YGR156W / PTI1

Essential protein that is a component of CPF (cleavage and polyadenylation factor); involved in 3' end formation of snoRNA and mRNA; interacts directly with Pta1p; has similarity to mammalian Cleavage-Stimulation Factor CstF-64

Zygosity: Heterozygous strain
fixedexpanded
Profile for YGR156W / PTI1

Click on Significant Values for Screen Details ID:SGTC_17|Compound:0960-0276|FD-Score:3.53|P-value:2.34E-4 ID:SGTC_125|Compound:0133-0007|FD-Score:3.51|P-value:2.54E-4 ID:SGTC_144|Compound:4161-2749|FD-Score:3.18|P-value:8.39E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:4.22|P-value:1.42E-5 ID:SGTC_259|Compound:usnic acid|FD-Score:5.30|P-value:7.31E-8 ID:SGTC_367|Compound:0335-0881|FD-Score:3.85|P-value:6.79E-5 ID:SGTC_467|Compound:ro 31-8220|FD-Score:3.83|P-value:7.48E-5 ID:SGTC_468|Compound:gf-109203x|FD-Score:4.79|P-value:1.03E-6 ID:SGTC_469|Compound:w7|FD-Score:3.98|P-value:4.04E-5 ID:SGTC_470|Compound:aa-861|FD-Score:5.75|P-value:5.82E-9 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:8.98|P-value:2.39E-19 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:-3.43|P-value:2.93E-4 ID:SGTC_511|Compound:blebbistatin|FD-Score:3.69|P-value:1.32E-4 ID:SGTC_512|Compound:prima-1|FD-Score:4.10|P-value:2.47E-5 ID:SGTC_547|Compound:1120-0019|FD-Score:3.44|P-value:3.34E-4 ID:SGTC_561|Compound:1550-0330|FD-Score:4.57|P-value:2.93E-6 ID:SGTC_576|Compound:1073-0113|FD-Score:3.39|P-value:4.04E-4 ID:SGTC_633|Compound:0437-0093|FD-Score:3.81|P-value:8.18E-5 ID:SGTC_659|Compound:k018-0002|FD-Score:-3.22|P-value:6.21E-4 ID:SGTC_727|Compound:3032-0951|FD-Score:5.10|P-value:2.09E-7 ID:SGTC_731|Compound:3966-0296|FD-Score:3.46|P-value:3.11E-4 ID:SGTC_780|Compound:0109-0199|FD-Score:3.83|P-value:7.58E-5 ID:SGTC_867|Compound:0518-0118|FD-Score:4.55|P-value:3.31E-6 ID:SGTC_869|Compound:0564-0080|FD-Score:3.59|P-value:1.87E-4 ID:SGTC_872|Compound:0588-0139|FD-Score:4.38|P-value:7.08E-6 ID:SGTC_939|Compound:1165-0479|FD-Score:3.46|P-value:3.04E-4 ID:SGTC_950|Compound:1165-0508|FD-Score:-3.16|P-value:7.61E-4 ID:SGTC_966|Compound:1300-0360|FD-Score:-3.64|P-value:1.35E-4 ID:SGTC_1186|Compound:1319-0216|FD-Score:3.21|P-value:7.62E-4 ID:SGTC_1194|Compound:1488-0194|FD-Score:3.69|P-value:1.31E-4 ID:SGTC_1208|Compound:2323-2347|FD-Score:-3.97|P-value:3.52E-5 ID:SGTC_1214|Compound:0358-0031|FD-Score:4.54|P-value:3.47E-6 ID:SGTC_1255|Compound:0566-0045|FD-Score:-3.28|P-value:5.04E-4 ID:SGTC_1258|Compound:0671-0043|FD-Score:-3.85|P-value:5.92E-5 ID:SGTC_1278|Compound:0874-0585|FD-Score:3.37|P-value:4.27E-4 ID:SGTC_1290|Compound:0986-0249|FD-Score:3.35|P-value:4.62E-4 ID:SGTC_1299|Compound:1079-1439|FD-Score:3.44|P-value:3.35E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:4.36|P-value:7.85E-6 ID:SGTC_1427|Compound:4048-4900|FD-Score:-3.13|P-value:8.55E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:4.22|P-value:1.45E-5 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:3.28|P-value:5.85E-4 ID:SGTC_1611|Compound:st001856|FD-Score:4.34|P-value:8.69E-6 ID:SGTC_1668|Compound:st014914|FD-Score:3.20|P-value:7.79E-4 ID:SGTC_1672|Compound:st016598|FD-Score:-3.16|P-value:7.69E-4 ID:SGTC_1750|Compound:st081859|FD-Score:-3.16|P-value:7.66E-4 ID:SGTC_1770|Compound:st043884|FD-Score:3.34|P-value:4.83E-4 ID:SGTC_1794|Compound:st048918|FD-Score:-3.36|P-value:3.82E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:9.41|P-value:4.27E-21 ID:SGTC_1947|Compound:st076332|FD-Score:3.27|P-value:6.17E-4 ID:SGTC_2055|Compound:5235184|FD-Score:-3.12|P-value:8.84E-4 ID:SGTC_2077|Compound:5212015|FD-Score:3.40|P-value:3.77E-4 ID:SGTC_2123|Compound:5259487|FD-Score:-3.12|P-value:8.93E-4 ID:SGTC_2371|Compound:9071574|FD-Score:-3.30|P-value:4.72E-4 ID:SGTC_2477|Compound:5967686|FD-Score:3.18|P-value:8.37E-4 ID:SGTC_2791|Compound:5663188|FD-Score:3.48|P-value:2.82E-4 ID:SGTC_3040|Compound:9091894|FD-Score:3.56|P-value:2.14E-4 ID:SGTC_3142|Compound:9086498|FD-Score:3.34|P-value:4.70E-4 ID:SGTC_3181|Compound:9108277|FD-Score:5.25|P-value:9.42E-8 ID:SGTC_3219|Compound:9131112|FD-Score:3.62|P-value:1.68E-4 ID:SGTC_3278|Compound:9139605|FD-Score:-3.37|P-value:3.64E-4 ID:SGTC_3283|Compound:9109332|FD-Score:4.07|P-value:2.72E-5 ID:SGTC_17|Compound:0960-0276|FD-Score:3.53|P-value:2.34E-4 ID:SGTC_125|Compound:0133-0007|FD-Score:3.51|P-value:2.54E-4 ID:SGTC_144|Compound:4161-2749|FD-Score:3.18|P-value:8.39E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:4.22|P-value:1.42E-5 ID:SGTC_259|Compound:usnic acid|FD-Score:5.30|P-value:7.31E-8 ID:SGTC_367|Compound:0335-0881|FD-Score:3.85|P-value:6.79E-5 ID:SGTC_467|Compound:ro 31-8220|FD-Score:3.83|P-value:7.48E-5 ID:SGTC_468|Compound:gf-109203x|FD-Score:4.79|P-value:1.03E-6 ID:SGTC_469|Compound:w7|FD-Score:3.98|P-value:4.04E-5 ID:SGTC_470|Compound:aa-861|FD-Score:5.75|P-value:5.82E-9 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:8.98|P-value:2.39E-19 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:-3.43|P-value:2.93E-4 ID:SGTC_511|Compound:blebbistatin|FD-Score:3.69|P-value:1.32E-4 ID:SGTC_512|Compound:prima-1|FD-Score:4.10|P-value:2.47E-5 ID:SGTC_547|Compound:1120-0019|FD-Score:3.44|P-value:3.34E-4 ID:SGTC_561|Compound:1550-0330|FD-Score:4.57|P-value:2.93E-6 ID:SGTC_576|Compound:1073-0113|FD-Score:3.39|P-value:4.04E-4 ID:SGTC_633|Compound:0437-0093|FD-Score:3.81|P-value:8.18E-5 ID:SGTC_659|Compound:k018-0002|FD-Score:-3.22|P-value:6.21E-4 ID:SGTC_727|Compound:3032-0951|FD-Score:5.10|P-value:2.09E-7 ID:SGTC_731|Compound:3966-0296|FD-Score:3.46|P-value:3.11E-4 ID:SGTC_780|Compound:0109-0199|FD-Score:3.83|P-value:7.58E-5 ID:SGTC_867|Compound:0518-0118|FD-Score:4.55|P-value:3.31E-6 ID:SGTC_869|Compound:0564-0080|FD-Score:3.59|P-value:1.87E-4 ID:SGTC_872|Compound:0588-0139|FD-Score:4.38|P-value:7.08E-6 ID:SGTC_939|Compound:1165-0479|FD-Score:3.46|P-value:3.04E-4 ID:SGTC_950|Compound:1165-0508|FD-Score:-3.16|P-value:7.61E-4 ID:SGTC_966|Compound:1300-0360|FD-Score:-3.64|P-value:1.35E-4 ID:SGTC_1186|Compound:1319-0216|FD-Score:3.21|P-value:7.62E-4 ID:SGTC_1194|Compound:1488-0194|FD-Score:3.69|P-value:1.31E-4 ID:SGTC_1208|Compound:2323-2347|FD-Score:-3.97|P-value:3.52E-5 ID:SGTC_1214|Compound:0358-0031|FD-Score:4.54|P-value:3.47E-6 ID:SGTC_1255|Compound:0566-0045|FD-Score:-3.28|P-value:5.04E-4 ID:SGTC_1258|Compound:0671-0043|FD-Score:-3.85|P-value:5.92E-5 ID:SGTC_1278|Compound:0874-0585|FD-Score:3.37|P-value:4.27E-4 ID:SGTC_1290|Compound:0986-0249|FD-Score:3.35|P-value:4.62E-4 ID:SGTC_1299|Compound:1079-1439|FD-Score:3.44|P-value:3.35E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:4.36|P-value:7.85E-6 ID:SGTC_1427|Compound:4048-4900|FD-Score:-3.13|P-value:8.55E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:4.22|P-value:1.45E-5 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:3.28|P-value:5.85E-4 ID:SGTC_1611|Compound:st001856|FD-Score:4.34|P-value:8.69E-6 ID:SGTC_1668|Compound:st014914|FD-Score:3.20|P-value:7.79E-4 ID:SGTC_1672|Compound:st016598|FD-Score:-3.16|P-value:7.69E-4 ID:SGTC_1750|Compound:st081859|FD-Score:-3.16|P-value:7.66E-4 ID:SGTC_1770|Compound:st043884|FD-Score:3.34|P-value:4.83E-4 ID:SGTC_1794|Compound:st048918|FD-Score:-3.36|P-value:3.82E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:9.41|P-value:4.27E-21 ID:SGTC_1947|Compound:st076332|FD-Score:3.27|P-value:6.17E-4 ID:SGTC_2055|Compound:5235184|FD-Score:-3.12|P-value:8.84E-4 ID:SGTC_2077|Compound:5212015|FD-Score:3.40|P-value:3.77E-4 ID:SGTC_2123|Compound:5259487|FD-Score:-3.12|P-value:8.93E-4 ID:SGTC_2371|Compound:9071574|FD-Score:-3.30|P-value:4.72E-4 ID:SGTC_2477|Compound:5967686|FD-Score:3.18|P-value:8.37E-4 ID:SGTC_2791|Compound:5663188|FD-Score:3.48|P-value:2.82E-4 ID:SGTC_3040|Compound:9091894|FD-Score:3.56|P-value:2.14E-4 ID:SGTC_3142|Compound:9086498|FD-Score:3.34|P-value:4.70E-4 ID:SGTC_3181|Compound:9108277|FD-Score:5.25|P-value:9.42E-8 ID:SGTC_3219|Compound:9131112|FD-Score:3.62|P-value:1.68E-4 ID:SGTC_3278|Compound:9139605|FD-Score:-3.37|P-value:3.64E-4 ID:SGTC_3283|Compound:9109332|FD-Score:4.07|P-value:2.72E-5

Top fitness defect scores for YGR156W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1926 methyl fluorone black 9.41 53.6 µM 4.27E-21 DNA intercalators 4 2.37E-21 1.91
2 SGTC_471 1-acyl-paf 8.98 4.0 µM 2.39E-19 DNA intercalators 2 1.38E-19 0.51
3 SGTC_470 aa-861 5.75 153.0 µM 5.82E-9 sphingolipid biosynthesis & PDR1 6 4.44E-9 0.07
4 SGTC_259 usnic acid 5.30 108.9 µM 7.31E-8 3 5.75E-8 0.04
5 SGTC_3181 9108277 5.25 49.5 µM 9.42E-8 iron homeostasis 5 7.43E-8 0.12
6 SGTC_727 3032-0951 5.10 202.0 µM 2.09E-7 1 1.66E-7 1.28
7 SGTC_468 gf-109203x 4.79 121.0 µM 1.03E-6 amide catabolism 3 8.35E-7 1.33
8 SGTC_561 1550-0330 4.57 72.9 µM 2.93E-6 1 2.42E-6 0.54
9 SGTC_867 0518-0118 4.55 155.0 µM 3.31E-6 DNA intercalators 9 2.73E-6 0.05
10 SGTC_1214 0358-0031 4.54 63.7 µM 3.47E-6 2 2.86E-6 0.35
11 SGTC_872 0588-0139 4.38 234.0 µM 7.08E-6 3 5.90E-6 0.17
12 SGTC_1415 3966-0071 4.36 78.1 µM 7.85E-6 DNA intercalators 9 6.54E-6 0.46
13 SGTC_1611 st001856 4.34 99.4 µM 8.69E-6 3 7.26E-6 0.15
14 SGTC_145 3737-0113 4.22 38.4 µM 1.42E-5 DNA intercalators 41 1.20E-5 0.01
15 SGTC_1459 k035-0031 4.22 35.7 µM 1.45E-5 DNA intercalators 11 1.22E-5 0.02
16 SGTC_512 prima-1 4.10 270.0 µM 2.47E-5 DNA intercalators 12 2.09E-5 0.18
17 SGTC_3283 9109332 4.07 35.8 µM 2.72E-5 DNA intercalators 5 2.31E-5 0.53
18 SGTC_469 w7 3.98 172.0 µM 4.04E-5 ERG2 3 3.44E-5 0.05
19 SGTC_367 0335-0881 3.85 7.1 µM 6.79E-5 ubiquinone biosynthesis & proteasome 24 5.83E-5 0.04
20 SGTC_467 ro 31-8220 3.83 72.8 µM 7.48E-5 calcium & mitochondrial duress 22 6.42E-5 0.08

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.343 5.31E-93 YDR458C HEH2 hom Inner nuclear membrane (INM) protein; contains helix-extension-helix (HEH) motif, nuclear localization signal sequence; targeting to the INM requires the Srp1p-Kap95p karyopherins and the Ran cycle
0.332 3.68E-87 YMR208W ERG12 het Mevalonate kinase, acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate
0.309 6.48E-75 YDL058W USO1 het Essential protein involved in the vesicle-mediated ER to Golgi transport step of secretion; binds membranes and functions during vesicle docking to the Golgi; required for assembly of the ER-to-Golgi SNARE complex
0.286 2.84E-64 YOR294W RRS1 het Essential protein that binds ribosomal protein L11; required for nuclear export of the 60S pre-ribosomal subunit during ribosome biogenesis; localizes to the nucleolus and in foci along nuclear periphery; cooperates with Ebp2p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering; mouse homolog shows altered expression in Huntington's disease model mice
0.283 9.17E-63 YDR060W MAK21 het Constituent of 66S pre-ribosomal particles, required for large (60S) ribosomal subunit biogenesis; involved in nuclear export of pre-ribosomes; required for maintenance of dsRNA virus; homolog of human CAATT-binding protein
0.282 2.11E-62 YGL200C EMP24 hom Component of the p24 complex; binds to GPI anchor proteins and mediates their efficient transport from the ER to the Golgi; integral membrane protein that associates with endoplasmic reticulum-derived COPII-coated vesicles
0.270 5.64E-57 YER003C PMI40 het Mannose-6-phosphate isomerase, catalyzes the interconversion of fructose-6-P and mannose-6-P; required for early steps in protein mannosylation
0.256 1.61E-51 YOR278W HEM4 het Uroporphyrinogen III synthase, catalyzes the conversion of hydroxymethylbilane to uroporphyrinogen III, the fourth step in heme biosynthesis; deficiency in the human homolog can result in the disease congenital erythropoietic porphyria
0.235 3.91E-43 YJL085W EXO70 het Subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis prior to SNARE-mediated fusion; PtdIns[4,5]P2-binding protein that localizes to exocytic sites in an actin-independent manner, targeting and anchoring the exocyst with Sec3p; involved in exocyst assembly; direct downstream effector of Rho3p and Cdc42p; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.230 1.94E-41 YMR119W ASI1 hom Putative integral membrane E3 ubiquitin ligase; acts with Asi2p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals; ASI1 has a paralog, ASI3, that arose from the whole genome duplication
0.225 1.52E-39 YDR362C TFC6 het One of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; cooperates with Tfc3p in DNA binding; human homolog is TFIIIC-110
0.220 7.95E-38 YNL317W PFS2 het Integral subunit of the pre-mRNA cleavage and polyadenylation factor (CPF) complex; plays an essential role in mRNA 3'-end formation by bridging different processing factors and thereby promoting the assembly of the processing complex
0.213 1.34E-35 YDL223C HBT1 hom Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis
0.210 1.15E-34 YPL175W SPT14 het UDP-GlcNAc-binding and catalytic subunit of the enzyme that mediates the first step in glycosylphosphatidylinositol (GPI) biosynthesis, mutations cause defects in transcription and in biogenesis of cell wall proteins
0.208 5.39E-34 YPL157W TGS1 hom Trimethyl guanosine synthase, conserved nucleolar methyl transferase that converts the m(7)G cap structure of snRNAs, snoRNAs, and telomerase TLC1 RNA to m(2,2,7)G; also required for nucleolar assembly and splicing of meiotic pre-mRNAs