YGR154C / GTO1

Omega-class glutathione transferase; induced under oxidative stress; putative peroxisomal localization

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR154C / GTO1

Click on Significant Values for Screen Details ID:SGTC_50|Compound:0929-0078|FD-Score:3.70|P-value:7.01E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.59|P-value:1.07E-4 ID:SGTC_245|Compound:methotrexate|FD-Score:4.10|P-value:1.20E-5 ID:SGTC_313|Compound:3474-0040|FD-Score:-3.69|P-value:7.05E-5 ID:SGTC_318|Compound:1488-0629|FD-Score:3.09|P-value:7.45E-4 ID:SGTC_536|Compound:3852-0578|FD-Score:3.67|P-value:8.05E-5 ID:SGTC_595|Compound:3909-8003|FD-Score:3.54|P-value:1.33E-4 ID:SGTC_739|Compound:1486-1183|FD-Score:3.04|P-value:8.72E-4 ID:SGTC_763|Compound:3453-1109|FD-Score:4.03|P-value:1.66E-5 ID:SGTC_766|Compound:1391-0721|FD-Score:4.28|P-value:5.29E-6 ID:SGTC_777|Compound:1315-0167|FD-Score:3.75|P-value:5.71E-5 ID:SGTC_868|Compound:0527-0199|FD-Score:-3.36|P-value:2.63E-4 ID:SGTC_935|Compound:2996-0153|FD-Score:3.80|P-value:4.58E-5 ID:SGTC_959|Compound:1222-0044|FD-Score:3.64|P-value:8.97E-5 ID:SGTC_973|Compound:1325-0077|FD-Score:3.06|P-value:8.12E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:-3.16|P-value:5.58E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:-3.78|P-value:4.93E-5 ID:SGTC_1259|Compound:0671-0132|FD-Score:4.75|P-value:5.13E-7 ID:SGTC_1262|Compound:0737-0114|FD-Score:3.97|P-value:2.19E-5 ID:SGTC_1265|Compound:0819-1001|FD-Score:-3.21|P-value:4.75E-4 ID:SGTC_1439|Compound:4092-1168|FD-Score:-3.09|P-value:7.31E-4 ID:SGTC_1714|Compound:st033236|FD-Score:-4.93|P-value:1.88E-7 ID:SGTC_1718|Compound:roemerine|FD-Score:3.16|P-value:5.68E-4 ID:SGTC_1731|Compound:st035964|FD-Score:3.48|P-value:1.74E-4 ID:SGTC_1732|Compound:st034308|FD-Score:-3.23|P-value:4.36E-4 ID:SGTC_1737|Compound:st035557|FD-Score:3.36|P-value:2.73E-4 ID:SGTC_1851|Compound:st056236|FD-Score:-3.15|P-value:5.90E-4 ID:SGTC_1855|Compound:st056195|FD-Score:4.55|P-value:1.45E-6 ID:SGTC_1857|Compound:st056007|FD-Score:-3.37|P-value:2.58E-4 ID:SGTC_1861|Compound:st057647|FD-Score:3.80|P-value:4.51E-5 ID:SGTC_1925|Compound:st057770|FD-Score:3.17|P-value:5.53E-4 ID:SGTC_1977|Compound:st070720|FD-Score:3.03|P-value:9.25E-4 ID:SGTC_2035|Compound:5154463|FD-Score:3.05|P-value:8.61E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:-3.09|P-value:7.35E-4 ID:SGTC_2796|Compound:7949634|FD-Score:3.50|P-value:1.55E-4 ID:SGTC_2935|Compound:9038016|FD-Score:3.25|P-value:4.13E-4 ID:SGTC_2954|Compound:9074818|FD-Score:5.68|P-value:2.49E-9 ID:SGTC_3070|Compound:9117005|FD-Score:-3.74|P-value:5.93E-5 ID:SGTC_3071|Compound:9117417|FD-Score:5.14|P-value:6.06E-8 ID:SGTC_3074|Compound:9116018|FD-Score:-3.45|P-value:1.86E-4 ID:SGTC_3242|Compound:9133940|FD-Score:3.55|P-value:1.28E-4 ID:SGTC_3322|Compound:9139058|FD-Score:-3.51|P-value:1.51E-4 ID:SGTC_3329|Compound:9141233|FD-Score:3.02|P-value:9.38E-4 ID:SGTC_3356|Compound:9151811|FD-Score:3.12|P-value:6.55E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:3.70|P-value:7.01E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.59|P-value:1.07E-4 ID:SGTC_245|Compound:methotrexate|FD-Score:4.10|P-value:1.20E-5 ID:SGTC_313|Compound:3474-0040|FD-Score:-3.69|P-value:7.05E-5 ID:SGTC_318|Compound:1488-0629|FD-Score:3.09|P-value:7.45E-4 ID:SGTC_536|Compound:3852-0578|FD-Score:3.67|P-value:8.05E-5 ID:SGTC_595|Compound:3909-8003|FD-Score:3.54|P-value:1.33E-4 ID:SGTC_739|Compound:1486-1183|FD-Score:3.04|P-value:8.72E-4 ID:SGTC_763|Compound:3453-1109|FD-Score:4.03|P-value:1.66E-5 ID:SGTC_766|Compound:1391-0721|FD-Score:4.28|P-value:5.29E-6 ID:SGTC_777|Compound:1315-0167|FD-Score:3.75|P-value:5.71E-5 ID:SGTC_868|Compound:0527-0199|FD-Score:-3.36|P-value:2.63E-4 ID:SGTC_935|Compound:2996-0153|FD-Score:3.80|P-value:4.58E-5 ID:SGTC_959|Compound:1222-0044|FD-Score:3.64|P-value:8.97E-5 ID:SGTC_973|Compound:1325-0077|FD-Score:3.06|P-value:8.12E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:-3.16|P-value:5.58E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:-3.78|P-value:4.93E-5 ID:SGTC_1259|Compound:0671-0132|FD-Score:4.75|P-value:5.13E-7 ID:SGTC_1262|Compound:0737-0114|FD-Score:3.97|P-value:2.19E-5 ID:SGTC_1265|Compound:0819-1001|FD-Score:-3.21|P-value:4.75E-4 ID:SGTC_1439|Compound:4092-1168|FD-Score:-3.09|P-value:7.31E-4 ID:SGTC_1714|Compound:st033236|FD-Score:-4.93|P-value:1.88E-7 ID:SGTC_1718|Compound:roemerine|FD-Score:3.16|P-value:5.68E-4 ID:SGTC_1731|Compound:st035964|FD-Score:3.48|P-value:1.74E-4 ID:SGTC_1732|Compound:st034308|FD-Score:-3.23|P-value:4.36E-4 ID:SGTC_1737|Compound:st035557|FD-Score:3.36|P-value:2.73E-4 ID:SGTC_1851|Compound:st056236|FD-Score:-3.15|P-value:5.90E-4 ID:SGTC_1855|Compound:st056195|FD-Score:4.55|P-value:1.45E-6 ID:SGTC_1857|Compound:st056007|FD-Score:-3.37|P-value:2.58E-4 ID:SGTC_1861|Compound:st057647|FD-Score:3.80|P-value:4.51E-5 ID:SGTC_1925|Compound:st057770|FD-Score:3.17|P-value:5.53E-4 ID:SGTC_1977|Compound:st070720|FD-Score:3.03|P-value:9.25E-4 ID:SGTC_2035|Compound:5154463|FD-Score:3.05|P-value:8.61E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:-3.09|P-value:7.35E-4 ID:SGTC_2796|Compound:7949634|FD-Score:3.50|P-value:1.55E-4 ID:SGTC_2935|Compound:9038016|FD-Score:3.25|P-value:4.13E-4 ID:SGTC_2954|Compound:9074818|FD-Score:5.68|P-value:2.49E-9 ID:SGTC_3070|Compound:9117005|FD-Score:-3.74|P-value:5.93E-5 ID:SGTC_3071|Compound:9117417|FD-Score:5.14|P-value:6.06E-8 ID:SGTC_3074|Compound:9116018|FD-Score:-3.45|P-value:1.86E-4 ID:SGTC_3242|Compound:9133940|FD-Score:3.55|P-value:1.28E-4 ID:SGTC_3322|Compound:9139058|FD-Score:-3.51|P-value:1.51E-4 ID:SGTC_3329|Compound:9141233|FD-Score:3.02|P-value:9.38E-4 ID:SGTC_3356|Compound:9151811|FD-Score:3.12|P-value:6.55E-4

Top fitness defect scores for YGR154C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2954 9074818 5.68 52.7 µM 2.49E-9 13 6.72E-9
2 SGTC_3071 9117417 5.14 49.5 µM 6.06E-8 fatty acid desaturase (OLE1) 8 1.37E-7
3 SGTC_1259 0671-0132 4.75 43.0 µM 5.13E-7 8 1.03E-6
4 SGTC_1855 st056195 4.55 39.6 µM 1.45E-6 60S ribosome export 7 2.75E-6
5 SGTC_766 1391-0721 4.28 126.0 µM 5.29E-6 9 9.36E-6
6 SGTC_245 methotrexate 4.10 289.6 µM 1.20E-5 43 2.03E-5
7 SGTC_763 3453-1109 4.03 128.0 µM 1.66E-5 13 2.76E-5
8 SGTC_1262 0737-0114 3.97 49.6 µM 2.19E-5 19 3.59E-5
9 SGTC_1861 st057647 3.80 17.4 µM 4.51E-5 24 7.12E-5
10 SGTC_935 2996-0153 3.80 430.0 µM 4.58E-5 PDR1 22 7.22E-5
11 SGTC_777 1315-0167 3.75 517.0 µM 5.71E-5 Golgi 34 8.88E-5
12 SGTC_50 0929-0078 3.70 56.4 µM 7.01E-5 57 1.08E-4
13 SGTC_536 3852-0578 3.67 10.6 µM 8.05E-5 36 1.23E-4
14 SGTC_959 1222-0044 3.64 107.0 µM 8.97E-5 28 1.36E-4
15 SGTC_3242 9133940 3.55 49.5 µM 1.28E-4 18 1.90E-4
16 SGTC_595 3909-8003 3.54 73.7 µM 1.33E-4 22 1.98E-4
17 SGTC_2796 7949634 3.50 45.5 µM 1.55E-4 34 2.29E-4
18 SGTC_1731 st035964 3.48 63.0 µM 1.74E-4 47 2.55E-4
19 SGTC_1737 st035557 3.36 69.7 µM 2.73E-4 28 3.91E-4
20 SGTC_2935 9038016 3.25 30.0 µM 4.13E-4 48 5.78E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.163 2.34E-21 YGL102C_d YGL102C_d het Dubious open reading frame unlikely to encode a functional protein; overlaps 3' end of essential RPL28 gene encoding a large subunit ribosomal protein
0.114 3.39E-11 YDL199C_p YDL199C_p hom Putative transporter, member of the sugar porter family
0.109 2.65E-10 YNL256W FOL1 het Multifunctional enzyme of the folic acid biosynthesis pathway, has dihydropteroate synthetase, dihydro-6-hydroxymethylpterin pyrophosphokinase, and dihydroneopterin aldolase activities
0.105 8.98E-10 YOL079W_d YOL079W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.101 4.44E-9 YDR480W DIG2 hom MAP kinase-responsive inhibitor of the Ste12p transcription factor, involved in the regulation of mating-specific genes and the invasive growth pathway; related regulators Dig1p and Dig2p bind to Ste12p
0.101 4.50E-9 YLR289W GUF1 hom Mitochondrial matrix GTPase that associates with mitochondrial ribosomes; important for translation under temperature and nutrient stress; may have a role in translational fidelity; similar to bacterial LepA elongation factor
0.098 1.50E-8 YKR009C FOX2 hom Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities
0.097 2.07E-8 YLL048C YBT1 hom Transporter of the ATP-binding cassette (ABC) family; involved in bile acid transport; negative regulator of vacuole fusion; regulates the release of lumenal Ca2+ stores; similar to mammalian bile transporters
0.095 3.27E-8 YOL158C ENB1 hom Endosomal ferric enterobactin transporter, expressed under conditions of iron deprivation; member of the major facilitator superfamily; expression is regulated by Rcs1p and affected by chloroquine treatment
0.093 7.14E-8 YGR127W_p YGR127W_p hom Putative protein of unknown function; expression is regulated by Msn2p/Msn4p, indicating a possible role in stress response
0.091 1.32E-7 YLR097C HRT3 hom Putative SCF-ubiquitin ligase F-box protein, based on both genetic and physical interactions and sequence similarity; identified in association with Cdc53p, Skp1p and Ubi4 in large and small-scale studies
0.088 3.21E-7 YGR211W ZPR1 het Essential protein with two zinc fingers; present in the nucleus of growing cells but relocates to the cytoplasm in starved cells via a process mediated by Cpr1p; binds to translation elongation factor eEF-1 (Tef1p); relative distribution to the nucleus increases upon DNA replication stress
0.087 4.47E-7 YLL063C AYT1 hom Acetyltransferase; catalyzes trichothecene 3-O-acetylation, suggesting a possible role in trichothecene biosynthesis
0.086 6.32E-7 YOR074C CDC21 het Thymidylate synthase, required for de novo biosynthesis of pyrimidine deoxyribonucleotides; expression is induced at G1/S
0.085 7.26E-7 YKL017C HCS1 hom Hexameric DNA polymerase alpha-associated DNA helicase A involved in lagging strand DNA synthesis; contains single-stranded DNA stimulated ATPase and dATPase activities; replication protein A stimulates helicase and ATPase activities