YGR153W_p

Putative protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR153W / YGR153W

Click on Significant Values for Screen Details ID:SGTC_54|Compound:0159-0055|FD-Score:3.25|P-value:4.80E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.10|P-value:8.67E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:-3.51|P-value:1.99E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:4.28|P-value:6.84E-6 ID:SGTC_285|Compound:1486-1325|FD-Score:3.42|P-value:2.51E-4 ID:SGTC_370|Compound:0180-0345|FD-Score:3.35|P-value:3.29E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:5.03|P-value:1.59E-7 ID:SGTC_660|Compound:4031-1742|FD-Score:3.41|P-value:2.59E-4 ID:SGTC_734|Compound:2023-0417|FD-Score:4.96|P-value:2.34E-7 ID:SGTC_740|Compound:k014-0057|FD-Score:3.69|P-value:8.88E-5 ID:SGTC_752|Compound:1896-0090|FD-Score:-5.92|P-value:1.04E-9 ID:SGTC_779|Compound:1360-0071|FD-Score:6.62|P-value:9.15E-12 ID:SGTC_781|Compound:4335-2806|FD-Score:3.33|P-value:3.60E-4 ID:SGTC_783|Compound:0848-0141|FD-Score:-6.95|P-value:1.06E-12 ID:SGTC_785|Compound:1270-0111|FD-Score:-3.72|P-value:8.64E-5 ID:SGTC_788|Compound:1182-0090|FD-Score:3.45|P-value:2.24E-4 ID:SGTC_792|Compound:4534-1957|FD-Score:-3.08|P-value:9.34E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:3.10|P-value:8.07E-4 ID:SGTC_1515|Compound:3460-0031|FD-Score:-3.92|P-value:3.71E-5 ID:SGTC_1555|Compound:citronellol|FD-Score:3.31|P-value:3.85E-4 ID:SGTC_1795|Compound:st049545|FD-Score:3.09|P-value:8.46E-4 ID:SGTC_1950|Compound:st077106|FD-Score:4.00|P-value:2.43E-5 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:-3.55|P-value:1.66E-4 ID:SGTC_2298|Compound:7976326|FD-Score:3.39|P-value:2.84E-4 ID:SGTC_2344|Compound:7990960|FD-Score:-3.15|P-value:7.45E-4 ID:SGTC_2346|Compound:9031566|FD-Score:3.56|P-value:1.45E-4 ID:SGTC_2370|Compound:9071495|FD-Score:3.75|P-value:6.76E-5 ID:SGTC_2411|Compound:st077133|FD-Score:3.29|P-value:4.10E-4 ID:SGTC_2433|Compound:5607874|FD-Score:-4.91|P-value:3.49E-7 ID:SGTC_2434|Compound:5670830|FD-Score:-3.12|P-value:8.08E-4 ID:SGTC_2443|Compound:5493264|FD-Score:3.63|P-value:1.14E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:7.62|P-value:5.41E-15 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:4.09|P-value:1.58E-5 ID:SGTC_2596|Compound:sinensetin|FD-Score:4.18|P-value:1.09E-5 ID:SGTC_2809|Compound:7964133|FD-Score:-3.85|P-value:4.96E-5 ID:SGTC_2812|Compound:7970281|FD-Score:3.69|P-value:8.62E-5 ID:SGTC_2880|Compound:9042983|FD-Score:3.17|P-value:6.20E-4 ID:SGTC_2947|Compound:9072639|FD-Score:3.45|P-value:2.26E-4 ID:SGTC_3047|Compound:9092122|FD-Score:-4.80|P-value:6.12E-7 ID:SGTC_3272|Compound:9137413|FD-Score:3.11|P-value:7.68E-4 ID:SGTC_3342|Compound:9147791|FD-Score:3.29|P-value:4.13E-4 ID:SGTC_54|Compound:0159-0055|FD-Score:3.25|P-value:4.80E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.10|P-value:8.67E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:-3.51|P-value:1.99E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:4.28|P-value:6.84E-6 ID:SGTC_285|Compound:1486-1325|FD-Score:3.42|P-value:2.51E-4 ID:SGTC_370|Compound:0180-0345|FD-Score:3.35|P-value:3.29E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:5.03|P-value:1.59E-7 ID:SGTC_660|Compound:4031-1742|FD-Score:3.41|P-value:2.59E-4 ID:SGTC_734|Compound:2023-0417|FD-Score:4.96|P-value:2.34E-7 ID:SGTC_740|Compound:k014-0057|FD-Score:3.69|P-value:8.88E-5 ID:SGTC_752|Compound:1896-0090|FD-Score:-5.92|P-value:1.04E-9 ID:SGTC_779|Compound:1360-0071|FD-Score:6.62|P-value:9.15E-12 ID:SGTC_781|Compound:4335-2806|FD-Score:3.33|P-value:3.60E-4 ID:SGTC_783|Compound:0848-0141|FD-Score:-6.95|P-value:1.06E-12 ID:SGTC_785|Compound:1270-0111|FD-Score:-3.72|P-value:8.64E-5 ID:SGTC_788|Compound:1182-0090|FD-Score:3.45|P-value:2.24E-4 ID:SGTC_792|Compound:4534-1957|FD-Score:-3.08|P-value:9.34E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:3.10|P-value:8.07E-4 ID:SGTC_1515|Compound:3460-0031|FD-Score:-3.92|P-value:3.71E-5 ID:SGTC_1555|Compound:citronellol|FD-Score:3.31|P-value:3.85E-4 ID:SGTC_1795|Compound:st049545|FD-Score:3.09|P-value:8.46E-4 ID:SGTC_1950|Compound:st077106|FD-Score:4.00|P-value:2.43E-5 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:-3.55|P-value:1.66E-4 ID:SGTC_2298|Compound:7976326|FD-Score:3.39|P-value:2.84E-4 ID:SGTC_2344|Compound:7990960|FD-Score:-3.15|P-value:7.45E-4 ID:SGTC_2346|Compound:9031566|FD-Score:3.56|P-value:1.45E-4 ID:SGTC_2370|Compound:9071495|FD-Score:3.75|P-value:6.76E-5 ID:SGTC_2411|Compound:st077133|FD-Score:3.29|P-value:4.10E-4 ID:SGTC_2433|Compound:5607874|FD-Score:-4.91|P-value:3.49E-7 ID:SGTC_2434|Compound:5670830|FD-Score:-3.12|P-value:8.08E-4 ID:SGTC_2443|Compound:5493264|FD-Score:3.63|P-value:1.14E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:7.62|P-value:5.41E-15 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:4.09|P-value:1.58E-5 ID:SGTC_2596|Compound:sinensetin|FD-Score:4.18|P-value:1.09E-5 ID:SGTC_2809|Compound:7964133|FD-Score:-3.85|P-value:4.96E-5 ID:SGTC_2812|Compound:7970281|FD-Score:3.69|P-value:8.62E-5 ID:SGTC_2880|Compound:9042983|FD-Score:3.17|P-value:6.20E-4 ID:SGTC_2947|Compound:9072639|FD-Score:3.45|P-value:2.26E-4 ID:SGTC_3047|Compound:9092122|FD-Score:-4.80|P-value:6.12E-7 ID:SGTC_3272|Compound:9137413|FD-Score:3.11|P-value:7.68E-4 ID:SGTC_3342|Compound:9147791|FD-Score:3.29|P-value:4.13E-4

Top fitness defect scores for YGR153W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2563 tomatine 7.62 8.5 µM 5.41E-15 4 1.31E-14
2 SGTC_779 1360-0071 6.62 233.0 µM 9.15E-12 fatty acid desaturase (OLE1) 3 1.82E-11
3 SGTC_515 4092-1064 5.03 102.0 µM 1.59E-7 plasma membrane duress 37 2.41E-7
4 SGTC_734 2023-0417 4.96 80.0 µM 2.34E-7 ergosterol biosynthesis 3 3.52E-7
5 SGTC_270 tamoxifen 4.28 5.5 µM 6.84E-6 NEO1 20 9.36E-6
6 SGTC_2596 sinensetin 4.18 100.0 µM 1.09E-5 24 1.47E-5
7 SGTC_2573 2',4'-dihydroxychalcone 4.09 15.0 µM 1.58E-5 43 2.11E-5
8 SGTC_1950 st077106 4.00 7.2 µM 2.43E-5 RNA processing & uracil transport 27 3.21E-5
9 SGTC_2370 9071495 3.75 200.0 µM 6.76E-5 mitochondrial processes 31 8.69E-5
10 SGTC_2812 7970281 3.69 58.4 µM 8.62E-5 39 1.10E-4
11 SGTC_740 k014-0057 3.69 261.0 µM 8.88E-5 30 1.13E-4
12 SGTC_2443 5493264 3.63 126.7 µM 1.14E-4 29 1.44E-4
13 SGTC_2346 9031566 3.56 143.8 µM 1.45E-4 Golgi 37 1.83E-4
14 SGTC_788 1182-0090 3.45 188.0 µM 2.24E-4 endomembrane recycling 109 2.78E-4
15 SGTC_2947 9072639 3.45 7.7 µM 2.26E-4 tubulin folding & SWR complex 67 2.80E-4
16 SGTC_285 1486-1325 3.42 46.0 µM 2.51E-4 31 3.11E-4
17 SGTC_660 4031-1742 3.41 102.0 µM 2.59E-4 redox potentiating 72 3.21E-4
18 SGTC_2298 7976326 3.39 193.8 µM 2.84E-4 20 3.50E-4
19 SGTC_370 0180-0345 3.35 38.7 µM 3.29E-4 DNA intercalators 28 4.04E-4
20 SGTC_781 4335-2806 3.33 94.4 µM 3.60E-4 40 4.42E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.147 9.31E-18 YDR534C FIT1 hom Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
0.141 2.49E-16 YNR032C-A HUB1 hom Ubiquitin-like protein modifier; promotes alternative splicing of SRC1 pre-mRNA; binds non-covalently to the HIND domain of Snu66, may function in modification of Sph1p and Hbt1p, functionally complemented by the human or S. pombe ortholog; mechanism of Hub1p adduct formation not yet clear
0.130 4.10E-14 YJR056C YJR056C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; relative distribution to the nucleus increases upon DNA replication stress
0.129 6.98E-14 YDR299W BFR2 het Essential protein that is a component of 90S preribosomes; may be involved in rRNA processing; multicopy suppressor of sensitivity to Brefeldin A; expression is induced during lag phase and also by cold shock
0.116 1.82E-11 YKL074C MUD2 hom Protein involved in early pre-mRNA splicing; component of the pre-mRNA-U1 snRNP complex, the commitment complex; interacts with Msl5p/BBP splicing factor and Sub2p; similar to metazoan splicing factor U2AF65
0.109 2.36E-10 YKL092C BUD2 hom GTPase activating factor for Rsr1p/Bud1p; required for both axial and bipolar budding patterns; mutants exhibit random budding in all cell types; mutant deficient in mitotic spindle position checkpoint
0.108 3.94E-10 YDR018C_p YDR018C_p hom Probable membrane protein with three predicted transmembrane domains; similar to C. elegans F55A11.5 and maize 1-acyl-glycerol-3-phosphate acyltransferase; YDR018C has a paralog, CST26, that arose from the whole genome duplication
0.102 3.70E-9 YDR328C SKP1 het Evolutionarily conserved kinetochore protein; part of multiple protein complexes, including the SCF ubiquitin ligase complex, the CBF3 complex that binds centromeric DNA, and the RAVE complex that regulates assembly of the V-ATPase; protein abundance increases in response to DNA replication stress
0.099 1.04E-8 YLR080W EMP46 hom Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport
0.098 1.50E-8 YLR077W FMP25 hom Mitochondrial inner membrane protein required for an early step in assembly of respiratory complex III (cytochrome bc1 complex); mRNA is targeted to mitochondria
0.097 1.77E-8 YNL212W VID27 hom Cytoplasmic protein of unknown function; possibly involved in vacuolar protein degradation; not essential for proteasome-dependent degradation of fructose-1,6-bisphosphatase (FBPase); null mutants exhibit normal growth
0.095 3.33E-8 YER159C BUR6 het Subunit of a heterodimeric NC2 transcription regulator complex with Ncb2p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2alpha
0.094 5.42E-8 YCR030C SYP1 hom Protein of unknown function that is involved in endocytic site formation; may regulate assembly and disassembly of the septin ring; colocalizes and interacts with septin subunits; potential role in actin cytoskeletal organization
0.093 6.51E-8 YOR130C ORT1 hom Ornithine transporter of the mitochondrial inner membrane, exports ornithine from mitochondria as part of arginine biosynthesis; human ortholog is associated with hyperammonaemia-hyperornithinaemia-homocitrullinuria (HHH) syndrome
0.092 8.67E-8 YMR184W ADD37 hom Protein of unknown function; involved in ER-associated protein degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YMR184W is not an essential gene; protein abundance increases in response to DNA replication stress