YGR155W / CYS4

Cystathionine beta-synthase, catalyzes synthesis of cystathionine from serine and homocysteine, the first committed step in cysteine biosynthesis; responsible for hydrogen sulfide generation; advances passage through START by promoting cell growth which requires catalytic activity, and reducing critical cell size independent of catalytic activity; mutations in human ortholog cause homocystinuria

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR155W / CYS4

Click on Significant Values for Screen Details ID:SGTC_73|Compound:0327-0325|FD-Score:-3.62|P-value:6.20E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:3.39|P-value:7.84E-4 ID:SGTC_179|Compound:1273-0063|FD-Score:9.36|P-value:3.62E-18 ID:SGTC_184|Compound:1494-0393|FD-Score:5.14|P-value:9.58E-7 ID:SGTC_207|Compound:4185-0010|FD-Score:3.45|P-value:6.50E-4 ID:SGTC_258|Compound:haloperidol|FD-Score:3.36|P-value:8.52E-4 ID:SGTC_278|Compound:4092-0821|FD-Score:5.39|P-value:3.00E-7 ID:SGTC_279|Compound:1273-0055|FD-Score:6.09|P-value:9.35E-9 ID:SGTC_284|Compound:0988-0104|FD-Score:-4.29|P-value:6.13E-5 ID:SGTC_299|Compound:1273-0059|FD-Score:-4.73|P-value:1.11E-5 ID:SGTC_304|Compound:1310-0298|FD-Score:-4.57|P-value:2.08E-5 ID:SGTC_308|Compound:4092-1169|FD-Score:5.53|P-value:1.52E-7 ID:SGTC_309|Compound:k408-0051|FD-Score:4.47|P-value:1.66E-5 ID:SGTC_312|Compound:4092-0653|FD-Score:5.13|P-value:1.03E-6 ID:SGTC_314|Compound:1671-0008|FD-Score:4.07|P-value:7.69E-5 ID:SGTC_328|Compound:k915-0120|FD-Score:3.72|P-value:2.67E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:-6.16|P-value:1.46E-8 ID:SGTC_347|Compound:4534-1311|FD-Score:3.37|P-value:8.30E-4 ID:SGTC_408|Compound:cantharidin|FD-Score:7.55|P-value:1.68E-12 ID:SGTC_422|Compound:cantharidin|FD-Score:10.30|P-value:1.32E-21 ID:SGTC_431|Compound:k089-0097|FD-Score:-9.37|P-value:1.16E-17 ID:SGTC_439|Compound:amiodarone|FD-Score:3.80|P-value:2.01E-4 ID:SGTC_444|Compound:curcumin|FD-Score:-4.18|P-value:9.31E-5 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:4.02|P-value:9.30E-5 ID:SGTC_550|Compound:4123-0385|FD-Score:3.47|P-value:5.99E-4 ID:SGTC_567|Compound:1080-0542|FD-Score:4.58|P-value:1.06E-5 ID:SGTC_637|Compound:1181-0519|FD-Score:4.54|P-value:1.28E-5 ID:SGTC_638|Compound:3970-0837|FD-Score:3.91|P-value:1.35E-4 ID:SGTC_641|Compound:4092-0595|FD-Score:3.86|P-value:1.66E-4 ID:SGTC_744|Compound:1594-0068|FD-Score:4.56|P-value:1.14E-5 ID:SGTC_835|Compound:0312-0010|FD-Score:3.88|P-value:1.50E-4 ID:SGTC_842|Compound:0271-0008|FD-Score:4.91|P-value:2.70E-6 ID:SGTC_848|Compound:0368-0089|FD-Score:-5.57|P-value:2.77E-7 ID:SGTC_852|Compound:0418-0143|FD-Score:5.94|P-value:1.98E-8 ID:SGTC_859|Compound:0439-0102|FD-Score:3.52|P-value:5.15E-4 ID:SGTC_868|Compound:0527-0199|FD-Score:-4.30|P-value:5.96E-5 ID:SGTC_881|Compound:0833-0569|FD-Score:3.72|P-value:2.69E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:3.87|P-value:1.56E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:3.34|P-value:8.96E-4 ID:SGTC_974|Compound:1326-0144|FD-Score:4.74|P-value:5.49E-6 ID:SGTC_975|Compound:1335-0046|FD-Score:4.72|P-value:5.92E-6 ID:SGTC_987|Compound:1497-1013|FD-Score:-3.77|P-value:3.77E-4 ID:SGTC_989|Compound:1501-0895|FD-Score:-5.25|P-value:1.20E-6 ID:SGTC_1005|Compound:4092-0690|FD-Score:3.75|P-value:2.41E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:3.37|P-value:8.31E-4 ID:SGTC_1072|Compound:oxiconazole|FD-Score:-3.54|P-value:7.99E-4 ID:SGTC_1089|Compound:terbinafine|FD-Score:7.69|P-value:6.61E-13 ID:SGTC_1101|Compound:ebselen|FD-Score:5.50|P-value:1.79E-7 ID:SGTC_1186|Compound:1319-0216|FD-Score:4.13|P-value:6.05E-5 ID:SGTC_1308|Compound:1187-1617|FD-Score:4.53|P-value:1.32E-5 ID:SGTC_1329|Compound:1447-1697|FD-Score:-4.49|P-value:2.83E-5 ID:SGTC_1503|Compound:4585-0012|FD-Score:3.60|P-value:4.00E-4 ID:SGTC_1573|Compound:oleylamine|FD-Score:4.48|P-value:1.57E-5 ID:SGTC_1581|Compound:himbacine|FD-Score:3.74|P-value:2.47E-4 ID:SGTC_1614|Compound:st002383|FD-Score:6.03|P-value:1.28E-8 ID:SGTC_1621|Compound:st003705|FD-Score:5.96|P-value:1.81E-8 ID:SGTC_1656|Compound:st012921|FD-Score:12.20|P-value:2.06E-29 ID:SGTC_1745|Compound:st081495|FD-Score:-3.94|P-value:2.11E-4 ID:SGTC_1750|Compound:st081859|FD-Score:8.86|P-value:1.74E-16 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.64|P-value:1.59E-5 ID:SGTC_1789|Compound:tunicamycin|FD-Score:3.64|P-value:3.42E-4 ID:SGTC_1797|Compound:st048695|FD-Score:7.32|P-value:7.46E-12 ID:SGTC_1839|Compound:st053978|FD-Score:3.46|P-value:6.24E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:5.36|P-value:3.45E-7 ID:SGTC_1955|Compound:wogonin|FD-Score:5.15|P-value:9.20E-7 ID:SGTC_2038|Compound:4100038|FD-Score:3.47|P-value:6.01E-4 ID:SGTC_2050|Compound:5263056|FD-Score:3.61|P-value:3.84E-4 ID:SGTC_2370|Compound:9071495|FD-Score:4.27|P-value:3.66E-5 ID:SGTC_2384|Compound:9036245|FD-Score:3.78|P-value:2.13E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:3.45|P-value:6.40E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:3.89|P-value:1.49E-4 ID:SGTC_2516|Compound:gossypol|FD-Score:-3.59|P-value:6.84E-4 ID:SGTC_2523|Compound:spermine|FD-Score:6.29|P-value:3.19E-9 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:4.83|P-value:3.69E-6 ID:SGTC_2607|Compound:solasodine|FD-Score:3.91|P-value:1.34E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:-3.65|P-value:5.64E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:4.06|P-value:8.02E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:5.69|P-value:7.11E-8 ID:SGTC_2679|Compound:rapamycin|FD-Score:3.71|P-value:2.76E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:4.97|P-value:2.06E-6 ID:SGTC_2896|Compound:9052656|FD-Score:3.82|P-value:1.87E-4 ID:SGTC_2938|Compound:9059746|FD-Score:3.68|P-value:3.03E-4 ID:SGTC_2947|Compound:9072639|FD-Score:4.25|P-value:3.91E-5 ID:SGTC_2948|Compound:9070189|FD-Score:6.64|P-value:4.50E-10 ID:SGTC_2960|Compound:9079389|FD-Score:4.03|P-value:8.84E-5 ID:SGTC_2993|Compound:9054257|FD-Score:7.41|P-value:4.28E-12 ID:SGTC_2996|Compound:9066192|FD-Score:3.49|P-value:5.66E-4 ID:SGTC_3003|Compound:9075612|FD-Score:3.62|P-value:3.69E-4 ID:SGTC_3020|Compound:9089140|FD-Score:-3.50|P-value:9.14E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:3.81|P-value:1.91E-4 ID:SGTC_3142|Compound:9086498|FD-Score:-5.86|P-value:6.59E-8 ID:SGTC_3143|Compound:9086658|FD-Score:-3.63|P-value:6.09E-4 ID:SGTC_3215|Compound:9129942|FD-Score:-3.76|P-value:3.91E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-7.37|P-value:1.44E-11 ID:SGTC_3305|Compound:9127027|FD-Score:3.58|P-value:4.26E-4 ID:SGTC_3308|Compound:9128332|FD-Score:6.14|P-value:7.01E-9 ID:SGTC_3345|Compound:9148410|FD-Score:-4.07|P-value:1.37E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:-3.62|P-value:6.20E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:3.39|P-value:7.84E-4 ID:SGTC_179|Compound:1273-0063|FD-Score:9.36|P-value:3.62E-18 ID:SGTC_184|Compound:1494-0393|FD-Score:5.14|P-value:9.58E-7 ID:SGTC_207|Compound:4185-0010|FD-Score:3.45|P-value:6.50E-4 ID:SGTC_258|Compound:haloperidol|FD-Score:3.36|P-value:8.52E-4 ID:SGTC_278|Compound:4092-0821|FD-Score:5.39|P-value:3.00E-7 ID:SGTC_279|Compound:1273-0055|FD-Score:6.09|P-value:9.35E-9 ID:SGTC_284|Compound:0988-0104|FD-Score:-4.29|P-value:6.13E-5 ID:SGTC_299|Compound:1273-0059|FD-Score:-4.73|P-value:1.11E-5 ID:SGTC_304|Compound:1310-0298|FD-Score:-4.57|P-value:2.08E-5 ID:SGTC_308|Compound:4092-1169|FD-Score:5.53|P-value:1.52E-7 ID:SGTC_309|Compound:k408-0051|FD-Score:4.47|P-value:1.66E-5 ID:SGTC_312|Compound:4092-0653|FD-Score:5.13|P-value:1.03E-6 ID:SGTC_314|Compound:1671-0008|FD-Score:4.07|P-value:7.69E-5 ID:SGTC_328|Compound:k915-0120|FD-Score:3.72|P-value:2.67E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:-6.16|P-value:1.46E-8 ID:SGTC_347|Compound:4534-1311|FD-Score:3.37|P-value:8.30E-4 ID:SGTC_408|Compound:cantharidin|FD-Score:7.55|P-value:1.68E-12 ID:SGTC_422|Compound:cantharidin|FD-Score:10.30|P-value:1.32E-21 ID:SGTC_431|Compound:k089-0097|FD-Score:-9.37|P-value:1.16E-17 ID:SGTC_439|Compound:amiodarone|FD-Score:3.80|P-value:2.01E-4 ID:SGTC_444|Compound:curcumin|FD-Score:-4.18|P-value:9.31E-5 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:4.02|P-value:9.30E-5 ID:SGTC_550|Compound:4123-0385|FD-Score:3.47|P-value:5.99E-4 ID:SGTC_567|Compound:1080-0542|FD-Score:4.58|P-value:1.06E-5 ID:SGTC_637|Compound:1181-0519|FD-Score:4.54|P-value:1.28E-5 ID:SGTC_638|Compound:3970-0837|FD-Score:3.91|P-value:1.35E-4 ID:SGTC_641|Compound:4092-0595|FD-Score:3.86|P-value:1.66E-4 ID:SGTC_744|Compound:1594-0068|FD-Score:4.56|P-value:1.14E-5 ID:SGTC_835|Compound:0312-0010|FD-Score:3.88|P-value:1.50E-4 ID:SGTC_842|Compound:0271-0008|FD-Score:4.91|P-value:2.70E-6 ID:SGTC_848|Compound:0368-0089|FD-Score:-5.57|P-value:2.77E-7 ID:SGTC_852|Compound:0418-0143|FD-Score:5.94|P-value:1.98E-8 ID:SGTC_859|Compound:0439-0102|FD-Score:3.52|P-value:5.15E-4 ID:SGTC_868|Compound:0527-0199|FD-Score:-4.30|P-value:5.96E-5 ID:SGTC_881|Compound:0833-0569|FD-Score:3.72|P-value:2.69E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:3.87|P-value:1.56E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:3.34|P-value:8.96E-4 ID:SGTC_974|Compound:1326-0144|FD-Score:4.74|P-value:5.49E-6 ID:SGTC_975|Compound:1335-0046|FD-Score:4.72|P-value:5.92E-6 ID:SGTC_987|Compound:1497-1013|FD-Score:-3.77|P-value:3.77E-4 ID:SGTC_989|Compound:1501-0895|FD-Score:-5.25|P-value:1.20E-6 ID:SGTC_1005|Compound:4092-0690|FD-Score:3.75|P-value:2.41E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:3.37|P-value:8.31E-4 ID:SGTC_1072|Compound:oxiconazole|FD-Score:-3.54|P-value:7.99E-4 ID:SGTC_1089|Compound:terbinafine|FD-Score:7.69|P-value:6.61E-13 ID:SGTC_1101|Compound:ebselen|FD-Score:5.50|P-value:1.79E-7 ID:SGTC_1186|Compound:1319-0216|FD-Score:4.13|P-value:6.05E-5 ID:SGTC_1308|Compound:1187-1617|FD-Score:4.53|P-value:1.32E-5 ID:SGTC_1329|Compound:1447-1697|FD-Score:-4.49|P-value:2.83E-5 ID:SGTC_1503|Compound:4585-0012|FD-Score:3.60|P-value:4.00E-4 ID:SGTC_1573|Compound:oleylamine|FD-Score:4.48|P-value:1.57E-5 ID:SGTC_1581|Compound:himbacine|FD-Score:3.74|P-value:2.47E-4 ID:SGTC_1614|Compound:st002383|FD-Score:6.03|P-value:1.28E-8 ID:SGTC_1621|Compound:st003705|FD-Score:5.96|P-value:1.81E-8 ID:SGTC_1656|Compound:st012921|FD-Score:12.20|P-value:2.06E-29 ID:SGTC_1745|Compound:st081495|FD-Score:-3.94|P-value:2.11E-4 ID:SGTC_1750|Compound:st081859|FD-Score:8.86|P-value:1.74E-16 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.64|P-value:1.59E-5 ID:SGTC_1789|Compound:tunicamycin|FD-Score:3.64|P-value:3.42E-4 ID:SGTC_1797|Compound:st048695|FD-Score:7.32|P-value:7.46E-12 ID:SGTC_1839|Compound:st053978|FD-Score:3.46|P-value:6.24E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:5.36|P-value:3.45E-7 ID:SGTC_1955|Compound:wogonin|FD-Score:5.15|P-value:9.20E-7 ID:SGTC_2038|Compound:4100038|FD-Score:3.47|P-value:6.01E-4 ID:SGTC_2050|Compound:5263056|FD-Score:3.61|P-value:3.84E-4 ID:SGTC_2370|Compound:9071495|FD-Score:4.27|P-value:3.66E-5 ID:SGTC_2384|Compound:9036245|FD-Score:3.78|P-value:2.13E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:3.45|P-value:6.40E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:3.89|P-value:1.49E-4 ID:SGTC_2516|Compound:gossypol|FD-Score:-3.59|P-value:6.84E-4 ID:SGTC_2523|Compound:spermine|FD-Score:6.29|P-value:3.19E-9 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:4.83|P-value:3.69E-6 ID:SGTC_2607|Compound:solasodine|FD-Score:3.91|P-value:1.34E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:-3.65|P-value:5.64E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:4.06|P-value:8.02E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:5.69|P-value:7.11E-8 ID:SGTC_2679|Compound:rapamycin|FD-Score:3.71|P-value:2.76E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:4.97|P-value:2.06E-6 ID:SGTC_2896|Compound:9052656|FD-Score:3.82|P-value:1.87E-4 ID:SGTC_2938|Compound:9059746|FD-Score:3.68|P-value:3.03E-4 ID:SGTC_2947|Compound:9072639|FD-Score:4.25|P-value:3.91E-5 ID:SGTC_2948|Compound:9070189|FD-Score:6.64|P-value:4.50E-10 ID:SGTC_2960|Compound:9079389|FD-Score:4.03|P-value:8.84E-5 ID:SGTC_2993|Compound:9054257|FD-Score:7.41|P-value:4.28E-12 ID:SGTC_2996|Compound:9066192|FD-Score:3.49|P-value:5.66E-4 ID:SGTC_3003|Compound:9075612|FD-Score:3.62|P-value:3.69E-4 ID:SGTC_3020|Compound:9089140|FD-Score:-3.50|P-value:9.14E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:3.81|P-value:1.91E-4 ID:SGTC_3142|Compound:9086498|FD-Score:-5.86|P-value:6.59E-8 ID:SGTC_3143|Compound:9086658|FD-Score:-3.63|P-value:6.09E-4 ID:SGTC_3215|Compound:9129942|FD-Score:-3.76|P-value:3.91E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-7.37|P-value:1.44E-11 ID:SGTC_3305|Compound:9127027|FD-Score:3.58|P-value:4.26E-4 ID:SGTC_3308|Compound:9128332|FD-Score:6.14|P-value:7.01E-9 ID:SGTC_3345|Compound:9148410|FD-Score:-4.07|P-value:1.37E-4

Top fitness defect scores for YGR155W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1656 st012921 12.20 11.0 µM 2.06E-29 7 1.61E-34
2 SGTC_422 cantharidin 10.30 155.0 µM 1.32E-21 cell wall signaling 4 3.22E-25
3 SGTC_179 1273-0063 9.36 6.8 µM 3.62E-18 2 3.98E-21
4 SGTC_1750 st081859 8.86 2.4 µM 1.74E-16 endomembrane recycling 54 3.98E-19
5 SGTC_1089 terbinafine 7.69 2.2 µM 6.61E-13 1 7.09E-15
6 SGTC_408 cantharidin 7.55 100.0 µM 1.68E-12 cell wall signaling 6 2.15E-14
7 SGTC_2993 9054257 7.41 71.4 µM 4.28E-12 fatty acid desaturase (OLE1) 11 6.48E-14
8 SGTC_1797 st048695 7.32 56.8 µM 7.46E-12 NEO1 25 1.26E-13
9 SGTC_2948 9070189 6.64 9.4 µM 4.50E-10 plasma membrane duress 19 1.61E-11
10 SGTC_2523 spermine 6.29 47.7 µM 3.19E-9 calcium & mitochondrial duress 9 1.63E-10
11 SGTC_3308 9128332 6.14 17.6 µM 7.01E-9 plasma membrane duress 35 4.14E-10
12 SGTC_279 1273-0055 6.09 2.9 µM 9.35E-9 azole & statin 13 5.82E-10
13 SGTC_1614 st002383 6.03 48.6 µM 1.28E-8 cell wall signaling 5 8.45E-10
14 SGTC_1621 st003705 5.96 32.4 µM 1.81E-8 calcium & mitochondrial duress 6 1.27E-9
15 SGTC_852 0418-0143 5.94 439.0 µM 1.98E-8 calcium & mitochondrial duress 27 1.41E-9
16 SGTC_2651 1327-0036 5.69 5.0 µM 7.11E-8 81 6.38E-9
17 SGTC_308 4092-1169 5.53 104.0 µM 1.52E-7 plasma membrane duress 25 1.56E-8
18 SGTC_1101 ebselen 5.50 5.3 µM 1.79E-7 7 1.90E-8
19 SGTC_278 4092-0821 5.39 23.9 µM 3.00E-7 plasma membrane duress 23 3.48E-8
20 SGTC_1844 rapamycin 5.36 4.0 nM 3.45E-7 104 4.11E-8

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.278 3.96E-60 YAL012W CYS3 hom Cystathionine gamma-lyase, catalyzes one of the two reactions involved in the transsulfuration pathway that yields cysteine from homocysteine with the intermediary formation of cystathionine; protein abundance increases in response to DNA replication stress
0.249 2.86E-48 YDR127W ARO1 hom Pentafunctional arom protein, catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids
0.217 6.52E-37 YJR105W ADO1 hom Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle
0.216 8.64E-37 YER031C YPT31 hom Rab family GTPase; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; YPT31 has a paralog, YPT32, that arose from the whole genome duplication
0.200 2.18E-31 YGL148W ARO2 hom Bifunctional chorismate synthase and flavin reductase; catalyzes the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to form chorismate, which is a precursor to aromatic amino acids; protein abundance increases in response to DNA replication stress
0.181 5.45E-26 YJL204C RCY1 hom F-box protein involved in recycling plasma membrane proteins internalized by endocytosis; localized to sites of polarized growth
0.171 2.72E-23 YIL154C IMP2' hom Transcriptional activator involved in maintenance of ion homeostasis and protection against DNA damage caused by bleomycin and other oxidants, contains a C-terminal leucine-rich repeat
0.169 9.78E-23 YJL207C LAA1 hom AP-1 accessory protein; colocalizes with clathrin to the late-Golgi apparatus; involved in TGN-endosome transport; physically interacts with AP-1; similar to the mammalian p200; may interact with ribosomes; YJL207C is a non-essential gene
0.159 2.82E-20 YCR094W CDC50 hom Endosomal protein that interacts with phospholipid flippase Drs2p; interaction with Cdc50p is essential for Drs2p catalytic activity; mutations affect cell polarity and polarized growth; similar to Lem3p; CDC50 has a paralog, YNR048W, that arose from the whole genome duplication
0.159 2.84E-20 YDL226C GCS1 hom ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p
0.155 2.34E-19 YHL019C APM2 hom Protein of unknown function, homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport
0.146 1.63E-17 YGL055W OLE1 het Delta(9) fatty acid desaturase, required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria
0.146 2.27E-17 YMR126C_p DLT1_p hom Protein of unknown function, mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA)
0.145 3.02E-17 YKL135C APL2 hom Beta-adaptin subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting; protein abundance increases in response to DNA replication stress
0.143 7.29E-17 YML007C-A_p YML007C-A_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria