YGR157W / CHO2

Phosphatidylethanolamine methyltransferase (PEMT), catalyzes the first step in the conversion of phosphatidylethanolamine to phosphatidylcholine during the methylation pathway of phosphatidylcholine biosynthesis

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR157W / CHO2

Click on Significant Values for Screen Details ID:SGTC_45|Compound:0kpi-0036|FD-Score:4.28|P-value:2.01E-5 ID:SGTC_103|Compound:0844-0104|FD-Score:4.73|P-value:2.91E-6 ID:SGTC_159|Compound:3970-0959|FD-Score:3.45|P-value:4.57E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:3.61|P-value:2.64E-4 ID:SGTC_214|Compound:4373-3496|FD-Score:5.22|P-value:2.79E-7 ID:SGTC_342|Compound:k048-0088|FD-Score:4.24|P-value:2.36E-5 ID:SGTC_676|Compound:falcarinol|FD-Score:4.98|P-value:8.93E-7 ID:SGTC_720|Compound:r052-1644|FD-Score:3.42|P-value:5.17E-4 ID:SGTC_775|Compound:4577-0580|FD-Score:-3.27|P-value:8.94E-4 ID:SGTC_790|Compound:1575-0012|FD-Score:-4.32|P-value:1.80E-5 ID:SGTC_794|Compound:k038-0031|FD-Score:3.91|P-value:8.63E-5 ID:SGTC_954|Compound:1189-0853|FD-Score:-5.16|P-value:4.11E-7 ID:SGTC_960|Compound:1222-0186|FD-Score:4.62|P-value:4.67E-6 ID:SGTC_999|Compound:4022-0066|FD-Score:-3.44|P-value:5.17E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.98|P-value:6.58E-5 ID:SGTC_1272|Compound:0839-0021|FD-Score:-3.66|P-value:2.40E-4 ID:SGTC_1284|Compound:0929-0043|FD-Score:4.11|P-value:4.08E-5 ID:SGTC_1348|Compound:1493-0373|FD-Score:3.43|P-value:5.03E-4 ID:SGTC_1358|Compound:1509-0022|FD-Score:3.78|P-value:1.43E-4 ID:SGTC_1362|Compound:1611-0397|FD-Score:-3.72|P-value:1.91E-4 ID:SGTC_1529|Compound:apigenin|FD-Score:3.56|P-value:3.19E-4 ID:SGTC_1588|Compound:farnesol|FD-Score:3.36|P-value:6.33E-4 ID:SGTC_1721|Compound:st082152|FD-Score:-5.58|P-value:4.90E-8 ID:SGTC_1722|Compound:st034304|FD-Score:3.62|P-value:2.58E-4 ID:SGTC_1760|Compound:st045453|FD-Score:3.46|P-value:4.42E-4 ID:SGTC_1846|Compound:st056244|FD-Score:-3.36|P-value:6.64E-4 ID:SGTC_1858|Compound:4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione|FD-Score:-3.35|P-value:6.90E-4 ID:SGTC_1971|Compound:st069429|FD-Score:-4.22|P-value:2.78E-5 ID:SGTC_2107|Compound:5363541|FD-Score:-3.67|P-value:2.32E-4 ID:SGTC_2121|Compound:5257820|FD-Score:-3.29|P-value:8.35E-4 ID:SGTC_2170|Compound:morpholine|FD-Score:3.38|P-value:5.84E-4 ID:SGTC_2175|Compound:5807670|FD-Score:-3.55|P-value:3.47E-4 ID:SGTC_2452|Compound:5863136|FD-Score:3.58|P-value:2.97E-4 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:-3.70|P-value:2.03E-4 ID:SGTC_2701|Compound:st077767|FD-Score:3.69|P-value:2.02E-4 ID:SGTC_2762|Compound:leflunomide|FD-Score:4.71|P-value:3.18E-6 ID:SGTC_2763|Compound:lisinopril|FD-Score:-3.41|P-value:5.75E-4 ID:SGTC_2776|Compound:terbinafine|FD-Score:3.38|P-value:5.89E-4 ID:SGTC_2830|Compound:7992007|FD-Score:4.57|P-value:5.73E-6 ID:SGTC_2868|Compound:9035608|FD-Score:3.35|P-value:6.41E-4 ID:SGTC_2935|Compound:9038016|FD-Score:-3.74|P-value:1.75E-4 ID:SGTC_3034|Compound:9090421|FD-Score:-3.69|P-value:2.09E-4 ID:SGTC_3037|Compound:9091026|FD-Score:3.88|P-value:9.99E-5 ID:SGTC_3118|Compound:9124250|FD-Score:-3.37|P-value:6.55E-4 ID:SGTC_45|Compound:0kpi-0036|FD-Score:4.28|P-value:2.01E-5 ID:SGTC_103|Compound:0844-0104|FD-Score:4.73|P-value:2.91E-6 ID:SGTC_159|Compound:3970-0959|FD-Score:3.45|P-value:4.57E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:3.61|P-value:2.64E-4 ID:SGTC_214|Compound:4373-3496|FD-Score:5.22|P-value:2.79E-7 ID:SGTC_342|Compound:k048-0088|FD-Score:4.24|P-value:2.36E-5 ID:SGTC_676|Compound:falcarinol|FD-Score:4.98|P-value:8.93E-7 ID:SGTC_720|Compound:r052-1644|FD-Score:3.42|P-value:5.17E-4 ID:SGTC_775|Compound:4577-0580|FD-Score:-3.27|P-value:8.94E-4 ID:SGTC_790|Compound:1575-0012|FD-Score:-4.32|P-value:1.80E-5 ID:SGTC_794|Compound:k038-0031|FD-Score:3.91|P-value:8.63E-5 ID:SGTC_954|Compound:1189-0853|FD-Score:-5.16|P-value:4.11E-7 ID:SGTC_960|Compound:1222-0186|FD-Score:4.62|P-value:4.67E-6 ID:SGTC_999|Compound:4022-0066|FD-Score:-3.44|P-value:5.17E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.98|P-value:6.58E-5 ID:SGTC_1272|Compound:0839-0021|FD-Score:-3.66|P-value:2.40E-4 ID:SGTC_1284|Compound:0929-0043|FD-Score:4.11|P-value:4.08E-5 ID:SGTC_1348|Compound:1493-0373|FD-Score:3.43|P-value:5.03E-4 ID:SGTC_1358|Compound:1509-0022|FD-Score:3.78|P-value:1.43E-4 ID:SGTC_1362|Compound:1611-0397|FD-Score:-3.72|P-value:1.91E-4 ID:SGTC_1529|Compound:apigenin|FD-Score:3.56|P-value:3.19E-4 ID:SGTC_1588|Compound:farnesol|FD-Score:3.36|P-value:6.33E-4 ID:SGTC_1721|Compound:st082152|FD-Score:-5.58|P-value:4.90E-8 ID:SGTC_1722|Compound:st034304|FD-Score:3.62|P-value:2.58E-4 ID:SGTC_1760|Compound:st045453|FD-Score:3.46|P-value:4.42E-4 ID:SGTC_1846|Compound:st056244|FD-Score:-3.36|P-value:6.64E-4 ID:SGTC_1858|Compound:4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione|FD-Score:-3.35|P-value:6.90E-4 ID:SGTC_1971|Compound:st069429|FD-Score:-4.22|P-value:2.78E-5 ID:SGTC_2107|Compound:5363541|FD-Score:-3.67|P-value:2.32E-4 ID:SGTC_2121|Compound:5257820|FD-Score:-3.29|P-value:8.35E-4 ID:SGTC_2170|Compound:morpholine|FD-Score:3.38|P-value:5.84E-4 ID:SGTC_2175|Compound:5807670|FD-Score:-3.55|P-value:3.47E-4 ID:SGTC_2452|Compound:5863136|FD-Score:3.58|P-value:2.97E-4 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:-3.70|P-value:2.03E-4 ID:SGTC_2701|Compound:st077767|FD-Score:3.69|P-value:2.02E-4 ID:SGTC_2762|Compound:leflunomide|FD-Score:4.71|P-value:3.18E-6 ID:SGTC_2763|Compound:lisinopril|FD-Score:-3.41|P-value:5.75E-4 ID:SGTC_2776|Compound:terbinafine|FD-Score:3.38|P-value:5.89E-4 ID:SGTC_2830|Compound:7992007|FD-Score:4.57|P-value:5.73E-6 ID:SGTC_2868|Compound:9035608|FD-Score:3.35|P-value:6.41E-4 ID:SGTC_2935|Compound:9038016|FD-Score:-3.74|P-value:1.75E-4 ID:SGTC_3034|Compound:9090421|FD-Score:-3.69|P-value:2.09E-4 ID:SGTC_3037|Compound:9091026|FD-Score:3.88|P-value:9.99E-5 ID:SGTC_3118|Compound:9124250|FD-Score:-3.37|P-value:6.55E-4

Top fitness defect scores for YGR157W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_214 4373-3496 5.22 70.0 µM 2.79E-7 24 9.01E-8
2 SGTC_676 falcarinol 4.98 140.0 µM 8.93E-7 32 3.18E-7
3 SGTC_103 0844-0104 4.73 51.8 µM 2.91E-6 ERAD & cell cycle 109 1.14E-6
4 SGTC_2762 leflunomide 4.71 42.1 µM 3.18E-6 12 1.26E-6
5 SGTC_960 1222-0186 4.62 7.7 µM 4.67E-6 16 1.92E-6
6 SGTC_2830 7992007 4.57 71.4 µM 5.73E-6 13 2.39E-6
7 SGTC_45 0kpi-0036 4.28 14.9 µM 2.01E-5 excess fatty acid 17 9.31E-6
8 SGTC_342 k048-0088 4.24 23.3 µM 2.36E-5 RSC & ERG11 13 1.11E-5
9 SGTC_1284 0929-0043 4.11 16.0 µM 4.08E-5 20 2.01E-5
10 SGTC_1263 0774-1208 3.98 64.8 µM 6.58E-5 47 3.38E-5
11 SGTC_794 k038-0031 3.91 316.0 µM 8.63E-5 ubiquinone biosynthesis & proteasome 108 4.54E-5
12 SGTC_3037 9091026 3.88 49.5 µM 9.99E-5 NEO1-PIK1 127 5.31E-5
13 SGTC_1358 1509-0022 3.78 2.5 µM 1.43E-4 10 7.82E-5
14 SGTC_2701 st077767 3.69 14.7 µM 2.02E-4 54 1.14E-4
15 SGTC_1722 st034304 3.62 3.6 µM 2.58E-4 mitochondrial processes 41 1.49E-4
16 SGTC_168 3970-0862 3.61 530.5 µM 2.64E-4 141 1.52E-4
17 SGTC_2452 5863136 3.58 48.4 µM 2.97E-4 37 1.73E-4
18 SGTC_1529 apigenin 3.56 74.0 µM 3.19E-4 43 1.87E-4
19 SGTC_1760 st045453 3.46 10.4 µM 4.42E-4 NEO1-PIK1 165 2.66E-4
20 SGTC_159 3970-0959 3.45 50.0 µM 4.57E-4 110 2.76E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.139 7.75E-16 YJR042W NUP85 het Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis and is involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP85 aka NUP75
0.113 4.75E-11 YDR005C MAF1 hom Highly conserved negative regulator of RNA polymerase III; binds to the N-terminal domain of the Rpc160p subunit of Pol III to prevent closed-complex formation; localization and activity are regulated by phosphorylation, mediated by TORC1, protein kinase A, and Sch9p; localizes to cytoplasm during vegetative growth and translocates to the nucleus and nucleolus under stress conditions
0.110 2.21E-10 YFL033C RIM15 hom Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase
0.107 4.80E-10 YAL066W_d YAL066W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.102 3.01E-9 YDR155C CPR1 hom Cytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds the drug cyclosporin A; protein abundance increases in response to DNA replication stress
0.101 4.87E-9 YGR110W CLD1 hom Mitochondrial cardiolipin-specific phospholipase; functions upstream of Taz1p to generate monolyso-cardiolipin; transcription increases upon genotoxic stress; involved in restricting Ty1 transposition; has homology to mammalian CGI-58
0.101 5.57E-9 YML097C VPS9 hom A guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport; specifically stimulates the intrinsic guanine nucleotide exchange activity of Vps21p/Rab5: similar to mammalian ras inhibitors; binds ubiquitin
0.100 6.81E-9 YPR177C_d YPR177C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the 5' end of the essential PRP4 gene encoding a component of the U4/U6-U5 snRNP complex
0.100 7.63E-9 YER041W YEN1 hom Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p
0.099 9.37E-9 YDL148C NOP14 het Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA
0.097 1.82E-8 YLR186W EMG1 het Methyltransferase for rRNA; catalyzes methylation of the pseudouridine residue 1191 of 18S rRNA; member of the SPOUT methyltransferase family; required for maturation of 18S rRNA and for 40S ribosomal subunit production independently of methyltransferase activity; forms homodimers; human ortholog is mutated in Bowen-Conradi syndrome, and the equivalent mutation in yeast affects Emg1p dimerization and localization but not its methyltransferase activity
0.094 5.00E-8 YCR050C_p YCR050C_p hom Non-essential protein of unknown function; deletion mutant is synthetically sick or lethal with alpha-synuclein
0.094 5.76E-8 YAL051W OAF1 hom Oleate-activated transcription factor; acts alone and as a heterodimer with Pip2p; activates genes involved in beta-oxidation of fatty acids and peroxisome organization and biogenesis; OAF1 has a paralog, PIP2, that arose from the whole genome duplication
0.094 6.12E-8 YJL101C GSH1 hom Gamma glutamylcysteine synthetase; catalyzes the first step in glutathione (GSH) biosynthesis; expression induced by oxidants, cadmium, and mercury; protein abundance increases in response to DNA replication stress
0.091 1.34E-7 YMR276W DSK2 hom Nuclear-enriched ubiquitin-like polyubiquitin-binding protein; required for spindle pole body (SPB) duplication and for transit through the G2/M phase of the cell cycle; involved in proteolysis; interacts with the proteasome; protein abundance increases in response to DNA replication stress