YGR158C / MTR3

Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hMtr3p (EXOSC6)

Zygosity: Heterozygous strain
fixedexpanded
Profile for YGR158C / MTR3

Click on Significant Values for Screen Details ID:SGTC_118|Compound:0083-0097|FD-Score:3.50|P-value:4.16E-4 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:14.80|P-value:7.91E-46 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:4.33|P-value:1.78E-5 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:11.60|P-value:7.07E-29 ID:SGTC_553|Compound:k007-0256|FD-Score:3.58|P-value:3.18E-4 ID:SGTC_605|Compound:1315-0399|FD-Score:3.76|P-value:1.68E-4 ID:SGTC_610|Compound:4215-0184|FD-Score:7.08|P-value:6.85E-12 ID:SGTC_617|Compound:3770-0098|FD-Score:16.60|P-value:9.64E-57 ID:SGTC_832|Compound:4083-0019|FD-Score:4.19|P-value:3.16E-5 ID:SGTC_879|Compound:0831-1030|FD-Score:4.42|P-value:1.22E-5 ID:SGTC_1036|Compound:k216-0215|FD-Score:-4.53|P-value:7.28E-6 ID:SGTC_1047|Compound:2043-3044|FD-Score:-3.41|P-value:5.33E-4 ID:SGTC_1051|Compound:3253-3903|FD-Score:3.55|P-value:3.50E-4 ID:SGTC_1052|Compound:3253-3998|FD-Score:3.32|P-value:7.71E-4 ID:SGTC_1074|Compound:carmofur|FD-Score:13.10|P-value:1.72E-36 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:7.95|P-value:1.53E-14 ID:SGTC_1276|Compound:0871-0068|FD-Score:4.27|P-value:2.29E-5 ID:SGTC_1389|Compound:3405-0187|FD-Score:3.94|P-value:8.43E-5 ID:SGTC_1567|Compound:st069303|FD-Score:3.26|P-value:9.23E-4 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:-4.32|P-value:1.76E-5 ID:SGTC_1581|Compound:himbacine|FD-Score:-3.53|P-value:3.58E-4 ID:SGTC_1583|Compound:clindamycin|FD-Score:3.64|P-value:2.58E-4 ID:SGTC_1600|Compound:coumarin 106|FD-Score:-3.29|P-value:8.17E-4 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:8.42|P-value:4.36E-16 ID:SGTC_1700|Compound:st030840|FD-Score:3.42|P-value:5.52E-4 ID:SGTC_1702|Compound:st027038|FD-Score:3.48|P-value:4.44E-4 ID:SGTC_1715|Compound:st032160|FD-Score:-3.75|P-value:1.61E-4 ID:SGTC_1720|Compound:st037298|FD-Score:-3.62|P-value:2.57E-4 ID:SGTC_1730|Compound:st033808|FD-Score:3.75|P-value:1.70E-4 ID:SGTC_1765|Compound:st044815|FD-Score:3.79|P-value:1.47E-4 ID:SGTC_1889|Compound:st059080|FD-Score:5.48|P-value:8.40E-8 ID:SGTC_1952|Compound:st077036|FD-Score:-3.42|P-value:5.15E-4 ID:SGTC_1981|Compound:st071826|FD-Score:-4.10|P-value:4.28E-5 ID:SGTC_1992|Compound:st073643|FD-Score:4.49|P-value:9.25E-6 ID:SGTC_1997|Compound:st073024|FD-Score:4.60|P-value:5.64E-6 ID:SGTC_2000|Compound:st075254|FD-Score:5.54|P-value:6.21E-8 ID:SGTC_2033|Compound:5192550|FD-Score:3.59|P-value:3.07E-4 ID:SGTC_2036|Compound:5160441|FD-Score:-4.99|P-value:9.00E-7 ID:SGTC_2038|Compound:4100038|FD-Score:-3.59|P-value:2.93E-4 ID:SGTC_2046|Compound:4110841|FD-Score:-3.41|P-value:5.39E-4 ID:SGTC_2114|Compound:5491910|FD-Score:3.48|P-value:4.56E-4 ID:SGTC_2158|Compound:5657123|FD-Score:6.06|P-value:3.65E-9 ID:SGTC_2161|Compound:5662504|FD-Score:-3.33|P-value:7.08E-4 ID:SGTC_2280|Compound:7785178|FD-Score:-3.62|P-value:2.59E-4 ID:SGTC_2290|Compound:7904846|FD-Score:3.92|P-value:9.08E-5 ID:SGTC_2325|Compound:6158266|FD-Score:3.79|P-value:1.50E-4 ID:SGTC_2511|Compound:berberine|FD-Score:-3.28|P-value:8.34E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:3.66|P-value:2.40E-4 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:-3.52|P-value:3.76E-4 ID:SGTC_2940|Compound:9060638|FD-Score:4.28|P-value:2.16E-5 ID:SGTC_2947|Compound:9072639|FD-Score:3.75|P-value:1.74E-4 ID:SGTC_3044|Compound:9093193|FD-Score:3.71|P-value:1.99E-4 ID:SGTC_3052|Compound:9092717|FD-Score:3.87|P-value:1.12E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:3.87|P-value:1.11E-4 ID:SGTC_3084|Compound:9116877|FD-Score:5.70|P-value:2.68E-8 ID:SGTC_3211|Compound:9128781|FD-Score:-5.66|P-value:2.94E-8 ID:SGTC_3242|Compound:9133940|FD-Score:3.68|P-value:2.25E-4 ID:SGTC_3254|Compound:9136651|FD-Score:3.91|P-value:9.41E-5 ID:SGTC_3269|Compound:9137823|FD-Score:3.37|P-value:6.53E-4 ID:SGTC_3286|Compound:9117135|FD-Score:3.31|P-value:7.92E-4 ID:SGTC_3323|Compound:9138564|FD-Score:3.31|P-value:7.87E-4 ID:SGTC_3324|Compound:9138759|FD-Score:4.35|P-value:1.65E-5 ID:SGTC_3337|Compound:9144342|FD-Score:8.31|P-value:1.01E-15 ID:SGTC_3352|Compound:9151559|FD-Score:3.29|P-value:8.62E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:3.50|P-value:4.16E-4 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:14.80|P-value:7.91E-46 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:4.33|P-value:1.78E-5 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:11.60|P-value:7.07E-29 ID:SGTC_553|Compound:k007-0256|FD-Score:3.58|P-value:3.18E-4 ID:SGTC_605|Compound:1315-0399|FD-Score:3.76|P-value:1.68E-4 ID:SGTC_610|Compound:4215-0184|FD-Score:7.08|P-value:6.85E-12 ID:SGTC_617|Compound:3770-0098|FD-Score:16.60|P-value:9.64E-57 ID:SGTC_832|Compound:4083-0019|FD-Score:4.19|P-value:3.16E-5 ID:SGTC_879|Compound:0831-1030|FD-Score:4.42|P-value:1.22E-5 ID:SGTC_1036|Compound:k216-0215|FD-Score:-4.53|P-value:7.28E-6 ID:SGTC_1047|Compound:2043-3044|FD-Score:-3.41|P-value:5.33E-4 ID:SGTC_1051|Compound:3253-3903|FD-Score:3.55|P-value:3.50E-4 ID:SGTC_1052|Compound:3253-3998|FD-Score:3.32|P-value:7.71E-4 ID:SGTC_1074|Compound:carmofur|FD-Score:13.10|P-value:1.72E-36 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:7.95|P-value:1.53E-14 ID:SGTC_1276|Compound:0871-0068|FD-Score:4.27|P-value:2.29E-5 ID:SGTC_1389|Compound:3405-0187|FD-Score:3.94|P-value:8.43E-5 ID:SGTC_1567|Compound:st069303|FD-Score:3.26|P-value:9.23E-4 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:-4.32|P-value:1.76E-5 ID:SGTC_1581|Compound:himbacine|FD-Score:-3.53|P-value:3.58E-4 ID:SGTC_1583|Compound:clindamycin|FD-Score:3.64|P-value:2.58E-4 ID:SGTC_1600|Compound:coumarin 106|FD-Score:-3.29|P-value:8.17E-4 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:8.42|P-value:4.36E-16 ID:SGTC_1700|Compound:st030840|FD-Score:3.42|P-value:5.52E-4 ID:SGTC_1702|Compound:st027038|FD-Score:3.48|P-value:4.44E-4 ID:SGTC_1715|Compound:st032160|FD-Score:-3.75|P-value:1.61E-4 ID:SGTC_1720|Compound:st037298|FD-Score:-3.62|P-value:2.57E-4 ID:SGTC_1730|Compound:st033808|FD-Score:3.75|P-value:1.70E-4 ID:SGTC_1765|Compound:st044815|FD-Score:3.79|P-value:1.47E-4 ID:SGTC_1889|Compound:st059080|FD-Score:5.48|P-value:8.40E-8 ID:SGTC_1952|Compound:st077036|FD-Score:-3.42|P-value:5.15E-4 ID:SGTC_1981|Compound:st071826|FD-Score:-4.10|P-value:4.28E-5 ID:SGTC_1992|Compound:st073643|FD-Score:4.49|P-value:9.25E-6 ID:SGTC_1997|Compound:st073024|FD-Score:4.60|P-value:5.64E-6 ID:SGTC_2000|Compound:st075254|FD-Score:5.54|P-value:6.21E-8 ID:SGTC_2033|Compound:5192550|FD-Score:3.59|P-value:3.07E-4 ID:SGTC_2036|Compound:5160441|FD-Score:-4.99|P-value:9.00E-7 ID:SGTC_2038|Compound:4100038|FD-Score:-3.59|P-value:2.93E-4 ID:SGTC_2046|Compound:4110841|FD-Score:-3.41|P-value:5.39E-4 ID:SGTC_2114|Compound:5491910|FD-Score:3.48|P-value:4.56E-4 ID:SGTC_2158|Compound:5657123|FD-Score:6.06|P-value:3.65E-9 ID:SGTC_2161|Compound:5662504|FD-Score:-3.33|P-value:7.08E-4 ID:SGTC_2280|Compound:7785178|FD-Score:-3.62|P-value:2.59E-4 ID:SGTC_2290|Compound:7904846|FD-Score:3.92|P-value:9.08E-5 ID:SGTC_2325|Compound:6158266|FD-Score:3.79|P-value:1.50E-4 ID:SGTC_2511|Compound:berberine|FD-Score:-3.28|P-value:8.34E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:3.66|P-value:2.40E-4 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:-3.52|P-value:3.76E-4 ID:SGTC_2940|Compound:9060638|FD-Score:4.28|P-value:2.16E-5 ID:SGTC_2947|Compound:9072639|FD-Score:3.75|P-value:1.74E-4 ID:SGTC_3044|Compound:9093193|FD-Score:3.71|P-value:1.99E-4 ID:SGTC_3052|Compound:9092717|FD-Score:3.87|P-value:1.12E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:3.87|P-value:1.11E-4 ID:SGTC_3084|Compound:9116877|FD-Score:5.70|P-value:2.68E-8 ID:SGTC_3211|Compound:9128781|FD-Score:-5.66|P-value:2.94E-8 ID:SGTC_3242|Compound:9133940|FD-Score:3.68|P-value:2.25E-4 ID:SGTC_3254|Compound:9136651|FD-Score:3.91|P-value:9.41E-5 ID:SGTC_3269|Compound:9137823|FD-Score:3.37|P-value:6.53E-4 ID:SGTC_3286|Compound:9117135|FD-Score:3.31|P-value:7.92E-4 ID:SGTC_3323|Compound:9138564|FD-Score:3.31|P-value:7.87E-4 ID:SGTC_3324|Compound:9138759|FD-Score:4.35|P-value:1.65E-5 ID:SGTC_3337|Compound:9144342|FD-Score:8.31|P-value:1.01E-15 ID:SGTC_3352|Compound:9151559|FD-Score:3.29|P-value:8.62E-4

Top fitness defect scores for YGR158C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_617 3770-0098 16.60 35.0 µM 9.64E-57 exosome 2 6.52E-62 3.16
2 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 14.80 4.6 µM 7.91E-46 heat shock/prefoldin 4 5.64E-50 5.16
3 SGTC_1074 carmofur 13.10 3.8 µM 1.72E-36 exosome 3 9.21E-40 0.53
4 SGTC_423 5-fluorouracil 11.60 457.0 µM 7.07E-29 exosome 4 1.95E-31 2.32
5 SGTC_1698 5-fluorocytosine 8.42 1.1 µM 4.36E-16 exosome 5 1.89E-17 1.46
6 SGTC_3337 9144342 8.31 33.5 µM 1.01E-15 1 4.72E-17 1.40
7 SGTC_1077 5-fluorocytosine 7.95 377.0 nM 1.53E-14 exosome 8 9.22E-16 1.07
8 SGTC_610 4215-0184 7.08 155.0 µM 6.85E-12 exosome 7 7.30E-13 0.09
9 SGTC_2158 5657123 6.06 3.6 µM 3.65E-9 4 6.96E-10 0.31
10 SGTC_3084 9116877 5.70 49.5 µM 2.68E-8 1 6.15E-9 2.11
11 SGTC_2000 st075254 5.54 36.4 µM 6.21E-8 2 1.54E-8 1.39
12 SGTC_1889 st059080 5.48 5.2 µM 8.40E-8 1 2.14E-8 0.95
13 SGTC_1997 st073024 4.60 93.8 µM 5.64E-6 1 2.12E-6 0.55
14 SGTC_1992 st073643 4.49 23.3 µM 9.25E-6 mitochondrial processes 6 3.63E-6 0.13
15 SGTC_879 0831-1030 4.42 162.0 µM 1.22E-5 18 4.92E-6 0.25
16 SGTC_3324 9138759 4.35 60.8 µM 1.65E-5 4 6.81E-6 0.68
17 SGTC_261 5-fluorouridine 4.33 15.4 µM 1.78E-5 exosome 11 7.41E-6 0.28
18 SGTC_2940 9060638 4.28 45.9 µM 2.16E-5 amide catabolism 5 9.18E-6 0.35
19 SGTC_1276 0871-0068 4.27 94.2 µM 2.29E-5 4 9.75E-6 0.07
20 SGTC_832 4083-0019 4.19 164.0 µM 3.16E-5 translation 22 1.38E-5 0.02

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.599 0 YGR195W SKI6 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp41p (EXOSC4)
0.516 1.70E-227 YDL111C RRP42 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp42p (EXOSC7)
0.500 4.19E-212 YOL021C DIS3 het Exosome core complex catalytic subunit; possesses both endonuclease and 3'-5' exonuclease activity; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase R and to human DIS3; protein abundance increases in response to DNA replication stress
0.385 4.74E-119 YDR280W RRP45 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp45p (PM/SCL-75, EXOSC9); protein abundance increases in response to DNA replication stress
0.373 1.53E-111 YPL044C_d YPL044C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP4/YPL043W
0.359 9.51E-103 YGR095C RRP46 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp46p (EXOSC5)
0.334 2.78E-88 YPL043W NOP4 het Nucleolar protein, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; contains four RNA recognition motifs (RRMs)
0.330 6.06E-86 YNL232W CSL4 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain an S1 RNA binding domain; has similarity to human hCsl4p (EXOSC1)
0.319 2.19E-80 YKL172W EBP2 het Required for 25S rRNA maturation and 60S ribosomal subunit assembly; localizes to the nucleolus and in foci along nuclear periphery; constituent of 66S pre-ribosomal particles; cooperates with Rrs1p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering
0.310 8.38E-76 YPR142C_d YPR142C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RRP15, which is required for ribosomal RNA processing
0.276 6.49E-60 YPR143W RRP15 het Nucleolar protein, constituent of pre-60S ribosomal particles; required for proper processing of the 27S pre-rRNA at the A3 and B1 sites to yield mature 5.8S and 25S rRNAs
0.237 5.24E-44 YNL061W NOP2 het Probable RNA m(5)C methyltransferase, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; localized to the nucleolus; constituent of 66S pre-ribosomal particles
0.219 1.51E-37 YNL002C RLP7 het Nucleolar protein with similarity to large ribosomal subunit L7 proteins; constituent of 66S pre-ribosomal particles; plays an essential role in processing of precursors to the large ribosomal subunit RNAs
0.208 4.52E-34 YHR069C RRP4 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain RNA binding domains; has similarity to human hRrp4p (EXOSC2)
0.189 2.26E-28 YNL140C_p YNL140C_p hom Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps THO2/YNL139C