-Score:3.90|P-value:4.92E-5 ID:SGTC_937|Compound:3122-0005|FD-Score:3.49|P-value:2.46E-4 ID:SGTC_997|Compound:3996-0078|FD-Score:3.26|P-value:5.58E-4 ID:SGTC_1004|Compound:4084-0029|FD-Score:3.25|P-value:5.73E-4 ID:SGTC_1023|Compound:4482-3888|FD-Score:-3.15|P-value:8.69E-4 ID:SGTC_1093|Compound:fluphenazine|FD-Score:-3.50|P-value:2.46E-4 ID:SGTC_1094|Compound:duloxetine|FD-Score:3.14|P-value:8.53E-4 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:4.48|P-value:3.93E-6 ID:SGTC_1115|Compound:galangin|FD-Score:3.19|P-value:7.26E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:-3.60|P-value:1.74E-4 ID:SGTC_1169|Compound:aniline yellow|FD-Score:3.76|P-value:8.54E-5 ID:SGTC_1186|Compound:1319-0216|FD-Score:4.19|P-value:1.42E-5 ID:SGTC_1243|Compound:0416-0003|FD-Score:-3.27|P-value:5.69E-4 ID:SGTC_1343|Compound:1487-0095|FD-Score:3.29|P-value:5.05E-4 ID:SGTC_1519|Compound:esterone|FD-Score:3.14|P-value:8.57E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.50|P-value:2.34E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-3.30|P-value:5.22E-4 ID:SGTC_1915|Compound:st067105|FD-Score:-3.79|P-value:8.09E-5 ID:SGTC_1922|Compound:5578187|FD-Score:-4.66|P-value:1.76E-6 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:3.45|P-value:2.88E-4 ID:SGTC_1932|Compound:st074806|FD-Score:3.29|P-value:5.02E-4 ID:SGTC_2088|Compound:5278280|FD-Score:-3.78|P-value:8.46E-5 ID:SGTC_2110|Compound:5483698|FD-Score:-3.20|P-value:7.25E-4 ID:SGTC_2116|Compound:5511452|FD-Score:3.43|P-value:3.05E-4 ID:SGTC_2175|Compound:5807670|FD-Score:4.52|P-value:3.21E-6 ID:SGTC_2398|Compound:5228213|FD-Score:3.44|P-value:2.97E-4 ID:SGTC_2402|Compound:5553605|FD-Score:3.68|P-value:1.18E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.52|P-value:2.15E-4 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:5.36|P-value:4.34E-8 ID:SGTC_2605|Compound:digitonin|FD-Score:3.28|P-value:5.23E-4 ID:SGTC_2616|Compound:abietic acid|FD-Score:4.54|P-value:2.85E-6 ID:SGTC_3006|Compound:9075424|FD-Score:-3.97|P-value:3.98E-5 ID:SGTC_3068|Compound:9116768|FD-Score:4.73|P-value:1.17E-6 ID:SGTC_3146|Compound:9095609|FD-Score:-3.94|P-value:4.37E-5 ID:SGTC_3148|Compound:9097893|FD-Score:-4.26|P-value:1.14E-5 ID:SGTC_3153|Compound:9100258|FD-Score:3.60|P-value:1.64E-4 ID:SGTC_3173|Compound:9105693|FD-Score:3.73|P-value:9.88E-5 ID:SGTC_3179|Compound:9107801|FD-Score:3.33|P-value:4.40E-4 ID:SGTC_3182|Compound:9108849|FD-Score:3.79|P-value:7.70E-5 ID:SGTC_3195|Compound:9113082|FD-Score:3.16|P-value:7.90E-4 ID:SGTC_3304|Compound:9125678|FD-Score:4.20|P-value:1.35E-5 ID:SGTC_3330|Compound:9141424|FD-Score:3.30|P-value:4.89E-4 ID:SGTC_3334|Compound:9142812|FD-Score:3.90|P-value:4.95E-5 ID:SGTC_3353|Compound:9151644|FD-Score:-3.36|P-value:4.23E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:-4.28|P-value:1.03E-5 ID:SGTC_143|Compound:4032-1194|FD-Score:4.18|P-value:1.48E-5 ID:SGTC_145|Compound:3737-0113|FD-Score:3.10|P-value:9.74E-4 ID:SGTC_196|Compound:k015-0023|FD-Score:3.87|P-value:5.64E-5 ID:SGTC_230|Compound:MPP+|FD-Score:3.19|P-value:7.11E-4 ID:SGTC_247|Compound:mechlorethamine|FD-Score:3.38|P-value:3.68E-4 ID:SGTC_355|Compound:1311-2252|FD-Score:3.22|P-value:6.38E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:3.22|P-value:6.47E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:-3.84|P-value:6.57E-5 ID:SGTC_531|Compound:3788-1495|FD-Score:-3.16|P-value:8.31E-4 ID:SGTC_538|Compound:2922-0838|FD-Score:3.76|P-value:8.68E-5 ID:SGTC_542|Compound:3381-0244|FD-Score:4.01|P-value:3.14E-5 ID:SGTC_599|Compound:1935-0052|FD-Score:-3.19|P-value:7.66E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:3.87|P-value:5.63E-5 ID:SGTC_786|Compound:4544-0069|FD-Score:3.88|P-value:5.34E-5 ID:SGTC_902|Compound:1120-0002|FD-Score:3.90|P-value:4.92E-5 ID:SGTC_937|Compound:3122-0005|FD-Score:3.49|P-value:2.46E-4 ID:SGTC_997|Compound:3996-0078|FD-Score:3.26|P-value:5.58E-4 ID:SGTC_1004|Compound:4084-0029|FD-Score:3.25|P-value:5.73E-4 ID:SGTC_1023|Compound:4482-3888|FD-Score:-3.15|P-value:8.69E-4 ID:SGTC_1093|Compound:fluphenazine|FD-Score:-3.50|P-value:2.46E-4 ID:SGTC_1094|Compound:duloxetine|FD-Score:3.14|P-value:8.53E-4 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:4.48|P-value:3.93E-6 ID:SGTC_1115|Compound:galangin|FD-Score:3.19|P-value:7.26E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:-3.60|P-value:1.74E-4 ID:SGTC_1169|Compound:aniline yellow|FD-Score:3.76|P-value:8.54E-5 ID:SGTC_1186|Compound:1319-0216|FD-Score:4.19|P-value:1.42E-5 ID:SGTC_1243|Compound:0416-0003|FD-Score:-3.27|P-value:5.69E-4 ID:SGTC_1343|Compound:1487-0095|FD-Score:3.29|P-value:5.05E-4 ID:SGTC_1519|Compound:esterone|FD-Score:3.14|P-value:8.57E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.50|P-value:2.34E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-3.30|P-value:5.22E-4 ID:SGTC_1915|Compound:st067105|FD-Score:-3.79|P-value:8.09E-5 ID:SGTC_1922|Compound:5578187|FD-Score:-4.66|P-value:1.76E-6 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:3.45|P-value:2.88E-4 ID:SGTC_1932|Compound:st074806|FD-Score:3.29|P-value:5.02E-4 ID:SGTC_2088|Compound:5278280|FD-Score:-3.78|P-value:8.46E-5 ID:SGTC_2110|Compound:5483698|FD-Score:-3.20|P-value:7.25E-4 ID:SGTC_2116|Compound:5511452|FD-Score:3.43|P-value:3.05E-4 ID:SGTC_2175|Compound:5807670|FD-Score:4.52|P-value:3.21E-6 ID:SGTC_2398|Compound:5228213|FD-Score:3.44|P-value:2.97E-4 ID:SGTC_2402|Compound:5553605|FD-Score:3.68|P-value:1.18E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.52|P-value:2.15E-4 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:5.36|P-value:4.34E-8 ID:SGTC_2605|Compound:digitonin|FD-Score:3.28|P-value:5.23E-4 ID:SGTC_2616|Compound:abietic acid|FD-Score:4.54|P-value:2.85E-6 ID:SGTC_3006|Compound:9075424|FD-Score:-3.97|P-value:3.98E-5 ID:SGTC_3068|Compound:9116768|FD-Score:4.73|P-value:1.17E-6 ID:SGTC_3146|Compound:9095609|FD-Score:-3.94|P-value:4.37E-5 ID:SGTC_3148|Compound:9097893|FD-Score:-4.26|P-value:1.14E-5 ID:SGTC_3153|Compound:9100258|FD-Score:3.60|P-value:1.64E-4 ID:SGTC_3173|Compound:9105693|FD-Score:3.73|P-value:9.88E-5 ID:SGTC_3179|Compound:9107801|FD-Score:3.33|P-value:4.40E-4 ID:SGTC_3182|Compound:9108849|FD-Score:3.79|P-value:7.70E-5 ID:SGTC_3195|Compound:9113082|FD-Score:3.16|P-value:7.90E-4 ID:SGTC_3304|Compound:9125678|FD-Score:4.20|P-value:1.35E-5 ID:SGTC_3330|Compound:9141424|FD-Score:3.30|P-value:4.89E-4 ID:SGTC_3334|Compound:9142812|FD-Score:3.90|P-value:4.95E-5 ID:SGTC_3353|Compound:9151644|FD-Score:-3.36|P-value:4.23E-4

Top fitness defect scores for YGR151C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2574 2',4'-dihydroxychalcone 5.36 14.6 µM 4.34E-8 8 4.12E-8
2 SGTC_3068 9116768 4.73 49.5 µM 1.17E-6 11 1.13E-6
3 SGTC_2616 abietic acid 4.54 100.0 µM 2.85E-6 22 2.76E-6
4 SGTC_2175 5807670 4.52 165.3 µM 3.21E-6 14 3.10E-6
5 SGTC_1106 tegaserod maleate 4.48 11.7 µM 3.93E-6 9 3.81E-6
6 SGTC_3304 9125678 4.20 46.1 µM 1.35E-5 38 1.31E-5
7 SGTC_1186 1319-0216 4.19 26.0 µM 1.42E-5 15 1.38E-5
8 SGTC_143 4032-1194 4.18 15.7 µM 1.48E-5 56 1.45E-5
9 SGTC_542 3381-0244 4.01 89.3 µM 3.14E-5 37 3.08E-5
10 SGTC_902 1120-0002 3.90 2.1 µM 4.92E-5 azole & statin 49 4.83E-5
11 SGTC_3334 9142812 3.90 21.9 µM 4.95E-5 29 4.86E-5
12 SGTC_786 4544-0069 3.88 423.0 µM 5.34E-5 33 5.23E-5
13 SGTC_785 1270-0111 3.87 65.3 µM 5.63E-5 25 5.52E-5
14 SGTC_196 k015-0023 3.87 18.1 µM 5.64E-5 PDR1 23 5.53E-5
15 SGTC_3182 9108849 3.79 49.5 µM 7.70E-5 RPP1 & pyrimidine depletion 14 7.56E-5
16 SGTC_1169 aniline yellow 3.76 25.8 µM 8.54E-5 13 8.39E-5
17 SGTC_538 2922-0838 3.76 53.3 µM 8.68E-5 Golgi 33 8.54E-5
18 SGTC_3173 9105693 3.73 49.5 µM 9.88E-5 26 9.71E-5
19 SGTC_2402 5553605 3.68 200.0 µM 1.18E-4 38 1.16E-4
20 SGTC_3153 9100258 3.60 49.5 µM 1.64E-4 35 1.62E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.128 8.36E-14 YKL058W TOA2 het TFIIA small subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to smallest subunit of human and Drosophila TFIIA; protein abundance increases in response to DNA replication stress
0.114 3.51E-11 YMR213W CEF1 het Essential splicing factor; associated with Prp19p and the spliceosome, contains an N-terminal c-Myb DNA binding motif necessary for cell viability but not for Prp19p association, evolutionarily conserved and homologous to S. pombe Cdc5p
0.112 8.10E-11 YHR149C SKG6 hom Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p
0.107 5.97E-10 YDL223C HBT1 hom Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis
0.106 6.46E-10 YPR085C ASA1 het Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1
0.101 5.28E-9 YPL157W TGS1 hom Trimethyl guanosine synthase, conserved nucleolar methyl transferase that converts the m(7)G cap structure of snRNAs, snoRNAs, and telomerase TLC1 RNA to m(2,2,7)G; also required for nucleolar assembly and splicing of meiotic pre-mRNAs
0.100 7.26E-9 YMR168C CEP3 het Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain
0.097 1.70E-8 YGL118C_d YGL118C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.095 3.89E-8 YGL155W CDC43 het Beta subunit of geranylgeranyltransferase type I, catalyzes geranylgeranylation to the cysteine residue in proteins containing a C-terminal CaaX sequence ending in Leu or Phe; has substrates important for morphogenesis
0.094 4.50E-8 YDR275W BSC2 hom Protein of unknown function; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; BSC2 has a paralog, IRC23, that arose from the whole genome duplication
0.093 7.79E-8 YHR164C DNA2 het Tripartite DNA replication factor; has single-stranded DNA-dependent ATPase, ATP-dependent nuclease, and helicase activities; required for Okazaki fragment processing; involved in DNA repair; cell-cycle dependent localization; forms nuclear foci upon DNA replication stress
0.092 8.22E-8 YDR314C RAD34 hom Protein involved in nucleotide excision repair (NER); homologous to RAD4
0.092 9.56E-8 YER062C HOR2 hom Glycerol-1-phosphatase involved in glycerol biosynthesis; induced in response to hyperosmotic or oxidative stress, and during diauxic shift; HOR2 has a paralog, RHR2, that arose from the whole genome duplication
0.092 1.05E-7 YKL019W RAM2 het Alpha subunit of both the farnesyltransferase and type I geranylgeranyltransferase that catalyze prenylation of proteins containing a CAAX consensus motif; essential protein required for membrane localization of Ras proteins and a-factor
0.088 3.59E-7 YHL039W EFM1 hom Lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm