HIPHOP chemogenomics database
YGR154C / GTO1 
Omega-class glutathione transferase; induced under oxidative stress; putative peroxisomal localization
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YGR154C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.163 | 2.34E-21 | YGL102C_d | YGL102C_d | het | Dubious open reading frame unlikely to encode a functional protein; overlaps 3' end of essential RPL28 gene encoding a large subunit ribosomal protein |
| 0.114 | 3.39E-11 | YDL199C_p | YDL199C_p | hom | Putative transporter, member of the sugar porter family |
| 0.109 | 2.65E-10 | YNL256W | FOL1 | het | Multifunctional enzyme of the folic acid biosynthesis pathway, has dihydropteroate synthetase, dihydro-6-hydroxymethylpterin pyrophosphokinase, and dihydroneopterin aldolase activities |
| 0.105 | 8.98E-10 | YOL079W_d | YOL079W_d | hom | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
| 0.101 | 4.44E-9 | YDR480W | DIG2 | hom | MAP kinase-responsive inhibitor of the Ste12p transcription factor, involved in the regulation of mating-specific genes and the invasive growth pathway; related regulators Dig1p and Dig2p bind to Ste12p |
| 0.101 | 4.50E-9 | YLR289W | GUF1 | hom | Mitochondrial matrix GTPase that associates with mitochondrial ribosomes; important for translation under temperature and nutrient stress; may have a role in translational fidelity; similar to bacterial LepA elongation factor |
| 0.098 | 1.50E-8 | YKR009C | FOX2 | hom | Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities |
| 0.097 | 2.07E-8 | YLL048C | YBT1 | hom | Transporter of the ATP-binding cassette (ABC) family; involved in bile acid transport; negative regulator of vacuole fusion; regulates the release of lumenal Ca2+ stores; similar to mammalian bile transporters |
| 0.095 | 3.27E-8 | YOL158C | ENB1 | hom | Endosomal ferric enterobactin transporter, expressed under conditions of iron deprivation; member of the major facilitator superfamily; expression is regulated by Rcs1p and affected by chloroquine treatment |
| 0.093 | 7.14E-8 | YGR127W_p | YGR127W_p | hom | Putative protein of unknown function; expression is regulated by Msn2p/Msn4p, indicating a possible role in stress response |
| 0.091 | 1.32E-7 | YLR097C | HRT3 | hom | Putative SCF-ubiquitin ligase F-box protein, based on both genetic and physical interactions and sequence similarity; identified in association with Cdc53p, Skp1p and Ubi4 in large and small-scale studies |
| 0.088 | 3.21E-7 | YGR211W | ZPR1 | het | Essential protein with two zinc fingers; present in the nucleus of growing cells but relocates to the cytoplasm in starved cells via a process mediated by Cpr1p; binds to translation elongation factor eEF-1 (Tef1p); relative distribution to the nucleus increases upon DNA replication stress |
| 0.087 | 4.47E-7 | YLL063C | AYT1 | hom | Acetyltransferase; catalyzes trichothecene 3-O-acetylation, suggesting a possible role in trichothecene biosynthesis |
| 0.086 | 6.32E-7 | YOR074C | CDC21 | het | Thymidylate synthase, required for de novo biosynthesis of pyrimidine deoxyribonucleotides; expression is induced at G1/S |
| 0.085 | 7.26E-7 | YKL017C | HCS1 | hom | Hexameric DNA polymerase alpha-associated DNA helicase A involved in lagging strand DNA synthesis; contains single-stranded DNA stimulated ATPase and dATPase activities; replication protein A stimulates helicase and ATPase activities |