YGR161C_p / RTS3

Putative component of the protein phosphatase type 2A complex

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR161C / RTS3

Click on Significant Values for Screen Details ID:SGTC_47|Compound:0149-0135|FD-Score:-3.66|P-value:1.07E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:-3.40|P-value:2.93E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:-3.13|P-value:7.83E-4 ID:SGTC_198|Compound:3454-2873|FD-Score:-3.24|P-value:5.18E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:3.71|P-value:8.74E-5 ID:SGTC_278|Compound:4092-0821|FD-Score:-6.51|P-value:2.35E-11 ID:SGTC_359|Compound:0081-0058|FD-Score:3.85|P-value:4.99E-5 ID:SGTC_541|Compound:4513-1321|FD-Score:-4.76|P-value:7.44E-7 ID:SGTC_602|Compound:3130-1533|FD-Score:3.63|P-value:1.21E-4 ID:SGTC_703|Compound:3875-0075|FD-Score:3.70|P-value:9.16E-5 ID:SGTC_726|Compound:3448-4391|FD-Score:3.15|P-value:7.24E-4 ID:SGTC_738|Compound:1315-0003|FD-Score:3.96|P-value:3.16E-5 ID:SGTC_751|Compound:0833-0568|FD-Score:-3.20|P-value:5.94E-4 ID:SGTC_803|Compound:4488-1585|FD-Score:3.32|P-value:4.00E-4 ID:SGTC_921|Compound:1561-0023|FD-Score:4.61|P-value:1.61E-6 ID:SGTC_933|Compound:2914-0560|FD-Score:3.68|P-value:1.01E-4 ID:SGTC_961|Compound:1252-1571|FD-Score:3.57|P-value:1.55E-4 ID:SGTC_1073|Compound:triclabendazole|FD-Score:3.51|P-value:1.95E-4 ID:SGTC_1480|Compound:1070-0044|FD-Score:3.28|P-value:4.51E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:3.07|P-value:9.64E-4 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:4.07|P-value:1.96E-5 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:3.17|P-value:6.70E-4 ID:SGTC_1713|Compound:st033146|FD-Score:-3.56|P-value:1.56E-4 ID:SGTC_1720|Compound:st037298|FD-Score:-3.60|P-value:1.36E-4 ID:SGTC_1819|Compound:st053448|FD-Score:3.88|P-value:4.35E-5 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:4.73|P-value:8.54E-7 ID:SGTC_1844|Compound:rapamycin|FD-Score:4.49|P-value:2.87E-6 ID:SGTC_1950|Compound:st077106|FD-Score:3.19|P-value:6.23E-4 ID:SGTC_1956|Compound:st077085|FD-Score:-3.10|P-value:8.64E-4 ID:SGTC_2011|Compound:4012611|FD-Score:3.44|P-value:2.54E-4 ID:SGTC_2051|Compound:5263410|FD-Score:-3.77|P-value:6.82E-5 ID:SGTC_2055|Compound:5235184|FD-Score:-5.88|P-value:1.39E-9 ID:SGTC_2185|Compound:6113692|FD-Score:-3.54|P-value:1.73E-4 ID:SGTC_2412|Compound:st077135|FD-Score:3.62|P-value:1.28E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:3.61|P-value:1.34E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-3.41|P-value:2.81E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:-4.42|P-value:3.99E-6 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.68|P-value:1.01E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:3.85|P-value:4.99E-5 ID:SGTC_2881|Compound:9058953|FD-Score:3.43|P-value:2.61E-4 ID:SGTC_2887|Compound:9044784|FD-Score:3.95|P-value:3.20E-5 ID:SGTC_2896|Compound:9052656|FD-Score:4.05|P-value:2.11E-5 ID:SGTC_3149|Compound:9097855|FD-Score:-4.46|P-value:3.26E-6 ID:SGTC_3153|Compound:9100258|FD-Score:5.59|P-value:8.01E-9 ID:SGTC_3198|Compound:9112019|FD-Score:4.10|P-value:1.71E-5 ID:SGTC_3233|Compound:9132340|FD-Score:-3.23|P-value:5.41E-4 ID:SGTC_47|Compound:0149-0135|FD-Score:-3.66|P-value:1.07E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:-3.40|P-value:2.93E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:-3.13|P-value:7.83E-4 ID:SGTC_198|Compound:3454-2873|FD-Score:-3.24|P-value:5.18E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:3.71|P-value:8.74E-5 ID:SGTC_278|Compound:4092-0821|FD-Score:-6.51|P-value:2.35E-11 ID:SGTC_359|Compound:0081-0058|FD-Score:3.85|P-value:4.99E-5 ID:SGTC_541|Compound:4513-1321|FD-Score:-4.76|P-value:7.44E-7 ID:SGTC_602|Compound:3130-1533|FD-Score:3.63|P-value:1.21E-4 ID:SGTC_703|Compound:3875-0075|FD-Score:3.70|P-value:9.16E-5 ID:SGTC_726|Compound:3448-4391|FD-Score:3.15|P-value:7.24E-4 ID:SGTC_738|Compound:1315-0003|FD-Score:3.96|P-value:3.16E-5 ID:SGTC_751|Compound:0833-0568|FD-Score:-3.20|P-value:5.94E-4 ID:SGTC_803|Compound:4488-1585|FD-Score:3.32|P-value:4.00E-4 ID:SGTC_921|Compound:1561-0023|FD-Score:4.61|P-value:1.61E-6 ID:SGTC_933|Compound:2914-0560|FD-Score:3.68|P-value:1.01E-4 ID:SGTC_961|Compound:1252-1571|FD-Score:3.57|P-value:1.55E-4 ID:SGTC_1073|Compound:triclabendazole|FD-Score:3.51|P-value:1.95E-4 ID:SGTC_1480|Compound:1070-0044|FD-Score:3.28|P-value:4.51E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:3.07|P-value:9.64E-4 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:4.07|P-value:1.96E-5 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:3.17|P-value:6.70E-4 ID:SGTC_1713|Compound:st033146|FD-Score:-3.56|P-value:1.56E-4 ID:SGTC_1720|Compound:st037298|FD-Score:-3.60|P-value:1.36E-4 ID:SGTC_1819|Compound:st053448|FD-Score:3.88|P-value:4.35E-5 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:4.73|P-value:8.54E-7 ID:SGTC_1844|Compound:rapamycin|FD-Score:4.49|P-value:2.87E-6 ID:SGTC_1950|Compound:st077106|FD-Score:3.19|P-value:6.23E-4 ID:SGTC_1956|Compound:st077085|FD-Score:-3.10|P-value:8.64E-4 ID:SGTC_2011|Compound:4012611|FD-Score:3.44|P-value:2.54E-4 ID:SGTC_2051|Compound:5263410|FD-Score:-3.77|P-value:6.82E-5 ID:SGTC_2055|Compound:5235184|FD-Score:-5.88|P-value:1.39E-9 ID:SGTC_2185|Compound:6113692|FD-Score:-3.54|P-value:1.73E-4 ID:SGTC_2412|Compound:st077135|FD-Score:3.62|P-value:1.28E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:3.61|P-value:1.34E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-3.41|P-value:2.81E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:-4.42|P-value:3.99E-6 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.68|P-value:1.01E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:3.85|P-value:4.99E-5 ID:SGTC_2881|Compound:9058953|FD-Score:3.43|P-value:2.61E-4 ID:SGTC_2887|Compound:9044784|FD-Score:3.95|P-value:3.20E-5 ID:SGTC_2896|Compound:9052656|FD-Score:4.05|P-value:2.11E-5 ID:SGTC_3149|Compound:9097855|FD-Score:-4.46|P-value:3.26E-6 ID:SGTC_3153|Compound:9100258|FD-Score:5.59|P-value:8.01E-9 ID:SGTC_3198|Compound:9112019|FD-Score:4.10|P-value:1.71E-5 ID:SGTC_3233|Compound:9132340|FD-Score:-3.23|P-value:5.41E-4

Top fitness defect scores for YGR161C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3153 9100258 5.59 49.5 µM 8.01E-9 3 1.14E-8
2 SGTC_1823 3-hydroxy-2-naphthoic acid 4.73 106.0 µM 8.54E-7 5 1.10E-6
3 SGTC_921 1561-0023 4.61 372.0 µM 1.61E-6 9 2.05E-6
4 SGTC_1844 rapamycin 4.49 4.0 nM 2.87E-6 127 3.61E-6
5 SGTC_3198 9112019 4.10 49.5 µM 1.71E-5 mitochondrial processes 13 2.07E-5
6 SGTC_1551 6-bromo-3'-methylflavone 4.07 63.5 µM 1.96E-5 9 2.37E-5
7 SGTC_2896 9052656 4.05 71.4 µM 2.11E-5 endomembrane recycling 107 2.55E-5
8 SGTC_738 1315-0003 3.96 72.4 µM 3.16E-5 21 3.79E-5
9 SGTC_2887 9044784 3.95 58.4 µM 3.20E-5 fatty acid desaturase (OLE1) 26 3.84E-5
10 SGTC_1819 st053448 3.88 58.6 µM 4.35E-5 amide catabolism 22 5.18E-5
11 SGTC_359 0081-0058 3.85 15.9 µM 4.99E-5 60S ribosome export 47 5.92E-5
12 SGTC_2679 rapamycin 3.85 1.0 nM 4.99E-5 151 5.92E-5
13 SGTC_212 3807-4682 3.71 38.8 µM 8.74E-5 tubulin folding & SWR complex 85 1.03E-4
14 SGTC_703 3875-0075 3.70 71.8 µM 9.16E-5 11 1.07E-4
15 SGTC_2651 1327-0036 3.68 5.0 µM 1.01E-4 181 1.18E-4
16 SGTC_933 2914-0560 3.68 114.0 µM 1.01E-4 30 1.19E-4
17 SGTC_602 3130-1533 3.63 38.1 µM 1.21E-4 23 1.41E-4
18 SGTC_2412 st077135 3.62 33.4 µM 1.28E-4 35 1.50E-4
19 SGTC_2563 tomatine 3.61 8.5 µM 1.34E-4 68 1.56E-4
20 SGTC_961 1252-1571 3.57 372.0 µM 1.55E-4 44 1.80E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.168 1.32E-22 YKL203C TOR2 het PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; TOR2 has a paralog, TOR1, that arose from the whole genome duplication
0.162 3.40E-21 YJR066W TOR1 hom PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication
0.157 7.71E-20 YLR114C AVL9 hom Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.135 3.68E-15 YGR163W GTR2 hom Putative GTP binding protein that negatively regulates Ran/Tc4 GTPase cycle; activates transcription; subunit of EGO and GSE complexes; required for sorting of Gap1p; localizes to cytoplasm and to chromatin; homolog of human RagC and RagD
0.130 5.14E-14 YHR186C KOG1 het Subunit of TORC1, a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors
0.129 5.48E-14 YJL054W TIM54 het Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane
0.126 2.58E-13 YHR187W IKI1 hom Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; iki1 mutations confer resistance to the K. lactis toxin zymocin
0.124 7.44E-13 YDR158W HOM2 hom Aspartic beta semi-aldehyde dehydrogenase, catalyzes the second step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.120 3.43E-12 YFL024C EPL1 het Subunit of NuA4, an essential histone H4/H2A acetyltransferase complex; conserved region at N-terminus is essential for interaction with the NPC (nucleosome core particle); required for autophagy; homologous to Drosophila Enhancer of Polycomb
0.120 3.38E-12 YKL110C KTI12 hom Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p
0.118 7.88E-12 YOR297C TIM18 hom Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; may mediate assembly or stability of the complex
0.117 1.13E-11 YHR036W BRL1 het Essential nuclear envelope integral membrane protein identified as a suppressor of a conditional mutation in the major karyopherin, CRM1; homologous to and interacts with Brr6p, a nuclear envelope protein involved in nuclear export
0.117 1.16E-11 YLR384C IKI3 hom Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD)
0.116 1.64E-11 YKR007W MEH1 hom Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; loss results in a defect in vacuolar acidification
0.116 1.61E-11 YML121W GTR1 hom Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB